MedWorm: Clobetasol

  Adjuvant triamcinolone acetonide injections in oro-pharyngeal pemphigus vulgaris

Conclusion Perilesional/intralesional triamcinolone acetonide injections seems to represent a helpful clinical tool to successfully join CIST, in terms of shortening the time of complete clinical remission, reducing the total amount of corticosteroids and obtaining an acceptable compliance. (Source: Journal of the European Academy of Dermatology and Venereology)

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  Review: Lichen sclerosus

Source: BMJ Area: News The British Medical Journal has featured a review on the diagnosis and management of lichen sclerosis. The review starts with a case vignette, and discusses clinical features and investigations required for the diagnosis.   In terms of management, the review states, "After diagnosis, the accepted treatment is with the very potent topical steroid clobetasol propionate ointment. No controlled trials have been published to establish the best regime, but the guidelines suggest a single application at night for four weeks followed by alternate nights for four weeks and then twice a week for four weeks. Once symptoms are well controlled, the steroid ointment is used as required. Some patients will achieve complete remission; others will require ongoing treatment....

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  HPA-suppressive effects of aqueous clobetasol propionate in the treatment of patients with oral lichen planus

Conclusions Hypothalamus[ndash]pituitary[ndash]adrenal inhibition is substantial during initial treatment with aqueous CP three times daily. (Source: Journal of the European Academy of Dermatology and Venereology)

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  CORMAX (Clobetasol Propionate) Ointment [DPT Laboratories, Ltd.]

Updated Date: Jan 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CORMAX (Clobetasol Propionate) Ointment [Watson Pharma, Inc. ]

Updated Date: Jan 27, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice

Please cite this paper as: Topical hydrocortisone, clobetasol propionate, and calcipotriol do not increase photocarcinogenesis induced by simulated solar irradiation in hairless mice. Experimental Dermatology 2010.Abstract: Topical corticosteroids such as hydrocortisone-17-butyrate (HCB) and clobetasol-17-propionate (CP) and vitamin D3 derivatives such as calcipotriol (CAL) are widely used to treat psoriasis. The immunosuppressive effects of corticosteroids make their topical use a concern for skin carcinogenicity. Few studies have assessed the effect of topical corticosteroids and topical vitamin D3 derivatives on photocarcinogenesis induced by ultraviolet radiation. We investigated whether HCB, CP, or CAL can accelerate photocarcinogenesis using simulated solar radiation (SSR). HCB, CP, ...

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  CLOBETASOL PROPIONATEaerosol, Foam [Prasco LLC]

Updated Date: Jan 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Rapid resolution of primary vulval adult Langerhans cell histiocytosis with very potent topical corticosteroids

We report a 62-year-old female patient presenting with an 18-month history of pruritus and burning of the vulva. Clinical examination of the vulva showed a tender nodule of the right labium minus. Histology confirmed Langerhans cell histiocytosis. Systemic involvement was excluded. Within 1 month the use of clobetasol propionate ointment led to resolution of both the patient's symptoms and the clinical appearance of the affected right labium minus. This resolution was maintained 12 months later. (Source: Australasian Journal of Dermatology)

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  Erosive pustular dermatosis of the leg: Long-term control with topical tacrolimus

We report the cases of two women who developed erythematous skin plaques with pustules that coalesced and evolved into erosions and crusted areas. Histology showed epidermal spongiosis with subcorneal pustules and a dermal infiltrate with eosinophils and neutrophils. Lesions were treated with topical clobetasol propionate 0.05% for 10 days followed by topical tacrolimus daily until complete resolution, and then twice weekly for 1 year, without relapse. The response to topical corticosteroids and tacrolimus further support the close relationship with erosive pustular dermatosis of the scalp. Topical therapy with tacrolimus may offer good long-term disease control. (Source: Australasian Journal of Dermatology)

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  Perrigo Confirms Filing For Generic Version Of Clobex® Spray And Announcement Of Lawsuit By Galderma And Dermalogix

Perrigo Company (Nasdaq: PRGO ; TASE) today announced that it has filed an Abbreviated New Drug Application for Clobetasol Propionate Topical Spray, 0.05%, a generic form of Clobex® Spray. (Source: Pharmaceutical Online News)

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  Severe 20-nail psoriasis successfully treated by low dose methotrexate.

We report a case of severe psoriatic nail dystrophy involving all 20 nails successfully treated by low dose MTX. A previously healthy 11-year-old girl presented with painful deformity involving all 20 nails that developed over a one-month period. Examination revealed geographic and fissured tongue, as well as severe nail dystrophy of all 20 nails characterized by erythematous swelling of the nail folds, yellowish discoloration of nail plates with pitting, severe crumbling and destruction, transverse depressions, prominent oil spots, and swelling of proximal nail. Topical clobetasol propionate and calcipotriol were tried first but the nail dystrophy continued to progress. Low dose of MTX (5 mg per week) was initiated. The response was fairly satisfactory with emergence of normal plate proxi...

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  CLOBETASOL PROPIONATEointment CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEgel [E. FOUGERA CO., A Division Of Nycomed US Inc.]

Updated Date: Dec 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Clobetasol: Mood disorders in an elderly patient: case report

(Source: Reactions)

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  Ultrasound evaluation of clobetasol propionate 0.05% foam application in psoriatic and healthy skin: a pilot study

The aim of the present study was to evaluate through ultrasound imaging the response to treatment of twice and once daily application of clobetasol propionate 0.05% foam on psoriatic skin as well as the atrophogenic potential of once daily application of the foam on healthy skin. The study included a total of 40 participants, 30 affected by Psoriasis vulgaris and 10 healthy volunteers. Patients with psoriasis were branched in two groups of 15 subjects: in the first group, clobetasol propionate 0.05% foam was applied twice daily for up to 2 weeks on targeted plaques, in the second group, it was applied once daily for up to 4 weeks. Ten healthy adult volunteers were instructed to apply the foam to a 4 × 4 cm area on the volar aspect of the forearm once daily for 4 weeks. Ultrasound evaluati...

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  CLOBETASOL PROPIONATEaerosol, Foam [DPT Laboratories, Ltd.]

Updated Date: Oct 26, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Treatment of scalp psoriasis with clobetasol-17 propionate 0.05% shampoo: a study on daily clinical practice

Conclusions Short-contact treatment with clobetasol-17 propionate 0.05% shampoo has high user convenience and patient satisfaction rates. Moreover, the treatment is well-tolerated and efficacious from patients' perspective. Subgroup analyses did not reveal factors predicting treatment outcome, although treatment success tended to be more evident in patients who had received fewer treatments previously. (Source: Journal of the European Academy of Dermatology and Venereology)

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  CLOBETASOL PROPIONATEsolution [E. FOUGERA CO. A Division Of Nycomed US Inc.]

Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Topical Clobetasol Propionate in the Treatment of Psoriasis: A Review of Newer Formulations

(Source: American Journal of Clinical Dermatology)

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  Repeated mechanical trauma to the hands: the use of anti-impaction gloves for treatment and return to work.

CONCLUSION: Anti-impaction gloves are shown to aid in the return-to-work process for those with FHD but not for those with HHD. PMID: 19808004 [PubMed - in process] (Source: Dermatitis)

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  Double-blind, crossover, placebo-controlled clinical trial with clobetasol propionate in desquamative gingivitis.

Authors: Motta AC, Domaneschi C, Komesu MC, Souza Cda S, Aoki V, Migliari DA The aim of this study was to evaluate the efficacy of a 0.05% clobetasol propionate ointment administered in trays to 22 patients with desquamative gingivitis in a double-blind, crossover, placebo-controlled trial. Patients received container number 1 and were instructed to apply the ointment 3 times a day for 2 weeks, and to reduce the application to once a day in the third week. Next, the patients were then instructed to discontinue the treatment for 2 weeks, and were then given container 2, used in the same way and for the same length of time as container 1. Regarding signs, 17 patients presented some improvement, while 5 experienced worsening with clobetasol propionate. With the placebo, 14 patients presen...

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  TEMOVATE (Clobetasol Propionate) Solution [PharmaDerm, A Division Of Nycomed US Inc.]

Updated Date: Sep 24, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  What's new in urticaria ?

Ghosh SanjayIndian Journal of Dermatology 2009 54(3):280-282Urticaria, a perplexing disease of ever-changing explanations, is being renovated almost everyday by newer facts and findings accumulated from different parts of the globe. Cost of the urticaria treatment gradually grows higher and higher whereas the ailment disturbs the quality of life very adversely. Disorder of coagulation cascade has recently thrown some new light into its mechanism. Non-allergic angioedema induced by bradykinin caused by genetic defects and ACE-inhibitors has also been noted. Role of <i> H. pylori </i> in the pathogenesis of urticaria has also been re-reviewed. Urticaria could sometimes mimic erythema multiforme and is termed urticaria multiforme. Skin biopsy showed fea...

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  CLOBETASOL PROPIONATEemulsion [Glenmark Generics Inc., USA]

Updated Date: Aug 26, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CLOBEX (Clobetasol Propionate) Shampoo [DPT Laboratories, Ltd.]

Updated Date: Aug 25, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CORMAX (Clobetasol Propionate) Ointment [DPT Laboratories, Ltd.]

Updated Date: Aug 25, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CLOBETASOL PROPIONATEaerosol, Foam [DPT Laboratories, Ltd.]

Updated Date: Aug 25, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CLOBETASOL PROPIONATEsolution [Glenmark Generics Inc., USA]

Updated Date: Aug 25, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEointment [Glenmark Generics Inc., USA]

Updated Date: Aug 21, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Effects of topical treatment with the raft modulator miltefosine and clobetasol in cutaneous mastocytosis: a randomized, double-blind, placebo-controlled trial

Conclusions Raft modulators such as miltefosine are promising candidates for novel therapeutic strategies in patients with cutaneous mastocytosis. Future studies should be performed with improved formulations using nonirritant vehicles. (Source: British Journal of Dermatology)

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  Refractory subacute cutaneous lupus erythematosus successfully treated with rituximab.

Authors: Kieu V, O'Brien T, Yap LM, Baker C, Foley P, Mason G, Prince HM, McCormack C A 48-year-old woman presented with pruritic, scaly, annular plaques over her upper back and chest that were clinically, serologically and histologically characteristic of subacute cutaneous lupus erythematosus (SCLE). She failed to respond to conventional treatment, which included high-dose hydroxychloroquine, methotrexate, prednisolone, chloroquine, acitretin, thalidomide, dapsone and azathioprine. Subsequently treated with intravenous rituximab 375 mg/m(2) weekly for 4 weeks, she remained on adjuvant oral hydrochloroquine 600 mg daily and topical clobetasol propionate 0.05% ointment as required. Clearing of annular plaques was noted 8 weeks after the initial course of rituximab. By 12 weeks there we...

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  Refractory subacute cutaneous lupus erythematosus successfully treated with rituximab

A 48-year-old woman presented with pruritic, scaly, annular plaques over her upper back and chest that were clinically, serologically and histologically characteristic of subacute cutaneous lupus erythematosus (SCLE). She failed to respond to conventional treatment, which included high-dose hydroxychloroquine, methotrexate, prednisolone, chloroquine, acitretin, thalidomide, dapsone and azathioprine. Subsequently treated with intravenous rituximab 375 mg/m2 weekly for 4 weeks, she remained on adjuvant oral hydrochloroquine 600 mg daily and topical clobetasol propionate 0.05% ointment as required. Clearing of annular plaques was noted 8 weeks after the initial course of rituximab. By 12 weeks there were no new lesions and only post-inflammatory hyperpigmentation remained. Both hyper- and hyp...

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  CLOBETASOL PROPIONATEgel CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEointment [E. FOUGERA CO.]

Updated Date: Jun 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Nanoencapsulation as a Way to Control the Release and to Increase the Photostability of Clobetasol Propionate: Influence of the Nanostructured System

(Source: Journal of Biomedical Nanotechnology)

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  CLOBETASOL PROPIONATEgel [Glenmark Generics Inc., USA]

Updated Date: Jun 24, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CLOBETASOL PROPIONATEgel CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEointment [E. FOUGERA CO.]

Updated Date: Jun 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CLOBETASOL PROPIONATEsolution [E. FOUGERA CO.]

Updated Date: Jun 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Efficacy of topical tacrolimus 0.3% in clobetasol propionate 0.05% ointment in therapy-resistant cutaneous lupus erythematosus: a cohort study

Conclusion. The results of our small retrospective study suggest that TCPO may be more effective than either 0.1% tacrolimus or clobetasol propionate 0.05% ointment monotherapy in the treatment of recalcitrant CLE. Randomized controlled trials are needed to confirm these preliminary findings. (Source: Clinical And Experimental Dermatology)

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  Clobevate (Clobetasol Propionate Gel) - new on RxList

Clobevate (Clobetasol Propionate Gel) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

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  Effect of Intracanal Corticosteroids on Healing of Replanted Dog Teeth after Extended Dry Times

This study investigated the effect of potent intracanal corticosteroids on periodontal healing of replanted avulsed teeth and evaluated the systemic absorption of these corticosteroids. Sixty-seven extracted dog premolar roots were randomly assigned to one of the following groups: groups 1–3 filled with gutta-percha and replanted immediately and after 40 and 60 minutes, respectively; groups 4 and 5 filled with 0.05% clobetasol; and groups 6 and 7 filled with 0.05 % fluocinonide. Groups 4 and 6 were replanted after 40 minutes and groups 5 and 7 after 60 minutes. After 4 months, roots were evaluated histologically for signs of periodontal healing. Roots treated with clobetasol and fluocinonide healed more favorably than roots filled with gutta-percha and were different from each other at 6...

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  [Efficacy of rituximab in a case of refractory bullous pemphigoid]

CONCLUSION: Rituximab could offer a safe and effective therapeutic alternative for refractory BP. PMID: 19442800 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)

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  Melanocytic proliferations associated with lichen sclerosus in adolescence

In this report, we describe the case of a prepubertal girl presenting with a junctional melanocytic nevus of the labia minora superimposed by lichen sclerosus. The lesion was completely excised and free margins confirmed by histological examination. After a 3 months course of topical clobetasol treatment the girl remained asymptomatic. No local recurrence was notified with a follow-up time of 12 months. Content Type Journal ArticleCategory Case ReportDOI 10.1007/s00404-009-1049-5Authors Stefanie Susanne Bussen, Women’s University Hospital of Mannheim Rathausstr. 25 68519 Viernheim Germany Journal Archives of Gynecology and ObstetricsOnline ISSN 1432-0711Print ISSN 0932-0067 (Source: Archives of Gynecology and Obstetrics)

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  Docetaxel: Dermatitis treated with clobetasol: case report

(Source: Reactions)

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  Docetaxel: Dermatitis treated with clobetasol: case report.

Page: 20 (Source: Reactions Weekly)

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  Halobetasol versus clobetasol: A study of potency

Mohandas Soumya, Rai Reena, Srinivas C RIndian Journal of Dermatology, Venereology and Leprology 2009 75(2):186-187 (Source: Indian Journal of Dermatology, Venereology and Leprology)

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  Galderma Announces Interim Data Relating To Sequential Treatment Regimen Of Clobex(R) Spray Followed By Vectical(TM) Ointment In Managing Psoriasis

Galderma Laboratories, L.P. announced interim findings from a study of sequential treatment of plaque psoriasis using Clobex(R) (clobetasol propionate) Spray 0.05% followed by treatment with Vectical(TM) (calcitriol) Ointment 3mcg/g. (Source: Health News from Medical News Today)

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  Galderma Announces Interim Data Relating to Sequential Treatment Regimen of Clobex Spray Followed by Vectical Ointment in Managing Plaque Psoriasis

SAN FRANCISCO, March 06, 2009 /PRNewswire/ -- Galderma Laboratories, L.P. today announced interim findings from a study of sequential treatment of plaque psoriasis using Clobex (clobetasol propionate) Spray 0.05% followed by treatment with... (Source: Drugs.com - Clinical Trials)

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  Capsaicin vs. clobetasol for the treatment of localized alopecia areata

(Source: Journal of the European Academy of Dermatology and Venereology)

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  Clobetasol: Cushing's syndrome in an infant: case report.

Page: 15 (Source: Reactions Weekly)

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  Clobetasol: Cushing's syndrome in an infant: case report

(Source: Reactions)

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  Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis

Please cite this paper as: Activators of PPARs and LXR decrease the adverse effects of exogenous glucocorticoids on the epidermis. Experimental Dermatology 2009.Abstract: While glucocorticoids (GC) exert beneficial effects (anti-inflammatory), they also have adverse effects on the epidermis including decreased epidermal differentiation, decreased keratinocyte proliferation, and decreased cutaneous permeability barrier homeostasis. Thus, the purpose of this study was to develop strategies to prevent these GC toxicities using simultaneous topical treatments in clobetasol-treated mice. While a triple-lipid mixture of stratum corneum lipids (ceramide, free fatty acid and cholesterol) was previously shown to reverse the GC-induced abnormality in cutaneous barrier function [J Invest Dermatol, 12...

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  Clobetasol: Cushing's syndrome with adrenal suppression in an elderly patient: case report.

Page: 11 (Source: Reactions Weekly)

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  Clobetasol: Cushing's syndrome with adrenal suppression in an elderly patient: case report

(Source: Reactions)

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  CLOBETASOL PROPIONATEgel [Perrigo]

Updated Date: Jan 5, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Topical clobetasol in the treatment of atrophic-erosive oral lichen planus: a randomized controlled trial to compare two preparations with different concentrations

J Oral Pathol Med (2008) Oral lichen planus (OLP) is a chronic inflammatory disease that can be painful, mainly in the atrophic and erosive forms. Numerous drugs have been used with dissimilar results, but most treatments are empirical and do not have adequate control groups or correct study designs. However, to date, the most commonly employed and useful agents for the treatment of LP are topical corticosteroids. A randomized, double-blind, placebo-controlled trial has been designed to compare the efficacy and safety of two different formulations of clobetasol, a very potent topical steroid, in the topical management of OLP and to evaluate which gives the longest remission from signs and symptoms. Thirty-five consecutive patients were divided into two groups: the first received clobetasol...

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  Clobetasol: Cushing's syndrome in infants: 2 case reports.

Page: 11 (Source: Reactions Weekly)

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  Clobetasol: Cushing's syndrome in infants: 2 case reports

(Source: Reactions)

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  CLOBETASOL PROPIONATEgel [Taro Pharmaceuticals U.S.A., Inc.]

Updated Date: Dec 4, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CLOBETASOL PROPIONATEcream [Taro Pharmaceuticals U.S.A., Inc.]

Updated Date: Dec 4, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CLOBETASOL PROPIONATEcream CLOBETASOL PROPIONATEointment [Actavis Mid Atlantic LLC]

Updated Date: Dec 2, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CLOBETASOL PROPIONATEcream [Stiefel Laboratories, Inc.]

Updated Date: Dec 2, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CLOBETASOL PROPIONATEointment [Stiefel Laboratories, Inc.]

Updated Date: Dec 2, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Bone-anchored hearing aid abutment skin overgrowth reduction with clobetasol.

CONCLUSION: Clobetasol is an effective treatment for abutment skin/scar overgrowth. Clobetasol allows patients to resume BAHA use and obviates the need for scar revision. PMID: 19041511 [PubMed - in process] (Source: Otolaryngology - Head and Neck Surgery)

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  Clobetasol withdrawal: Pustular psoriasis in a child, after discontinuing topical therapy: case report

(Source: Reactions)

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  Clobetasol withdrawal: Pustular psoriasis in a child, after discontinuing topical therapy: case report.

Page: 9 (Source: Reactions Weekly)

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  [Oral ulcers in kidney allograft recipients treated with sirolimus.]

This study confirmed the incidence of mouth ulcers in renal transplant patients treated with sirolimus. The ulcers did not appear to be attributable to a dose-dependent mechanism, thus corroborating the results reported in the literature. However, a contributory role of transition from tacrolimus to sirolimus in their appearance was not seen in this study. Combination of sirolimus with mycophenolate mofetil appeared to have no bearing on the incidence of mouth ulcers. Clobetasol cream, whether or not given together with an anaesthetic solution, appears to reduce pain and shorten healing times, and could thus avoid discontinuation of treatment on account of mouth ulcers. PMID: 19061651 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)

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  [Oral ulcers in kidney allograft recipients treated with sirolimus]

This study confirmed the incidence of mouth ulcers in renal transplant patients treated with sirolimus. The ulcers did not appear to be attributable to a dose-dependent mechanism, thus corroborating the results reported in the literature. However, a contributory role of transition from tacrolimus to sirolimus in their appearance was not seen in this study. Combination of sirolimus with mycophenolate mofetil appeared to have no bearing on the incidence of mouth ulcers. Clobetasol cream, whether or not given together with an anaesthetic solution, appears to reduce pain and shorten healing times, and could thus avoid discontinuation of treatment on account of mouth ulcers. PMID: 19061651 [PubMed - in process] (Source: Annales de Dermatologie et de Cenereologie)

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  Formulation affects clobetasol propionate efficacy

The efficacy of some formulations of clobetasol propionate is limited by their labelling restrictions, research suggests. (Source: MedWire News - Psoriasis)

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  Formulation affects clobetasol propionate efficacy

The efficacy of some formulations of clobetasol propionate is limited by their labeling restrictions, research suggests. (Source: MedWire News - Dermatology)

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  Treatment of erosive vulvovaginal lichen planus with methotrexate.

We report the successful treatment of severe long-standing erosive vulvovaginal lichen planus in four adult female patients using 2.5-7.5 mg of oral methotrexate once weekly in conjunction with topical clobetasol dipropionate 0.05% ointment and tacrolimus 0.03-0.10% ointment. All cases experienced improvement in symptoms and healing of lesions within 4-8 weeks. Methotrexate was well tolerated and no adverse events have been observed in any of the patients at follow up 4-6 months later. PMID: 18855784 [PubMed - in process] (Source: The Australasian Journal of Dermatology)

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  Treatment of erosive vulvovaginal lichen planus with methotrexate

We report the successful treatment of severe long-standing erosive vulvovaginal lichen planus in four adult female patients using 2.5[ndash]7.5 mg of oral methotrexate once weekly in conjunction with topical clobetasol dipropionate 0.05% ointment and tacrolimus 0.03[ndash]0.10% ointment. All cases experienced improvement in symptoms and healing of lesions within 4[ndash]8 weeks. Methotrexate was well tolerated and no adverse events have been observed in any of the patients at follow up 4[ndash]6 months later. (Source: Australasian Journal of Dermatology)

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  Clobetasol Foam Safe, Effective for Some Dermatoses

An emulsion formulation foam of clobetasol propionate 0.05% is safe and effective for treating moderate to severe atopic dermatitis and mild to moderate plaque-type psoriasis in patients ages 12 years or older, according to a series of four trials reported in the September issue of the Journal of the American Academy of Dermatology. Reuters Health Information (Source: Medscape Dermatology Headlines)

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  Two Cases of Cushing's Syndrome Due to Overuse of Topical Steroid in the Diaper Area1

We report two cases with iatrogenic Cushing's syndrome with different clinical outcomes due to abuse of same potent topical steroid clobetasol propionate. One of them died because of fatal disseminated cytomegalovirus infection. The other patient recovered completely. Physicians and parents should be informed about the adverse effects of such potent topical corticosteroids and physicians should prescribe less potent agents, especially during infancy. (Source: Pediatric Dermatology)

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  Clobetasol: Cushing's syndrome in an infant: case report

(Source: Reactions)

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  Clobetasol: Cushing's syndrome in an infant: case report.

Page: 12 (Source: Reactions Weekly)

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  Interventions to reduce Staphylococcus aureus in the management of atopic eczema.

CONCLUSIONS: We failed to find clear evidence of benefit for antimicrobial interventions for people with atopic eczema, despite their widespread use. This does not necessarily mean they do not work because the studies were small and poorly reported. Further large studies with long-term outcomes and clearly defined participants are urgently required. PMID: 18646096 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

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  Comparative analysis between Chamomilla recutita and corticosteroids on wound healing. An in vitro and in vivo study

The comparison of chamomile and corticosteroids for treating ulcers was done in vitro and in vivo. The experimental groups were: control; chamomile recutita; triamcinolone acetonide and clobetasol propionate. For the in vitro study the cell viability of fibroblasts cultured for 24 h in media conditioned by the substances was obtained by the MTT reduction analysis. For the in vivo study, 125 male rats were submitted to experimental ulcers treated or not (control) by the substances tested. At 1, 3, 5, 7 and 14 days later 5 animals of each group were sacrificed. The lesions were analyzed by means of clinical observation and histological wound-healing grading. Data were compared by ANOVA (p [le] 0.05). All experimental groups presented positive cell viability in 24 h. The cultures treated with...

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  Clobetasol Propionate(Clobetasol Propionate) Ointment [Taro Pharmaceuticals U.S.A., Inc.]

Updated Date: Sep 4, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  A multitechnique evaluation of topical corticosteroid treatment

Cortiscosteroids are widely prescribed for systemic or local treatment of inflammatory autoimmune disorders. Long-term therapy is associated with side effects and causes cutaneous atrophy of the epidermis and the dermis. The present study aims to evaluate with several noninvasive techniques, the skin modifications observed during cortiscosteroids treatment. The potential of skin mechanical measurement and ultrasound radio frequency (RF) signal analysis are proposed as new measures more closely related to the functional impairments. Thirteen young healthy women volunteers had two applications per day on one arm of topical Clobetasol propionate 0.05% for 28 days, and they were followed for 28 days more. Skin modifications were studied by high-frequency ultrasound imaging, ultrasound RF signa...

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  Interstitial granulomatous dermatitis.

Authors: Johnson H, Mengden S, Brancaccio RR A 59-year-old woman with arthritis presented to the Skin Institute of New York with a 2-month history of asymptomatic, small, skin-colored papules that erupted symmetrically on the chest, back, and proximal extremities. Histopathologic examination of a biopsy specimen showed findings of interstitial granulomatous dermatitis. Clinical correlation suggested a diagnosis of interstitial granulomatous dermatitis with arthritis. No change in the lesions resulted from application of clobetasol 0.05 percent ointment to the affected areas. PMID: 18627754 [PubMed - in process] (Source: Dermatol Online J)

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  Clobetasol propionate emollient formulation foam in the treatment of corticosteroid-responsive dermatoses

Expert Opinion on Pharmacotherapy , August 2008, Vol. 9, No. 11, Pages 2001-2007. Background: Topical corticosteroids are the most common treatment modality for patients with psoriasis and atopic dermatitis; however, the efficacy of topical corticosteroids is often hampered by barriers to patient adherence, such as lack of efficacy, ... (Source: Expert Opinion: Expert Opinion on Pharmacotherapy: Table of Contents)

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  Clobetasol overdose: Cushing's syndrome: case report

(Source: Reactions)

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  Clobetasol overdose: Cushing's syndrome: case report.

Page: 15 (Source: Reactions Weekly)

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  Clobetasol foam effective in adolescents with psoriasis

A clobetasol emulsion formulation foam is a well-tolerated and effective treatment for mild-to-moderate plaque-type psoriasis and moderate-to-severe atopic dermatitis, say US researchers. (Source: MedWire News - Psoriasis)

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  Clobetasol propionate emulsion formulation foam 0.05%: Review of phase II open-label and phase III randomized controlled trials in steroid-responsive dermatoses in adults and adolescents.

CONCLUSION: Clobetasol emulsion formulation foam is safe and effective for treatment of moderate-to-severe AD and mild-to-moderate plaque-type psoriasis in patients aged 12 years or older. PMID: 18539358 [PubMed - as supplied by publisher] (Source: Journal of the American Academy of Dermatology)

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  Olux-E(Clobetasol Propionate) Aerosol, Foam [Stiefel Laboratories]

Updated Date: Jun 2, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Clobetasol Propionate(Clobetasol Propionate) Cream [Stiefel Laboratories, Inc.]

Updated Date: May 5, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Bioequivalence assessment of topical clobetasol propionate products using visual and chromametric assessment of skin blanching.

CONCLUSIONS: Whereas visual data indicated bioequivalence using either data from "detectors" or data from all subjects, the chromameter data from "detectors" only indicated bioinequivalence but inclusion of all subject data fell within the acceptance range to be declared bioequivalent. PMID: 18445371 [PubMed - in process] (Source: J Pharm Pharm Sci)

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  Five clobetasol products launched in US.

(Source: Inpharma)

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  Five clobetasol products launched in US.

Page: 26 (Source: Inpharma Weekly)

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  Generic clobetasol foam given thumbs up in US.

(Source: Inpharma)

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  Generic clobetasol foam given thumbs up in US.

Page: 18 (Source: Inpharma Weekly)

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  Clobetasol: Cushing's syndrome: case report

(Source: Reactions)

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  Clobetasol: Cushing's syndrome: case report.

Page: 8 (Source: Reactions Weekly)

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  Bullous eruption in a patient infected with the human immunodeficiency virus.

Authors: De D, Kanwar AJ, Radotra BD, Narang T A 30-year-old man diagnosed with human immunodeficiency virus (HIV) infection 10 years earlier, presented with large tense blisters associated with minimal itching of 10 days' duration. He had no history of oral or genital erosions or ulcerations and showed no symptoms of HIV-related illnesses. Highly active antiretroviral therapy (HAART) had been started 6 weeks earlier when his CD4 count was 116/mL. He initially received nevirapine 200 mg once daily; after 2 weeks with no skin eruptions or other adverse reactions, the dose was increased to 200 mg twice daily. Other components of his HAART included lamivudine and stavudine. The patient was not taking any other prescription or alternative medicines. During the past year, he experienced 4 e...

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  Ulcus vulvae acutum in a 13-year-old girl after influenza A infection.

Authors: Wetter DA, Bruce AJ, MacLaughlin KL, Rogers RS A 13-year-old otherwise healthy premenarchal girl presented with acute onset of painful vulvar ulcerations. One day before developing vulvar ulcerations, she experienced flu-like symptoms, including a low-grade fever, cough, sore throat, and myalgia. Results of a throat swab were positive for influenza A infection (polymerase chain reaction [PCR] assay), and the patient was treated with oseltamivir. The patient's constitutional symptoms improved slightly, but within 2 days after her initial presentation, she returned to her primary care provider and described 24 hours of dysuria and vulvar swelling. She had a history of herpes labialis (cold sores) and rare episodes of minor oral aphthae (canker sores) that occurred less than twic...

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  Clobetasol: Cushing's syndrome: case report

(Source: Reactions)

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  Clobetasol/diflucortolone: Cushing's syndrome and adrenal insufficiency (first reports for diflucortolone) in infants: 5 case reports

(Source: Reactions)

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  Clobetasol: Cushing's syndrome: case report.

Page: 12 (Source: Reactions Weekly)

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  Clobetasol/diflucortolone: Cushing's syndrome and adrenal insufficiency (first reports for diflucortolone) in infants: 5 case reports.

Page: 13 (Source: Reactions Weekly)

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  Clinical Picture - The pursuit of beauty – risks associated with skin lightening creams

The authors of this case report highlight the risks associated with using skin-lightening creams. They describe a case in which a 28 year old woman used skin lightening creams for 7 years. She presented with weight gain (12.7kg in 3 years), inability to conceive successfully, recurrent vulval candidiasis, bruising, pigmented striae on her body and a round face. An initial diagnosis of Cushing’s syndrome was made, however, blood results found low levels of cortisol and corticotrophin. After enquiring further about drugs, the patient told the clinicians about the cream she had been applying. The cream had been bought from a local shop not authorised to sell it and the patient was using 60g a week. Further investigations found the cream to contain clobetasol. The authors write, “Patients ...

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  SMC rejects clobetasol propionate 0.05% shampoo (Etrivex) for scalp psoriasis

The Scottish Medicines Consortium (SMC) has rejected the use of clobetasol propionate 0.05% shampoo (Etrivex®) within NHS Scotland for the topical treatment of moderate scalp psoriasis in adults. The drug advice notes that clinical equivalence to existing topical formulations of clobetasol propionate has not been demonstrated. (Source: NeLM Headline News)

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  Clobetasol Propionate(Clobetasol Propionate) Gel [Glades Pharmaceuticals, LLC]

Updated Date: Feb 8, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus

Journal of Clinical Periodontology, Volume 35, Issue 3, Page 244-249, March 2008. Corrocher G, Di Lorenzo G, Martinelli N, Mansueto P, Biasi D, Nocini PF, Lombardo G, Fior A, Corrocher R, Bambara LM, Gelio S, Pacor ML. Comparative effect of tacrolimus 0.1% ointment and clobetasol 0.05% ointment in patients with oral lichen planus. J ... (Source: Journal of Clinical Periodontology)

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  Evaluation of beneficial and adverse effects of glucocorticoids on a newly developed full-thickness skin model.

Authors: Zöller NN, Kippenberger S, Thaçi D, Mewes K, Spiegel M, Sättler A, Schultz M, Bereiter-Hahn J, Kaufmann R, Bernd A Glucocorticoids (GCs) are highly effective compounds widely used in the treatment of inflammatory diseases; however, they offer distinct adverse effects such as skin thinning in response to long-term topical treatment. Nevertheless it is difficult to deduce the safety of a newly synthesized compound from its structural formula. Efficient assay systems that measure beneficial and adverse effects are needed. In the present study the applicability of a three-dimensional full-thickness skin model (FTSM) is tested to display GC-induced effects regarding anti-inflammation and atrophy. It is shown that topical application of a commercial GC ointment suppre...

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  Cutaneous penile and perianal Crohn's disease treated with a combination of medical and surgical interventions.

Authors: Rajpara SM, Siddha SK, Ormerod AD, Kerr KM, Kolhe PS A 73-year-old man presented with fistulizing cutaneous Crohn's disease of the penis and perianal area without involvement of the gastrointestinal tract. The disease failed to respond to topical clobetasol propionate and oral cyclosporin and methotrexate. A combination treatment of minocycline, thalidomide and prednisolone brought the disease under control and induced remission. Surgery with excision and skin grafting were required to produce cure. PMID: 18186842 [PubMed - indexed for MEDLINE] (Source: The Australasian Journal of Dermatology)

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  A comparative treatment study of topical tacrolimus and clobetasol in oral lichen planus.

CONCLUSION: We found tacrolimus to be as useful as clobetasol in treatment of OLP. We believe that up-to-date evidence indicates the effectiveness of tacrolimus in treating OLP. PMID: 18230389 [PubMed - in process] (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

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  Clobex(Clobetasol Propionate) Shampoofor Topical Use [Galderma Laboratories L.P.]

Updated Date: Jan 31, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Cutaneous penile and perianal Crohn's disease treated with a combination of medical and surgical interventions

Australasian Journal of Dermatology, Volume 49, Issue 1, Page 21-24, January 2008. SUMMARY A 73-year-old man presented with fistulizing cutaneous Crohn's disease of the penis and perianal area without involvement of the gastrointestinal tract. The disease failed to respond to topical clobetasol propionate and oral cyclosporin and ... (Source: Australasian Journal of Dermatology)

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  [Diagnosis and management of nail psoriasis.]

Authors: Sánchez-Regaña M, Umbert P Nail psoriasis has traditionally been considered as one of the most difficult forms of psoriasis to treat. The most recent studies have found a higher prevalence of fungal infections in psoriatic nails and therefore cultures before and during treatment are necessary. Over the last few years, novel psoriatic therapies have been developed, some of which are effective for both skin and nail lesions (cyclosporine and biologic agents). Of the topical agents, vitamin D and A derivatives as well as nail lacquer containing 8 % clobetasol propionate can help improve lesions of both the nail bed and matrix. PMID: 18206085 [PubMed - in process] (Source: Actas Dermo-Sifiliograficas)

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  Topical tacrolimus and pimecrolimus in the treatment of cutaneous lupus erythematosus: an evidence-based evaluation

Conclusion  The lack of RCTs is characteristic. Future studies should focus on efficacy, short- and long-term effects and cost-effectiveness. However, tacrolimus and pimecrolimus show efficacy, and such effort is worthwhile. Content Type Journal ArticleCategory Review ArticleDOI 10.1007/s00228-007-0421-2Authors Thrasivoulos George Tzellos, School of Medicine, Aristotle University of Thessaloniki Department of Pharmacology Thessaloniki GreeceDimitrios Kouvelas, School of Medicine, Aristotle University of Thessaloniki Department of Pharmacology Thessaloniki Greece Journal European Journal of Clinical PharmacologyOnline ISSN 1432-1041Print ISSN 0031-6970 (Source: European Journal of Clinical Pharmacology)

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  Clobetasol: Trichostasis spinulosa: case report

(Source: Reactions)

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  Clobetasol: Trichostasis spinulosa: case report.

Page: 10 (Source: Reactions Weekly)

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  Clobetasol Propionate(Clobetasol Propionate) Cream [Stiefel Laboratories, Inc.]

Updated Date: Oct 19, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Clobetasol Propionate(Clobetasol Propionate) Cream Clobetasol Propionate(Clobetasol Propionate) Ointment [Actavis Mid Atlantic LLC]

Updated Date: Oct 19, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Systopic Laboratories

Pvt Ltd specialises in innovative therapeutic solutions and is one of the top 60 companies in India. Some of the unique formulations offered by the company are Rextop-1% / topical methotrexate, Acnesone gel / anti-acne, AF-400 anti-fungal, Topisal / topical steroid + karatolytic, AMACE-BP for hypertension. The New Delhi-based Systopic has emerged as a company of eminence in the domestic therapeutic solutions area. Since its inception in 1984, the company has been practising the concept of 'excellence through people and innovation' in terms of methodology and work culture. REXTOP-1% Systopic Lab is a pioneer in developing Rextop-1% gel with one per cent concentration. Rextop-1% gel is a methotrexate in a hydroxyl gel base for psoriasis. Rextop-1% gel reduces the side effects of methot...

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  Clobetasol Propionate(Clobetasol Propionate) Ointment [Glades Pharmaceuticals, Inc.]

Updated Date: Oct 4, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Clobetasol Propionate(Clobetasol Propionate) Gel Clobetasol Propionate(Clobetasol Propionate) Cream Clobetasol Propionate(Clobetasol Propionate) Ointment [E. FOUGERA CO.]

Updated Date: Sep 14, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Temovate(Clobetasol Propionate) Cream [PharmaDerm]

Updated Date: Sep 6, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Trichostasis spinulosa: possible association with prolonged topical application of clobetasol propionate 0.05% cream

International Journal of Dermatology Volume 46, Issue 9, Page 982-985, Sep 2007. A 20-year-old woman of south Asian descent was concerned about her dark complexion, predominantly affecting the exposed areas of her body, including the face, neck, upper chest, and extremities. She tried multiple over-the-counter products, including topi... (Source: International Journal of Dermatology)

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  Phase I study of vinorelbine and irinotecan in previously untreated patients with advanced non-small cell lung cancer

Conclusion  Use of 20 mg/m2 vinorelbine on days 1 and 8 followed by 50 mg/m2 irinotecan on days 1, 8, and 15 every 4 weeks warrants a phase II study. Content TypeJournal Article JournalCancer Chemotherapy and PharmacologyOnline ISSN 1432-0843Print ISSN 0344-5704 (Source: Cancer Chemotherapy and Pharmacology)

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  Olux(Clobetasol Propionate) Aerosol, Foam [Connetics Corporation]

Updated Date: Aug 24, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Testosterone Versus Clobetasol for Maintenance of Vulvar Lichen Sclerosus Associated With Variable Degrees of Squamous Cell Hyperplasia.

Page: 581DOI: 10.1097/01.ogx.0000280192.39997.adAuthors: Ayhan, Ali; Guven, Emine Seda Guvendag; Guven, Suleyman; Sakinci, Mehmet; Dogan, N Utku; Kucukali, Turkan (Source: Obstetrical & Gynecological Survey)

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  Solid lipid nanoparticles prepared by solvent diffusion method in a nanoreactor system.

In this study, water-in-oil (W/O) miniemulsion was used as nanoreactor to prepare solid lipid nanoparticles (SLN) by solvent diffusion method. n-Hexane, Tween 80 and Span 80 were used as the oil phase and surfactant combination for preparation of W/O miniemulsion, respectively. The stable miniemulsion with the particle size of 27.1+/-7.6nm was obtained when the composition of water/Tween 80/Span 80/n-hexane was 1ml/18mg/200mg/10ml. Clobetasol propionate (CP) was used as a model drug. The physicochemical properties of the SLN, such as particle size, zeta potential, surface morphology, drug entrapment efficiency, drug loading capacity and in vitro drug release behaviors were investigated, comparing with those of SLN prepared by conventional aqueoethod. The SLN prepared by the novel method di...

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  Clobetasol shampoo is effective in the treatment of seborrhoeic dermatitis of the scalp,.

Page: 14 (Source: Inpharma Weekly)

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  Clobetasol shampoo is effective in the treatment of seborrhoeic dermatitis of the scalp

(Source: Inpharma)

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  Sirolimus: Aphthous ulcers treated with clobetasol: 8 case reports

(Source: Reactions)

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  Sirolimus: Aphthous ulcers treated with clobetasol: 8 case reports.

Page: 24 (Source: Reactions Weekly)

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  Sirolimus: Aphthous ulcers treated with clobetasol: 8 case reports.

Page: 24 (Source: Reactions Weekly)

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  Clobetasol: Cushing's syndrome following topical administration in an infant: case report

(Source: Reactions)

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  Clobetasol/prednicarbate: Cushing's syndrome and adrenal insufficiency (first report with prednicarbate) following topical administration in infants: 3 case reports

(Source: Reactions)

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  Clobetasol/prednicarbate: Cushing's syndrome and adrenal insufficiency (first report with prednicarbate) following topical administration in infants: 3 case reports.

Page: 11 (Source: Reactions Weekly)

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  Clobetasol: Cushing's syndrome following topical administration in an infant: case report.

Page: 11 (Source: Reactions Weekly)

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  Clobetasol Propionate(Clobetasol Propionate) Solution [E. FOUGERA CO.]

Updated Date: May 22, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Clobetasol: Cushing's syndrome: case report

(Source: Reactions)

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  Clobetasol: Cushing's syndrome: case report.

Page: 11 (Source: Reactions Weekly)

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  Lichen striatus following solarium exposure.

Authors: Ciconte A, Bekhor P Two cases of lichen striatus occurring after solarium exposure are presented. Both patients were adult females who regularly attended a solarium prior to the development of their skin lesions. A 19-year-old woman attended the solarium twice weekly for 8 weeks prior to the appearance of lichen striatus on the chest and epigastrium. The condition resolved completely with the twice daily application of calcipotriol ointment for 6 months. The second patient, a 40-year-old woman, attended the solarium once weekly for 3 months before lichen striatus developed on the abdomen. She was treated with clobetasol propionate ointment, calcipotriol ointment and intralesional triamcinolone acetonide and the eruption cleared 7 months after onset. The histopathological pictu...

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  GSK discontinues Dermovate-NN cream

GlaxoSmithKline has announced that due to raw material supply and manufacturing issues related to the requirements of the production of Dermovate-NN cream, it is discontinuing the manufacture of this product. GSK will cease to supply the product from June 2007, and due to the manufacturing issues, it is likely that supply will be restricted to hospital pharmacy only until this time. (Dermovate-NN contains clobetasol propionate 0.05%, neomycin sulphate 0.5% and nystatin 100,000 units/g) (Source: NeLM Headline News)

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  Clobetasol Ameliorates Aphthous Ulceration in Renal Transplant Patients on Sirolimus. The potent topical steroid clobetasol applied to oral ulcers associated with sirolimus therapy can lead to prompt resolution of the ulcers.

American Journal of Transplantation Volume 7, Issue 3, Page 714-717, Mar 2007. (Source: American Journal of Transplantation)

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  Comparison of clinical efficacy of topical tazarotene 0.1% cream with topical clobetasol propionate 0.05% cream in chronic plaque psoriasis: A double-blind, randomized, right-left comparison study

Conclusion:</b> Topical tazarotene 0.1% cream is less effective than topical clobetasol propionate 0.05% cream in the treatment of plaque psoriasis. It has more effect on induration than on erythema and scaling of psoriatic lesions. (Source: Indian Journal of Dermatology, Venereology and Leprology)

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  Tacrolimus may be preferable to clobetasol in the treatment of facial cutaneous lupus erythematosus,.

(Source: Inpharma Weekly)

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  Clinical review of 202 patients with vulval lichen sclerosus: A possible association with psoriasis.

Authors: Simpkin S, Oakley A Two hundred and two patients with clinically typical or biopsy-confirmed vulval lichen sclerosus were reviewed either at consultation (75%) or by retrospectively examining their chart. At diagnosis, 79% were 50 years or older. Ninety-six per cent complained of itching, pain and/or dyspareunia. Lichen sclerosus most often affected the labia minora and perineum but 50% had perianal and 13% had extragenital disease. Thirty-five patients gave a history of psoriasis (17%), which affected the vulval area in 10. Thyroid disease was reported in 39 patients (19%), and 33 gave a family history of thyroid disease. Of those tested (142), 20% had elevated thyroid antibodies. Topical clobetasol propionate was very effective but at least intermittent treatment was require...

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  FDA Approvals: Lialda and Olux-E

The FDA has approved mesalamine 1.2-g delayed-release tablets (Lialda) and clobetasol propionate 0.05% foam (Olux-E). (CME)Medscape Medical News (Source: Medscape Gastroenterology Headlines)

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  Clobetasol Ameliorates Aphthous Ulceration in Renal Transplant Patients on Sirolimus

American Journal of Transplantation Volume 0, Issue 0, Page ???-???. (Source: American Journal of Transplantation)

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  Evaluation of the effects of topical clobetasol propionate by visual score, electrical impedance and laser Doppler flowmetry

Online early issue. (Source: Skin Research and Technology)

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  Tacrolimus vs. clobetasol propionate in the treatment of facial cutaneous lupus erythematosus: a randomized, double-blind, bilateral comparison study

British Journal of Dermatology Volume 0, Issue 0, Page ???-???. (Source: British Journal of Dermatology)

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  Comparison of topical tacrolimus 0.1 % in pectin ointment with clobetasol 0.5% ointment in adults with moderate to severe desquamative gingivitis: A 4-week, randomized, double-blind clinical trial.

CONCLUSIONS: The results of this small study suggest that topical tacrolimus 0.1 % in pectin was more effective compared with clobetasol propionate 0.5% ointment in the treatment of DG. Both treatments were generally well tolerated in the population studied. PMID: 17062302 [PubMed - indexed for MEDLINE] (Source: Clinical Therapeutics)

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  SMC accepts Clarelux (clobetasol cutaneous foam) for use in steroid-responsive dermatoses of the scalp

The Scottish Medicines Consortium (SMC) has advised that Clobetasol propionate 0.05% cutaneous foam (Clarelux®) is accepted for use within NHS Scotland for short-course treatment of steroid responsive dermatoses of the scalp such as psoriasis, which do not respond satisfactorily to less potent steroids. The Committee noted that Clarelux offered an alternative to other scalp applications of clobetasol propionate at a similar cost (depending on the rate of application). (Source: NeLM Headline News)

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  SMC issues new drug advice

The Scottish Medciines cosortium has accepted a number of new drugs for us ein Scotland in cluding clobetasol propionate, ropinirole and cetuximab. (Source: OnMedica Latest News)

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  Topical mechlorethamine and clobetasol in multifocal primary cutaneous marginal zone-B cell lymphoma

British Journal of Dermatology Volume 154, Issue 6, Page 1207-1209, Jun 2006 (Source: British Journal of Dermatology)

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Top Viagra Store

A first shop in the series of one-pill shops is rightfully viagra-targeted. The index page offers only Viagra, both generic and original.It is possible to purchase other ED products from other pagers, but the main accent is on Viagra.

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Indian Meds

A most recent indian-themed, ethnic site. Includes generic and original (brand) products. al our standard navigational tools and support options are available. This site converts nicely on general pharmaceutical traffic as it has products for vurtually any need.

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Friendly ED Pharmacy

Many ED customers are anxious about the status their orders. This special friendly site is here to solve the problem. "State of the art" design features high usability and clearly visible support options. All this helps to satisfy even the most demanding customer and results in increased sales ratio.

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Popular ED Products

This ED site offers simplistic design that gets right to the point - this IS the site for ED. Popular ED list the top selling products and converts best on ED-targeted, pill-specific traffic.

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Perfect ED Store

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Delhi Drugs

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Indian Generics

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