MedWorm: Chantix

  CHANTIX (Varenicline Tartrate) Kit CHANTIX (Varenicline Tartrate) Tablet, Film Coated [Pfizer Laboratories Div Pfizer Inc]

Updated Date: Mar 4, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Varenicline and pheochromocytoma.

Authors: Hukkanen J, Ukkola O, Benowitz NL PMID: 20194248 [PubMed - in process] (Source: Annals of Internal Medicine)

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  Neuronal nicotinic acetylcholine receptors as pharmacotherapeutic targets for the treatment of alcohol use disorders.

Authors: Chatterjee S, Bartlett SE Alcohol use disorders (AUDs) are complex, and developing effective treatments will require the combination of novel medications and cognitive behavioral therapy approaches. Epidemiological studies have shown there is a high correlation between alcohol consumption and tobacco use, and the prevalence of smoking in alcoholics is as high as 80% compared to about 30% for the general population. Both preclinical and clinical data provide evidence that nicotine administration increases alcohol intake and non-specific nicotinic receptor antagonists reduce alcohol-mediated behaviors. As nicotine interacts specifically with the neuronal nicotinic acetylcholine receptor (nAChR) system, this suggests that nAChRs play an important role in the behavioral effects of...

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  Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain

Abstract: Nicotinic acetylcholine receptors (nAChRs) are longstanding targets for a next generation of pain therapeutics, but the nAChR subtypes that govern analgesia remain unknown. We tested a series of nicotinic agonists, including many molecules used or tried clinically, on a panel of cloned neuronal nAChRs for potency and selectivity using patch-clamp electrophysiology and a live cell-based fluorescence assay. Nonselective nicotinic agonists as well as compounds selective either for α4β2 or for α7 nAChRs were then tested in the formalin and complete Freund’s adjuvant models of pain. Nonselective nAChR agonists ABT-594 and varenicline were effective analgesics. By contrast, the selective α4β2 agonist ispronicline and a novel α4β2-selective potentiator did not appear to produce...

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  Varenicline: A Pharmacoeconomic Review of its Use as an Aid to Smoking Cessation

(Source: PharmacoEconomics)

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  Varenicline Helps COPD Patients Quit Smoking

SAN DIEGO — Varenicline is a particularly effective and well tolerated smoking cessation therapy in one of the toughest-to-treat of all groups: long-time smokers with chronic obstructive pulmonary disease. (Source: Internal Medicine News)

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  A Randomized Controlled Open Comparative Trial of Varenicline vs Nicotine Patch in Adult Smokers:

Conclusions: The selection of treatment depends on the balance of desired acuteness of cessation of smoking and side-effects, such as psychiatric and gastrointestinal problems or skin allergy. PMID: 20154405 [PubMed - as supplied by publisher] (Source: Circulation Journal)

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  South Carolina Attorney Says Legal Options Still Available To Those Harmed By Chantix

Bert Louthian, a lawyer with the Louthian Law Firm in Columbia, S.C., says developments in lawsuits pending against a Pfizer anti-smoking drug don’t mean other consumers who have been harmed cannot seek justice. (PRWeb Feb 11, 2010) Read the full story at http://www.prweb.com/releases/Chantix/lawyer/prweb3594234.htm (Source: PRWeb: Medical Pharmaceuticals)

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  CVN: Varenicline

Varenicline for Smokers with CAD (Source: Cardiosource)

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  Varenicline Bolsters Cessation in COPD Patients

SAN DIEGO — Varenicline is a particularly effective and well-tolerated smoking cessation therapy in one of the toughest-to-treat of all groups: long-time smokers with chronic obstructive pulmonary disease. (Source: Family Practice News)

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  Quantitative Assessment of Exposure-Response Relationships for the Efficacy and Tolerability of Varenicline for Smoking Cessation.

Authors: Ravva P, Gastonguay MR, French JL, Tensfeldt TG, Faessel HM Population exposure-response analyses involving ~2,000 cigarette smokers provided an integrated understanding of dose, exposure, patient characteristics, and response relating to the efficacy and tolerability of varenicline for smoking cessation. Full models with a linear function of area under the concentration-time curve at steady state AUC(0-24)(ss) and covariate effects on the baseline probability of response were constructed. Logistic regression results consistently showed that the end-of-treatment abstinence rate increased with increasing varenicline exposure, from 38% at 0.5 mg b.i.d. to 56% at 1 mg b.i.d. (vs. 22% for placebo). Baseline smoking status and age were predictive of smoking cessation, whereas race ...

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  Varenicline May Help Smokers With Heart Disease to Quit

Promising news for smokers with cardiovascular disease: the nicotine receptor partial agonist varenicline helps treat the addiction not only in healthy smokers but also in smokers with cardiovascular disease (CVD), say researchers in the January 19 issue of Circulation. Reuters Health Information (Source: Medscape Medical News Headlines)

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  Statistics on NHS Stop Smoking Services: England, April 2009 to September 2009

Source: NHS Information Centre Area: News This quarterly report presents provisional results from the monitoring of the NHS Stop Smoking Services in England from 1 April 2009 to 30 September 2009. Key facts on treatments include the following, though these data should not be used to assess or compare the clinical effectiveness of the various pharmacotherapies:   . The majority of those setting a quit date received Nicotine Replacement Therapy (NRT) only (65%), 23% varenicline, 1% bupropion, 1% both NRT and varenicline and < 1% received both NRT and bupropion, whilst 5% did not receive any pharmacotherapy.   . Of those who used varenicline 59% successfully quit, compared with 50% who received bupropion only, and 48% who received NRT only, whilst 42% of people...

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  Varenicline appears effective, well-tolerated smoking cessation aid in stable CAD

Varenicline is effective and well tolerated for smoking cessation in smokers with stable coronary heart disease, a study suggests. (Source: MedWire News - Cardiology)

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  Varenicline: Acute generalised exanthematous pustulosis: case report

(Source: Reactions)

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  Suits allege harm from Pfizer quit-smoking drug

NEW YORK (Reuters) - Three personal injury lawsuits were filed against Pfizer Inc on Thursday, claiming its smoking-cessation drug Chantix caused attempted suicides or death. (Source: Reuters: Health)

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  Clinical Trial Summary: Efficacy and Safety of Varenicline for Smoking Cessation in Patients With Cardiovascular Disease (Efficacy and Safety of Varenicline)

The goal of the trial was to evaluate smoking cessation treatment with varenicline (Chantix), a partial α4β2 nicotinic acetylcholine receptor agonist, compared with placebo among patients with stable coronary disease. (Source: Cardiosource)

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  Modulation of ethanol consumption by genetic and pharmacological manipulation of nicotinic acetylcholine receptors in mice

Conclusions  This study provides evidence that α7 nAChRs are involved in ethanol consumption and supports the idea that pharmacological manipulation of nAChRs reduces ethanol intake. Additional nAChRs may also be involved in ethanol intake, and there may be functional redundancy in the nicotinic control of alcohol drinking. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1759-1Authors Helen M. Kamens, Yale University Department of Psychiatry, School of Medicine 34 Park Street—3rd floor research New Haven CT 06508 USAJimena Andersen, Yale University Department of Psychiatry, School of Medicine 34 Park Street—3rd floor research New Haven CT 06508 USAMarina R. Picciotto, Yale University Department of Psychiatry, School of Medicine 34...

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  Varenicline and suicide. Safety data from New Zealand. - Harrison-Woolrych M.

[Abstract unavailable] Language: Eng... (Source: SafetyLit: All (Unduplicated))

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  Varenicline Safe and Effective in Cardiovascular Disease

The smoking cessation agent varenicline is safe and effective to use in patients with stable cardiovascular disease, a new study concludes. The agent should be part of the physician's armamentarium when it comes to smoking cessation, an often-neglected part of the treatment of CVD, says the lead author. Heartwire (Source: Medscape Today Headlines)

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  Varenicline safe and effective in cardiovascular disease

The smoking cessation agent varenicline is safe and effective to use in patients with stable cardiovascular disease, a new study concludes. The agent should be part of the physician's armamentarium... For complete story visit theheart.org. (Source: theHeart.org)

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  Safety and efficacy of varenicline for smoking cessation in cardiovascular disease patients

Source: Circulation Area: News According to research published early online in Circulation, varenicline is effective for smoking cessation in smokers with cardiovascular disease.   Researchers conducted a randomised, double-blind, placebo-controlled trial comparing the efficacy and safety of varenicline (1mg twice daily) (n=355) with placebo (n=359) for smoking cessation in smokers with stable cardiovascular disease. All patients also received smoking-cessation counselling for 12 weeks, and follow-up lasted 52 weeks. The primary end point was carbon monoxide-confirmed continuous abstinence rate for weeks 9 through 12 (last 4 weeks of treatment).   The following results were reported: . The continuous abstinence rate was higher for varenicline than placebo during wee...

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  Efficacy and Safety of Varenicline for Smoking Cessation in Patients With Cardiovascular Disease. A Randomized Trial.

Conclusions-Varenicline is effective for smoking cessation in smokers with cardiovascular disease. It was well tolerated and did not increase cardiovascular events or mortality; however, trial size and duration limit definitive conclusions about safety. Clinical Trial Registration Information-URL: http://www.clinicaltrials.gov/ct2/show/NCT00282984. Unique identifier: NCT00282984. PMID: 20048210 [PubMed - as supplied by publisher] (Source: Circulation)

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  Varenicline for Smoking Cessation in Patients With Coronary Heart Disease.

Authors: Ockene I, Salmoirago-Blotcher E PMID: 20048200 [PubMed - as supplied by publisher] (Source: Circulation)

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  Varenicline With Counseling Helps in Smoking Cessation

MONTREAL — The first real-world effectiveness trial of varenicline for smoking cessation showed that combining the medication with behavioral counseling results in fairly substantial quit rates at 6 months. (Source: Clinical Psychiatry News)

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  Working memory deficits predict short-term smoking resumption following brief abstinence

This study examined whether objective cognitive performance after 3 days of abstinence predicts smoking resumption in a 7-day simulated quit attempt. Sixty-seven treatment-seeking smokers received either varenicline or placebo (randomized double-blind) for 21 days. Following medication run-up (days 1–10), there was a 3-day mandatory (biochemically confirmed) abstinence period (days 11–13) during which working memory (Letter-N-Back Task) and sustained attention (Continuous Performance Task) were assessed (day 13). Participants were then exposed to a scheduled smoking lapse and instructed to try to remain abstinent for the next 7 days (days 15–21). Poorer cognitive performance (slower correct reaction time on Letter-N-Back task) during abstinence predicted more rapid smoking resumption...

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  Pilot safety evaluation of varenicline for the treatment of methamphetamine dependence

Todd Zorick, Rajkumar J Sevak, Karen Miotto, et al (Source: International Journal of Nanomedicine)

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  Varenicline and P50 auditory gating in medicated schizophrenic patients: A pilot study

Abstract: Most schizophrenic patients have a deficit in auditory sensory gating that appears to be mediated by the α-7 nicotinic receptor. This pilot study examines the effects of varenicline, an α-7 agonist, on the P50 auditory evoked potential in six schizophrenic patients. The study was canceled because of concerning side effects consistent with those reported by the FDA. However, in this small group of subjects, varenicline did not consistently enhance P50 auditory gating. (Source: Psychiatry Research)

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  Champix 0.5mg, 1mg tablets (varenicline) - Revised SPC

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes Revised SPC includes changes to section 4.4 (special warnings and precautions for use) and section 4.8 (undesirable effects) - addition of changes in behaviour or thinking, anxiety, psychosis, mood swings and aggressive behaviour. Also, addition of post marketing reports on cutaneous reactions, including Stevens-Johnson Syndrome and Erythema Multiforme in patients using varenicline.    (Source: NeLM - SPC Changes)

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  MTRAC verdict and summary: Varenicline (Champix): An aid to smoking cessation

Source: MTRAC Area: Evidence > Drug Specific Reviews The Midlands Therapeutic Review and Advisory Committee (MTRAC) has issued a verdict and summary on the use of varenicline (Champix®) as an aid to smoking cessation. The Committee states: "Varenicline is suitable for prescribing in primary care for healthy adult smokers with no serious medical conditions.  Patients using varenicline should be carefully monitored for psychiatric adverse effects.  Prescribers may wish to screen patients for depression before prescribing and during treatment with varenicline." (Source: NeLM - Drug Specific Reviews)

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  Clinical experience of varenicline for smoking cessation

Conclusion: Although varenicline was effective in reducing the desire to smoke, poor dosing compliance needs to be overcome in clinical practice. Please cite this paper as: Jung JW, Jeon EJ, Kim JG, Yang S-Y, Choi JC, Shin JW, Park IW, Choi BW, Kim D-K and Kim JY. Clinical experience of varenicline for smoking cessation. The Clinical Respiratory Journal 2009; DOI:10.1111/j.1752-699X.2009.00178.x. (Source: The Clinical Respiratory Journal)

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  Varenicline: Mixed mood and a psychotic episode in a patient with schizoaffective disorder: case report

(Source: Reactions)

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  A Retrospective Poison Center Review of Varenicline-Exposed Patients(December). - Kreshak AA, Clark AK, Clark RF, Ly BT, Cantrell FL.

BACKGROUND: Varenicline was approved by the Food and Drug Administration (FDA) as a prescription smoking cessation aid in May 2006. Varenicline is both a partial nicotine agonist and an antagonist. Recent reports by the Institute of Safe Medication Practic... (Source: SafetyLit: All (Unduplicated))

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  The α4β2 nicotinic acetylcholine-receptor partial agonist varenicline inhibits both nicotine self-administration following repeated dosing and reinstatement of nicotine seeking in rats

Conclusion  The effects of varenicline on nicotine-induced reinstatement of drug-seeking are consistent with the demonstrated clinical efficacy of varenicline for smoking cessation. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1739-5Authors Eoin C. O’Connor, University of Sussex, Falmer School of Psychology Brighton BN1 9QG UKDale Parker, Pfizer Global Research and Development Global Safety Pharmacology, Drug Safety Research and Development Sandwich CT13 9NJ UKHans Rollema, Pfizer Global Research and Development Systems Neurobiology Groton CT 06340 USAAndy N. Mead, Pfizer Global Research and Development Global Safety Pharmacology, Drug Safety Research and Development Sandwich CT13 9NJ UK Journal PsychopharmacologyOnline ISSN...

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  The nicotinic acetylcholine receptor partial agonist varenicline and the treatment of drug dependence: A review

Abstract: Drug dependence is a chronic brain disease characterized by recurrent episodes of relapse, even when the person is motivated to quit. Relapse is a major problem and new pharmacotherapies are needed to prevent relapse episodes. The nicotinic acetylcholine receptor (nAChR) plays an important role in nicotine dependence, alcohol consumption and cue-induced cocaine craving. Stimulation of the nAChR has been found to alter and modulate cell firing in brain areas important for the maintenance of drug dependence. Varenicline, an α4β2 nAChR partial agonist and an α7 nAChR full agonist registered for the treatment of nicotine dependence, significantly reduces nicotine craving and prevents relapse. In addition, varenicline reduces alcohol consumption in rats. Based on a review of the av...

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  Risk of psychiatric side effects with varenicline

(Source: BMJ Online First)

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  Cost-effectiveness of varenicline compared with nicotine patches for smoking cessation--results from four European countries

Conclusion: This cost-effectiveness analysis demonstrated that since varenicline treatment was more effective, the result was increased healthcare cost savings in Belgium, Sweden and the UK. Our results suggest that funding varenicline as a smoking cessation aid is justifiable from a healthcare resource allocation perspective. (Source: The European Journal of Public Health)

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  A Retrospective Poison Center Review of Varenicline-Exposed Patients(December).

CONCLUSIONS: Patients exposed to varenicline in our study had favorable outcomes. Gastrointestinal and neuropsychiatric effects were the most commonly reported adverse events. A dose-response relationship could not be determined and triage criteria to a healthcare facility remain undetermined. PMID: 19934384 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

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  Varenicline: Lambert-Eaton Myasthenic Syndrome: case report

(Source: Reactions)

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  Varenicline: Hallucinations, increased dreaming and mood disorders: case report

(Source: Reactions)

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  The Cost-Effectiveness of an Extended Course (12 + 12 Weeks) of Varenicline Compared with Other Available Smoking Cessation Strategies in the United States: An Extension and Update to the BENESCO Model

Conclusions: A total of 12 weeks of varenicline followed by a further 12-week course for successful quitters is a highly cost-effective alternative compared with currently available smoking cessation options. (Source: Value in Health)

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  Varenicline: First report of liver injury: case report

(Source: Reactions)

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  Varenicline May Not Be Linked to Increased Risk for Self-Harm

A cohort study shows no clear evidence of an increased risk for fatal or nonfatal self-harm or depression with varenicline use, but a 2-fold increased risk cannot be ruled out. Medscape Medical News (Source: Medscape Today Headlines)

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  Varenicline Effective for Highly Nicotine-Dependent Smokers With COPD

Varenicline was associated with a 42.3% quit rate at 40 weeks for the hard-to-treat population of smokers with mild to moderate chronic obstructive pulmonary disease (COPD). Medscape Medical News (Source: Medscape Today Headlines)

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  Significantly More Smokers With Mild-To-Moderate COPD Quit Smoking Using CHANTIX/CHAMPIX(R) (Varenicline) Compared With Placebo

New study results showed that 42.3 percent of smokers with mild-to-moderate chronic obstructive pulmonary disease (COPD) who took CHANTIX/CHAMPIX® (varenicline) were able to quit smoking and remain abstinent during the last four weeks of treatment (weeks 9-12) compared with 8. (Source: Health News from Medical News Today)

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  Significantly More Smokers With Mild-To-Moderate COPD Quit Smoking Using CHANTIX/CHAMPIX(R) (Varenicline) Compared With Placebo

New study results showed that 42.3 percent of smokers with mild-to-moderate chronic obstructive pulmonary disease (COPD) who took CHANTIX/CHAMPIX® (varenicline) were able to quit smoking and remain abstinent during the last four weeks of treatment (weeks 9-12) compared with 8.8 percent of those given placebo (p (Source: Asthma / Respiratory News From Medical News Today)

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  Significantly More Smokers With Mild-To-Moderate COPD Quit Smoking Using CHANTIX/CHAMPIX (Varenicline) Compared With Placebo

Findings from Pfizer-Sponsored Study Presented as Late-Breaker at American College of Chest Physicians Annual Meeting SAN DIEGO--(BUSINESS WIRE)--Nov 4, 2009 - New study results showed that 42.3 percent of smokers with mild-to-moderate... (Source: Drugs.com - Clinical Trials)

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  CHEST: Varenicline Helps Patients with COPD Quit Smoking (CME/CE, with video)

SAN DIEGO (MedPage Today) -- Much as it aided the general population of smokers, varenicline (Chantix) helped patients with chronic obstructive pulmonary disorder (COPD) quit too, a randomized trial showed. (Source: MedPage Today Meeting Coverage)

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  Study: Varenicline Safe for Depressed Smokers

MONTREAL — Despite postmarketing concerns about the psychiatric side effects of varenicline for smoking cessation, the medication appears to be safe in patients who are depressed or at risk for depression, Jennifer B. McClure, Ph.D., reported at the annual meeting of the Society of Behavioral Medicine. (Source: Clinical Psychiatry News)

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  Varenicline: First report of acute generalised exanthematous pustulosis: case report

(Source: Reactions)

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  Effect of the alpha4beta2( *) nicotinic acetylcholine receptor partial agonist varenicline on dopamine release in beta2 knock-out mice with selective re-expression of the beta2 subunit in the ventral tegmental area.

Authors: Reperant C, Pons S, Dufour E, Rollema H, Gardier AM, Maskos U We studied the effects of 1mg/kg doses of nicotine and the alpha4beta2* nicotinic acetylcholine receptor (nAChR) partial agonist, varenicline, on extracellular dopamine (DA) levels in the nucleus accumbens (NuAcc) of lentivirally vectorized male mice. Three separate experimental groups were injected with a lentiviral vector transducing the ventral tegmental area (VTA): wild-type C57BL/6J mice with a vector expressing eGFP only, beta2 knock-out mice (beta2KO) with the eGFP-only vector, and beta2KO mice with a bi-cistronic vector reintroducing beta2 and eGFP into the VTA as recently described (Maskos et al., 2005). Our results suggest that the neurochemical effects of varenicline as measured by using microdialysis in ...

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  Chantix slash costs

The maker of Lipitor, Viagra and anti-smoking drug Chantix is $2.88 billion in the black after slashing costs (Source: Pharmacy Europe)

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  Varenicline: Mania: case report

(Source: Reactions)

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  Varenicline link to self harm not confirmed

(Source: Reactions)

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  Varenicline and suicidal behaviour: a cohort study based on data from the General Practice Research Database. - Gunnell D, Irvine D, Wise L, Davies C, Martin RM.

OBJECTIVE: To determine whether varenicline, a recently licensed smoking cessation product, is associated with an increased risk of suicide and suicidal behaviour compared with alternative treatments bupropion and nicotine replacement therapy. DESIGN: Coho... (Source: SafetyLit: All (Unduplicated))

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  Study Provides Boost for Chantix

British researchers say they found no evidence that the stop-smoking drug varenicline leads to depression or increased suicide risk. (Source: Alcohol, Tobacco and Other Drugs News)

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  Varenicline takes the top spot in Belgium

(Source: PharmacoEconomics and Outcomes News)

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  Smoking Cessation Drug Not Linked To An Increased Risk Of Self Harm Or Depression

There is no strong evidence that the popular smoking cessation drug varenicline increases the risk of self harm or depression compared to other cessation products, according to new research published on http://www.bmj.com today. (Source: Health News from Medical News Today)

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  No Link Between Suicide and Stop-Smoking Drugs (CME/CE)

Contrary to information that led the FDA and other regulatory agencies to release warnings about varenicline (Chantix), a new study has found "no clear evidence" of a relationship between the risk of suicide and the smoking-cessation drug. (Source: MedPage Today Primary Care)

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  No link found between popular smoking cessation drug and depression

There is no strong evidence that the popular smoking cessation drug varenicline increases the risk of self harm or depression compared to other cessation products, according to a new study by researchers at the University of Bristol, published today on bmj.com. (Source: University of Bristol news)

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  Smoking cessation drug "not linked to depression"

There is no strong evidence that the popular smoking cessation drug varenicline increases the risk of self harm or depression (Source: Nursing in Practice)

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  Research rejects smoking drug risks

New research published into the varenicline, a drug used by people wanting to give up smoking, has shown it does not increase the risk of self harm or depression any more than its competitors (Source: Pharmacy Europe)

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  Doubts on suicide-anti-smoking drug Chantix link

NEW YORK (Reuters Health) - Despite earlier health agency warnings, there is no strong evidence that the anti-smoking drug Chantix raises the risk of suicidal thoughts or depression compared to other stop-smoking products, researchers reported Thursday in the British Medical Journal. (Source: Reuters: Health)

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  Doubts on Suicide-Anti-Smoking Drug Chantix Link

Despite earlier health agency warnings, there is no strong evidence that the anti-smoking drug Chantix raises the risk of suicidal thoughts or depression compared to other stop-smoking products, researchers reported Thursday in the British Medical Journal. Source: Reuters Health Related MedlinePlus Topics: Medicines, Quitting Smoking, Suicide (Source: MedlinePlus Health News)

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  Study Counters Warnings on Quit-Smoking Drug

No clear evidence found that Chantix has dangerous side effects, say UK researchers (Source: Forbes.com Health News)

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  'No Clear Evidence' That Chantix Increases Risk for Self-Harm

(Source: Physician's First Watch current issue)

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  Health News of the Day

is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day:Novo Nordisk's insulin Levemir was not associated with any increase in cancer in studies including 9,000 patients http://bit.ly/1pJY8UJAMA: Plain surgical mask prevents influenza as well as N95 respirator http://bit.ly/cSr2y - Doubtful."Safety Gurus: Penalize Doctors Who Don’t Follow the Rules" - WSJ http://bit.ly/2ttXpPAntismoking drug Chantix has been linked to suicide but a new study shows that such risk is nonexistent or small http://bit.ly/PijafAmericans turning their cars into wired offices claiming efficiency far outweigh the risk of a wreck. http://bit.ly/h7PdH - So wrong.Do people...

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  Study disputes MHRA warnings over varenicline suicide link

A new study disputes claims of a link between the smoking cessation drug varenicline and an increased risk of suicide and suicidal behaviour. (Source: Pulse)

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  No Link Between Smoking Cessation Drug And Increased Risk Of Self Harm Or Depression

New research published today on bmj.com suggests there is no strong evidence that the popular smoking cessation drug varenicline increases the risk of self harm or depression compared to other cessation products. The newly introduced Varenicline is a smoking cessation product of proven effectiveness. (Source: Health News from Medical News Today)

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  Study: Chantix Has Little or No Suicide Risk

Title: Study: Chantix Has Little or No Suicide RiskCategory: Health NewsCreated: 10/2/2009 10:56:00 AMLast Editorial Review: 10/2/2009 10:56:57 AM (Source: MedicineNet Cancer General)

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  Study: Chantix Has Little or No Suicide Risk

Title: Study: Chantix Has Little or No Suicide RiskCategory: Health NewsCreated: 10/2/2009 10:56:00 AMLast Editorial Review: 10/2/2009 10:56:57 AM (Source: MedicineNet Senior Health General)

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  Chantix Has Little or No Suicide Risk

Study: Chantix Has Little or No Suicide Risk (Source: eMedicineHealth.com)

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  Study: Chantix Has Little or No Suicide Risk

Title: Study: Chantix Has Little or No Suicide RiskCategory: Health NewsCreated: 10/2/2009 10:56:00 AMLast Editorial Review: 10/2/2009 10:56:57 AM (Source: MedicineNet Depression General)

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  Varenicline and suicidal behaviour: a cohort study based on data from the General Practice Research Database

Source: BMJ Area: News According to the authors of a cohort study published early online in the British Medical Journal, an increased risk of self-harm with varenicline cannot be ruled out.  They do note however that their results 'provide some reassurance concerning its association with suicidal behaviour'.   The MHRA issued a warning in December 2007, after reports of depression and suicidal thoughts among people prescribed varenicline; further warnings were issued in July and November 2008.  Similar warnings have been issued by regulatory authorities worldwide, and the US FDA recently required the manufacturers of both varenicline and bupropion to add a new "boxed warning" to the product labelling based on the continued review of post-marketing adverse event reports....

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  Smoking Cessation Drug Likely Doesn't Raise Self-Harm Odds

The smoking cessation drug varenicline is likely not associated with increased risk of self-harm, although a two-fold increased risk cannot be ruled out, according to a study published Oct. 2 in BMJ. (Source: Modern Medicine)

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  Chantix-Suicide Link Questioned

Earlier this year, the FDA ordered a "black box" warning be added to the drugs Chantix (varenicline) and Zyban (bupropion), which are both used as aids in quitting smoking. ... (Source: About.com Depression)

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  Study: Chantix Has Little or No Suicide Risk

The antismoking drug Chantix has been linked to suicide and suicidal thoughts, but a new study shows that if such a risk exists it is likely to be very small. (Source: WebMD Health)

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  Crossing Borders: Factors Affecting Differences in Cost-Effectiveness of Smoking Cessation Interventions between European Countries

Conclusions: Although all INMBs were positive, there were significant differences across countries. These were primarily related to choice of discount rate and epidemiology of diseases. (Source: Value in Health)

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  Varenicline: Worsening psychosis: case report

(Source: Reactions)

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  Efficacy of pharmacotherapies for short-term smoking abstinence: A systematic review and meta-analysis.

Background: Smoking cessation has important immediate health benefits. The comparative short-term effectiveness of smoking cessation interventions is not well known. We aimed to determine the relative effectiveness of nicotine replacement therapy (NRT), bupropion and varenicline at 4 weeks post-target quit date. Methods: We searched 10 electronic medical databases (inception to October 2008). We selected randomized clinical trials [RCTs] evaluating interventions for our primary outcome of abstinence from smoking at at-least 4 weeks post-target quit date, with biochemical confirmation. We conducted random-effects odds ratio (OR) meta-analysis and meta-regression. We compared treatment effects across interventions using head-to-head trials and calculated indirect comparisons. Results: We com...

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  Varenicline: First report of heart arrest: case report

(Source: Reactions)

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  [Care Results in a Specialist Stop-Smoking Unit.]

CONCLUSIONS: A stop-smoking clinic that is designed according to SEPAR Recommendations is effective and has a good cost/effective ratio. PMID: 19758742 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)

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  A Method for Educating Patients and Documenting Smoking Status in an Electronic Medical Record(October).

CONCLUSIONS: Incorporating a smoking cessation template into existing progress notes and providing education during existing pharmacy referral visits is a simple and effective method to assist patients in achieving smoking cessation. PMID: 19737992 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

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  Varenicline: First report of proximal myopathy: case report

(Source: Reactions)

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  [Tolerability profile of varenicline in current medical practice.]

CONCLUSION: This retrospective study confirmed the tolerability issues for varenicline, identified during the phase II-phase III development program and confirmed afterwards. It raises the following questions: Should varenicline be prescribed as a second-line therapy? Is there a patient type for which varenicline would be more - or less - appropriate? Can the tolerability profile be improved by reducing dosage while maintaining the level of efficacy or by co-administering symptomatic treatment more systematically? These are questions that new studies evaluating varenicline tolerability should answer. PMID: 19740621 [PubMed - as supplied by publisher] (Source: Presse Medicale)

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  Cost Effectiveness of Varenicline in Belgium, Compared with Bupropion, Nicotine Replacement Therapy, Brief Counselling and Unaided Smoking Cessation: A BENESCO Markov Cost-Effectiveness Analysis

(Source: Clinical Drug Investigation)

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  Recalls and Safety Alerts: Warning on Neuropsychiatric Effects from Smoking Cessation Drugs

FDA is requiring that two drugs used to help people stop smoking carry new warnings about the risk of serious neuropsychiatric effects. The drugs are Chantix (varenicline) and Zyban (bupropion). The same warnings will be required for other bupropio... (Source: Food and Drug Adminstration (FDA): Patient Safety News)

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  MEDICAL NEWS & PERSPECTIVES: Varenicline Gets Stronger Warnings About Psychiatric Problems, Vehicle Crashes

(Source: JAMA)

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  [Treatment of tobacco dependence : A responsibility of psychiatry and addiction medicine.]

Authors: Batra A, Friederich HM, Lutz U The World Health Organisation (WHO) considers smoking to be the biggest avoidable health risk. The consumption of tobacco leads to health hazards and resulting diseases, the consequences of which are far more serious than those emanating from other addictive substances. Approximately 27% of the German adult population smoke regularly and the proportion of smokers addicted to tobacco or nicotine is estimated to be around 60%. Many of these smokers have undertaken numerous unsuccessful attempts at abstinence. A professional support for smokers who are motivated to give up smoking enhances the chances of success. The current treatment guidelines recommend a combination of psychotherapeutic techniques (e.g. motivational interviewing, behavioural ther...

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  Lambert-Eaton myasthenic syndrome following varenicline (Chantix) use

No abstract. (Source: Muscle and Nerve)

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  Varenicline attenuates some of the subjective and physiological effects of intravenous nicotine in humans

Conclusions  These findings provide new insights into the mechanisms of action of varenicline in smoking cessation. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1643-zAuthors Mehmet Sofuoglu, Yale University School of Medicine Department of Psychiatry and VA Connecticut Healthcare System 950 Campbell Ave., Bldg. 36/116A4 West Haven CT 06516 USAAryeh I. Herman, Yale University School of Medicine Department of Psychiatry and VA Connecticut Healthcare System 950 Campbell Ave., Bldg. 36/116A4 West Haven CT 06516 USAMarc Mooney, University of Minnesota Minneapolis MN USAAndrew J. Waters, Uniformed Services University of the Health Sciences Bethesda MA USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: P...

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  FDA Safety Changes: Chantix, DiaBeta, Aralen

The FDA has approved safety labeling revisions for varenicline tartrate tablets (Chantix), glyburide tablets (DiaBeta), and chloroquine phosphate tablets (Aralen). Medscape Medical News (Source: Medscape Today Headlines)

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  Varenicline: Paranoia, anxiety and suicidal ideation: case report

(Source: Reactions)

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  Saudi bans anti-smoking drugs

Saudi Arabia's Ministry of Health has banned two popular smoking cessation drugs as their side-effects include suicidal tendencies, the Saudi Gazette has reported. The drugs containing varenicline, with the trade name of Champix from Pfizer, and Bupropion were banned after the US Food and Drugs Administration (FDA) had issued a black box warning, the toughest warning on risks associated with a medicine, on serious mental health risks of the drugs. (Source: Healthcare)

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  Table of Contents

Study Finds Modafinil Increases Dopamine in Brain, Suggesting Potential for AbuseCase Report Highlights Possible Influence of Smoking on Clozapine ConcentrationModafinil: A Different Kind of Stimulus PackageEfficacy of Add-On Mirtazapine for Schizophrenia Not ClearLamotrigine and Divalproex Augmentation for SchizophreniaDepressive Relapse During Lithium Treatment and Thyroid FunctionN-acetylcysteine for TrichotillomaniaDextroamphetamine vs. Caffeine for Symptoms of OCDPersistent Psychosis Associated With Salvia DivinorumNew Warnings for Pain Meds Containing PropoxypheneNew Warnings for Chantix and Zyban (Source: The Brown University Psychopharmacology Update)

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  Varenicline increases striatal dopamine D2/3 receptor binding in rats

Increasing dopamine D2/3 receptor availability is postulated to be a treatment for drug addiction. Varenicline, an [alpha]4[beta]2-nicotinic partial agonist, is effective for nicotine dependence. We hypothesize that varenicline increases dopamine D2/3 receptor availability. Twenty male drug-naïve rats were randomized to varenicline (2 mg/kg) or placebo for 14 days, and then injected with the dopamine D2/3 radiotracer 123I-IBZM. We found significantly higher striatum-to-cerebellum binding ratios in both dorsal and ventral striatum for the varenicline group compared with placebo. Varenicline increases dopamine D2/3 receptor availability in drug-naïve rats. Therefore, varenicline may be an effective treatment for addictions other than smoking. (Source: Addiction Biology)

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  Varenicline: Acute interstitial nephritis: case report

(Source: Reactions)

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  Smoking Cessation Drugs Get Boxed Warning

Accumulating reports of serious neuropsychiatric symptoms associated with the smoking cessation medications varenicline and bupropion have prompted the Food and Drug Administration to require new boxed warnings for the drugs. (Source: Internal Medicine News)

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  News from the FDA

Accumulating reports of serious neuropsychiatric symptoms associated with the smoking cessation medications varenicline and bupropion prompted the Food and Drug Administration to require new boxed warnings for the drugs. (Source: Family Practice News)

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  Smoking Cessation Drugs Get Boxed Warning

Accumulating reports of serious neuropsychiatric symptoms associated with the smoking cessation medications varenicline and bupropion have prompted the Food and Drug Administration to require new boxed warnings for the drugs. (Source: Clinical Psychiatry News)

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  CHANTIX (Varenicline Tartrate) Kit CHANTIX (Varenicline Tartrate) Tablet, Film Coated [Pfizer Laboratories Div Pfizer Inc]

Updated Date: Jul 29, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Acute Hepatic Injury Associated with Varenicline in a Patient with Underlying Liver Disease (September).

CONCLUSIONS: While the benefits of smoking cessation are likely greater than the risk of hepatic injury, clinicians should be cognizant of this reaction associated with varenicline. PMID: 19638471 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

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  Smoking cessation pharmacotherapy

Cigarette smoking remains an important risk factor for premature cardiovascular disease and its many complications. There are clear benefits from treating tobacco dependence on the rate of clinical outcomes. In addition to behavioral therapies, various pharmacologic strategies have been developed to help achieve this goal. First-line therapies include nicotine replacement, bupropion and varenicline, a partial nicotine antagonist. Second-line treatments include clonidine and nortriptyline. Additional treatment strategies with less proven efficacy include monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, opioid receptor antagonists, bromocriptine, anti-anxiety drugs, nicotinic receptor antagonists (e.g. mecamylamine) and glucose tablets. Various approaches under investig...

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  Varenicline overdose: Hyperadrenergic symptoms: case report

(Source: Reactions)

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  Chantix MDL Sought For Personal, Economic Injuries

WASHINGTON, D.C. - Twenty-four plaintiffs this month asked to have federal Chantix cases centralized in a multidistrict litigation (In Re: Chantix (Varenicline) Products Liability Litigation, MDL Docket No. 2092, JPMDL). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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  Chantix Plaintiff's Claims Well-Pleaded; Jurisdiction OK; Dismissal Motion Denied

OMAHA, Neb. - A Nebraska federal judge on July 2 denied Pfizer Inc.'s motion to dismiss a Chantix suicide case, finding that the plaintiff stated a claim for relief and that she can sue on behalf of the decedent (Carol A. Jensen, et al. v. Pfizer, Inc., No. 08-414, D. Neb.; See 10/2/08, Page 19). Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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  ACP Journal Club. Review: Nicotine gum and varenicline, but not behavioral interventions, reduce relapse in persons who have stopped smoking.

Authors: Bentz CJ PMID: 19620155 [PubMed - in process] (Source: Annals of Internal Medicine)

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  Chantix (Varenicline) - updated on RxList

Chantix (Varenicline) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

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  Black boxes for Chantix and Zyban

(Source: Reactions)

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  Anti-Smoking Drugs May Have Psychological Effects

The FDA will now require warning labels on Chantix and Zyban, two popular anti-smoking prescription drugs that it says could spark changes in a patient, including depression, hostility and suicidal thoughts.» E-Mail This     » Add to Del.icio.us (Source: NPR Health and Science)

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  Anti-Smoking Drugs May Have Psychological Effects

The FDA will now require warning labels on Chantix and Zyban, two popular anti-smoking prescription drugs that it says could spark changes in a patient, including depression, hostility and suicidal thoughts.» E-Mail This     » Add to Del.icio.us (Source: NPR Health and Science)

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  Black boxes for Chantix and Zyban.

Page: 2 (Source: Reactions Weekly)

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  Varenicline: A Novel Pharmacotherapy for Smoking Cessation

(Source: Drugs)

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  Varenicline: A Novel Pharmacotherapy for Smoking Cessation.

Supplemental Digital Content is available in the textPage: 1319DOI: 10.2165/00003495-200969100-00003Authors: Jimenez-Ruiz, Carlos 1; Berlin, Ivan 2; Hering, Thomas 3 (Source: Drugs)

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  NIDA NewsScan #62

NewsScan #62 is a compilation of research studies that address such issues as hepatitis C and HIV infections in drug users, HIV prevalence at the U.S.-Mexico border, the effect of varenicline on learning deficits caused by nicotine withdrawal in mice as well as the effect of denicotinized cigarettes on smokers' brains, how family-based intervention helps male children of drug users, computerized cognitive-behavioral therapy and its effect on drug use, and how vigabatrin prevents relapse to methamphetamine use in an animal addiction model. (Source: National Institutes of Health (NIH) News Releases)

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  FDA Issues Suicide Warnings on Chantix, Zyban

Patients taking the stop-smoking drugs Chantix and Zyban/Wellbutrin should be closely monitored for symptoms of serious mental illness that could lead to the risk of suicide, according to a new directive from the U.S. Food and Drug Administration (FDA). (Source: Alcohol, Tobacco and Other Drugs News)

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  Chantix

Drug/Device: Chantix Defendant(s): Pfizer Inc. Case name: Lauren Crislip v. Pfizer, Inc., No. 09-2403 Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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  Smoking Cessation Drugs Chantix, Zyban, Generics, Get Black Box Suicide Warning

ROCKVILLE, Md. - Smoking cessation drugs Chantix, Zyban and Zyban-based generics must carry a black box warning of serious neuropsychiatric symptoms, the Food and Drug Administration announced July 1. Full story on lexis.com (Source: LexisNexis® Mealey's™ Emerging Drugs & Devices Legal News)

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  Varenicline withdrawal: Visual hallucinations: case report.

Page: 29 (Source: Reactions Weekly)

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  Varenicline withdrawal: Visual hallucinations: case report

(Source: Reactions)

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  Table of Contents

Impact of Depression During Pregnancy vs Impact of TreatmentCANMAT and ISBD Release Updated Bipolar Disorder Guidelines for 2009Influence of Concurrent Drugs on Aripiprazole and Its MetaboliteMeta-Analysis Assesses Antidepressants for FibromyalgiaZiprasidone With Mood Stabilizer in Maintenance Treatment of Bipolar DisorderMethylphendiate Transdermal System in Adults With ADHDLurasidone for Acute SchizophreniaWisner et al. 2009 Study DetailsPediatric Bipolar DisorderZiprasidone for Medical Morbidity With Olanzapine or ClozapineQuetiapine Plus Citalopram for OCDHallucinations in the Context of Varenicline WithdrawalNew Drug: Fanapt for SchizophreniaNew Indication: Risperdal Consta for Bipolar I DisorderNew Formulation: Lamictal Orally Disintegrating Tablets (Source: The Brown University Psyc...

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  FDA: Boxed Warning On Serious Mental Health Events To Be Required For Chantix And Zyban

The U.S. Food and Drug Administration announced that it is requiring manufacturers to put a Boxed Warning on the prescribing information for the smoking cessation drugs Chantix (varenicline) and Zyban (bupropion). The warning will highlight the risk of serious mental health events including changes in behavior, depressed mood, hostility, and suicidal thoughts when taking these drugs. (Source: Health News from Medical News Today)

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  FDA orders boxed warning for smoking cessation drugs

The Food and Drug Administration (FDA) has announced that it is requiring manufacturers to put a boxed warning on the prescribing information for the smoking cessation drugs Chantix and Zyban. (Source: Drug Topics - Clinical News)

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  FDA orders boxed warning for smoking cessation drugs

The Food and Drug Administration (FDA) has announced that it is requiring manufacturers to put a boxed warning on the prescribing information for the smoking cessation drugs Chantix and Zyban. (Source: Drug Topics - Top News)

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  FDA orders boxed warning for smoking cessation drugs

The Food and Drug Administration (FDA) has announced that it is requiring manufacturers to put a boxed warning on the prescribing information for the smoking cessation drugs Chantix and Zyban. (Source: Drug Topics - Pharmacy News)

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  FDA Adds Strong Warnings To Anti-Smoking Drug Labels

"The Food and Drug Administration announced (Wednesday) that it is requiring the smoking-cessation drugs Chantix and Zyban to carry the strongest type of safety warning possible to alert patients that the medications can cause serious mental health problems, including depression and suicide," the Washington Post reports (Stein, 7/1). (Source: Health News from Medical News Today)

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  Chantix and Zyban to Get Boxed Warning on Serious Mental Health Events

FDA is requiring manufacturers to put a Boxed Warning on the prescribing information for the smoking cessation drugs Chantix (varenicline) and Zyban (buproprion). (Source: FDA Consumer Updates)

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  Warnings for smoking-cessation drugs varenicline, bupropion

Smoking-cessation drugs varenicline and bupropion must carry a boxed warning in their labeling stating that use of the drugs has been associated with serious mental-health events, the US FDA has announced. (Source: theHeart.org)

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  Pfizer Updates CHANTIX(R) (varenicline) Labeling In The United States

Pfizer Inc announced that it has updated the U.S. product labeling for CHANTIX® (varenicline), a prescription aid to smoking cessation treatment, to communicate important safety information in a boxed warning as well as in revised warnings and precautions. These updates are based on post-marketing reports and are being made in agreement with the U.S. Food and Drug Administration (FDA). (Source: Health News from Medical News Today)

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  Smoking cessation drugs to have warnings

The US Food and Drugs Administration (FDA) has ordered Pfizer Inc. and GlaxoSmithKline PLC to add strong ‘black box’ warnings on Pfizer's Chantix and Glaxo's Zyban, smoking cessation drugs to highlight a risk of serious mental health problems including changes in behavior, depressed mood, hostility, and suicidal thoughts. Pfizer has said it had added the warning to the prescribing instructions for its drug. (Source: Healthcare)

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  Boxed Warning on Serious Mental Health Events to Be Required for Chantix and Zyban

Source: Food and Drug Administration Related MedlinePlus Topic: Quitting Smoking (Source: MedlinePlus Health News)

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  FDA orders boxed warning for smoking cessation drugs

The Food and Drug Administration (FDA) has announced that it is requiring manufacturers to put a boxed warning on the prescribing information for the smoking cessation drugs Chantix and Zyban. (Source: Modern Medicine)

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  FDA: Stop-smoking drugs Chantix, Zyban must carry suicide warning

The smoking cessation drugs Chantix and Zyban must now carry a boxed warning the strongest type possible about the risk of ... (Source: USATODAY.com Health)

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  Stop-Smoking Meds Get Suicide Warning

The FDA will immediately require drugs like Chantix to carry boxed warnings. (Source: ABC News: Health)

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  Chantix Gets Boxed In

The FDA says patients taking Chantix or Zyban need to be watched for suicide and other psychiatric problems. (Source: Forbes.com Healthcare News)

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  FDA: Anti-smoking drugs Chantix, Zyban must warn of depression

The Food and Drug Administration will require two smoking-cessation drugs, Chantix and Zyban, to carry the agency's strongest ... (Source: USATODAY.com Health)

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  Anti-Smoking Drugs Get FDA 'Black-Box' Warning

Reports link Chantix and Zyban to risk of psychiatric side effects, including suicidal thoughts Source: HealthDay Related MedlinePlus Topics: Drug Safety, Quitting Smoking (Source: MedlinePlus Health News)

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  Pfizer Updates Chantix (varenicline) Labeling in the United States

Provides Specific Instruction to Physicians and Patients About Quitting Smoking with CHANTIX NEW YORK--(BUSINESS WIRE)--Jul 1, 2009 - Pfizer Inc announced that it has updated the U.S. product labeling for CHANTIX® (varenicline), a prescription aid... (Source: Drugs.com - Pharma News)

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  FDA Requires Chantix, Zyban To Have Warning

The Food and Drug Administration will require two smoking-cessation drugs, Chantix and Zyban, to carry the agency's strongest safety warning over side effects including depression and suicidal thoughts. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)

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  FDA: Chantix To Have Mental Health Warning

The Food and Drug Administration will require Pfizer Inc.'s smoking cessation drug Chantix to carry the agency's strongest safety warning over a series of mental health side effects, including depression and suicidal thoughts. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)

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  Chantix and Zyban to Receive Boxed Warnings for Serious Neuropsychiatric Symptoms

Varenicline and bupropion are receiving boxed warnings regarding the risks for changes in behavior, hostility, agitation, depressed mood, suicidal thoughts and behavior, and attempted suicide. Medscape Medical News (Source: Medscape Today Headlines)

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  FDA: Chantix must have mental health warning

The Food and Drug Administration will require Pfizer Inc.'s smoking cessation drug Chantix to carry the agency's strongest safety ... (Source: USATODAY.com Health)

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  Popular Stop-Smoking Drugs to Carry Mental Health Risk Warnings

WASHINGTON (MedPage Today) -- The FDA announced that it will require the labels of varenicline (Chantix) and bupropion (Zyban, Wellbutrin, and generics) to carry boxed warnings on the risk of serious neuropsychiatric symptoms starting today. (Source: MedPage Today Campaign '08)

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  FDA: Boxed Warning on Serious Mental Health Events to be Required for Chantix and Zyban

The U.S. Food and Drug Administration today announced that it is requiring manufacturers to put a Boxed Warning on the prescribing information for the smoking cessation drugs Chantix (varenicline) and Zyban (bupropion). The warning will highlight the risk of serious mental health events including changes in behavior, depressed mood, hostility, and suicidal thoughts when taking these drugs. (Source: Food and Drug Administration)

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  FDA: Boxed Warning on Serious Mental Health Events to be Required for Chantix

Title: FDA: Boxed Warning on Serious Mental Health Events to be Required for ChantixCategory: Health FactsCreated: 7/1/2009Last Editorial Review: 7/1/2009 (Source: MedicineNet Cancer General)

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  FDA: Boxed Warning on Serious Mental Health Events to be Required for Chantix

Title: FDA: Boxed Warning on Serious Mental Health Events to be Required for ChantixCategory: Health FactsCreated: 7/1/2009Last Editorial Review: 7/1/2009 (Source: MedicineNet Depression General)

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  Varenicline (marketed as Chantix) and Bupropion (marketed as Zyban, Wellbutrin, and generics)

FDA requires new Boxed Warnings and patient Medication Guides highlighting the risk of serious neuropsychiatric symptoms (Source: FDA MedWatch)

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  Varenicline (marketed as Chantix) and Bupropion (marketed as Zyban, Wellbutrin, and generics)

Audience: Neuropsychiatric healthcare professionals, patients FDA notified healthcare professionals and patients that it has required the manufacturers of the smoking cessation aids varenicline (Chantix) and bupropion (Zyban and generics) to add... (Source: Drugs.com - FDA MedWatch Alerts)

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  FDA Calls for Chantix, Zyban to Feature Boxed Warning

Prescribing information for the smoking cessation drugs varenicline (Chantix) and buproprion (Zyban) must feature a boxed warning that discusses potentially serious mental health changes linked to the drugs, according to an announcement July 1 from the U.S. Food and Drug Administration. (Source: Modern Medicine)

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  Varenicline Safe for Depressed Patients

MONTREAL — Despite postmarketing concerns about the psychiatric side effects of varenicline for smoking cessation, the medication appears to be safe in patients who are depressed or at risk for depression, Jennifer B. McClure, Ph.D., reported at the annual meeting of the Society of Behavioral Medicine. (Source: Internal Medicine News)

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