MedWorm: Bupropion

  EVITA: a tool for the early EValuation of pharmaceutical Innovations with regard to Therapeutic Advantage

Conclusions: The strength of EVITA appears to lie in its speedy assessment of the potential therapeutic advantage of a new drug for a given indication. At the same time, this approach draws attention to the typical deficits of data used for drug approval. EVITA is not intended to replace classical health technology assessment reports but rather serves as a screening tool in the sense of horizon scanning. (Source: BioMed Central)

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  Combination of antidepressant medications from treatment initiation for major depressive disorder: a double-blind randomized study

Source: American Journal of Psychiatry Area: Evidence > Medicines Management > References > 2010 - March > 16 Various classes of antidepressant medications generally induce remission of major depressive disorder in only about one-third of patients. In a previous study using mirtazapine or paroxetine alone or in combination from treatment initiation, the rate of patients who remitted within a 6-week period was twice that of patients using either drug alone. In this double-blind study, the authors sought to produce evidence for the superiority of different combinations of antidepressant drugs from treatment initiation. Patients (n = 105) meeting DSM-IV criteria for major depressive disorder were randomly assigned to receive, from treatment initiation, either fluoxetine monotherapy (20 mg/da...

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  The Outcome of Unintentional Pediatric Bupropion Ingestions: A NPDS Database Review. - Beuhler MC, Spiller HA, Sasser HC.

Unintentional bupropion pediatric exposures uncommonly report severe clinical effects such as seizures. We sought to determine the clinical effects and case outcomes for unintentional bupropion ingestions in children age ... (Source: SafetyLit: All (Unduplicated))

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  BUPROPION HYDROCHLORIDEtablet, Film Coated, Extended Release [Watson Laboratories, Inc.]

Updated Date: Mar 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [Contract Pharmacy Services-PA]

Updated Date: Mar 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [Sandoz Inc]

Updated Date: Mar 9, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  The Outcome of Unintentional Pediatric Bupropion Ingestions: A NPDS Database Review.

Authors: Beuhler MC, Spiller HA, Sasser HC Unintentional bupropion pediatric exposures uncommonly report severe clinical effects such as seizures. We sought to determine the clinical effects and case outcomes for unintentional bupropion ingestions in children age </=6 years. The National Poison Data System was queried for unintentional, acute, single substance bupropion ingestions in children age </=6 years for the time period January 1, 2000 to February 27, 2007 for cases followed to a known outcome. If exposure amount was reported, a mg/kg dose was determined; when weight was absent, it was interpolated from the available data set. An adverse neurological effect (ANE) was defined as seizure (single, multi/discrete, and status) or coma. For analysis, the outcomes of no effect an...

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  APLENZIN (Bupropion Hydrobromide) Tablet, Extended Release [Sanofi-Aventis U.S. LLC]

Updated Date: Mar 5, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  WELLBUTRIN XL (Bupropion Hydrochloride) Tablet, Extended Release [BTA Pharmaceuticals]

Updated Date: Mar 4, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Combination of Antidepressant Medications From Treatment Initiation for Major Depressive Disorder: A Double-Blind Randomized Study [Articles]

Conclusions The combination treatments were as well tolerated as fluoxetine monotherapy and more clinically effective. The study results, which add to a growing body of evidence, suggest that use of antidepressant combinations from treatment initiation may double the likelihood of remission compared with use of a single medication. (Source: Am J Psychiatry)

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  Bupropion: Parkinsonism and dystonia in an elderly patient: case report

(Source: Reactions)

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  Use PDE-5 Inhibitors for Antidepressant Side Effects

SANTA FE, N.M. — Skip the yohimbe. Don't switch your patients to bupropion. Do you really want to tell them to stop taking their antidepressants before the weekend? Men and women who develop sexual dysfunction while on serotonin reuptake inhibitors (SRIs) should be treated with phosphodiesterase-5 (PDE-5) inhibitors, Dr. H. George Nurnberg told attendees at an annual psychiatric symposium sponsored by the University of Arizona. He dismissed as “clinical folklore” virtually all the commonly used remedies for sexual dysfunction associated with SRIs. (Source: Clinical Psychiatry News)

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  Buproprion Shows Benefits for Women With Hypoactive Sexual Desire Disorder

The antidepressant bupropion (Wellbutrin) may hold promise for improving symptoms in younger women with hypoactive sexual desire disorder (HSDD), a small study suggests. Reuters Health Information (Source: Medscape Medical News Headlines)

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  Effectiveness of Pharmacotherapy and Behavioral Interventions for Smoking Cessation in Actual Clinical Practice

This study looked at the effectiveness of behavioral interventions in combination with bupropion SR for smoking cessation. Therapeutic Advances in Respiratory Disease (Source: Medscape Today Headlines)

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [Contract Pharmacy Services-PA]

Updated Date: Feb 26, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Antidepressant shows benefits for low sex drive

NEW YORK (Reuters Health) - The antidepressant bupropion may hold promise for improving symptoms in younger women diagnosed with so-called hypoactive sexual desire disorder, a small study suggests. (Source: Reuters: Health)

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  Antidepressant Shows Benefits for Low Sex Drive

The antidepressant bupropion may hold promise for improving symptoms in younger women diagnosed with so-called hypoactive sexual desire disorder, a small study suggests.Source: Reuters Health Related MedlinePlus Pages: Antidepressants, Sexual Health, Women's Health (Source: MedlinePlus Health News)

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  Bupropion for the Treatment of Neuropathic Pain.

Authors: Shah TH, Moradimehr A Neuropathic pain is a common problem in clinical practice, affecting patients physically, emotionally, financially, and socially. Current treatment includes antidepressants, antiepileptics, and opioid analgesics. Bupropion is a specific inhibitor of neuronal noradrenaline reuptake and a weak inhibitor of dopamine reuptake, which shows some promise in the treatment of neuropathic pain. PMID: 20185402 [PubMed - as supplied by publisher] (Source: The American Journal of Hospice and Palliative Care)

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  Efficacy of psychostimulant drugs for cocaine dependence.

CONCLUSIONS: This review found mixed results, therefore evidence of the efficacy of psychostimulants for cocaine dependence is inconclusive. Nevertheless promising results exist for methadone maintained dual heroin-cocaine addicts and for some specific drugs such as dexamphetamine and bupropion. PMID: 20166094 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

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  A contingency-management intervention to promote initial smoking cessation among opioid-maintained patients.

Prevalence of cigarette smoking among opioid-maintained patients is more than threefold that of the general population and associated with increased morbidity and mortality. Relatively few studies have evaluated smoking interventions in this population. The purpose of the present study was to examine the efficacy of contingency management for promoting initial smoking abstinence. Forty methadone- or buprenorphine-maintained cigarette smokers were randomly assigned to a contingent (n = 20) or noncontingent (n = 20) experimental group and visited the clinic for 14 consecutive days. Contingent participants received vouchers based on breath carbon monoxide levels during Study Days 1 to 5 and urinary cotinine levels during Days 6 to 14. Voucher earnings began at $9.00 and increased by $1.50 wit...

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  Bupropion-Induced Status Epilepticus and Retrograde Amnesia [LETTERS TO THE EDITOR]

(Source: J Neuropsychiatry Clin Neurosci)

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  Synthesis and Biological Evaluation of Bupropion Analogues as Potential Pharmacotherapies for Smoking Cessation

Journal of Medicinal Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Medicinal Chemistry)

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [Mylan Pharmaceuticals Inc.]

Updated Date: Feb 16, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective ...

Urology and Nephrology Research Center, Shahid Beheshti University (MC), Tehran, Iran. (Source: UroToday)

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  Pharmacologically Induced/Exacerbated Restless Legs Syndrome, Periodic Limb Movements of Sleep, and REM Behavior Disorder/REM Sleep Without Atonia: Literature Review, Qualitative Scoring, and Comparative Analysis

Conclusion: Based on scores ≥ 10 and trials of medication reduction/cessation, the strongest evidence available for drug induced RLS are for the following drugs: escitalopram; fluoxetine; L-dopa/carbidopa and pergolide; L-thyroxine; mianserin; mirtazapine; olanzapine; and tramadol. Since none of the PLMS articles assessed PLMI in trials of medication reduction/cessation, the strongest evidence based on scores ≥ 10 are for the following drugs: bupropion, citalopram, fluoxetine, paroxetine, sertraline, and venlafaxine. Based on scores ≥ 10 and/or trials of medication cessation, the strongest evidence for drug induced RBD/RSWA is for the following drugs: clomipramine, selegiline, and phenelzine. Keywords: Pharmacologically induced, periodic limb movements of sleep, rapid eye movemen...

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [UDL Laboratories, Inc.]

Updated Date: Feb 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  WELLBUTRIN (Bupropion Hydrochloride) Tablet, Extended Release [GlaxoSmithKline LLC]

Updated Date: Feb 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [KAISER FOUNDATION HOSPITALS]

Updated Date: Feb 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Paxil May Raise Death Risk for Those Taking Tamoxefin

Breast cancer patients who are taking Tamoxefin to prevent a recurrence of the disease should not take the antidepressant Paxil (paroxetine), a new study suggests. Women in the study who took both drugs together had a greater than average risk of dying from breast cancer. The study looked at medical records for 2,430 breast cancer patients who had been taking tamoxefin. About 1 out 4 of these women had also taken Paxil; and, on average, about 41% of the time that the women were taking tamoxefin they were also taking Paxil. The researchers found that there was about one extra death from breast cancer for every 20 women who had taken the two drugs together. The researchers believe that the risk of death from breast cancer was increased because Paxil interferes with the cancer-preventing a...

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  A randomized, double-blind, placebo-controlled study of the efficacy and safety of bupropion for treating hypoactive sexual desire disorder in ovulating women

Study Type [ndash] Therapy (RCT)Level of Evidence 1b To compare the efficacy of sustained-release (SR) bupropion to placebo in treating hypoactive sexual desire disorder (HSDD) in ovulating women. After a 1-week, placebo lead-in phase, 232 treatment-seeking women with regular menstrual cycles were randomly assigned to bupropion SR 150 mg/daily (116) or placebo (116) for 12 weeks under double-blind conditions. Efficacy was assessed with the Brief Index of Sexual Functioning for Women (BISF-W), the Personal Distress Scale (PDS), the global efficacy question (GEQ; 'Did the treatment you received during the 12-week improve meaningful your sexual desire?') and overall patient satisfaction question ('Are you satisfied with the efficacy of your treatment?'). The mean (sd) composite score on the B...

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  Electrophysiological effects of the co-administration of escitalopram and bupropion on rat serotonin and norepinephrine neurons

This study was designed to investigate the effects of co-administration of bupropion with escitalopram on the firing rate of 5-HT and norepinephrine (NE) neurons in anesthetized rats. Escitalopram (10 mg/kg/day x 2 days), given via subcutaneously (s.c.) implanted minipumps, decreased the firing of 5-HT and NE neurons by 70% and 55%, respectively. The firing of 5-HT neurons, unlike that of NE neurons, recovered after the 14-day escitalopram regimen. Bupropion, injected once daily (30 mg/kg/day, s.c. x 2 days), did not increase 5-HT firing but decreased that of NE by 55%. After 14 days of repeated bupropion administration, 5-HT firing was increased by 50%, and NE firing was back to baseline. Co-administration of escitalopram and bupropion doubled 5-HT firing after 2 and 14 days, whereas NE n...

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  Use of Enantiomeric Bupropion and Hydroxybupropion to Assess CYP2B6 Activity in Glomerular Kidney Diseases.

Authors: Joy MS, Frye RF, Stubbert K, Brouwer KR, Falk RJ, Kharasch ED There are limited data describing the influence of chronic kidney diseases on the cytochrome P450 2B6 pathway. The purpose of this study was to evaluate the pharmacokinetics of enantiomeric bupropion and hydroxybupropion in patients with glomerulonephritis. Ten patients with biopsy-confirmed lupus nephritis or antineutrophil-associated vasculitis were enrolled for CYP2B6 phenotyping with oral bupropion. Blood and urine were collected over 72 hours for pharmacokinetic analysis. R- and S-bupropion and (R,R) and (S,S) hydroxybupropion were analyzed by high-performance liquid chromatography tandem mass spectrometry. Statistics included paired t tests or nonparametric equivalent. Bupropion (2329 +/- 953 mug*h/L vs 1240 +...

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  Biovail Comments On Proposed Generic Wellbutrin XL(R) Trial

Biovail Corporation (NYSE/TSX: BVF) today commented on a proposed clinical trial recently announced by Teva Pharmaceutical Industries Ltd. According to Teva, the trial is intended to address reports of inefficacy and adverse events by consumers who switched from Wellbutrin XL® 300 mg, Biovail's FDA-approved brand of the antidepressant, bupropion hydrochloride, to Budeprion XL, Teva's generic formulation of the drug. The trial was described in a Dow Jones Newswire article dated December 2, 2009... (Source: Health News from Medical News Today)

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  Bupropion metabolism by human placenta.

Authors: Wang X, Abdelrahman DR, Zharikova OL, Patrikeeva SL, Hankins GD, Ahmed MS, Nanovskaya TN Smoking during pregnancy is the largest modifiable risk factor for pregnancy-related morbidity and mortality. The success of bupropion for smoking cessation warrants its investigation for treatment of pregnant patients. Nevertheless, the use of bupropion for the treatment of pregnant smokers requires additional data on its biodisposition during pregnancy. Therefore, the aim of this investigation was to determine the metabolism of bupropion in placentas obtained from nonsmoking and smoking women, identify metabolites formed and the enzymes catalyzing their formation, as well as the kinetics of the reaction. Data obtained revealed that human placentas metabolized bupropion to hydroxybupropio...

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  Biovail Comments on Proposed Generic Wellbutrin XL(R) Trial

TORONTO--(HSMN NewsFeed)--Biovail Corporation (NYSE/TSX: BVF) today commented on a proposed clinical trial recently announced by Teva Pharmaceutical Industries Ltd. According to Teva, the trial is intended to address reports of inefficacy and adverse event... Biopharmaceuticals, GenericsBiovail, Wellbutrin, Teva Pharmaceutical, bupropion (Source: HSMN NewsFeed)

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  Statistics on NHS Stop Smoking Services: England, April 2009 to September 2009

Source: NHS Information Centre Area: News This quarterly report presents provisional results from the monitoring of the NHS Stop Smoking Services in England from 1 April 2009 to 30 September 2009. Key facts on treatments include the following, though these data should not be used to assess or compare the clinical effectiveness of the various pharmacotherapies:   . The majority of those setting a quit date received Nicotine Replacement Therapy (NRT) only (65%), 23% varenicline, 1% bupropion, 1% both NRT and varenicline and < 1% received both NRT and bupropion, whilst 5% did not receive any pharmacotherapy.   . Of those who used varenicline 59% successfully quit, compared with 50% who received bupropion only, and 48% who received NRT only, whilst 42% of people...

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  A bupropion smoking cessation clinical trial for cancer patients

Conclusions  For patients with depression symptoms, bupropion increases abstinence rates, lowers withdrawal, and increases quality of life. However, abstinence rates among patients with depression symptoms were low vs. patients without depression symptoms, who exhibited similar abstinence rates when treated with bupropion or transdermal nicotine and counseling alone. These results can guide future smoking cessation intervention studies with cancer patients. Content Type Journal ArticleCategory Original paperDOI 10.1007/s10552-010-9507-8Authors Robert A. Schnoll, University of Pennsylvania Department of Psychiatry 3535 Market Street, 4th Floor Philadelphia PA 19104 USAElisa Martinez, Fox Chase Cancer Center 333 Cottman Avenue Philadelphia PA 19111 USAKristina L. Tatum,...

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  Design, recruitment, and retention of African-American smokers in a pharmacokinetic study

Conclusions: Although recruitment of African-American smokers into a non-treatment, pharmacokinetic study poses challenges, retention is feasible. The results provide valuable information for investigators embarking on non-treatment laboratory-based studies among minority populations. (Source: BioMed Central)

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  Modeling smoking cessation data with alternating states and a cure fraction using frailty models

We propose a flexible parametric model to describe alternating states recurrent-event data where there is a possibility of cure with each type of event. We begin by introducing a novel cure model in which a common frailty influences both the cure probability and the hazard function given not cured. We then extend our model to data with recurring events of two alternating types. We assume that each type of event has a gamma frailty, and we link the frailties by a Clayton copula. We illustrate the model with an analysis of data from two smoking cessation trials comparing bupropion and placebo, in which each subject potentially experienced a series of lapse and recovery events. Our analysis suggests that bupropion increases the probability of permanent cure and decreases the hazard of lapse, ...

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  BUPROPION HYDROCHLORIDEtablet, Extended Release [KAISER FOUNDATION HOSPITALS]

Updated Date: Jan 13, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  BUPROPION HYDROCHLORIDEtablet, Extended Release [KAISER FOUNDATION HOSPITALS]

Updated Date: Jan 12, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Amitriptyline/bupropion/fluspirilene interaction: First report of an interaction, leading to tonic-clonic seizure in a sleep-deprived patient: case report

(Source: Reactions)

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  Bupropion: Neck and shoulder pain in an elderly patient: case report

(Source: Reactions)

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  The effects of the adjunctive bupropion on male sexual dysfunction induced by a selective serotonin reuptake inhibitor: a double-blind placebo-controlled and randomized study

Study Type [ndash] Therapy (RCT)Level of Evidence 1b To determine the safety and efficacy of adjunctive bupropion sustained-release (SR) on male sexual dysfunction (SD) induced by a selective serotonin reuptake inhibitor (SSRI), as SD is a common side-effect of SSRIs and the most effective treatments have yet to be determined. The randomized sample consisted of 234 euthymic men who were receiving some type of SSRI. The men were randomly assigned to bupropion SR (150 mg twice daily, 117) or placebo (twice daily, 117) for 12 weeks. Efficacy was evaluated using the Clinical Global Impression-Sexual Function (CGI-SF; the primary outcome measure), the International Index of Erectile Function (IIEF), Arizona Sexual Experience Scale (ASEX), and Erectile Dysfunction Inventory of Treatment Satisfac...

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  Answers to your questions about SSRIs.

Authors: White C, Wigle PR, Albert LG, Eichel E, Udorn L Avoid prescribing a highly activating SSRI, such as fluoxetine, for patients for whom agitation is a presenting symptom. Consider citalopram and escitalopram, which have less potential for drug interactions and less complex dose titration compared with other SSRIs, as first-line agents for depressed patients with complex medication profiles. For patients with sexual side effects caused by SSRIs, consider augmentation therapy with bupropion or mirtazapine; for male sexual dysfunction, a trial of a phosphodiesterase inhibitor is another alternative. PMID: 20074497 [PubMed - in process] (Source: The Journal of Family Practice)

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  The Relationship between Antidepressant Use and Smoking Cessation in Pregnant Women in Treatment for Substance Abuse.

Conclusions: Trend for greater decrease in smoking for the bupropion vs. citalopram/escitalopram group [-6.4 vs. -.4 cigarettes/day (p = .276)], although the bupropion decrease was similar to that seen in the no antidepressant group [-5.3 cigarettes/day]. Scientific Significance: Data support continued study of bupropion in depressed pregnant substance-dependent smokers. PMID: 20141396 [PubMed - in process] (Source: The American Journal of Drug and Alcohol Abuse)

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  Bupropion Plus Naltrexone Improves Weight Loss in Obese Patients

Bupropion plus naltrexone led to greater weight loss than monotherapy or placebo in a preliminary study in obese patients. Reuters Health Information (Source: Medscape Today Headlines)

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  BUPROPION HYDROCHLORIDEtablet, Extended Release [Watson Laboratories, Inc.]

Updated Date: Dec 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  WELLBUTRIN XL (Bupropion Hydrochloride) Tablet, Extended Release [BTA Pharmaceuticals]

Updated Date: Dec 24, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Combination Antidepressant Therapy More Effective for MDD Than Fluoxetine Alone

The combinations of mirtazapine with fluoxetine, venlafaxine, or bupropion from treatment initiation are more clinically effective when treating MDD than fluoxetine alone. Medscape Medical News (Source: Medscape Today Headlines)

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  Combination Antidepressant Therapy May Be More Effective for Major Depression Than Monotherapy

Initial treatment with mirtazapine in combination with fluoxetine, venlafaxine, or bupropion is more effective in the treatment of MDD than fluoxetine alone. Medscape Medical News (Source: Medscape Psychiatry Headlines)

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  Mirtazapine and Bupropion Combined Treatment in Treatment-resistant Depression

We present a case of treatment-resistant depression with fu ...more (Source: Tzu Chi Medical Journal)

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  Antidepressant Pharmacotherapy in Adults with Type 2 Diabetes: Rates and Predictors of Initial Response.

Conclusions: In patients with type 2 diabetes, poor initial response to antidepressant medication is predicted by multiple factors. Auxiliary treatment of pain and impairment may be required to achieve better outcomes. PMID: 20032276 [PubMed - as supplied by publisher] (Source: Diabetes Care)

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  Preliminary effects of bupropion and the promoter region (HTTLPR) serotonin transporter (SLC6A4) polymorphism on smoking behavior in schizophrenia

This study provides preliminary evidence of how polymorphisms in the serotonin transporter can be informative in predicting individual responses to smoking reduction therapy. (Source: Psychiatry Research)

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  BUPROPION HYDROCHLORIDEtablet, Extended Release [Watson Laboratories, Inc.]

Updated Date: Dec 22, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Journal Scan: Comparative Effectiveness of 5 Smoking Cessation Pharmacotherapies in Primary Care Clinics (Arch Intern Med 2009;169:2148-2155.)

A total of 1,346 primary care patients attending routine appointments were recruited by medical assistants in 12 primary care clinics. Patients were randomly assigned to five active pharmacotherapies: three monotherapies (nicotine patch, nicotine lozenge, and bupropion hydrochloride sustained releas. . . (Source: Cardiosource)

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  A new model of the disrupted latent inhibition in C57BL/6J mice after bupropion treatment

Conclusions  Efficacy of rolipram but not antipsychotics to reverse the effects of bupropion suggests novel cAMP-dependent and D2 receptor-independent mechanisms of the bupropion-induced LI deficit. Further detailed biochemical analysis of bupropion-induced LI deficit might be a fruitful approach in developing new antipsychotics. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1749-3Authors Tatiana Lipina, Mount Sinai Hospital Samuel Lunenfeld Research Institute 600 University Avenue Toronto ON Canada M5G 1X5John Roder, Mount Sinai Hospital Samuel Lunenfeld Research Institute 600 University Avenue Toronto ON Canada M5G 1X5 Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-3158 (Source: Psychopharmacology)

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  In practice, anti-smoking drug combinations give greater smoking quit rates than monotherapy

This study aimed to determine what proportion of smokers visiting a primary care clinic for routine appointments will make a quit attempt when pharmacotherapy is available at no charge, and which of a range of treatments was most effective. Participants were adults smoking 10 or more cigarettes daily who were suitable for treatment with the study medications recruited at a visit to their primary care clinic. They were randomised to receive one of five open-label interventions, three monotherapy and two combinations: nicotine patch, bupropion SR, nicotine lozenge, bupropion SR + lozenge, and patch + ... (Source: NeLM - News)

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  Comparative Effectiveness of 5 Smoking Cessation Pharmacotherapies in Primary Care Clinics [Original Investigation]

Conclusions  One in 5 smokers attending a routine primary care appointment was willing to make a serious quit attempt that included evidence-based counseling and medication. In this comparative effectiveness study of 5 tobacco dependence treatments, combination pharmacotherapy significantly increased abstinence compared with monotherapies. Provision of free cessation medications plus quit line counseling arranged in the primary care setting holds promise for assisting large numbers of smokers to quit. Trial Registration  clinicaltrials.gov Identifier: NCT00296647 (Source: Archives of Internal Medicine)

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  Bupropion for Depression in Schizophrenia: A Case Report

PharmacopsychiatryDOI: 10.1055/s-0029-1242818© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Full text (Source: Pharmacopsychiatry)

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [Mylan Pharmaceuticals Inc.]

Updated Date: Dec 11, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Interaction of the human plasma membrane monoamine transporter (hPMAT) with antidepressants and antipsychotics

Abstract  Monoamine neurotransmission is efficiently terminated through synaptic reuptake of released neurotransmitters by high-affinity Na+- and Cl−-dependent neuronal monoamine transporters of the SLC6A family located in the plasma membrane of presynaptic nerve terminals. Recently, a low-affinity, high-capacity Na+- and Cl−-independent plasma membrane monoamine transporter (PMAT) belonging to the SLC29 solute carrier family has been cloned. PMAT was shown to transport monoamine neurotransmitters as well as organic cations such as 1-phenyl-4-methyl-pyridinium (MPP+). Thus, the PMAT which is highly expressed in the human brain may be involved in the modulation of central monoaminergic neurotransmission and it may be a target for drugs used to treat depression and schizoph...

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [TEVA Pharmaceuticals USA Inc]

Updated Date: Dec 8, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Blockade of dopamine, but not noradrenaline, transporters produces hyperthermia in rats that lack serotonin transporters.

Authors: Olivier JD, Cools AR, Deen PM, Olivier B, Ellenbroek BA To investigate whether life-long disturbed serotonin neurotransmission may result in adaptive changes of dopaminergic and noradrenergic systems, effects of drugs on stress-induced hyperthermia were studied in serotonin transporter knockout rats. The noradrenalin transporter blocker atomoxetine was more effective in reducing stress-induced hyperthermia, induced by an injection, in serotonin transporter (SERT) knockout (SERT(-/-)) rats compared to SERT(+/+) rats. The dopamine transporter blocker GBR12909 increased the core body temperature in SERT(-/-) rats, and had no effect on the SERT(+/+) rats. Finally, the noradrenalin transporter together with dopamine transporter blocker bupropion was more effective in decreasing the...

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  Effects of antidepressant treatment on heart rate variability in major depression: a quantitative review

Source: DARE Area: Evidence > Medication Safety CRD Summary: This review concluded that the use of tricyclic antidepressants in patients diagnosed with major depressive disorder lead to changes in heart rate variability that were associated with an increased risk of mortality. The authors' conclusions appeared to reflect the evidence but, given the methodological limitations, these conclusions should be interpreted with caution as they may not be reliable. [Of the included studies, tricyclic antidepressants included amitriptyline, imipramine and doxepin. Selective serotonin reuptake inhibitor medications included fluvoxamine, paroxetine and fluoxetine. Other drugs included bupropion, mirtazapine, nefazodone and reboxetine. ] CRD Commentary: This review addressed a clear question in t...

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  Wellbutrin alternative didn't help

Is there anything new on the generic version of Wellbutrin XL? My wife had done well on the brand name and then the Watson generic bupropion for several years. She was abruptly switched to Teva's Budeprion last spring. Her depression returned. (Source: L.A. Times - Health)

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  Antidepressants: Benefit Of Reboxetine Not Proven

There is no scientific proof that people suffering from depression can benefit from taking reboxetine. However, clinical trials do provide proof of benefit of bupropion XL and mirtazapine: both agents can alleviate symptoms. This is the conclusion of the final report of the Institute for Quality and Efficiency in Health Care (IQWiG) published on 24 November 2009. (Source: Health News from Medical News Today)

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  Antidepressants: Benefit Of Reboxetine Not Proven

There is no scientific proof that people suffering from depression can benefit from taking reboxetine. However, clinical trials do provide proof of benefit of bupropion XL and mirtazapine: both agents can alleviate symptoms. This is the conclusion of the final report of the Institute for Quality and Efficiency in Health Care (IQWiG) published on 24 November 2009. (Source: Pharma Industry News From Medical News Today)

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  Benefit of Reboxetine Antidepressant not Proven

There is no scientific proof that people suffering from depression can benefit from taking reboxetine. However, clinical trials do provide proof of benefit of bupropion XL and mirtazapine: both agents can alleviate symptoms. (Source: Disabled World)

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  Antidepressants: Benefit of reboxetine not proven

(Institute for Quality and Efficiency in Health Care) There is no scientific proof that people suffering from depression can benefit from taking reboxetine. However, clinical trials do provide proof of benefit of bupropion XL and mirtazapine. This is the conclusion of the final report of the Institute for Quality and Efficiency in Health Care published on Nov. 24, 2009. The final evaluation of reboxetine and mirtazapine was only possible after manufacturers disclosed data that had previously been concealed. (Source: EurekAlert! - Social and Behavioral Science)

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  Gemfibrozil-Induced Myositis in a Patient with Normal Renal Function (January).

CONCLUSIONS: Although the risk of myositis appears to be low with gemfibrozil monotherapy, clinicians should be aware of the potential for this adverse event. For patients taking gemfibrozil monotherapy who present with myalgia, discontinuation of the medication may be necessary for the alleviation of pain. PMID: 19934390 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

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  Bupropion: Delirium in a patient with bipolar disorder: case report

(Source: Reactions)

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  Incidence and onset of delayed seizures after overdoses of extended-release bupropion. - Starr P, Klein-Schwartz W, Spiller H, Kern P, Ekleberry SE, Kunkel S.

This study systematically evaluates the frequency and timing of seizures and an association between other toxic effects (ie, agitation, tremors, and hallucin... (Source: SafetyLit: All (Unduplicated))

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  The Cost-Effectiveness of an Extended Course (12 + 12 Weeks) of Varenicline Compared with Other Available Smoking Cessation Strategies in the United States: An Extension and Update to the BENESCO Model

Conclusions: A total of 12 weeks of varenicline followed by a further 12-week course for successful quitters is a highly cost-effective alternative compared with currently available smoking cessation options. (Source: Value in Health)

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  BUPROPION (Bupropion Hydrochloride) Tablet, Extended Release [Physicians Total Care, Inc.]

Updated Date: Nov 10, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Repeated medication-assisted smoking cessation may be effective

Source: Arch Internal Med Area: News A case series report suggests that smokers who fail to quit after one cycle of pharmacotherapy may benefit from repeated cycles.   The authors note that while controlled trials show benefit in improving quit rates in smokers using cessation therapy, many will not be successful on the first attempt and there is little published information on the outcome of subsequent attempts. They therefore followed a cohort of smokers who were offered up to four courses of pharmacotherapy for smoking cessation over a two year period.   The cohort was recruited from rural primary care clinics in Kansas USA; there were 726 initially and they were offered pharmacotherapy to help quitting at six month intervals. Options offered were nicotine replacement...

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  Addition of psychotherapy to medication in patients with inadequate response to antidepressants no better than optimisation of pharmacotherapy?

Source: Arch Gen Psychiatry Area: News The results of a study (REVAMP trial) designed to evaluate the effects of adding psychotherapy to medication in patients with chronic depression not responding adequately to a trial of antidepressants has been published in the Archives of General Psychiatry.    The trial included chronically depressed patients with a major depressive episode (according to DSM-IV criteria) who had persistent depressive symptoms for more than two years.  There were two 12-week phases.  During phase 1 (n=808), patients were assigned to receive an antidepressant according to an algorithm, based on their previous response to treatment (choices were escitalopram, sertraline, bupropion SR, venlafaxine SR, or mirtazapine).  Patients achieving les...

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  Nicotine patch plus lozenge best for smoking cessation?

Source: Arch Gen Psychiatry Area: News The results of a randomised, placebo-controlled trial evaluating the relative efficacies of nicotine lozenges, nicotine patches, bupropion, nicotine patches plus nicotine lozenges, and bupropion plus nicotine lozenges in smoking cessation has been published in the Archives of General Psychiatry.   A total of 1,504 adult smokers were recruited into this US study; all smoked an average of ?10 cigarettes per day for at least the past 6 months and were motivated to quit smoking.  Those using any other form of tobacco, currently taking bupropion, or with a current psychosis or schizophrenia diagnosis were excluded from the study.  Participants were randomised in a double-blind fashion to one of the following, in addition to individual c...

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  ORIGINAL ARTICLE: A Randomized Placebo-Controlled Clinical Trial of 5 Smoking Cessation Pharmacotherapies

Conclusion  While the nicotine lozenge, bupropion, and bupropion plus lozenge produced effects that were comparable with those reported in previous research, the nicotine patch plus lozenge produced the greatest benefit relative to placebo for smoking cessation. (Source: Archives of General Psychiatry)

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  A Randomized Placebo-Controlled Clinical Trial of 5 Smoking Cessation Pharmacotherapies [Original Article]

Conclusion  While the nicotine lozenge, bupropion, and bupropion plus lozenge produced effects that were comparable with those reported in previous research, the nicotine patch plus lozenge produced the greatest benefit relative to placebo for smoking cessation. (Source: Archives of General Psychiatry)

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  Combination Smoking Cessation Therapy Increases Abstinence Rates in Teens

The first study of combination therapy of bupropion SR and contingency management for smoking cessation in adolescents suggests that a combination of the 2 is superior to either treatment alone. Medscape Medical News (Source: Medscape Today Headlines)

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  Treatment for SRI-Linked Sex Problems Studied

SANTA FE, N.M. — Skip the yohimbe. Don't switch your patients to bupropion, and don't tell them to stop taking their antidepressants before the weekend. Men and women who develop sexual dysfunction while on serotonin reuptake inhibitors (SRIs) should be treated with phosphodiesterase-5 (PDE-5) inhibitors, Dr. H. George Nurnberg told attendees at an annual psychiatric symposium sponsored by the University of Arizona. He dismissed as “clinical folklore” virtually all the commonly used remedies for sexual dysfunction associated with SRIs. (Source: Ob.Gyn. News)

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  Use and reimbursement costs of smoking cessation medication under the Quebec public drug insurance plan.

CONCLUSION: The reimbursement provisions put in place in Quebec in 2000 were successful in reaching financially disadvantaged smokers, at a cost that was comparable with other effective smoking cessation services. PMID: 20209733 [PubMed - in process] (Source: Canadian Journal of Public Health)

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  The Roles of Dopamine Transport Inhibition and Dopamine Release Facilitation in Wake Enhancement and Rebound Hypersomnolence Induced by Dopaminergic Agents

Conclusions: All DA releasing agents tested, and some DAT-inhibiting agents, produced RHS at equal wake-promoting doses. Thus amphetamine-like DA release appears sufficient for inducing RHS, but additional properties (pharmacologic and/or pharmacokinetic) evidently underlie RHS of other DAT inhibitors. Enhancing wake while mitigating RHS can be achieved by combining DAT-inhibiting and DA-releasing agents. Keywords: Sleep/wake, dopamine transporter, amphetamine, hypersomnolence, pharmacokinetic, rat (Source: Sleep)

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  An open-label study of naltrexone and bupropion combination therapy for smoking cessation in overweight and obese subjects.

Authors: Wilcox CS, Oskooilar N, Erickson JS, Billes SK, Katz BB, Tollefson G, Dunayevich E A combination of sustained release (SR) naltrexone (32mg/day) and bupropion SR (360mg/day) plus behavioral counseling was evaluated for the treatment of smoking cessation and mitigation of nicotine withdrawal and weight gain. Thirty overweight or obese nicotine-dependent subjects were enrolled in a 24-week, open-label study; 85% and 63% completed 12 and 24weeks, respectively. The target quit date was Week 4. Week 4-12 continuous abstinence rate was 48%, 78% of subjects achieved CO</=10ppm, serum cotinine decreased from 185 to 48mug/L, and tobacco use decreased from 129 to 14 cigarettes/week. Similar results were seen at Week 24. Body weight was essentially unchanged (Week 12: -0.1%; Week 24: ...

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  Gestational Exposure to Antidepressants and the Risk of Spontaneous Abortion: A Review.

Conclusions. This review suggests that gestational exposure to antidepressants, especially paroxetine and venlafaxine, can lead to spontaneous abortion. PMID: 19863482 [PubMed - as supplied by publisher] (Source: Current Drug Delivery)

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  Effects of Treatment for Tobacco Dependence on Resting Cerebral Glucose Metabolism

Authors: Matthew R Costello, Mark A Mandelkern, Stephen Shoptaw, Stephanie Shulenberger, Stephanie K Baker, Anna L Abrams, Catherine Xia, Edythe D London & Arthur L Brody Keywords: tobacco dependence, nicotine, cigarette, 18F-fluorodeoxyglucose–positron emission tomography (FDG–PET), statistical parametric mapping, bupropion HCl (Source: Neuropsychopharmacology)

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  Orexigen Therapeutics Releases New Efficacy Data for Contrave(R) in Late Breaker Presentations at the 27th Annual Scientific Meeting of The Obesity Society

SAN DIEGO, October 27, 2009 /PRNewswire-FirstCall/ -- Orexigen(R) Therapeutics, Inc. today announced results from new intent to treat (ITT) analyses from the COR-I and COR-II Phase 3 trials of Contrave(R) (naltrexone SR/bupropion SR), the first... (Source: Drugs.com - Clinical Trials)

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  A randomised trial of glucose tablets to aid smoking cessation

Conclusions  No significant effect of glucose tablets over and above sweet tasting tablets could be detected overall, but the possibility of an effect as an adjunct to NRT or bupropion merits further investigation. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1692-3Authors Robert West, University College London Cancer Research UK Health Behaviour Research Centre, Department of Epidemiology and Public Health London WC1E 6BT UKSylvia May, University College London Health Behaviour Research Centre London UKAndy McEwen, University College London Health Behaviour Research Centre London UKHayden McRobbie, University of Auckland Clinical Trials Research Unit Auckland New ZealandPeter Hajek, Barts and the London, Queen Mary’s School of Med...

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  BUPROPION (Bupropion Hydrochloride) Tablet, Extended Release [Physicians Total Care, Inc.]

Updated Date: Oct 26, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [Contract Pharmacy Services-PA]

Updated Date: Oct 22, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Comparison of Combined Bupropion and Naltrexone Therapy for Obesity with Monotherapy and Placebo.

Conclusions: NB caused gradual sustained weight loss over 48 wk; NB32 and NB16 demonstrated greater weight loss in the intent-to-treat population due to lower attrition rates. Further study is needed to demonstrate long-term efficacy and safety of NB. PMID: 19846734 [PubMed - as supplied by publisher] (Source: The Journal of Clinical Endocrinology and Metabolism)

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [Sandoz Inc]

Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Synthesis and Biological Evaluation of Bupropion Analogues as Potential Pharmacotherapies for Cocaine Addiction

Journal of Medicinal Chemistry, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Journal of Medicinal Chemistry)

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  Varenicline and suicidal behaviour: a cohort study based on data from the General Practice Research Database. - Gunnell D, Irvine D, Wise L, Davies C, Martin RM.

OBJECTIVE: To determine whether varenicline, a recently licensed smoking cessation product, is associated with an increased risk of suicide and suicidal behaviour compared with alternative treatments bupropion and nicotine replacement therapy. DESIGN: Coho... (Source: SafetyLit: All (Unduplicated))

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  WELLBUTRIN (Bupropion Hydrochloride) Tablet, Film Coated [SmithKline Beecham Corporation]

Updated Date: Oct 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Intravenous Lipid Emulsion as Antidote (review)

CONCLUSION: Available data, though limited,  suggest that ILE may be beneficial in treating life-threatening cardiotoxicity induced by highly lipophilic drugs.  Physicians managing these cases should follow established guidelines and consult at an early stage with a poison center. (66 references) COMMENT:  This thoughtful review is well worth reading. Although ILE is not yet ready for routine use in the early stages of resuscitation, many toxicologists would recommend it as a last-ditch effort when a lipophilic drug has caused cardiovascular collapse not improved by standard treatment.  The strongest statement to this effect has been by Jeffrey Brent in a recent editorial: “It is fair to say that based on what we know so far, no patient dying of cadiotoxic drug poisoning should d...

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  Varenicline and suicidal behaviour: a cohort study based on data from the General Practice Research Database

Source: BMJ Area: News According to the authors of a cohort study published early online in the British Medical Journal, an increased risk of self-harm with varenicline cannot be ruled out.  They do note however that their results 'provide some reassurance concerning its association with suicidal behaviour'.   The MHRA issued a warning in December 2007, after reports of depression and suicidal thoughts among people prescribed varenicline; further warnings were issued in July and November 2008.  Similar warnings have been issued by regulatory authorities worldwide, and the US FDA recently required the manufacturers of both varenicline and bupropion to add a new "boxed warning" to the product labelling based on the continued review of post-marketing adverse event reports....

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  Chantix-Suicide Link Questioned

Earlier this year, the FDA ordered a "black box" warning be added to the drugs Chantix (varenicline) and Zyban (bupropion), which are both used as aids in quitting smoking. ... (Source: About.com Depression)

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  Smoking Cessation Strategies Now Numerous: Try nicotine replacement therapy plus bupropion or high-dose NRT plus nicotine gum or lozenges.

ESTES PARK, COLO. — Three major drug classes with diverse mechanisms of action are now approved for smoking cessation, providing an unprecedented array of options in terms of sequential and combination therapies. (Source: Clinical Psychiatry News)

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  Crossing Borders: Factors Affecting Differences in Cost-Effectiveness of Smoking Cessation Interventions between European Countries

Conclusions: Although all INMBs were positive, there were significant differences across countries. These were primarily related to choice of discount rate and epidemiology of diseases. (Source: Value in Health)

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  Incidence and onset of delayed seizures after overdoses of extended-release bupropion

Conclusion: Delayed seizure onset suggests a minimum observation period of 24 hours after bupropion XL overdose. Although patients experiencing agitation or tremors may be at greater risk, seizures can occur without preceding central nervous system toxicity. (Source: The American Journal of Emergency Medicine)

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  Efficacy of pharmacotherapies for short-term smoking abstinence: A systematic review and meta-analysis.

Background: Smoking cessation has important immediate health benefits. The comparative short-term effectiveness of smoking cessation interventions is not well known. We aimed to determine the relative effectiveness of nicotine replacement therapy (NRT), bupropion and varenicline at 4 weeks post-target quit date. Methods: We searched 10 electronic medical databases (inception to October 2008). We selected randomized clinical trials [RCTs] evaluating interventions for our primary outcome of abstinence from smoking at at-least 4 weeks post-target quit date, with biochemical confirmation. We conducted random-effects odds ratio (OR) meta-analysis and meta-regression. We compared treatment effects across interventions using head-to-head trials and calculated indirect comparisons. Results: We com...

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  Bupropion and nicotine enhance responding for nondrug reinforcers via dissociable pharmacological mechanisms in rats

Conclusion  The reinforcement enhancing effects of nicotine and bupropion increased over time and repeated treatments suggesting a shared mechanism of action. However, the reinforcement enhancing effects of nicotine are mediated by nicotinic acetylcholine receptors, whereas the reinforcement enhancing effects of bupropion were mediated by alpha noradrenergic receptors. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1666-5Authors Matthew I. Palmatier, Kansas State University Department of Psychology 469 Bluemont Hall Manhattan KS 66502 USAMelissa E. Levin, University of Pittsburgh Department of Psychology Pittsburgh PA 15260 USAKara L. Mays, University of Pittsburgh Department of Neuroscience Pittsburgh PA 15260 USAEric C. Donny, Unive...

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  Comparative benefits and harms of competing medications for adults with attention-deficit hyperactivity disorder: a systematic review and indirect comparison meta-analysis

Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: This generally well-conducted review assessed the efficacy and safety of treatments for attention-deficit hyperactivity disorder in adults. The authors concluded that the use of immediate release methylphenidate as a first-line treatment was supported. The questionable quality of many of the included studies and some concerns over the appropriateness of the synthesis may mean these conclusions were overstated. [Studies of the following treatments were eligible: amphetamine mixture, dextroamphetamine sulphate, methylphenidate HCl, dexmethylphenidate HCl, modafinil, atomoxetine HCl and bupropion HCl. ] CRD Commentary: The review question and inclusion criteria were clearly specified. The authors searched a number of rele...

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  Predicting adherence to treatment for methamphetamine dependence from neuropsychological and drug use variables

Abstract: Although some individuals who abuse methamphetamine have considerable cognitive deficits, no prior studies have examined whether neurocognitive functioning is associated with outcome of treatment for methamphetamine dependence. In an outpatient clinical trial of bupropion combined with cognitive behavioral therapy and contingency management (Shoptaw, S., Heinzerling, K.G., Rotheram-Fuller, E., Steward, T., Wang, J., Swanson, A.N., De La Garza, R., Newton, T., Ling, W., 2008. Randomized, placebo-controlled trial of bupropion for the treatment of methamphetamine dependence. Drug Alcohol Depend 96, 222-232.), 60 methamphetamine-dependent adults completed three tests of reaction time and working memory at baseline. Other variables that were collected at baseline included measures of ...

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  [Care Results in a Specialist Stop-Smoking Unit.]

CONCLUSIONS: A stop-smoking clinic that is designed according to SEPAR Recommendations is effective and has a good cost/effective ratio. PMID: 19758742 [PubMed - as supplied by publisher] (Source: Archivos de Bronconeumologia)

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  UCLA researchers develop biomarker for rapid relief of major depression

It is a long, slow slog to treat major depression. Many antidepressant medications are available, but no single biomarker or diagnostic test exists to predict which one is right for an individual. As a result, for more than half of all patients, the first drug prescribed doesn't work, and it can take months to figure out what does. Now, based on the final results of a nationwide study led by UCLA, clinicians may be able to accurately predict within a week whether a particular drug will be effective by using a non-invasive test that takes less than 15 minutes to administer. The test will allow physicians to quickly switch patients to a more effective treatment, if necessary. The study, called the Biomarkers for Rapid Identification of Treatment Effectiveness in Major Depression, or BRITE-...

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  Low-Dose Buspirone, Melatonin and Low-Dose Bupropion Added to Mood Stabilizers for Severe Treatment-Resistant Bipolar Depression

Psychother Psychosom 2009;78:391-393 (DOI:10.1159/000235985) (Source: Karger Publishers)

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  Effectiveness of a quantitative electroencephalographic biomarker for predicting differential response or remission with escitalopram and bupropion in major depressive disorder

We examined the Antidepressant Treatment Response (ATR) index as a predictor of differential response and remission to escitalopram, bupropion, or a combination of the two medications, in subjects with major depressive disorder (MDD). Three hundred seventy-five subjects had a baseline quantitative electroencephalographic (QEEG) study preceding 1 week of treatment with escitalopram, 10 mg, after which a second QEEG was performed and the ATR index was calculated. Subjects then were randomized to continue escitalopram, switch to bupropion, or receive a combination of the two. Clinical response was assessed using the 17-item Hamilton Depression Rating Scale at 49 days of treatment. Accuracy of ATR in predicting response and remission was calculated. There were no significant differences betwe...

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  Bupropion-Induced Neck and Shoulder Pain

Pharmacopsychiatry 2009; 42: 203-204DOI: 10.1055/s-0029-1220934© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Full text (Source: Pharmacopsychiatry)

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  Cost Effectiveness of Varenicline in Belgium, Compared with Bupropion, Nicotine Replacement Therapy, Brief Counselling and Unaided Smoking Cessation: A BENESCO Markov Cost-Effectiveness Analysis

(Source: Clinical Drug Investigation)

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  Recalls and Safety Alerts: Warning on Neuropsychiatric Effects from Smoking Cessation Drugs

FDA is requiring that two drugs used to help people stop smoking carry new warnings about the risk of serious neuropsychiatric effects. The drugs are Chantix (varenicline) and Zyban (bupropion). The same warnings will be required for other bupropio... (Source: Food and Drug Adminstration (FDA): Patient Safety News)

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  Significant Weight Loss Shown With Naltrexone/Bupropion Combo

NEW ORLEANS — An investigational oral agent that combines naltrexone and bupropion produced clinically meaningful weight loss at 56 weeks, results from a multicenter phase III trial showed. (Source: Cardiology News)

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  WELLBUTRIN (Bupropion Hydrochloride) Tablet, Film Coated [SmithKline Beecham Corporation]

Updated Date: Aug 31, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Substrate Specificity, Regulation, and Polymorphism of Human Cytochrome P450 2B6.

Authors: Mo SL, Liu YH, Duan W, Wei MQ, Kanwar JR, Zhou SF CYP2B6 is mainly expressed in the liver that has been thought historically to play an insignificant role in human drug metabolism. However, increased interest in this enzyme has been stimulated by the discovery of polymorphic and ethnic differences in CYP2B6 expression, identification of additional substrates for CYP2B6, and evidence for co-regulation with CYP3A4. This paper updates our knowledge about the structure, function, regulation and polymorphism of CYP2B6. CYP2B6 can metabolise approximately 8% of clinically used drugs (n > 60), including cyclophosphamide, ifosfamide, tamoxifen, ketamine, artemisinin, nevirapine, efavirenz, bupropion, sibutramine, and propofol. CYP2B6 is one of the CYP enzymes that bioactivate sever...

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  Table of Contents

Transdermal Methylphenidate Absorption Differs Based on Patch's Application SiteBipolar Youths Receiving Mood Stabilizers Show Some Cognitive Impairments in StudyMethylphenidate Side Effects in Childhood Cancer SurvivorsQuetiapine Equal to Placebo for Teen Bipolar DepressionADHD Treatment: Duration of Action of LisdexamfetamineAripiprazole Assessed for Bipolar Disorder Comorbid With ADHDControlled Atomoxetine Trial for ADHD Children in RussiaPregabalin for Treating Dysautonomic CrisisAripiprazole for Psychosis in a Child With Arachnoid CystBlack Box Warnings for Bupropion and VareniclineAtomoxetine Safety Labeling Changes (Source: The Brown University Child & Adolescent Psychopharmacology Update)

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  Saudi bans anti-smoking drugs

Saudi Arabia's Ministry of Health has banned two popular smoking cessation drugs as their side-effects include suicidal tendencies, the Saudi Gazette has reported. The drugs containing varenicline, with the trade name of Champix from Pfizer, and Bupropion were banned after the US Food and Drugs Administration (FDA) had issued a black box warning, the toughest warning on risks associated with a medicine, on serious mental health risks of the drugs. (Source: Healthcare)

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  I'm new here, I'm looking for understanding and advise

Author: Diary of a Quitter Posted: Sat Aug 15, 2009 11:32 am Hmm...It's funny you should mention that Matt. I also take bupropion, but for depression. Perhaps that influenced my ability to quit smoking and stay quit this time. I smoked from age 13 to 29 when I got pregnant. I quit, then picked it up again after my daughter was 2 or so - when I went back to school. My partner had quit for the most part too, and since we had a kid we didn't allow smoking in the house or in the car. Living in a place where it's cold and rainy 9 months of the year doesn't make it real appealing to go outside and smoke all the time. Anyway, I was a "sympathetic smoker" off and on for the next few years. I'd go months without smoking, then go ...

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  Effects of bupropion augmentation on pro-inflammatory cytokines in escitalopram-resistant patients with major depressive disorder

AbstractStudies so far have provided contradictory results on immune system markers during use of antidepressants. There are no data on changes in immune parameters after treatment augmentation. The present study aimed to clarify whether the addition of bupropion in escitalopram-resistant patients with major depression causes changes in the immune system and whether treatment response could be predicted by baseline levels of cytokines. We recruited 28 depressive patients (11 men and 17 women) who did not respond to 12-week treatment with escitalopram (20 mg/d) for an augmentation trial with bupropion (150–300 mg/day). The levels of soluble interleukin-2 receptor, interleukin-8 (IL-8) and tumor-necrosis factor- were measured before and 6 weeks after addition of bupropio...

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  Use Generic Zyban to Quit Unhealthy Habit of Smoking

Generic Zyban is the smoking cessation drug that helps the smokers to quit the unhealthy habit of smoking. Generic Zyban contains Bupropion as an active constituent that helps the person to overcome the unhealthy habit of smoking. It reduces the person urge to smoke. The habit of smoking is hard to... (Source: Networks Talk)

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  Sexual side-effects of contemporary antidepressants: review.

Authors: Schweitzer I, Maguire K, Ng C The aim of the present study was to review the sexual side-effects of contemporary antidepressants in Australia, comparing the selective serotonin re-uptake inhibitors (SSRIs) with venlafaxine, reboxetine, mirtazepine, duloxetine, bupropion, desvenlafaxine and agomelatine. Double-blind, randomized comparative studies of these antidepressants that included assessment of sexual dysfunction with validated rating scales in patients with major depressive disorder were identified from the literature using MEDLINE, EMBASE and PsychINFO databases. Bupropion and duloxetine caused significantly less sexual dysfunction than the SSRIs in short-term studies and reboxetine significantly less in both short- and longer term studies. Bupropion and agomelatine caus...

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  Racial differences in smoking abstinence rates in a multicenter, randomized, open-label trial in the United States

Conclusion  Regardless of the treatment used, minority smokers in the US have lower smoking abstinence after treatment for tobacco dependence. Future research should focus on the improvement in treatment strategies for minority smokers. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10389-009-0277-2Authors Ivana T. Croghan, Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USARichard D. Hurt, Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USAJon O. Ebbert, Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USAGary A. Croghan, Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USAOctavius D. Polk, Howard University Cancer Center 2041 Georgia Avenue, N.W. Washington DC ...

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  Table of Contents

Lithium Fails to Show Efficacy for Mild Alzheimer's DiseaseStudy Finds Important Differences Between Young and Old Bipolar Manic PatientsMirtazapine-Induced HyponatremiaIncreased Dementia Risk Linked to Long-Term Benzodiazepine UseAcetylcholinesterase Inhibitors Studied in a Real-World SettingEditorial Weighs in on Lithium and Alzheimer'sCombination Cilostazol and Donepezil Treatment for ADAdjunctive Valproate and Pleural EffusionBlack Box Warnings for Bupropion and VareniclineAtomoxetine Safety Labeling Changes (Source: The Brown University Geriatric Psychopharmacology Update)

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  Use Generic Zyban to Quit Unhealthy Habit of Smoking

Generic Zyban is the smoking cessation drug that helps the smokers to quit the unhealthy habit of smoking. Generic Zyban contains Bupropion as an active constituent that helps the person to overcome the unhealthy habit of smoking. It reduces the person urge to smoke. The habit of smoking is hard to... (Source: Networks Talk)

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  ZYBAN (Bupropion Hydrochloride) Tablet, Film Coated [SmithKline Beecham Corporation]

Updated Date: Aug 3, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Smoking Cessation Drugs Get Boxed Warning

Accumulating reports of serious neuropsychiatric symptoms associated with the smoking cessation medications varenicline and bupropion have prompted the Food and Drug Administration to require new boxed warnings for the drugs. (Source: Internal Medicine News)

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  News from the FDA

Accumulating reports of serious neuropsychiatric symptoms associated with the smoking cessation medications varenicline and bupropion prompted the Food and Drug Administration to require new boxed warnings for the drugs. (Source: Family Practice News)

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  Smoking Cessation Drugs Get Boxed Warning

Accumulating reports of serious neuropsychiatric symptoms associated with the smoking cessation medications varenicline and bupropion have prompted the Food and Drug Administration to require new boxed warnings for the drugs. (Source: Clinical Psychiatry News)

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  Smoking cessation pharmacotherapy

Cigarette smoking remains an important risk factor for premature cardiovascular disease and its many complications. There are clear benefits from treating tobacco dependence on the rate of clinical outcomes. In addition to behavioral therapies, various pharmacologic strategies have been developed to help achieve this goal. First-line therapies include nicotine replacement, bupropion and varenicline, a partial nicotine antagonist. Second-line treatments include clonidine and nortriptyline. Additional treatment strategies with less proven efficacy include monoamine oxidase inhibitors, selective serotonin reuptake inhibitors, opioid receptor antagonists, bromocriptine, anti-anxiety drugs, nicotinic receptor antagonists (e.g. mecamylamine) and glucose tablets. Various approaches under investig...

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  Bupropion/escitalopram: Skin disorders: 2 case reports

(Source: Reactions)

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  Zyban (Bupropion Hcl) - updated on RxList

Zyban (Bupropion Hcl) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

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  Wellbutrin SR (Bupropion Hydrochloride Sustained-Release) - updated on RxList

Wellbutrin SR (Bupropion Hydrochloride Sustained-Release) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

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  Prefrontal cognitive dysfunction is associated with tobacco dependence treatment failure in smokers with schizophrenia

Abstract: Background: Patients with schizophrenia have higher rates of smoking (58–88%) than in the general population (∼22%), and are more refractory to smoking cessation. These patients also exhibit numerous neurocognitive deficits, some of which may be ameliorated by cigarette smoking. The neurocognitive benefits derived from nicotine may, in turn, contribute to elevated rates of smoking and smoking persistence in schizophrenia. The present study examined the relationship between neurocognitive function and smoking cessation in schizophrenia.Methods: Treatment-seeking smokers with schizophrenia (N=58) participated in a 10-week placebo-controlled trial of sustained-release (SR) bupropion plus transdermal nicotine patch. Neuropsychological performance was evaluated in a subset of pati...

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  The Novel Nicotinic Receptor Antagonist, N,N'-Dodecane-1,12-diyl-bis not-3-picolinium Dibromide (bPiDDB), Inhibits Nicotine-evoked [(3)H]Norepinephrine Overflow from Rat Hippocampal Slices.

Authors: Smith AM, Dhawan GK, Zhang Z, Siripurapu KB, Crooks PA, Dwoskin LP Smoking is a significant health concern and strongly correlated with clinical depression. Depression is associated with decreased extracellular NE concentrations in brain. Smokers may be self-medicating and alleviating their depression through nicotine stimulated norepinephrine (NE) release. Several antidepressants inhibit NE transporter (NET) function, thereby augmenting extracellular NE concentrations. Antidepressants, such as bupropion, also inhibit nicotinic receptor (nAChR) function. The current study determined if a recently discovered novel nAChR antagonist, N,N'-dodecane-1,12-diyl-bis not-3-picolinium dibromide (bPiDDB), inhibits nicotine-evoked NE release from superfused rat hippocampal slices. Previou...

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  Suboxone and the sex drive. And bio identical hormones.

Author: Matt2 Posted: Thu Jul 09, 2009 7:52 pm I have heard some complain of reduced sex drive while on Sub but as Scape wrote I haven't had a single problem with it yet. I could also tell a HUGE difference between when I was using and even when I first started Suboxone. I recently started taking Zyban (bupropion) to help me quit smoking and let's just say there hasn't been anything close to a problem in that area of my life lately well perhaps some exhaustion rofl I think I've read Dr. Junig write somewhere about how bupropion is sometimes prescribed to people on SSRIs who experience sexual dysfunction to help things functioning normally again, I could be wrong though but I wonder if the same approach might help those having probl...

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  Beliefs and attitudes about bupropion: Implications for medication adherence and smoking cessation treatment.

Beliefs about medication are associated with treatment adherence and outcome. This is a secondary analysis of the role of beliefs and attitudes about bupropion in treatment adherence and smoking cessation outcomes using data from a smoking cessation trial of open-label sustained-release (SR) bupropion therapy reported previously (Toll et al., 2007). Positive beliefs and attitudes were positively correlated with intentions, desire, confidence, and motivation to quit smoking; expectation of quitting success; perceived benefits of quitting; and perceived disadvantages of smoking. Positive beliefs were also associated with greater medication adherence, an increased likelihood of completing treatment and being continuously abstinent, and a delayed latency to smoking lapse. These findings provid...

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  WELLBUTRIN (Bupropion Hydrochloride) Tablet, Film Coated [SmithKline Beecham Corporation]

Updated Date: Jul 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  BUPROPION HYDROCHLORIDEtablet, Film Coated [Mylan Pharmaceuticals Inc.]

Updated Date: Jul 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  WELLBUTRIN (Bupropion Hydrochloride) Tablet, Film Coated [SmithKline Beecham Corporation]

Updated Date: Jul 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FDA: Boxed Warning On Serious Mental Health Events To Be Required For Chantix And Zyban

The U.S. Food and Drug Administration announced that it is requiring manufacturers to put a Boxed Warning on the prescribing information for the smoking cessation drugs Chantix (varenicline) and Zyban (bupropion). The warning will highlight the risk of serious mental health events including changes in behavior, depressed mood, hostility, and suicidal thoughts when taking these drugs. (Source: Health News from Medical News Today)

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  Warnings for smoking-cessation drugs varenicline, bupropion

Smoking-cessation drugs varenicline and bupropion must carry a boxed warning in their labeling stating that use of the drugs has been associated with serious mental-health events, the US FDA has announced. (Source: theHeart.org)

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  Chantix and Zyban to Receive Boxed Warnings for Serious Neuropsychiatric Symptoms

Varenicline and bupropion are receiving boxed warnings regarding the risks for changes in behavior, hostility, agitation, depressed mood, suicidal thoughts and behavior, and attempted suicide. Medscape Medical News (Source: Medscape Today Headlines)

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  Popular Stop-Smoking Drugs to Carry Mental Health Risk Warnings

WASHINGTON (MedPage Today) -- The FDA announced that it will require the labels of varenicline (Chantix) and bupropion (Zyban, Wellbutrin, and generics) to carry boxed warnings on the risk of serious neuropsychiatric symptoms starting today. (Source: MedPage Today Campaign '08)

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  FDA: Boxed Warning on Serious Mental Health Events to be Required for Chantix and Zyban

The U.S. Food and Drug Administration today announced that it is requiring manufacturers to put a Boxed Warning on the prescribing information for the smoking cessation drugs Chantix (varenicline) and Zyban (bupropion). The warning will highlight the risk of serious mental health events including changes in behavior, depressed mood, hostility, and suicidal thoughts when taking these drugs. (Source: Food and Drug Administration)

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  Varenicline (marketed as Chantix) and Bupropion (marketed as Zyban, Wellbutrin, and generics)

FDA requires new Boxed Warnings and patient Medication Guides highlighting the risk of serious neuropsychiatric symptoms (Source: FDA MedWatch)

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  Varenicline (marketed as Chantix) and Bupropion (marketed as Zyban, Wellbutrin, and generics)

Audience: Neuropsychiatric healthcare professionals, patients FDA notified healthcare professionals and patients that it has required the manufacturers of the smoking cessation aids varenicline (Chantix) and bupropion (Zyban and generics) to add... (Source: Drugs.com - FDA MedWatch Alerts)

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  Genome-wide association for smoking cessation success: participants in a trial with adjunctive denicotinized cigarettes.

Authors: Drgon T, Johnson C, Walther D, Albino AP, Rose JE, Uhl GR The ability to quit smoking successfully displays substantial heritability in classical and molecular genetic studies. Twin studies suggest that some of the genetics for the ability to quit overlap with genetic components of nicotine dependence, but many do not. Genome-wide association (GWA) studies have demonstrated haplotypes that distinguish successful quitters from individuals who were not able to quit smoking in: i) clinical trials that employed nicotine replacement; ii) clinical trials that employed bupropion; and iii) community quitter samples. We now report novel GWA results from participants in a clinical trial that document the efficacy of adjunctive use of denicotinized cigarettes. These results buttress data...

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  Drug Combo Leads to Significant Weight Loss

NEW ORLEANS — An investigational oral agent that combines naltrexone and bupropion produced clinically meaningful weight loss at 56 weeks, results from a multicenter phase III trial showed. (Source: Clinical Endocrinology News)

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  HIV & smoking in India.

HIV & smoking in India. Indian J Med Res. 2009 Jul;130(1):15-22 Authors: Kumar SR, Swaminathan S, Flanigan T, Mayer KH, Niaura R There are approximately 2.5 million people living with HIV/AIDS (PLWHA) in India - the young being particularly vulnerable. The prevalence of smoking has increased in India especially among rural, lower socio-economic and illiterate men. Studies have shown that HIV-infected smokers may be at additional risk for several infectious and non-infectious complications, including malignancies and cardiovascular events. Smoking alters immunological mechanisms and suppresses host defenses in the alveolar environment. HIV-infected smokers have also been found to have a poorer response to antiretroviral therapy and a higher risk of death. HIV-infected indivi...

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