MedWorm: Botox

  Botulinum toxin injections for new onset bilateral vocal fold motion impairment in adults

Review of clinical experience and results using botulinum toxin type A (BTX) for the management of adult patients with respiratory compromise due to new onset bilateral vocal fold motion impairment (BVFMI).Retrospective case series.The records of 11 patients from two institutions with respiratory compromise due to bilateral vocal fold motion impairment were reviewed. Age, sex, etiology of motion impairment, subjective response to BTX injections, changes in pulmonary function studies pre- and postinjection when available, the dosage of botulinum toxin required to achieve response, the number of injections per patient, and complications were reported.All patients were over 18 years old. There were three male and eight female subjects. The etiology of BVFMI was due to previous anterior cervic...

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  Botox may help alleviate certain types of migraine pain

Botulinum toxin type A injections of cosmetic doses have the potential to alleviate symptoms of imploding and ocular migraines, report researchers. (Source: MedWire News - Dermatology)

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  Use of Botulinum Toxin Type A Injection for Neuropathic Pain after Trigeminal Nerve Injury

Conclusions. This case report suggests an effective new modality for treating neuropathic pain after trigeminal nerve injury. A further randomized controlled study involving a large number of patients is needed. (Source: Pain Medicine)

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  Predicting migraine responsiveness to botulinum toxin type A injections

(Source: NHS Evidence - Neurological conditions - News)

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  Single CT-Guided Chemodenervation of the Anterior Scalene Muscle with Botulinum Toxin for Neurogenic Thoracic Outlet Syndrome

Conclusion. Patients experienced substantial pain relief in months 1 and 2 following a single Botox injection into the ASM under CT guidance. Significant pain reduction was noted for 3 months after Botox injection with respect to both sensory and VAS scores, and the total and PPI scores approximated statistical significance. After 3 months, patients experienced a 29% decrease in the sensory component of their pain as well as an approximate 15% reduction in their VAS score. A single, CT-guided Botox injection into the ASM may offer an effective, minimally invasive treatment for NTOS. (Source: Pain Medicine)

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  Neurogenic temporomandibular joint dislocation treated with botulinum toxin: report of 4 cases

In conclusion, the injection of botulinum toxin type A is an effective method in cases of neurogenic TMJ dislocation, with low morbididty and side effects, improving patients' quality of life. (Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics)

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  Injection of botulinum toxin type A (BOTOX) into trigger zone of trigeminal neuralgia as a means to control pain

This article illustrates a case of persistent trigeminal neuralgia in a medically compromised 65-year-old female who did not respond to pharmacotherapy. She had undergone several peripheral neurectomies as well as a failed right posterior fossa exploration that resulted in a cerebrospinal fluid leak. Persistent pain over the right external nasal area and right mental region was relieved for several hours after daily injections of bupivacaine. A trial of a single dose of 100 units of botulinum toxin type A (BOTOX) diluted in 2.5 mL saline was injected into the external nasal trigger zone (60 units) and to the mental nerve region (40 units). She achieved complete pain relief in the external nasal region for 5 months. Pain recurred and the site was again injected with 100 units of botulinum t...

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  [Effects of botulinum toxin type A in the single and repeated treatment of overactive bladder : A prospective analysis.]

CONCLUSION: The results of our prospective study show that the endoscopic application of BTX-A is a safe and highly effective treatment option for patients with OAB refractory to conventional treatment. PMID: 20182692 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)

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  Should Botox Users Switch to Dysport and Save Money

Dysport: Should Botox Users Switch and Save Money? CosmeticSurgeryGuru Investigates - Similar to Botox, Dysport is a botulinum toxin Type A injection for eliminating fine lines and wrinkles. It costs 20% less than Botox, despite needing two extra treatments. (Source: Disabled World)

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  Botulinum Toxin Type A for Chronic Migraine

Abstract  Chronic migraine (CM) is the leading cause of chronic daily headache, a common and debilitating headache syndrome. The management of CM patients is challenging, with only limited benefit from available oral preventive medications. Botulinum neurotoxin (BoNT) has been used extensively to treat disorders associated with increased muscle tone. More recent scientific data support an analgesic effect of the toxin. The pharmacokinetic and pharmacodynamic profiles of BoNT make it an appealing candidate for migraine prevention. Results from older clinical trials on the efficacy of the toxin in CM were inconclusive. However, recent trials using more stringent inclusion criteria have shown positive results, supporting the use of the toxin in some patients with this disorder...

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  Ultrasound-Guided Botox Injections of Salivary Glands in Children with Drooling

This study aimed to test the hypothesis that ultrasound-guided botox injection of the salivary glands in children is effective temporary palliation for excessive drooling. The study population consisted of 6 patients who underwent botox injection of salivary glands one or more times at a mid-Atlantic regional children's hospital. Parents were interviewed by telephone regarding the effects of the botox procedure on their child's drooling. The children who comprised our study population exhibited decreased drooling, less respiratory distress, and increased quality of life after the injections. Further research with a larger sample is warranted to support these findings. (Source: Journal of Radiology Nursing)

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  Assurance scheme for botox clinics

A new scheme will enable people considering botox and other facial treatments to check the reputation of their clinic (Source: Nursing in Practice)

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  Botox provider regulation plan announced

A registration scheme is to be set up for practitioners and organisations that provide injectable cosmetic treatments, such as Botox, for the first time. (Source: Nursing Times Breaking News)

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  Cosmetic jab clampdown criticised

An initiative to boost the safety of cosmetic treatments such as Botox does not go far enough, say surgeons. (Source: BBC News | Health | UK Edition)

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  Botox Smoothes Out Migraines

(Ivanhoe Newswire) -- New research brings good news for migraine sufferers: The same type of botulinum injection used for cosmetic purposes may be associated with reduced frequency of migraine headaches. (Source: Medical Headlines From Ivanhoe.com)

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  Botulinum toxin type A versus phenol. A clinical and neurophysiological study in the treatment of ankle clonus.

CONCLUSIONS: While both treatments led to reduction in ankle clonus, phenol showed greater clinical efficacy. The difference in the neurophysiological results suggests that the two drugs have different action mechanisms with a more prevalent reduction of alpha motoneuron excitability in phenol-treated patients. PMID: 20168277 [PubMed - as supplied by publisher] (Source: European Journal of Physical and Rehabilitation Medicine)

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  Botox may help some with migraines

ENCINCO, Calif., Feb. 17 (UPI) -- Botox injections used for cosmetic purposes may be associated with reduced frequency of some migraine headaches, U.S. researchers suggest. (Source: Health News - UPI.com)

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  Botox May Prevent Some Migraines

Title: Botox May Prevent Some MigrainesCategory: Health NewsCreated: 2/15/2010 4:10:00 PMLast Editorial Review: 2/16/2010 (Source: MedicineNet Skin General)

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  Botox May Prevent Some Migraines

Title: Botox May Prevent Some MigrainesCategory: Health NewsCreated: 2/15/2010 4:10:00 PMLast Editorial Review: 2/16/2010 (Source: MedicineNet Senior Health General)

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  Botox May Prevent Some Migraines

Title: Botox May Prevent Some MigrainesCategory: Health NewsCreated: 2/15/2010 4:10:00 PMLast Editorial Review: 2/16/2010 (Source: MedicineNet Hepatitis C General)

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  Botox May Prevent Some Migraines

Title: Botox May Prevent Some MigrainesCategory: Health NewsCreated: 2/15/2010 4:10:00 PMLast Editorial Review: 2/16/2010 (Source: MedicineNet Migraine General)

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  Botox Injections Found to Reduce Migraine Frequency

Migraineurs who received botulinum toxin type A injections have substantially decreased frequency of migraine headaches, but the relief is highly dependent on the type of migraine, according to a study in the February issue of the Archives of Dermatology. (Source: Modern Medicine)

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  Predicting Migraine Responsiveness to Botulinum Toxin Type A Injections [Observation]

Conclusions  Our study supports the hypothesis that patients with imploding and ocular migraines are more responsive to BTX than those with exploding migraines. Injections of BTX at doses appropriate for cosmetic purposes may be sufficient to prevent migraine attacks. (Source: Archives of Dermatology)

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  Botox May Have Migraine Potential (CME/CE)

Botulinum toxin type A (Botox) provided significant relief from certain types of migraine in a small clinical study of migraine patients undergoing cosmetic procedures of the upper face. (Source: MedPage Today Pain Management)

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  Evaluation and treatment of synkinesis with botulinum toxin following facial nerve palsy.

Conclusions. BTX-A injection treatment was effective in reducing facial synkinesis, thus improving facial expression symmetry both at rest and in voluntary movements. PMID: 20156046 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)

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  Thickened saliva after effective management of drooling with botulinum toxin A

Aim The aim of this study was to evaluate the rheological properties of saliva after submandibular botulinum toxin type A (BoNT-A) injections.Method We enrolled 15 children (11 males and six females; age range 3[ndash]17y, mean age 9y 10mo) diagnosed with spastic (n=9) or dyskinetic (n=6) quadriplegic cerebral palsy (CP); Gross Motor Function Classification System level IV or V; and two children with intellectual disability (IQ (Source: Developmental Medicine and Child Neurology)

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  Forget the Botox! New iPhone app 'zaps acne and wrinkles' with red and blue lights

Dr Greg Pearson’s AcneApp uses 420 nanometer blue light and 550 nanometer red light to help kill bacteria and promote collagen growth. (Source: the Mail online | Health)

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  Under the microscope: Marie Helvin on her secret alternative to Botox

In this week's health quiz, the model and author, 57, talks pills, depression and her fear of falling flat on her face. (Source: the Mail online | Health)

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  Comparing Botox((R)) and Xeomin ((R)) for axillar hyperhidrosis.

We report the first use of Xeomin((R)) in an autonomic indication. A total of 46 patients (34 females, 12 males, age 32.7 +/- 13.2 years, disease duration 14.2 +/- 12.0 years) with symmetric bilateral idiopathic axillar hyperhidrosis and a previously stable Botox((R)) treatment received 50 MU of BT in 5 ml of 0.9% NaCl/H(2)0 in each axilla. The patient, the injector and the observer were unaware of which axilla received Xeomin((R)) and which Botox((R)). The therapeutic effect as measured from the BT application to the onset of its decrease lasted 3.2 +/- 1.4 months and was excellent in 89% and good in 11% of the patients. Side-to-side differences of the therapeutic effect (onset latency, extent, duration) were neither detectable by the patient nor by the physician. Injection site pain was ...

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  Spring Botox Clinic

If you want real, noticeable results, discover what so many women have experienced - proven results with no surgery, no recovery time.  Read more...  (Source: Women Speak)

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  Spring Botox Clinic

If you want real, noticeable results, discover what so many women have experienced - proven results with no surgery, no recovery time.  Read more...  (Source: Women Speak)

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  AAPM: Botox May Relieve Postherpetic Neuralgia (CME/CE)

SAN ANTONIO (MedPage Today) -- Subcutaneous injection of botulinum toxin A (Botox) significantly reduced postherpetic neuralgia compared with lidocaine and saline placebo in a small randomized clinical study. (Source: MedPage Today Pain Management)

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  N.Y. Botox banks to begin Monday

NEW YORK, Feb. 7 (UPI) -- A New York physician said Monday he will launch an online discount Botox bank that he hopes will spread into branches nationwide. (Source: Health News - UPI.com)

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  Allergan sees 51% jump in 4Q profits

Allergan Inc., the pharmaceutical company responsible for Botox, posted a 51 percent jump in fourth-quarter profits, fueled by higher sales of beauty products and medical devices. (AGN) (Source: bizjournals.com Health Care:Biotechnology headlines)

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  Facial Expressions And The Way We Feel And Understand

Your facial expression may tell the world what you are thinking or feeling. But it also affects your ability to understand written language related to emotions, according to research that was presented to the Society for Personal and Social Psychology in Las Vegas, and will be published in the journal Psychological Science. The new study reported on 40 people who were treated with botulinum toxin, or Botox. Tiny applications of this powerful nerve poison were used to deactivate muscles in the forehead that cause frowning... (Source: Health News from Medical News Today)

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  Botox Therapy for Ischemic Digits

Conclusion: Botox appears to provide improvement in digital perfusion and pain reduction in patients with Raynaud's syndrome when conservative management fails. Summary: Digital ulceration associated with Raynaud's syndrome is painful, difficult to treat, and frequently results in patient debilitation and chronic depression. Reports by Sycha and Van Beek have indicated potential benefit for patients with ischemic digits with local injection of botulinum toxin (Euro J Clin Invest 2004;34:312-3; Plast Reconstr Surg 2007;119:217-26). This was a retrospective observational study on outcomes of 19 patients with Raynaud's syndrome treated with botulinum toxin. All patients had chronic ischemic hand pain, and vascular studies had ruled out proximal occlusive disease and underlying disorders, inc...

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  Botox Facial Slimming/Facial Sculpting: The Role of Botulinum Toxin-A in the Treatment of Hypertrophic Masseteric Muscle and Parotid Enlargement to Narrow the Lower Facial Width

Botulinum toxin A is a highly efficacious and cost-effective, nonsurgical option for reducing the width and shape of the lower face and jawline. The results can vary from the subtlest thinning of the face to an extremely thin, cachectic appearance. Many nuances can be achieved. The administration is simple, and the process takes barely 5 minutes in an office setting. Botulinum toxin A can also be effectively used to reduce the bulk of an enlarged parotid gland without affecting saliva production. (Source: Facial Plastic Surgery Clinics of North America)

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  Botulinum toxin type A reduces pain supersensitivity in experimental diabetic neuropathy: Bilateral effect after unilateral injection.

Authors: Bach-Rojecky L, Salković-Petrišić M, Lacković Z We investigated antinociceptive activity of botulinum toxin type A (BTX-A) in a model of diabetic neuropathic pain in rats. Male Wistar rats were made diabetic by a single intraperitoneal injection of streptozotocin (80mg/kg). Sensitivity to mechanical and thermal stimuli was measured with the paw-pressure and hot-plate test, respectively. The formalin test was used to measure sensitivity to chemical stimuli. Diabetic animals with pain thresholds lower for at least 25% compared to the non-diabetic group were considered neuropathic and were injected with BTX-A either subcutaneously (3, 5 and 7U/kg) or intrathecally (1U/kg). Mechanical and thermal sensitivity was measured at several time-points. After periph...

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  Doctors Feel 'Choosing To Be Thinner In 2010 Could Be Bad For Your Health'

Doctors are worried that as the New Year begins, many Americans will resolve to be thinner in 2010 by using over-the-counter supplements. According to a survey conducted by ADSAM and SenseUS polling companies, about 60 percent of physicians feel troubled about the safety of taking diet pills. Not surprisingly, while physicians feel negatively about the safety of over-the-counter diet pills, they are much more comfortable about the use of injections like Botox and Restylane or even breast implants... (Source: Health News from Medical News Today)

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  Quintastic: 50 is the new 30

2010 is the year of the Quintastics, women who discover that turning 50 brings with it a ferocious second wind. (Source: Telegraph Health)

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  BOTOX (Onabotulinumtoxina) Injection, Powder, Lyophilized, For Solution [Allergan, Inc.]

Updated Date: Jan 27, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Prolonged vastus lateralis denervation after botulinum toxin type a injection

We present evidence of prolonged denervation following BoNT injection of the vastus lateralis (VL) muscle to correct quadriceps muscle imbalance in patients with chronic anterior knee pain. Needle electromyography data were obtained from 10 subjects who had received a single BoNT treatment 5 to 19 months earlier as part of a clinical trial. Insertional and spontaneous activity, recruitment, and motor unit action potentials were examined. Clear differences between the injected and non-injected VL muscles, which correlated with the time since injection, were identified in all subjects. All 10 subjects studied with needle EMG showed evidence of persisting denervation in the BoNT-A injected VL muscle beyond the period of neuromotor recovery expected from animal experimental studies. © 2010 Mo...

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  AAN Evaluates Cerebral Palsy Treatments for Kids

A new guideline from the American Academy of Neurology and the Child Neurology Society finds botulinum toxin type A to be an effective treatment for spasticity, muscle tightness that interferes with movement, in children and adolescents with cerebral palsy, but poses some risk. (Source: Disabled World)

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  AAN Guideline Evaluates Treatments For Kids With Cerebral Palsy

A new guideline from the American Academy of Neurology and the Child Neurology Society finds botulinum toxin type A to be an effective treatment for spasticity, muscle tightness that interferes with movement, in children and adolescents with cerebral palsy, but poses some risk. The guideline is published in the January 26, 2010, issue of Neurology®, the medical journal of the American Academy of Neurology. "Spasticity in children with cerebral palsy is best treated by a multidisciplinary medical and surgical team," said lead guideline author Mauricio R... (Source: Health News from Medical News Today)

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  AAN Guideline Evaluates Treatments For Kids With Cerebral Palsy

A new guideline from the American Academy of Neurology and the Child Neurology Society finds botulinum toxin type A to be an effective treatment for spasticity, muscle tightness that interferes with movement, in children and adolescents with cerebral palsy, but poses some risk... (Source: Pediatrics News From Medical News Today)

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  New Guidelines Suggest Botox for Cerebral Palsy

Title: New Guidelines Suggest Botox for Cerebral PalsyCategory: Health NewsCreated: 1/25/2010 4:10:00 PMLast Editorial Review: 1/26/2010 (Source: MedicineNet Hepatitis C General)

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  Botox Found Effective for Children With Cerebral Palsy

Botulinum toxin is a safe and effective treatment for localized spasticity in children with cerebral palsy, according to a review in the Jan. 26 issue of Neurology. (Source: Modern Medicine)

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  Practice Parameter: Pharmacologic treatment of spasticity in children and adolescents with cerebral palsy (an evidence-based review): Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society

Objective: To evaluate published evidence of efficacy and safety of pharmacologic treatments for childhood spasticity due to cerebral palsy. Methods: A multidisciplinary panel systematically reviewed relevant literature from 1966 to July 2008. Results: For localized/segmental spasticity, botulinum toxin type A is established as an effective treatment to reduce spasticity in the upper and lower extremities. There is conflicting evidence regarding functional improvement. Botulinum toxin type A was found to be generally safe in children with cerebral palsy; however, the Food and Drug Administration is presently investigating isolated cases of generalized weakness resulting in poor outcomes. No studies that met criteria are available on the use of phenol, alcohol, or botulinum toxin type B inj...

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  New Guidelines Suggest Botox for Cerebral Palsy

Drug injections can reduce muscle spasticity, experts say Source: HealthDay Related MedlinePlus Topics: Botox, Cerebral Palsy (Source: MedlinePlus Health News)

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  AAN guideline evaluates treatments for kids with cerebral palsy

(American Academy of Neurology) A new guideline from the American Academy of Neurology and the Child Neurology Society finds botulinum toxin type A to be an effective treatment for spasticity, muscle tightness that interferes with movement, in children and adolescents with cerebral palsy, but poses some risk. The guideline is published in the January 26, 2010, issue of Neurology, the medical journal of the American Academy of Neurology. (Source: EurekAlert! - Social and Behavioral Science)

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  U.S. Attorney New Release: Bellevue, Washington Salon Owner Sentenced in Connection with Unlicensed Cosmetic Treatments

According to testimony at trial and records filed in the case, FAITH HE used counterfeit Botox© and Restylane© on customers at her Bellevue beauty salon. FAITH HE was not a medical doctor licensed to use injectable treatments for wrinkle removal such as Botox and Restylane. (Source: Food and Drug Administration)

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  U.S. Attorney New Release: Bellevue, Washington Salon Owner Sentenced in Connection with Unlicensed Cosmetic Treatments

According to testimony at trial and records filed in the case, FAITH HE used counterfeit Botox© and Restylane© on customers at her Bellevue beauty salon. FAITH HE was not a medical doctor licensed to use injectable treatments for wrinkle removal such as Botox and Restylane. (Source: Food and Drug Administration)

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  Botox and Dysport: Is there a dose conversion ratio in dermatology and aesthetic medicine?

To the Editor: The use of botulinum neurotoxin A is the most frequent intervention in aesthetic medicine. Sales of the two main preparations—Botox (Allergan Inc, Irvine, CA) and Dysport (Ipsen Ltd, Slough, Berkshire, UK)—amounted to USD $1 billion in 2007, and the trend is still growing. (Source: Journal of the American Academy of Dermatology)

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  Four unrelated patients with lubs X-linked mental retardation syndrome and different Xq28 duplications

The Lubs X-linked mental retardation syndrome (MRXSL) is caused by small interstitial duplications at distal Xq28 including the MECP2 gene. Here we report on four novel male patients with MRXSL and different Xq28 duplications delineated by microarray-based chromosome analysis. All mothers were healthy carriers of the duplications. Consistent with an earlier report [Bauters et al. (2008); Genome Res 18: 847-858], the distal breakpoints of all four Xq28 duplications were located in regions containing low-copy repeats (LCRs; J, K, and L groups), which may facilitate chromosome breakage and reunion events. The proximal breakpoint regions did not contain known LCRs. Interestingly, we identified apparent recurrent breakage sites in the proximal and distal breakpoint regions. Two of the four pati...

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  Combined Botulinum Toxin Type A With Modified Constraint-Induced Movement Therapy for Chronic Stroke Patients With Upper Extremity Spasticity: A Randomized Controlled Study

Conclusions. Combining BtxA and mCIMT is an effective and safe intervention for improving spasticity and motor function in chronic stroke patients. The results are promising enough to justify further studies. We recommend future research to address the likely need for including rehabilitation with BtxA to improve function in patients with poststroke spasticity. (Source: Neurorehabilitation and Neural Repair)

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  Outcome of prenatally diagnosed isolated clubfoot.

CONCLUSIONS:: When counselling prenatal patients regarding sonographically diagnosed isolated clubfoot, it is important to convey that approximately 10% of individuals will have a normal foot or positional foot deformity requiring minimal treatment. Conversely, 10-13% of prenatally diagnosed cases of isolated clubfoot will have complex clubfoot postnatally, based on the finding of additional structural or neurodevelopmental abnormalities. Although this study did not identify an increased risk of fetal aneuploidy associated with isolated clubfoot, a review of the literature indicates a risk of 1.7-3.6% with predominance of sex chromosome aneuploidy. Copyright (c) 2010 ISUOG. Published by John Wiley & Sons, Ltd. PMID: 20069547 [PubMed - as supplied by publisher] (Source: The Ultrasou...

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  DIY Plastic Surgery A Trend In North Texas

Just a week into the New Year and some doctors say they're seeing a growing trend with do-it-yourself plastic surgery!  From skincare, to laser treatments, to even do-it-yourself Botox… instructions and products are available online. But doctors say while DIY procedures can be cheaper, they're also dangerous. (Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire)

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  Botulinum Toxin Type A for Upper Limb Spasticity After Stroke

This article will review the pharmacology of botulinum toxin type A and its clinical efficacy when used to treat upper limb spasticity after stroke. Expert Review of Neurotherapeutics (Source: Medscape Today Headlines)

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  Xeomin 100 units (botulinum toxin type A) - Change to theraeputic indication

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes ??Main change is the addition of a new indication for the symptomatic treatment of post-stroke spacsticity of the upper limb presenting with flexed wrist and clenched fist in adults. This change is reflected in sections: 4.1; 4.2; 4.4; 4.8 and 5.1. Other updates not related to the new indication include:- Section 4.4 Special Warnings & Precautions for use: addition of dyphagia Section 4.8 Undesirable effects: localised effects; addition of dysphagia, angle closure glaucoma, seizures, hypersensitivity and other generalised Botulinum toxins. (Source: NeLM - SPC Changes)

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  Experience with Injections of Botulinum Toxin Type A into the Detrusor Muscle.

CONCLUSIONS: Injecting 300 units of BTX-A into 30 sites in the muscle located in the body of the bladder region is effective for neurogenic bladder patients with intermittent catheterization who have urge and reflective types of incontinence. Injec-tions of 100 and 200 units of BTX-A to treat non-neurogenic overactive bladder with urinary incontinence provided together without retention. The optimal dose of BTX-A requires further investigation. Injection with 200 units of BTX-A was not useful against interstitial cystitis. None of the patients developed any adverse effects after injecting the bladder wall with BTX-A. PMID: 20094947 [PubMed - as supplied by publisher] (Source: Aktuelle Urologie)

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  Botulinum Toxin Type A Reduces Histamine-induced Itch and Vasomotor Responses in Human Skin

A clinical study has revealed that botulinum toxin type-A is effective against histamine-induced itch. The British Journal of Dermatology (Source: Medscape Today Headlines)

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  Health news: Use oxygen to zap a headache and could Botox beat baldness?

Inhaling oxygen could zap the agony of cluster headaches, according to research. Also could a jab of Botox in the scalp be a new way to treat some forms of baldness? (Source: the Mail online | Health)

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  Botox spared over tanning beds in health fight

WASHINGTON (Reuters) - In the rush to fund a U.S. healthcare overhaul, Botox injections to smooth wrinkles will not be taxed, but visiting a tanning salon will be. (Source: Reuters: Health)

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  An electrophysiological approach to the diagnosis of neurogenic dysphagia: implications for botulinum toxin treatment

Conclusions: This electrophysiological method can recognise swallowing abnormalities which may affect the outcome of the therapeutic approach to dysphagia with BTX treatment. (Source: Journal of Neurology, Neurosurgery & Psychiatry)

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  Got Handshake? The Silent Communicator

It's stealth. It's power. And it's at your own fingertips. Forward to the office staff and print for the kids at home, for we have ten suggestions for handshakes done right. Pictures included! <!--break-->1. Stand for handshakes. Unless you're physically unable or cannot move within the confines of space (at a booth in a restaurant, for instance), handshakes are offered and received in an upright stance. 2. Know the rules of handshake initiation. I'm frequently asked which gender should first extend their hand. In business situations, gender is irrelevant. What matters, however, is a person's organizational rank. Generally, a handshake should be offered by the person of higher authority to the person of lower status. Examples? The Director of HR extends to the job candidate, the dinn...

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  DYSPORT (Botulinum Toxin Type A) Injection, Powder, Lyophilized, For Solution [Tercica, Inc.]

Updated Date: Dec 16, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Prospective Randomized Evaluation of Periureteral Botulinum Toxin Type A Injection for Ureteral Stent Pain Reduction

Conclusions: Periureteral botulinum toxin type A injection improves ureteral stent tolerability by significantly decreasing postoperative pain and narcotic requirements. Improvement in irritative symptoms was not observed. (Source: The Journal of Urology)

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  Botulinum Toxin Type A May Effectively Treat Stroke-Related Upper Limb Spasticity

This review discusses the therapeutic use of botulinum toxin type A in upper limb spasticity. Medscape Neurology & Neurosurgery (Source: Medscape Today Headlines)

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  Pharma firms, surgeons battle 'Botax'

Irvine, Calif. ? Botox-maker Allergan, based here, has joined with cosmetic surgeons and other pharma firms to fight a proposed tax that would help fund healthcare reform, the Orange County (Calif.) Business Journal reports. (Source: Modern Medicine)

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  Can occlusal devices prolong the effect of botulinum toxin type A in the contouring of the lower face?

This study analyzes the efficacy of occlusal devices for the long-term stability of contouring of the lower face by injection of Botulinum toxin type A in a prospective clinical protocol. Ten patients (seven female and three male) with a widened lower face were recruited consecutively between January 2006 and January 2007. Each patient was advised to wear an occlusal device to release masticatory muscles, and percutaneous intramuscular injections of Botulinum toxin type A were used. The follow-up study was 18 months. Facial changes were noted by the patients as early as 2 weeks after the injection and lasted for 18 months; all patients reported an improved facial profile. There were no complications. Botulinum toxin type A injection for the contouring of the lower face...

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  Botox, facelifts may cost more as Senate eyes cosmetic surgery tax

The Senate debate on an $848 billion health care reform bill includes a 5% excise tax on elective cosmetic surgery, beginning ... (Source: USATODAY.com Health)

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  Cosmetic Surgery Industry Lobbies Against The 'Botax' In Senate Health Bill

"Leading makers of antiwrinkle drugs, breast implants and other appearance-related products are trying to derail a proposed tax on elective cosmetic surgery in the Senate's health-overhaul bill," The Wall Street Journal reports. "The proposed 5% levy -- dubbed the 'Botax' after the antiwrinkle treatment product Botox -- would raise an estimated $5.8 billion over 10 years." The tax proposal has raised the ire of the cosmetic surgery industry. "Two leading companies in aesthetic treatments, Allergan Inc. and Medicis Pharmaceutical Corp... (Source: Health News from Medical News Today)

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  Cosmetic Surgery Industry Lobbies Against The 'Botax' In Senate Health Bill

"Leading makers of antiwrinkle drugs, breast implants and other appearance-related products are trying to derail a proposed tax on elective cosmetic surgery in the Senate's health-overhaul bill," The Wall Street Journal reports. "The proposed 5% levy -- dubbed the 'Botax' after the antiwrinkle treatment product Botox -- would raise an estimated $5.8 billion over 10 years... (Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today)

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  Cosmetic Surgery Industry Lobbies Against The 'Botax' In Senate Health Bill

"Leading makers of antiwrinkle drugs, breast implants and other appearance-related products are trying to derail a proposed tax on elective cosmetic surgery in the Senate's health-overhaul bill," The Wall Street Journal reports. "The proposed 5% levy -- dubbed the 'Botax' after the antiwrinkle treatment product Botox -- would raise an estimated $5.8 billion over 10 years... (Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today)

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  Botulinum Toxin Type A for the Treatment of Glabellar Lines in Chinese: A Double-Blind, Randomized, Placebo-Controlled Study

This is the first well-controlled study of the use of botulinum toxin type A (BoNTA) for glabellar lines in China. To evaluate the safety and efficacy of BoNTA in the treatment of glabellar lines in Chinese subjects. A total of 227 subjects received a single treatment in a 3:1 randomization ratio of BoNTA (20 U):placebo and were observed for 120 days after injection. Effective outcome measures included investigator's rating of wrinkle severity at maximum frown and rest and subjects' global assessment and self-perception of age. A significantly higher responder rate at maximum frown, ranging from 94.1% at day 30 to 52.9% at day 120, was noted in the BoNTA group. The proportion of subjects with none or mild glabellar lines at rest was 66.7% in the BoNTA group at day 30. Most (95.3%) of the s...

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  Grinding my teeth gave me a square jaw. Now I have the face I longed for - thanks to Botox

From an early age Louisa Smith hated the rather masculine shape of her face. But she never guessed her looks were the result of a nervous habit. (Source: the Mail online | Health)

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  Needle Preference in Patients Receiving Cosmetic Botulinum Toxin Type A

This study sought to determine whether patients receiving BTX-A have a preference for 30-gauge or 32-gauge needles based on the amount of pain and bruising experienced. Thirty-seven subjects received BTX-A on the right side of the face using a 30-gauge needle and on the left side using a 32-gauge needle. Subjects were masked to needle size. They were then asked to rate injection pain on an 11-point numerical rating scale and to note any bruising. Physician preference was also evaluated. There were no statistically significant differences in the amount of intra-procedural pain (p=.37) or the level of post-procedural pain and discomfort (p=.76) experienced. Twenty-seven percent of subjects reported greater bruising with the 32-gauge needle, versus 29.7% with the 30-gauge needle. The physicia...

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  Botox 200 Units (botulinum toxin A) - New formulation

Source: Manufacturer notification Area: Other Library Updates > SPC Changes Botox now available as a 200U/vial preparation Refer to SPC for full details (Source: NeLM - SPC Changes)

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  Botox Delivered on Sponge Reduces Symptoms of Rhinitis

OnabotulinumtoxinA administered via a sponge inserted into the nasal cavity may reduce symptoms in some patients with refractory idiopathic rhinitis, according to a small German study. (Source: Skin and Allergy News)

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  Policy & Practice

Can't get enough Policy & Practice? Check out our new podcast each Monday. egmnblog.wordpress.com Allergan just reported its third-quarter earnings, and although Botox (onabotulinumtoxinA) sales increased a scant 3%, the company said that the injectable contributed to a net profit rise of 8.3%. The company predicted that its total Botox sales for the year would be almost $1.3 billion. Also in the third quarter, Allergan filed for Food and Drug Administration approval to promote the use of Botox for migraine headaches and submitted additional data to the agency on the drug's use for upper limb spasticity. Allergan also stated that it expects sales of the eyelash lengthener Latisse (bimatoprost) to hit $70 million for the year. (Source: Skin and Allergy News)

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  Microbiological and clinical profiles of patients with microbial keratitis residing in nursing homes

Conclusions: Microbial keratitis in patients living in nursing homes is usually caused by Staphylococcus and is associated with dry eyes and ocular surface disease. Surgical intervention is required in majority of cases with poor visual outcome. (Source: British Journal of Ophthalmology)

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  MUSC Holiday Botox Clinic

Look stress-free for the holidays and start the new year with a new, more youthful You.  Treat yourself to the MUSC Holiday Botox Clinic and leave the scowling for the Grinch!  Read more... (Source: Women Speak)

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  MUSC Holiday Botox Clinic

Look stress-free for the holidays and start the new year with a new, more youthful You.  Treat yourself to the MUSC Holiday Botox Clinic and leave the scowling for the Grinch!  Read more... (Source: Women Speak)

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  Electrical activation of the orbicularis oculi muscle does not increase the effectiveness of botulinum toxin type a in patients with blepharospasm

Conclusions: In patients with BPS, the electrically induced muscle activation neither increases the effectiveness of BonT-A nor produces larger electrophysiological peripheral effects. The lack of BonT-A-induced changes in the blink reflex recovery cycle provides evidence that BonT-A therapy is safe in patients with BPS. (Source: European Journal of Neurology)

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  Plastic Surgeons Cry Foul Over Senate Health Bill's Cosmetic Surgery Tax

Kaiser Health News staff writer Phil Galewitz writes about the so-called "botax." "If you're considering Botox to erase frown lines or liposuction to get rid of love handles, you might want to move fast. ... The $848 billion health care bill unveiled Wednesday by Senate Majority Leader Harry Reid, D-Nev., includes a 5 percent tax on cosmetic procedures and surgeries" (11/19). (Source: Public Health News From Medical News Today)

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  Plastic Surgeons Cry Foul Over Senate Health Bill's Cosmetic Surgery Tax

Kaiser Health News staff writer Phil Galewitz writes about the so-called "botax." "If you're considering Botox to erase frown lines or liposuction to get rid of love handles, you might want to move fast. ... The $848 billion health care bill unveiled Wednesday by Senate Majority Leader Harry Reid, D-Nev., includes a 5 percent tax on cosmetic procedures and surgeries" (11/19). Read entire story. (Source: Health News from Medical News Today)

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  Plastic Surgeons Cry Foul Over Senate Health Bill's Cosmetic Surgery Tax

Kaiser Health News staff writer Phil Galewitz writes about the so-called "botax." "If you're considering Botox to erase frown lines or liposuction to get rid of love handles, you might want to move fast. ... The $848 billion health care bill unveiled Wednesday by Senate Majority Leader Harry Reid, D-Nev., includes a 5 percent tax on cosmetic procedures and surgeries" (11/19). Read entire story... (Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today)

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  [Treatment of drooling with botulinum toxin type A in cerebral palsy.]

Authors: Duarte CS, Alves TR, Azeredo PM, Almeida SI PMID: 19921629 [PubMed - as supplied by publisher] (Source: Revista de Neurologia)

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  Treatment success for overactive bladder with urinary urge incontinence refractory to oral antimuscarinics: a review of published evidence

Conclusions: A treatment success definition that encompasses the many components of underlying OAB with UUI symptoms is currently not practical as a consequence of difficulties in measuring urgency. The treatment success outcome of >=50% improvement in incontinence episodes was associated with a clinically meaningful improvement in disease-specific HRQoL for those with neurogenic OAB with UUI. The recommended success definition is less restrictive than a measure such as complete continence but includes patients who are satisfied with treatment and experience meaningful improvement in symptoms. A standardized measure of treatment success will be useful in clinical and health economic applications. (Source: BioMed Central)

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  Merz Pharmaceuticals Announces Approval Of Post-stroke Upper Limb Spasticity Indication For Xeomin(R) In The EU

Merz Pharmaceuticals announced Xeomin®, the first botulinum toxin type A free from complexing proteins has been granted an extension of indication for post-stroke spasticity of the upper limb presenting with flexed wrist and clenched fist in adults in various European countries. Xeomin® was already granted approval for post-stroke spasticity of the upper limb in early 2009 in Canada, Mexico and Argentina. (Source: Stroke / Neuroprotection News From Medical News Today)

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  Merz Pharmaceuticals Announces Approval Of Post-stroke Upper Limb Spasticity Indication For Xeomin(R) In The EU

Merz Pharmaceuticals announced Xeomin®, the first botulinum toxin type A free from complexing proteins has been granted an extension of indication for post-stroke spasticity of the upper limb presenting with flexed wrist and clenched fist in adults in various European countries. (Source: Health News from Medical News Today)

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  License extension for Xeomin® (botulinum toxin type A) in EU to include treatment of post-stroke upper limb spasticity

Source: PharmaLive Area: News The license for Xeomin® (botulinum toxin type A) has been extended in the EU to include the management of post-stroke spasticity of the upper limb presenting with flexed wrist and clenched fist in adults. Xeomin® is already licensed for the symptomatic management of blepharospasm and cervical dystonia of a predominantly rotational form (spasmodic torticollis) in adults. The current license extension is based on the Kanovsky study, the largest randomised, placebo-controlled, double-blind trial with a botulinum toxin in upper limb post-stroke spasticity to date. (Source: NeLM - News)

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  Cosmetic surgery 'needs regulation'

Several newspapers have reported the dangers associated with cosmetic surgery, including a lack of regulation in some areas of the industry. The reports also feature warnings from Nigel Mercer, the president of the British Association of Aesthetic Plastic Surgeons, who voiced his views as part of a series of medical articles on cosmetic surgery. Mr Mercer called for tighter regulation and testing of drugs, procedures and implants to offer more protection to patients. The Times reported that the number of cosmetic surgical operations conducted by “audited members of the profession” has more than tripled to 34,000 since 2003, but that many additional procedures are being carried out illegally on the black market. The newspaper says that these are “fuelled by internet promotions, magazi...

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  Botox Takes A Shot At Pain

No longer just a wrinkle fighter, Botox may have indications as a pain medication to fight Chronic Regional Pain Syndrome (CRPS), according to a new study. (Source: ScienceDaily Headlines)

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  The Lowe Law Firm Files Suit Over Alleged Botox Overdose

St. Louis-based The Lowe Law Firm has filed a lawsuit on behalf of a man who experienced partial respiratory paralysis and other side effects after receiving an overdose of the Botox being used to treat his muscle spasticity. The suit, Richard A. Hart v. Yi Pan, Tenet HealthSystem SL Inc., d/b/a St. Louis University Hospital and Allergan USA Inc., cause no. 0922-CC09485, was filed in St. (Source: Health News from Medical News Today)

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  The Lowe Law Firm Files Suit Over Alleged Botox Overdose

St. Louis-based The Lowe Law Firm has filed a lawsuit on behalf of a man who experienced partial respiratory paralysis and other side effects after receiving an overdose of the Botox being used to treat his muscle spasticity. The suit, Richard A. Hart v. Yi Pan, Tenet HealthSystem SL Inc., d/b/a St. Louis University Hospital and Allergan USA Inc., cause no. 0922-CC09485, was filed in St. Louis Circuit Court on Oct. 21. (Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today)

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  The Lowe Law Firm Files Suit Over Alleged Botox Overdose

St. Louis-based The Lowe Law Firm has filed a lawsuit on behalf of a man who experienced partial respiratory paralysis and other side effects after receiving an overdose of the Botox being used to treat his muscle spasticity. The suit, Richard A. Hart v. Yi Pan, Tenet HealthSystem SL Inc., d/b/a St. Louis University Hospital and Allergan USA Inc., cause no. 0922-CC09485, was filed in St... (Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today)

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  Botox gets a rival - but should you fall for the lure of Azzalure?

A serious contender to the celebrities' favourite frown-freezer has been launched in the UK. (Source: the Mail online | Health)

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  Botox gets a rival - but should you fall for the lure of Azzalure?

A serious contender to the celebrities' favourite frown-freezer has been launched in the UK. (Source: the Mail online | Health)

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  Botox for breasts: New treatment helps women lift sagging cleavage

With the treatment taking just half an hour, it is proving popular with busy young mothers who don't have time to go under the knife. (Source: the Mail online | Health)

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  Botox May Reduce Frequency of Migraines

PHILADELPHIA — OnabotulinumtoxinA appears to be a safe, effective, and well-tolerated headache prophylactic for patients with chronic migraine. Two large randomized controlled trials showed that the toxin significantly reduced migraine frequency and improved headache-related disability over a 24- week period, Dr. David W. Dodick reported at the International Headache Congress. (Source: Skin and Allergy News)

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  Policy & Practice: Can't get enough Policy & Practice? Check out our new podcast each Monday. egmnblog.wordpress.com

Allergan, the manufacturer of Botox (onabotulinumtoxinA), has sued the Food and Drug Administration, claiming that the agency's restrictions on off-label promotions are inhibiting the company's ability to “proactively share truthful and relevant information with the medical community,” according to a company statement. FDA's constraint that Allergan discuss off-label uses for Botox only in general terms violates the first amendment and hurts patients, Allergan claimed. To fully inform physicians, the company said it needs to describe dosing guidelines, patient selection criteria, and proper injection technique. “We believe that the inability to share such important information proactively with the medical community violates the First Amendment and potentially diminishes the quality o...

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  Botox May Reduce Frequency of Migraines

PHILADELPHIA — OnabotulinumtoxinA appears to be a safe, effective, and well-tolerated headache prophylactic for patients with chronic migraine. Two large randomized, controlled trials showed that the toxin significantly reduced migraine frequency and improved headache-related disability over 24 weeks, Dr. David W. Dodick reported at the International Headache Congress. (Source: Internal Medicine News)

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  A double-blind comparison of onabotulinumtoxina (BOTOX) and topiramate (TOPAMAX) for the prophylactic treatment of chronic migraine: a pilot study.

CONCLUSIONS: OnabotulinumtoxinA and topiramate demonstrated similar efficacy in the prophylactic treatment of CM. Patients receiving onabotulinumtoxinA had fewer AEs and discontinuations. PMID: 19912346 [PubMed - in process] (Source: Headache)

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  Botulinum Toxin for the Correction of Asymmetric Crying Facies

The clinical hallmark of asymmetric crying facies (ACF) is a symmetric appearance of the oral aperture and lips at rest, but significant depression of one side of the lower lip with animation (crying or smiling). ACF can resolve spontaneously in the first year of life, but surgical intervention may be required at some point to ensure a good cosmetic outcome. The authors report on the successful use of botulinum toxin type A to achieve temporary facial symmetry in two children with ACF with results lasting up to six months and suggest that such treatments may be helpful in providing more time to consider and/or plan surgical intervention. (Source: Aesthetic Surgery Journal)

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  The use of botulinum toxin type A in urological procedures.

This article will explore the use of Botox in urology and provide a brief review of the literature supporting its use. PMID: 20088238 [PubMed - in process] (Source: Urologic Nursing)

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  Lower urinary tract dysfunction in MS: management in the community.

Authors: Panicker J, Haslam C Lower urinary tract dysfunction in multiple sclerosis is common and is highly amenable to treatment. Individuals may have bladder storage and/or voiding dysfunction. The risk of progression to renal failure is low and hence lower urinary tract dysfunction should be considered medically manageable in most individuals. Evaluation begins with history taking and is supplemented by using a bladder diary. Ultrasonography is used to assess the degree of incomplete bladder emptying, and for assessing upper urinary tract damage. Incomplete bladder emptying is most often managed by clean intermittent self-catheterization and should be initiated if post-void residual urine is greater than 100 mls. Storage symptoms are most often managed using antimuscarinic medicatio...

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  Treatment of congenital esotropia with botulinum toxin type A

Conclusion: Botulinum toxin type A injections into the medial recti muscles are a valuable alternative to conventional strabismus surgery. (Source: Acta Ophthalmologica)

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  Ipsen Announces the Launch of Dysport(R) (abobotulinumtoxinA) in the United States for the Treatment of Cervical Dystonia

Dysport(R) represents the first new botulinum toxin type A treatment option in eight years to reach the U.S. market place PARIS--(HSMN NewsFeed)--Ipsen (Paris: IPN ), an innovation-driven global specialty pharmaceutical group, today announced that Dyspo... BiopharmaceuticalsIpsen, Dysport, abobotulinumtoxinA, cervical dystonia (Source: HSMN NewsFeed)

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  Allergan Wants Court To Find Off-Label Promotion Rules Are Unconstitutional

WASHINGTON, D.C. - Already under federal investigation for the off-label marketing of Botox, manufacturer Allergan Inc. on Oct. 1 asked a federal court to declare that federal regulations barring promotion of off-label uses of drugs are an unconstitutional violation of its First Amendment free speech rights (Allergan, Inc. v. United States of America, et al., No. 09-1879, D. D.C.). Full story on lexis.com (Source: LexisNexis® Mealey's™ Arthritis Drugs Legal News)

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  Botox as a Breast Lift?

Title: Botox as a Breast Lift?Category: Health NewsCreated: 10/27/2009 10:02:00 AMLast Editorial Review: 10/27/2009 10:02:27 AM (Source: MedicineNet Skin General)

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  Botox as a Breast Lift?

Title: Botox as a Breast Lift?Category: Health NewsCreated: 10/27/2009 10:02:00 AMLast Editorial Review: 10/27/2009 10:02:27 AM (Source: MedicineNet Senior Health General)

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  Botox as a Breast Lift?

Title: Botox as a Breast Lift?Category: Health NewsCreated: 10/27/2009 10:02:00 AMLast Editorial Review: 10/27/2009 10:02:27 AM (Source: MedicineNet HIV General)

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  Botox as a Breast Lift?

(Source: eMedicineHealth.com)

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  Botox as a Breast Lift?

Title: Botox as a Breast Lift?Category: Health NewsCreated: 10/27/2009 10:02:00 AMLast Editorial Review: 10/27/2009 10:02:27 AM (Source: MedicineNet Womens Health General)

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  Botox Fights Pain

Botox may have the power not only to remove wrinkles, but ease pain that's unresponsive to treatments like massage and heat/cold therapy. (Source: Medical Headlines From Ivanhoe.com)

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  Botox as a Breast Lift?

Add breast lifts to the growing list of potential uses for Botox. But not all experts think it's worth the trouble. (Source: WebMD Health)

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  Botox as a Breast Lift?

Add breast lifts to the growing list of potential uses for Botox. But not all experts think it's worth the trouble. (Source: WebMD Health)

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  News From Plastic Surgery 2009

Botox Takes a Shot at Pain No longer just a wrinkle fighter, Botox® may have indications as a pain medication to fight Chronic Regional Pain Syndrome (CRPS), reports a new study presented at the American Society of Plastic Surgeons (ASPS) Plastic Surgery 2009 conference, Oct. 23-27, in Seattle. (Source: Health News from Medical News Today)

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  Supraciliary wrinkles and botulinum toxin A

Conclusions. Injection of botulinum toxin type A through the temporal hairline to correct supraciliary wrinkles seems to be safe and effective. (Source: Clinical And Experimental Dermatology)

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  What Is Dystonia?

Dystonia is a rare neurological movement disorder characterized by involuntary muscle contractions, which force certain parts of the body into abnormal, sometimes painful, movements or postures. It can be inherited due to genetic abnormalities as seen in multiple sclerosis. It can also be caused by brain injuries, toxins and some medications. Antipsychotic medication, often prescribed in the treatment of bipolar disorder, is one class of drugs that can cause dystonia, which is one of several extrapyramidal side effects. Generally it is the first generation antipsychotics also known as typical antipyschotics that can cause these side effects. There is no cure for dystonia. However, there are a few options for treating the symptoms of the disorder. One of the most common treatments is Boto...

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  Botox sponge may benefit some patients with idiopathic rhinitis

A nasally-inserted sponge that is soaked with botulinum toxin A provides a minimally invasive, effective alternative to botox injections for patients with treatment-resistant idiopathic rhinitis, research shows. (Source: MedWire News - Respiratory)

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  Botox sponge treats allergic runny nose

GOTTINGEN, Germany, Oct. 16 (UPI) -- Injecting botulinum toxin -- botox -- to treat intrinsic or allergic rhinitis, or runny nose, may be a thing of the past, German researchers said. (Source: Health News - UPI.com)

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  No Need For Needles: Botox Sponge Treats Intrinsic Rhinitis

Injecting botulinum toxin (botox) to treat intrinsic or allergic rhinitis may be a thing of the past as researchers have now shown that sponges soaked in botox are equally effective in treating the condition. The research offers a potential needle-free treatment to the millions of people who suffer from rhinitis. (Source: ScienceDaily Headlines)

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  Botox Sponge Treats Intrinsic Rhinitis Without Needles

Injecting botulinum toxin (botox) to treat intrinsic or allergic rhinitis may be a thing of the past as researchers have now shown that sponges soaked in botox are equally effective in treating the condition. The research published in BioMed Central's open access journal Head & Face Medicine offers a potential needle-free treatment to the millions of people who suffer from rhinitis. (Source: Health News from Medical News Today)

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  Botox Sponge Replaces Needles for Rhinitis Patients

German researchers may have found a pain-free treatment for sneezing and sniffling rhinitis patients, replacing needles with soft sponges. (Source: Medical Headlines From Ivanhoe.com)

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  Dishler Introduces Latisse

We have signed on with Allergan Pharmaceuticals to dispense Latisse for our patients in Denver, Centennial, Aurora and from Colorado Springs and Fort Collins who wish to have longer, thicker, and darker eyelashes.  We have received numerous requests from existing patients to offer this product, and although it does not have the "gravity" of LASIK or laser vision correction, it is something that many of our female patients have been requesting.  Since Latisse can only be prescribed by medical doctors (MD) and not optometrists (OD) we are also providing this for patients referred by our network of co-managing Optometrists.  Tomorrow I am going for my weekly segment on the Tom Martino Show on Channel 31 and channel 2 in Denver, to introduce our Latisse program, and to...

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  Smile! It Could Make You Happier

We smile because we are happy, and we frown because we are sad. But does the causal arrow point in the other direction, too? A spate of recent studies of botox recipients and others suggests that our emotions are reinforced--perhaps even driven--by their corresponding facial expressions.Charles Darwin first posed the idea that emotional responses influence our feelings in 1872. “The free expression by outward signs of an emotion intensi­fies it,” he wrote. The esteemed 19th-cen­tury psychologist William James went so far as to assert that if a person does not express an emotion, he has not felt it at all. Although few scientists would agree with such a statement today, there is evidence that emotions in­volve more than just the brain. The face, in particular, appear...

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  Oromandibular dystonia and hormonal factors: twelve years follow-up of a case report

We report on a 30-year-old woman affected with OMD with a 12-year follow-up. Focal dystonia involved an involuntary activity of the lateral pterygoid muscles causing forceful jaw displacement in the maximal protrusive position. These episodes initially occurred during jaw function and increased up to an open-lock with bilateral pre-auricular pain. Dystonic spasms were absent during sleep and were reduced temporarily by sensory tricks. Treatment with botulinum toxin type A (BTX) was performed during three different sessions over a 1-year period. Electromyographic-guided BTX injections into the lateral pterygoid muscles were given with cannula electrodes. Botox reduced the involuntary activity of the muscles. Recurrence and exacerbation of dystonic symptoms occurred during the two pregnancie...

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  Sinitta's frozen shoulder was so painful she couldn't turn her head. Now she's cured - thanks to a Botox injection

The former Eighties pop star reveals how she can hardly bear to watch her debut as a presenter last year on TV’s Loose Women. ‘I looked so stiff and wooden,’ she says (Source: the Mail online | Health)

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  Merz Pharmaceuticals Announces Phase III Data For NT 201 In Post-stroke Upper Limb Spasticity

Data results published this month in Clinical Neuropharmacology, revealed that Merz Pharmaceuticals' NT 201 (botulinum toxin type A free from complexing proteins), also known by the brand name Xeomin in Europe and Canada, was statistically significantly more efficacious than placebo for the treatment of patients with post-stroke upper limb spasticity. (Source: Health News from Medical News Today)

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  Effect of Botulinum Toxin Type A on Transforming Growth Factor β1 in Fibroblasts Derived from Hypertrophic Scar: A Preliminary Report

Conclusion  These results suggest that BTXA effectively inhibited the growth of fibroblasts derived from hypertrophic scar and in turn caused a decrease in TGF-β1 protein, indicating that BTXA-based therapies for hypertrophic scar are promising and worth investigating further. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00266-009-9423-zAuthors Zhibo Xiao, Second Affiliated Hospital of Harbin Medical University Department of Plastic Surgery Harbin City People’s Republic of ChinaFengmin Zhang, College of Basic Medical Science, Harbin Medical University Department of Microbiology Harbin City People’s Republic of ChinaWeibin Lin, Second Affiliated Hospital of Harbin Medical University Department of Very Important Patient Harbin City People’s Re...

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  Botox Maker’s Suit Cites Free Speech

Allergan is suing the government, charging that restrictions on telling doctors about unapproved drug uses violates its free-speech rights. (Source: NYT)

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  Botox Maker’s Suit Cites Free Speech

Allergan is suing the government charging that restrictions on telling doctors about unapproved drug uses violates its free-speech rights. (Source: NYT > Health)

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  REMS Trigger Suit by Maker of Botulinum Toxin

The maker of Botox (onabotulinumtoxin A) is asking a federal district court to allow it to share "truthful" information about off-label uses of the drug without risk of penalty from either the FDA or the Department of Justice. (Source: MedPage Today Product Alert)

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  Allergan sues to discuss unapproved uses of drugs

Allergan, the maker of the Botox wrinkle treatment, challenged the government's ban on off-label drug marketing to doctors, saying ... (Source: USATODAY.com Health)

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  Botox Effective in Tough-To-Treat Urinary Incontinence

About half of patients with refractory idiopathic detrusor overactivity (IDO) incontinence have complete restoration of continence one month after treatment with botulinum neurotoxin type A (Botox), investigators reported at the 39th Annual Meeting of the International Continence Society (ICS) 2009. Reuters Health Information (Source: Medscape Medical News Headlines)

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  Allergan Files Federal Lawsuit to Allow It to Share Relevant Information with the Medical Community on the Safe Use of Botox for Common Therapeutic Off-Label Treatments

IRVINE, Calif.--(BUSINESS WIRE)--Oct 2, 2009 - Allergan, Inc. (NYSE: AGN) today filed a declaratory relief action in the United States District Court for the District of Columbia seeking a ruling that would allow Allergan to proactively share... (Source: Drugs.com - Pharma News)

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  Allergan Suit Seeks to Lift Botox Curbs

Allergan filed a lawsuit against health officials asserting that barring the company from offering information about the unapproved use of Botox violates its free-speech rights. (Source: WSJ.com: Health)

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  Allergan Suit Seeks to Lift Botox Curbs

Allergan filed a lawsuit against health officials asserting that barring the company from offering information about the unapproved use of Botox violates its free-speech rights. (Source: WSJ.com: Health)

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  Botox Maker Sues to Lift Promotion Ban

Allergan filed a lawsuit against health officials asserting that barring the company from offering information about the unapproved use of Botox violates its free-speech rights. (Source: WSJ.com: Health)

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  Botox Found to Reduce Frequency of Migraine

PHILADELPHIA — OnabotulinumtoxinA appears to be a safe, effective, and well-tolerated headache prophylactic for patients with chronic migraine. The PREEMPT 1 and 2 studies were conducted at centers in North America and Europe, and included 1,384 patients (average age 41 years). Each trial consisted of a 4-week baseline period, during which patients kept a headache diary, followed by 24 weeks of treatment during which patients received two injection cycles of either placebo or 155 U onabotulinumtoxinA (Botox), which has not been approved for migraine by the Food and Drug Administration. From 24 to 56 weeks, there was an open-label trial consisting of three injection cycles of the study drug, Dr. David W. Dodick of the Mayo Clinic Arizona, Phoenix, reported at the International Headache C...

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  Botulinum toxin type A in the treatment of painful adductor muscle contracture after total hip arthroplasty.

Authors: Santamato A, Ranieri M, Panza F, Solfrizzi V, Frisardi V, Lapenna LM, Moretti B, Fiore P Painful adductor muscle contracture is an important cause of failure during rehabilitation following total hip arthroplasty (THA). Adductor muscle contracture may be caused by postoperative muscle retractions, adhesive capsulitis, postoperative leg-length inequalities caused by implant failure, or preexisting hip pathologies. A 34-year-old woman experienced a persistent painful contracture into the left adductor magnus muscle after THA. She had no leg-length inequalities and, according to the Medical Research Council scale (grades 0-5), muscle strength of the quadriceps was 5/5 for the right side and 3/5 for the left. The degree of functionality according to the Harris hip score (HHS) was ...

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  Is active sweating during heat acclimation required for improvements in peripheral sweat gland function?

We investigated whether the eccrine sweat glands must actively produce sweat during heat acclimation if they are to adapt and increase their capacity to sweat. Eight volunteers received intradermal injections of BOTOX, to prevent neural stimulation and sweat production of the sweat glands during heat acclimation, and saline injections as a control in the contralateral forearm. Subjects performed 90 min of moderate-intensity exercise in the heat (35°C, 40% relative humidity) on 10 consecutive days. Heat acclimation decreased end-exercise heart rate (156 ± 22 vs. 138 ± 17 beats/min; P = 0.0001) and rectal temperature (38.2 ± 0.3 vs. 37.9 ± 0.3°C; P = 0.0003) and increased whole body sweat rate (0.70 ± 0.29 vs. 1.06 ± 0.50 l/h; P = 0.030). Dur...

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  Use of Botulinum Toxin Type A Before Abdominal Wall Hernia Reconstruction

Conclusions  BTA application before abdominal wall hernia repair seems to be useful. The lateral muscles paralysis achieved and transverse hernia defect reduction allows a minimal tension closure. To our knowledge, this is the first report of BTA application before abdominal wall hernia reconstruction. Content Type Journal ArticleDOI 10.1007/s00268-009-0203-3Authors Tomas R. Ibarra-Hurtado, Antiguo Hospital Civil de Guadalajara Department of General Surgery Av. Circunvalación Dr. Atl No. 154. Col. Independencia Guadalajara Jalisco 44340 MéxicoCarlos M. Nuño-Guzmán, Antiguo Hospital Civil de Guadalajara Department of General Surgery Av. Circunvalación Dr. Atl No. 154. Col. Independencia Guadalajara Jalisco 44340 MéxicoJorge E. Echeagaray-Herrera, Antiguo Hospital ...

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  Ipsen: AZZALURE(R) Approved In Spain For Aesthetic Use In The Treatment Of Glabellar Lines

Galderma, the leading pharmaceutical company in dermatology, and Ipsen (Euronext: IPN), an international innovation-driven specialty pharmaceutical group, announced that Azzalure® (botulinum toxin type A manufactured by Ipsen), a local muscle relaxant specifically developed for aesthetic use, has (Source: Health News from Medical News Today)

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  Botulinum toxin type A and a rehabilitation program in the treatment of Pisa syndrome in Parkinson’s disease

Content Type Journal ArticleCategory Letter to the EditorsDOI 10.1007/s00415-009-5310-4Authors Andrea Santamato, University of Foggia, “OORR” Department of Physical Medicine and Rehabilitation Viale Pinto 71100 Foggia ItalyMaurizio Ranieri, University of Bari Department of Neurological and Psychiatric Sciences Bari ItalyFrancesco Panza, University of Bari Department of Geriatrics, Center for Aging Brain, Memory Unit Bari ItalyStefano Zoccolella, University of Foggia Department of Medical and Neurological Sciences Foggia ItalyVincenza Frisardi, University of Bari Department of Geriatrics, Center for Aging Brain, Memory Unit Bari ItalyVincenzo Solfrizzi, University of Bari Department of Geriatrics, Center for Aging Brain, Memory Unit Bari ItalyMaria Teresa Amoruso, University of Fogg...

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  Current studies on myofascial pain syndrome

Abstract  Recent studies have clarified the nature of myofascial trigger points (MTrPs). In an MTrP region, multiple hyperirritable loci can be found. The sensory components of the MTrP locus are sensitized nociceptors that are responsible for pain, referred pain, and local twitch responses. The motor components are dysfunctional endplates that are responsible for taut band formation as a result of excessive acetylcholine (ACh) leakage. The concentrations of pain- and inflammation-related substances are increased in the MTrP region. It has been hypothesized that excessive ACh release, sarcomere shortening, and release of sensitizing substances are three essential features that relate to one another in a positive feedback cycle. This MTrP circuit is the connection among spin...

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  Scientific Studies Confirm The Value Of Botulinum Toxin Type A (Botox) In Treating And Preventing Chronic Migraine

Four separate studies[i] representing the findings of clinical trials in the U.S., Canada and Europe have confirmed the value of onabotulinumtoxinA in treating and preventing chronic migraine in adults. These studies found that treatment with botulinum toxin type A was associated with significantly fewer headache days, less headache-related disability, and significantly improved quality of life... (Source: Headache / Migraine News From Medical News Today)

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  Scientific Studies Confirm The Value Of Botulinum Toxin Type A (Botox) In Treating And Preventing Chronic Migraine

Four separate studies[i] representing the findings of clinical trials in the U.S., Canada and Europe have confirmed the value of onabotulinumtoxinA in treating and preventing chronic migraine in adults. These studies found that treatment with botulinum toxin type A was associated with significantly fewer headache days, less headache-related disability, and significantly improved quality of life. (Source: Health News from Medical News Today)

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