MedWorm: Benazepril

  BENAZEPRIL HYDROCHLORIDE AND HYDROCHLOROTHIAZIDEtablet, Film Coated [Sandoz Inc]

Updated Date: Mar 4, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Drug slows CKD progression

Using benazepril in combination with amlodipine could slow chronic kidney disease (CKD) progression, according to international researchers. (Source: Nursing Times Breaking News)

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  BENAZEPRIL HYDROCHLORIDEtablet, Film Coated [International Labs, Inc.]

Updated Date: Feb 25, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  BP drugs slow CKD progression

GPs should consider benazepril plus amlodipine for high blood pressure, say US researchers. (Source: Pulse)

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  Antihypertensive Combo May Save Kidney Function (CME/CE)

Patients with chronic kidney disease treated with benazepril (Lotensin) plus amlodipine (Norvasc) were less likely to experience worsening renal function than those treated with benazepril plus hydrochlorothiazide, researchers found. (Source: MedPage Today Cardiovascular)

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  Amlodipine/Benazepril Best for Slowing Progression of Chronic Kidney Disease

Heartwire (Source: Medscape Medical News Headlines)

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  Renal Outcomes Better with Benazepril plus Amlodipine vs. Benazepril plus Hydrochlorothiazide?

(Source: Physician's First Watch current issue)

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  ACCOMPLISH: Nephropathy progression slower with benazepril–amlodipine

Initial antihypertensive therapy with the combination of benazepril and amlodipine slows progression of nephropathy to a greater extent than does the combination of benazepril and hydrochlorothiazide, conclude the ACCOMPLISH trial investigators. (Source: MedWire News - Cardiology)

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  Does adding a CCB rather than diuretic to an ACE-inhibitor increase renal protection?

Source: Lancet Area: News Secondary analysis of the ACCOMPLISH trial suggests that in high-risk patients, combining a calcium-channel blocker (CCB) rather than a diuretic with an ACE-inhibitor reduces progression of nephropathy. An accompanying Comment, however, advises caution in interpreting the results, as they are unexpected and the outcome used is problematic.   ACCOMPLISH was a large (n=11,506) randomised controlled trial that compared benazepril (a standard ACE-inhibitor no longer marketed in the UK) plus amlodipine with benazepril plus hydrochlorothiazide in patients with hypertension who were at high risk for cardiovascular events. Primary outcome was cardiovascular mortality and morbidity; progression of chronic kidney disease was a pre-specified secondary outcome and w...

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  Drug Combo Shows Benefits in Chronic Kidney Disease

In hypertensive patients with high cardiovascular risk, benazepril and amlodipine are better at reducing progression of chronic kidney disease than benazepril with hydrochlorothiazide, according to research published online Feb. 18 in The Lancet. (Source: Modern Medicine)

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  ACCOMPLISH: Nephropathy progression slower with benazepril–amlodipine

Initial antihypertensive therapy with the combination of benazepril and amlodipine slows progression of nephropathy to a greater extent than does the combination of benazepril and hydrochlorothiazide, conclude the ACCOMPLISH trial investigators. (Source: MedWire News - Hypertension)

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  Amlodipine/benazepril best for slowing progression of chronic kidney disease

An analysis of the ACCOMPLISH study showed that after a mean follow-up of three years, amlodipine and benazepril significantly reduced the progression to chronic kidney disease 48%, an absolute... For complete story visit theheart.org. (Source: theHeart.org)

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  BENAZEPRIL HYDROCHLORIDEtablet [Stat Rx USA]

Updated Date: Feb 16, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Lupin Receives FDA Approval for Amlodipine/Benazepril Capsules

BALTIMORE, Feb. 8 (HSMN NewsFeed) -- Lupin Pharmaceuticals, Inc. announced today that the U.S. Food and Drug Administration (U.S. FDA) has granted final approval for its Amlodipine/Benazepril 2.5mg/10mg, 5mg/10mg, 5mg/20mg and 10mg/20mg capsules. Commer... Biopharmaceuticals, FDA, GenericsLupin Pharmaceuticals, Amlodipine, Benazepril, Novartis, Lotrel (Source: HSMN NewsFeed)

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  Lupin Receives FDA Approval For Amlodipine/Benazepril Capsules

Lupin Pharmaceuticals, Inc. announced recently that the U.S. Food and Drug Administration (U.S. FDA) has granted final approval for its Amlodipine/Benazepril 2.5mg/10mg, 5mg/10mg, 5mg/20mg and 10mg/20mg capsules. (Source: Pharmaceutical Online News)

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  BENAZEPRIL HYDROCHLORIDEtablet [Amneal Pharmaceuticals]

Updated Date: Feb 3, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  LOTENSIN HCT (Benazepril Hydrochloride And Hydrochlorothiazide) Tablet [Physicians Total Care, Inc.]

Updated Date: Feb 2, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  BENAZEPRIL HYDROCHLORIDEtablet, Film Coated [Greenstone LLC]

Updated Date: Feb 2, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  LOTREL (Amlodipine Besylate And Benazepril Hydrochloride) Capsule [Novartis Pharmaceuticals Corporation]

Updated Date: Jan 26, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Benazepril: Visceral angioedema: case report

(Source: Reactions)

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  BENAZEPRIL HYDROCHLORIDEtablet, Film Coated [Aurobindo Pharma Limited]

Updated Date: Jan 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Benazepril/valsartan: Hyperkalaemia in an elderly patient with diabetes: case report

(Source: Reactions)

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  LOTREL (Amlodipine Besylate And Benazepril Hydrochloride) Capsule [Novartis Pharmaceuticals Corporation]

Updated Date: Dec 24, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  BENAZEPRIL HYDROCHLORIDEtablet [Benazepril]

Updated Date: Dec 22, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Cardioprotective effects of benazepril, an angiotensin-converting enzyme inhibitor, in an ischaemia-reperfusion model of myocardial infarction in rats

Conclusion. This study demonstrates that benazepril upregulated Bcl-2 protein and decreased Bax protein expression, thus exhibiting anti-apoptotic effects. These beneficial effects of benazepril will have an important implication in the therapeutic use of benazepril in ischaemic heart disease. (Source: Journal of the Renin-Angiotensin-Aldosterone System : JRAAS)

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  Lotensin Hct (Benazepril HCl and HCTZ) - updated on RxList

Lotensin Hct (Benazepril HCl and HCTZ) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

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  BENAZEPRIL HYDROCHLORIDEtablet, Film Coated [Greenstone LLC]

Updated Date: Dec 4, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Lotensin (Benazepril) - updated on RxList

Lotensin (Benazepril) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

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  BENAZEPRIL HYDROCHLORIDEtablet [Amneal Pharmaceuticals]

Updated Date: Dec 2, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Simultaneous determination of amlodipine besylate and benazepril hydrochloride in pharmaceutical dosage form by LC.

Authors: Kasawar GB, Farooqui MN A rapid, precise, specific, and accurate ultra performance liquid chromatography (UPLC) method has been developed and subsequently validated for simultaneous determination of amlodipine present as amlodipine basylate (AB) and benazepril hydrochloride (BH) in capsule dosage form. The chromatographic separation was achieved on an Acquity UPLC, BEH C8 (100 mm x 2.1 mm, 1.7 microm) column using a photodiode array detector. The mobile phase used consisted of a mixture of phosphate buffer pH 3.0 (0.01 M aqueous potassium dihydrogen phosphate, pH 3.0 adjusted with orthophosphoric acid) and solvent mixture (equal mixture of acetonitrile and methanol) in the ratio of 45:55 (v/v) at a flow rate of 0.3 mL/min. The described method was linear over ranges of 5.21-15...

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  Lotrel (Amlodipine Besylate and Benazepril HCl) - updated on RxList

Lotrel (Amlodipine Besylate and Benazepril HCl) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

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  LOTENSIN (Benazepril Hydrochloride) Tablet [Novartis Pharmaceuticals Corporation]

Updated Date: Oct 27, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Renal failure (chronic)

New evidence; conclusions changed for: Statins versus placebo or no treatment One systematic review and two subsequent RCTs added. The review found that statins reduced all-cause mortality and cardiovascular mortality compared with placebo or no treatment. The first subsequent RCT found that simvastatin decreased all-cause mortality, major coronary events, and the composite outcome of death from coronary disease and non-fatal MI compared with placebo. The second subsequent RCT found no significant difference between pravastatin and placebo or no treatment in rates of progression to end-stage renal disease (ESRD), composite outcome of ESRD or 50% decrease in glomerular filtration rate (GFR), or the composite outcome of ESRD or 25% decrease in GFR. Categor...

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  Decreasing risk of death by 80% at the cost of $12 per month

High-risk patients who took 3 older drugs - statin, lisinopril, aspirin - cut risk of a heart attack or stroke by 80% (source: Reuters).All of those are on the Walmart's $4 list which means you can decrease your risk of death by 80% for $12 per month (if you have the risk factors)."Even in people who took it less than half the time, they got over a 60 percent drop in heart attacks and strokes," said Dr. R. James Dudl of Kaiser Permanente in California, whose study was published in the American Journal of Managed Care. "Those who took it more than half the time -- they got more like an 80 percent drop."It also suggests that people do not need to take a name-brand statin drug -- which Dudl said costs up to eight times more than a generic -- to achieve a major reduction in risks.From Twitter:...

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  Is Choice of Antihypertensive Agent Important in Improving Cardiovascular Outcomes in High-Risk Hypertensive Patients?

Commentary on Jamerson K, Weber MA, Bakris GL, et al; ACCOMPLISH Trial Investigators. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008;359(23):2417-2428. (Source: American Journal of Kidney Diseases)

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  PRMT-1 and DDAHs-induced ADMA upregulation is involved in ROS- and RAS-mediated diabetic retinopathy.

Authors: Chen Y, Xu X, Sheng M, Zhang X, Gu Q, Zheng Z Asymmetric dimethylarginine (ADMA), an endogenous competitive inhibitor of nitric oxide synthase, is generated in presence of type 1 protein arginine N-methyltransferase (PRMT-1) and is metabolized by dimethylarginine dimethylaminohydrolases (DDAHs). Reportedly ADMA is associated with endothelial dysfunction. The aim of this study is to investigate whether PRMT-1- and DDAHs-induced ADMA increase in diabetic rat retina and high glucose-treated bovine retinal capillary endothelial cells (BRCECs) is involved in reactive oxygen species (ROS)- and renin-angiotensin system (RAS)-mediated diabetic retinopathy. Rats were divided into four groups: sham-injected group, streptozotocin (STZ)-induced diabetic model group, STZ-induced diabetic m...

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  Benazepril and heparin for treatment of chronic kidney disease

Systemic hypertension is common in dogs with chronic kidney disease (CKD). In turn, hypertension may lead to a more rapid progression of renal insufficiency. Because activation of the renin-angiotensin-aldosterone system is one of the main causes of hypertension in dogs with CKD, treatment with angiotensin-converting enzyme inhibitors (ACEIs) is considered effective therapeutic strategy. Reported benefits of treatment with ACEIs include decreases in glomerular capillary hypertension, severity of proteinuria, and the progression of renal lesions. (Source: Advances in Small Animal Medicine and Surgery)

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  LOTENSIN HCT (Benazepril Hydrochloride And Hydrochlorothiazide) Tablet [Novartis Pharmaceuticals Corporation]

Updated Date: Jul 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  BENAZEPRIL HYDROCHLORIDEtablet, Coated [TEVA Pharmaceuticals USA Inc]

Updated Date: Jul 30, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Efficacy of Benazepril Hydrochloride to Delay the Progression of Occult Dilated Cardiomyopathy in Doberman Pinschers

Angiotensin converting enzyme inhibitors (ACEIs) are recommended in people to treat asymptomatic (occult) dilated cardiomyopathy (DCM). Efficacy of therapy in occult DCM in dogs is unknown. ACEIs, specifically benazepril hydrochloride (BH), will delay the onset of overt DCM in Doberman Pinschers. Ninety-one Doberman Pinschers were studied, 57 dogs received BH, and 34 dogs no ACEI. Retrospective study of the medical records of all Doberman Pinschers with occult DCM that received BH or no ACEI between April 1989 and February 2003. Two criteria of left ventricular enlargement were used for enrollment: one independent of body weight (BW) (C1) and the other indexed to BW (C2). Cox proportional hazards analyses were used to identify variables associated with the onset of overt DCM. On univariate...

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  BENAZEPRIL HYDROCHLORIDEtablet [Aurobindo Pharma Limited]

Updated Date: Jun 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Analysis Backs Benazepril-Amlodipine Combo

SAN FRANCISCO — A new analysis supports a controversial study that challenged the favored role of diuretics in combination therapy for hypertension, but some experts remain skeptical. (Source: Family Practice News)

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  ACCOMPLISH: Systolic blood pressure with 24-hour monitoring no different in treatment arms

Investigators say the results support their earlier conclusions that the difference in morbidity and mortality was driven by a more effective combination therapy with the ACE inhibitor benazepril plus the calcium-channel blocker amlodipine and not by differences in blood pressure. (Source: theHeart.org)

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  Comparison of cardioprotective effects using salvianolic acid B and benazepril for the treatment of chronic myocardial infarction in rats

Content Type Journal ArticleCategory Retraction NoteDOI 10.1007/s00210-009-0417-9Authors Haibo He, Zhejiang University Institute of Chinese Herbal Medicine, College of Pharmaceutical Sciences Zijingang Campus Hangzhou 310058 People’s Republic of ChinaMengqiong Shi, Dahe Clique Center of Medical Science Analysis Hangzhou ChinaXianzhe Yang, Zhejiang University Institute of Chinese Herbal Medicine, College of Pharmaceutical Sciences Zijingang Campus Hangzhou 310058 People’s Republic of ChinaXiaowei Zeng, Zhejiang University Institute of Chinese Herbal Medicine, College of Pharmaceutical Sciences Zijingang Campus Hangzhou 310058 People’s Republic of ChinaLimao Wu, Zhejiang University Institute of Chinese Herbal Medicine, College of Pharmaceutical Sciences Zijingang Campus Hangzhou 31...

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  Effect of all- trans retinoic acid on renal expressions of matrix metalloproteinase-2, matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in rats with glomerulosclerosis

In conclusion, ATRA may protect renal function and step down the progression of GS by reducing the expression of TIMP-1, enhancing the expression and activity of MMP-2 and MMP-9, and regulating the ratio of MMPs/TIMPs to dynamic balance, so as to reduce the accumulation of ECM. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00467-009-1166-1Authors Yuan-Han Qin, The First Affiliated Hospital of Guangxi Medical University Department of Pediatrics Nanning 530021 ChinaFeng-Ying Lei, The First Affiliated Hospital of Guangxi Medical University Department of Pediatrics Nanning 530021 ChinaPeng Hu, The Affiliated Hospital of Anhui Medical University Pediatrics Hefei ChinaJuan Pei, The Medical Collage of Wannan Wuhu ChinaZhen-bo Feng, The First Affiliated Hospital of Guang...

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  Benazepril: First report of cholestasis: case report.

Page: 9 (Source: Reactions Weekly)

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  BENAZEPRIL HYDROCHLORIDEtablet, Film Coated [Apotex Corp.]

Updated Date: Mar 23, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FDA Safety Changes: Hycodan, Lotensin, Lotensin HCT, Omnicef

The FDA has approved revisions to the safety labeling for hydrocodone bitartrate and homatropine methylbromide, benazepril, benazepril plus hydrochlorothiazide, and cefdinir. Medscape Medical News (Source: Medscape Today Headlines)

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  FDA Safety Changes: Hycodan, Lotensin, Lotensin HCT, Omnicef

The FDA has approved revisions to the safety labeling for hydrocodone bitartrate and homatropine methylbromide, benazepril, benazepril plus hydrochlorothiazide, and cefdinir. Medscape Medical News (Source: Medscape Today Headlines)

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  Benazepril: Fatal pulmonary hypoplasia (first report) after in utero exposure: case report

(Source: Reactions)

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  Benazepril: Fatal pulmonary hypoplasia (first report) after in utero exposure: case report.

Page: 10 (Source: Reactions Weekly)

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  BENAZEPRIL HYDROCHLORIDEtablet, Film Coated [Sandoz Inc.]

Updated Date: Mar 13, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CORRESPONDENCE: Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension

To the Editor: In their report on the Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension ... (Source: New England Journal of Medicine)

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  Hemodynamic effects of benazepril, an angiotensin-converting enzyme inhibitor, as studied in conscious normotensive dogs

Summary  Hemodynamic effects and inhibitory effects on the pressor response to exogenous angiotensin I of benazepril (CGS 14824A), a new angiotensin-converting enzyme (ACE) inhibitor, were examined in conscious chronically instrumented normotensive dogs in comparison with those of captorpil. Oral administration of benazepril (1–10 mg/kg) and captopril (3 and 10 mg/kg) reduced the blood pressure and inhibited the pressor response to angiotensin I dose-dependently. The blood-pressure-lowering effect of benazepril was as potent as that of captopril. The onset of effects of benazepril was slower and the duration longer than that of captopril. There was no close correlation between the attenuation of pressor response to exogenous angiotensin I and the blood-pressure-lowering e...

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  Could mycophenolate mofetil combined with benazapril delay tubulointerstitial fibrosis in 5/6 nephrectomized rats?

CONCLUSIONS: MMF, especially combined with benazepril, can reduce proteinuria, improve renal function, ameliorate tubulointerstitial fibrosis in 5/6 nephrectomized rats. These effects might be, in part, associated with down-regulation of PDGF-BB and TIMP-1, and MMP-9 up-regulation in renal tissues. PMID: 19187647 [PubMed - in process] (Source: Chinese Medical Journal)

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  Interesting Articles: A Weekly Review of the "Big Five" Medical Journals

This study showed that among healthy middle-aged women, consumption of up to 2 alcoholic beverages per day was not associated with an increased risk of incident atrial fibrillation. More than 2 drinks per day was associated with a small but statistically significant increased risk of atrial fibrillation.------------------Hospital-wide Code Rates and Mortality Before and After Implementation of a Rapid Response TeamJAMA. 2008;300(21):2506-2513.Rapid response teams have been shown in adult inpatients to decrease cardiopulmonary arrest (code) rates outside of the intensive care unit (ICU). In this large single-institution study, rapid response team implementation was not associated with reductions in hospital-wide code rates or mortality.------------------Circumcision — A Surgical Strategy ...

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  ACCOMPLISH: ‘Increased options’ for combination antihypertensive therapy

Full data from the ACCOMPLISH trial have been published in the New England Journal of Medicine, showing greater reductions in cardiovascular morbidity and mortality in high-risk patients receiving combined antihypertensive therapy with the ACE inhibitor benazepril and calcium channel blocker amlodipine, compared with those receiving benazepril and the diuretic hydrochlorothiazide. (Source: MedWire News - Hypertension)

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  ORIGINAL ARTICLE: Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients

The optimal combination drug therapy for treatment of hypertension is not established, although current U.S. guidelines recommend inclusion of a diuretic. This double-blind trial, in which high-risk patients with hypertension were randomly assigned to treatment with benazepril plus either amlodipine or hydrochlorothiazide, showed that benazepril plus amlodipine was superior to benazepril plus hydrochlorothiazide in reducing cardiovascular events in this population. (Source: New England Journal of Medicine)

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  CME: Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients

(No abstract is available for this citation) (Source: New England Journal of Medicine)

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  Intracellular Angiotensin II Production in Diabetic Rats is Correlated with Cardiomyocyte Apoptosis, Oxidative Stress, and Cardiac Fibrosis.

Conclusions: Diabetes activates the cardiac intracellular RAS, which increases oxidative stress and cardiac fibrosis. Renin inhibition has a more pronounced effect than ARBs and ACE inhibitors on these diabetic complications and may be clinically more efficacious. PMID: 18829990 [PubMed - as supplied by publisher] (Source: Diabetes)

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  Benazepril Hydrochloride(Benazepril Hydrochloride) Tablet [Aurobindo Pharma Limited]

Updated Date: Sep 11, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Landmark research heralds new era in dog heart treatment and longer life for dogs

Ingelheim/Germany, 4 September 2008 - Veterinarians and dog owners are today welcoming new research that delivers the promise of an extended happy life together for millions of dog owners and their pets. The three-year study demonstrates that dogs suffering from the most common type of heart failure live on average 91% (267 days vs. 140 days) longer when treated with the product Vetmedin® (pimobendan) compared with another common treatment option.1 Results from the QUEST (Quality of Life and Extension of Survival Time) study, published in the current issue of the Journal of Veterinary Internal Medicine, mark a significant milestone in canine cardiac health. Experts report that 25% of all small to medium-sized dogs over the age of seven are likely to suffer from heart disease at some poi...

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  Comparison of cardioprotective effects of salvianolic acid B and benazepril on large myocardial infarction in rats.

Authors: PMID: 19177602 [PubMed - in process] (Source: Pharmacological Reports)

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  Transforming growth factor-{beta}1 is associated with kidney damage in patients with essential hypertension: renoprotective effect of ACE inhibitor and/or angiotensin II receptor blocker

Conclusions. TGF-β1 is highly elevated and strongly associated with urinary albumin excretion in patients with EH. Treatment with benazepril or valsartan attenuates serum TGF-β1 levels and microalbuminuria with the combined therapy receiving the greater effect. TGF-β1 could be a potential surrogate marker in monitoring the development and progression of kidney damage in EH. (Source: Nephrology Dialysis Transplantation)

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  Benazepril And Hydrochlorothiazide(Benazepril And Hydrochlorothiazide) Tablet, Film Coated [Ivax Pharmaceuticals, Inc.]

Updated Date: Aug 7, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Dog owners unaware that their pet may be suffering from serious heart disease

Ingelheim/Germany,Vancouver/Canada - 30 July 2008: Recently released global research shows that over 50% of dog owners are unaware that their dog may be at risk of heart failure. Heart disease affects one in four dogs over seven years of age1, yet the lack of knowledge about this serious, life-threatening condition calls for better education amongst dog owners on how to recognise the disease, and how to maintain their dogs’ heart health. These statistics indicate a critical need to raise general awareness about congestive heart failure in dogs. If more dog owners are aware of the disease and the signs to look out for in their pet, heart failure could be detected and treated at an earlier stage, allowing for timely management and a potentially longer and more comfortable life for their do...

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  Dog owners unaware that their pet may be suffering from serious heart disease

Ingelheim/Germany,Vancouver/Canada - 30 July 2008: Recently released global research shows that over 50% of dog owners are unaware that their dog may be at risk of heart failure. Heart disease affects one in four dogs over seven years of age1, yet the lack of knowledge about this serious, life-threatening condition calls for better education amongst dog owners on how to recognise the disease, and how to maintain their dogs’ heart health. These statistics indicate a critical need to raise general awareness about congestive heart failure in dogs. If more dog owners are aware of the disease and the signs to look out for in their pet, heart failure could be detected and treated at an earlier stage, allowing for timely management and a potentially longer and more comfortable life for their do...

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  Effect of Pimobendan or Benazepril Hydrochloride on Survival Times in Dogs with Congestive Heart Failure Caused by Naturally Occurring Myxomatous Mitral Valve Disease: The QUEST Study.

Conclusions and Clinical Importance: Pimobendan plus conventional therapy prolongs time to sudden death, euthanasia for cardiac reasons, or treatment failure in dogs with CHF caused by MMVD compared with benazepril plus conventional therapy. PMID: 18638016 [PubMed - as supplied by publisher] (Source: Journal of Veterinary Internal Medicine)

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  Lotensin(Benazepril Hydrochloride) Tablet [Novartis Pharmaceuticals Corporation]

Updated Date: Jul 2, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Benazepril: Angioedema of the tongue in an elderly patient: case report

(Source: Reactions)

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  Benazepril: Angioedema of the tongue in an elderly patient: case report.

Page: 8 (Source: Reactions Weekly)

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  Effect of Pimobendan on Case Fatality Rate in Doberman Pinschers with Congestive Heart Failure Caused by Dilated Cardiomyopathy.

Conclusions and Clinical Importance: Pimobendan should be used as a first-line therapeutic in Doberman Pinschers for the treatment of CHF caused by DCM. PMID: 18537880 [PubMed - as supplied by publisher] (Source: Journal of Veterinary Internal Medicine)

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  Comparison of cardioprotective effects using salvianolic acid B and benazepril for the treatment of chronic myocardial infarction in rats

Abstract  The aim of this study was to compare the cardioprotective effects of salvianolic acid B (Sal B) and the angiotension-converting enzyme inhibitor, benazepril, in rats with chronic myocardial infarction (MI) that resulted from a coronary artery ligation for 4 weeks. The rats were divided into four groups: those undergoing a sham operation; a MI group; a MI+SalB group (100 mg/kg by a gavage, once a day for 4 weeks); a MI+benazepril group (10 mg/kg by a gavage, once a day for 4 weeks). The following parameters were measured: echocardiographic, hemodynamic and hemorheological changes, angiogenesis, infarct size and cardiac remodeling and the messenger ribonucleic acid (mRNA) of vascular endothelium growth factor (VEGF). Rats treated with SalB o...

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  Olmesartan medoxomil combined with hydrochlorothiazide for the treatment of hypertension

In conclusion, olmesartan medoxomil/HCTZ is an effective and well-tolerated combination antihypertensive therapy that results in significant BP reductions and BP control in many patients. Keywords: olmesartan medoxomil, hydrochlorothiazide, angiotensin II receptor blocker, hypertension (Source: Vascular Health and Risk Management)

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  Effect of Benazepril on Survival and Cardiac Events in Dogs with Asymptomatic Mitral Valve Disease: A Retrospective Study of 141 Cases.

Conclusions and Clinical Relevance: BNZ had beneficial effects in asymptomatic dogs other than CKC and KC affected by MVD with moderate-to-severe MR. Breed distribution should be taken into account for interpretation of clinical trials performed in dogs with cardiac disease. PMID: 18482278 [PubMed - as supplied by publisher] (Source: Journal of Veterinary Internal Medicine)

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  Benazepril Hydrochloride And Hydrochlorothiazide(Benazepril Hydrochloride And Hydrochlorothiazide) Tablet, Film Coated [Sandoz Inc.]

Updated Date: May 5, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Comparison of cardioprotective effects of salvianolic acid B and benazepril on large myocardial infarction in rats.

Authors: He HB, Yang XZ, Shi MQ, Zeng XW, Wu LM, Li LD In the present study, we compared cardioprotective effects of salvianolic acid B (Sal B) and the angiotension-converting enzyme inhibitor, benazepril, in rats with large myocardial infarction (MI). The large MI was produced by coronary artery ligation for 4 weeks in rats. The rats were divided into the following groups: sham operation; MI; MI + Sal B (100 mg/kg by a gavage, once a day for 4 weeks) and MI + benazepril (1 mg/kg by a gavage, once a day for 4 weeks). Echocardiogram, hemodynamic and hemorheological changes, angiogenesis, infarct size and cardiac remodeling, as well as messenger ribonucleic acid (mRNA) of vascular endothelium growth factor (VEGF) were measured. The following similar effects were observed in MI rats treat...

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  Benazepril Hydrochloride And Hydrochlorothiazide(Benazepril Hydrochloride And Hydrochlorothiazide) Tablet, Film Coated [Andrx Pharmaceuticals, Inc.]

Updated Date: Apr 25, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Benazepril Hydrochloride(Benazepril Hydrochloride) Tablet, Film Coated [Andrx Pharmaceuticals]

Updated Date: Apr 25, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Lotrel, A Single Pill Combination For Treating High Blood Pressure, Reduced Cardiovascular Events By 20% In High-Risk Patients

Interim results from the ACCOMPLISH (Avoiding Cardiovascular Events through COMbination Therapy in Patients LIving with Systolic Hypertension) trial demonstrate that high-risk, high blood pressure patients treated with Lotrel(R) (amlodipine besylate and benazepril HCl) had 20% fewer cardiovascular events than those taking a benazepril and hydrochlorothiazide (HCTZ) combination. (Source: Hypertension News From Medical News Today)

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  Benazepril Hydrochloride(Benazepril Hydrochloride) Tablet, Film Coated [ETHEX]

Updated Date: Mar 13, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Compliance with Antihypertensive Therapy in the Elderly: A Comparison of Fixed-Dose Combination Amlodipine/Benazepril versus Component-Based Free-Combination Therapy.

Page: 45Authors: Dickson, Michael 1; Plauschinat, Craig A 2 (Source: American Journal of Cardiovascular Drugs)

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  Compliance with Antihypertensive Therapy in the Elderly: A Comparison of Fixed-Dose Combination Amlodipine/Benazepril versus Component-Based Free-Combination Therapy

(Source: American Journal of Cardiovascular Drugs)

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  Review: Concomitant calcium entry blockade and inhibition of the renin-angiotensin system: a rational and effective means for treating hypertension

Pharmacological treatment of hypertension is effective in preventing cardiovascular and renal complications. Calcium antagonists (CAs) and blockers of the renin-angiotensin system [angiotensin-converting enzyme (ACE) inhibitors and angiotensin II antagonists (ARBs)] are widely used today to initiate antihypertensive treatment but, when given as monotherapy, do not suffice in most patients to normalise blood pressure (BP). Combining a CA and either an ACE-inhibitor or an ARB considerably increases the antihypertensive efficacy, but not at the expense of a deterioration of tolerability. Several fixed-dose combinations are available (CA + ACE-inhibitors: amlodipine + benazepril, felodipine + ramipril, verapamil + trandolapril; CA + ARB: amlodipine + valsartan). They are expected not only to i...

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  Dual blockade of the rennin–angiotensin system versus maximal recommended dose of angiotensin II receptor blockade in chronic glomerulonephritis

Conclusion  Long-term dual blockade decreased proteinuria more than single blockade with ARB. Although ARB and ACEI have a glomerular size-selective function for proteinuria, a greater antiproteinuric effect may depend on renal hemodynamics, especially FF. Increased levels of bradykinin after ACEI can decrease FF and ameliorate proteinuria. Dry cough is a significant adverse effect of ACE inhibitor. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10157-007-0013-6Authors Urara Mori-Takeyama, Gifu University Second Department of Internal Medicine 1-1 Yanagido Gifu 501-1194 JapanShinya Minatoguchi, Gifu University Second Department of Internal Medicine 1-1 Yanagido Gifu 501-1194 JapanIchijirou Murata, Gifu University Second Department of Internal Medici...

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  Benazepril Hydrochloride(Benazepril Hydrochloride) Tablet, Film Coated [Mylan Pharmaceuticals Inc.]

Updated Date: Dec 21, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Benazepril Hydrochloride And Hydrochlorothiazide(Benazepril Hydrochloride And Hydrochlorothiazide) Tablet [GENHARM, L.P.]

Updated Date: Nov 30, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Efficacy and Safety of Olmesartan Medoxomil and Hydrochlorothiazide Compared with Benazepril and Amlodipine Besylate.

Page: 361Authors: Kereiakes, Dean J 1; Neutel, Joel M 2; Punzi, Henry A 3 4; Xu, Jianbo 5; Lipka, Leslie J 6; Dubiel, Robert 5 (Source: American Journal of Cardiovascular Drugs)

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  Efficacy and Safety of Olmesartan Medoxomil and Hydrochlorothiazide Compared with Benazepril and Amlodipine Besylate

(Source: American Journal of Cardiovascular Drugs)

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  Combined Therapy of Rhein and Benazepril on the Treatment of Diabetic Nephropathy in db/db Mice

Exp Clin Endocrinol Diabetes 2007; 115: 571-576DOI: 10.1055/s-2007-981469Abstract Rhein and angiotensin-converting enzyme inhibitor (ACEI) have been reported to prevent the progression of diabeic nephropahthy (DN). We futher explore the unknown ability to induce renal-protection of rhein and ACEI combined therapy in DN compared with the therapeutic effects of single treatment of them by using db/db mouse of type 2 diabetes model.[...]© J. A. Barth Verlag in Georg Thieme Verlag KG · Stuttgart · New YorkGet connected:Table of contents  |  Abstract  |  Full text (Source: Experimental and Clinical Endocrinology and Diabetes)

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  Systopic Laboratories

Pvt Ltd specialises in innovative therapeutic solutions and is one of the top 60 companies in India. Some of the unique formulations offered by the company are Rextop-1% / topical methotrexate, Acnesone gel / anti-acne, AF-400 anti-fungal, Topisal / topical steroid + karatolytic, AMACE-BP for hypertension. The New Delhi-based Systopic has emerged as a company of eminence in the domestic therapeutic solutions area. Since its inception in 1984, the company has been practising the concept of 'excellence through people and innovation' in terms of methodology and work culture. REXTOP-1% Systopic Lab is a pioneer in developing Rextop-1% gel with one per cent concentration. Rextop-1% gel is a methotrexate in a hydroxyl gel base for psoriasis. Rextop-1% gel reduces the side effects of methot...

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  Benazepril And Hydrochlorothiazide(Benazepril Hydrochloride And Hydrochlorothiazide) Tablet, Film Coated [Ivax Pharmaceuticals, Inc.]

Updated Date: Sep 28, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Benazepril Hydrochloride And Hydrochlorothiazide(Benazepril Hydrochloride And Hydrochlorothiazide) Tablet, Film Coated [Sandoz Inc.]

Updated Date: Sep 28, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Epidemiology, Major Outcomes, Risk Factors, Prevention and Management of Chronic Kidney Disease in China.

Authors: Xie Y, Chen X Chronic kidney disease (CKD) is common in China. In residents older than 40 years in Beijing, China, 11.3% of subjects had at least one indicator of kidney damage. The primary cause of chronic renal failure in China was glomerulonephritis, which was followed by diabetic nephropathy and hypertensive nephrosclerosis. Renal failure, cardiovascular disease and infection were important complications. IgA nephropathy (IgAN) is the most common CKD in China. The prevalence of hypertension, intrarenal artery lesions and tubulointerstitial lesions in patients with IgAN at the time of renal biopsy was approximately 40, 55 and 85%, respectively. The genetic variation in Megsin confers susceptibility to IgAN in Chinese. The patients with SL/LL genotypes of the MUC20 gene, the...

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  Lotrel(Amlodipine Besylate And Benazepril Hydrochloride) Capsule [Novartis Pharmaceuticals Corporation]

Updated Date: Aug 24, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Benazepril Hydrochloride And Hydrochlorothiazide(Benazepril Hydrochloride And Hydrochlorothiazide) Tablet [GENHARM, L.P.]

Updated Date: Aug 24, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Benazepril Hydrochloride(Benazepril Hydrochloride) Tablet, Film Coated [Mylan Pharmaceuticals Inc.]

Updated Date: Aug 8, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Benazepril Hydrochloride(Benazepril Hydrochloride) Tablet, Coated [TEVA PHARMACEUTICALS USA]

Updated Date: Aug 6, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Benazepril Hydrochloride And Hydrochlorothiazide(Benazepril Hydrochloride And Hydrochlorothiazide) Tablet, Film Coated [Sandoz Inc.]

Updated Date: Jun 14, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  First-Time Generic Approvals: Toprol-XL, Suprax, Lotrel

The FDA has approved generic formulations for metoprolol succinate extended-release tablets for treatment of hypertension and other conditions, cefixime oral suspension for treatment of bacterial infections, and amlodipine besylate-benazepril for treatment of hypertension.Medscape Medical NewsJill Taylor (Source: Medscape PublicHealth Headlines)

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  Benazepril Hydrochloride(Benazepril Hydrochloride) Tablet, Film Coated [Andrx Pharmaceuticals]

Updated Date: May 22, 2007 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Teva Provides Update on Generic Lotrel(R) Litigation

JERUSALEM--(HSMN NewsFeed)--Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA ) announced today that the United States District Court for the District of New Jersey has vacated a temporary order restraining Teva's launch of its amlodipine besylate/benazepr... Biopharmaceuticals, Generics, LitigationTeva Pharmaceutical, amlodipine, benazepril, Novartis, Lotrel (Source: HSMN NewsFeed)

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  BENICAR HCT(R) Reductions in Seated Systolic Blood Pressure for Stage 2 Patients Compared With Amlodipine + Benazepril

Comparison of BENICAR HCT 40/12.5 and 40/25 mg/day and Amlodipine + Benazepril 5/20 and 10/20 mg/day Presented at American Society of Hypertension Twenty-Second Annual Scientific Meeting PARSIPPANY, N.J., May 21 (HSMN NewsFeed) -- New data presented t... Biopharmaceuticals, CardiologyDaiichi Sankyo, BENICAR HCT, olmesartan, medoxomil, hydrochlorothiazide (Source: HSMN NewsFeed)

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  Daiichi-Sankyo: BENICAR HCT(R) Reductions in Seated Systolic Blood Pressure for Stage 2 Patients Compared With Amlodipine + Benazepril

PARSIPPANY, NJ (MARKET WIRE) New data presented today at the American Society of Hypertension's Twenty-Second Annual Scientific Meeting (ASH 2007) in Chicago demonstrated that the fixed-dose combination BENICAR HCT (olmesartan medoxomil/hydrochlorothiazide) was associated with a greater mean reduction in seated systolic blood pressure (SeSBP) at 12 weeks (primary endpoint) in patients with Stage 2 hypertension, compared with (Source: Market Wire - Pharmaceuticals and Biotech)

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  Teva Provides Update on Generic Lotrel(R)

JERUSALEM, Israel--(HSMN NewsFeed)--Teva Pharmaceutical Industries Ltd. (Nasdaq:TEVA ) announces that on May 18, 2007 the U.S. Food and Drug Administration granted to Teva final approval of its amlodipine besylate/benazepril products in 2.5 mg/10 mg, 5 mg/... Biopharmaceuticals, Generics, FDATeva Pharmaceutical, amlodipine, benazepril, Novartis, Lotrel (Source: HSMN NewsFeed)

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  Effect of benazepril on heart rate turbulence in patients with dilated cardiomyopathy

Clinical and Experimental Pharmacology and Physiology Volume 0, Issue 0, Page ???-???. (Source: Clinical and Experimental Pharmacology and Physiology)

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  FDA Safety Changes: Actiq, Lotensin HCT, Lotrel, Prinivil

The Food and Drug Administration has approved revisions to the safety labeling for fentanyl citrate, benazepril HCl plus hydrochlorothiazide, amlodipine besylate plus benazepril HCl, and lisinopril. (CME)Medscape Medical News (Source: Medscape Pharmacist Headlines)

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  FDA Safety Changes: Lotensin, Sustiva, Zevalin

The Food and Drug Administration has approved revisions to the safety labeling for benazepril HCl tablets, efavirenz tablets and capsules, and ibritumomab tiuxetan injection. (CME)Medscape Medical News (Source: Medscape Cardiology Headlines)

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  Pharmacokinetic interaction study between benazepril and amlodipine in healthy subjects

Abstract  Pharmacokinetic interaction between benazepril (ACE inhibitor) and amlodipine (calcium channel blocker) was studied in 12 healthy subjects. Single doses of benazepril hydrochloride (10-mg tablet) and amlodipine besylate (tablet equivalent to 5 mg amlodipine) were administered alone or in combination according to a three-way, Latin-Square, randomized crossover design. Serial blood samples were collected following each administration for the determination of benazepril and its active metabolite benazeprilat and amlodipine.The mean values of AUC (0–4 h), CmaxandTmaxfor benazepril given as combination versus given alone were 161 vs 140 ng·h·ml−1, 168 vs 149 ng·ml−1, and 0.5 vs 0.6 h. The mean values of AUC (0–24 h), CmaxandTmaxfor benazeprilat after benazepril gi...

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  Benazepril slows progression of renal dysfunction in patients with non-diabetic renal disease

Nephrology Volume 0, Issue 0, Page ???-???. (Source: Nephrology)

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  Amlodipine/benazepril: Angioedema of the stomach and small intestine: case report.

(Source: Reactions Weekly)

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  The effect of different antihypertensive drugs on cavernous tissue in experimental chronic renal insufficiency.

Conclusion:These results suggest that the interactions against the renin-angiotensin system (RAS) either by ACE inhibitors or angiotensin AT1 receptor blockers produce considerable benefits regarding structural abnormalities in CT in this animal model of renal insufficiency beyond blood pressure control. PMID: 17048199 [PubMed - in process] (Source: Journal of Nephrology)

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  Addition angiotensin receptor blocker to ACE inhibitor therapy in patients with proteinuric chronic kidney diseases

A study published in the Clinical Journal of the American Society of Nephrology has examined if adding candesartan to ACE inhibitors therapy would delay progression of nephropathy in hypertensive patient with non-diabetic renal disease. The study involved 90 hypertensive patients with chronic renal insufficiency, who had urinary protein excretion exceeding 1.0g/d despite treatment with ACE inhibitors. They were randomised to ACE inhibitor (either benazepril 2.5 to 10 mg daily or trandolapril 2 to 4 mg daily) plus candesartan (2 to 12 mg/d), or to control group (ACE inhibitors only). The target BP was 130/80 mmHg or less and the primary outcome was the changes in serum creatinine and the reduction of proteinuria. The mean duration of follow-up was 3.1 years. The study reported the followi...

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  Mylan Announces Tentative Approval For Amlodipine Besylate And Benazepril Hydrochloride Capsules

Mylan Laboratories Inc.(NYSE: MYL) today announced that the U.S. Food and Drug Administration hasgranted tentative approval for Mylan Pharmaceuticals Inc.'s Abbreviated NewDrug Application for Amlodipine Besylate and Benazepril HydrochlorideCapsules, 2.5 mg (base)/10 mg, 5 mg (base)/10 mg, 5 mg (base)/20 mg and 10 mg (base)/20 mg. Amlodipine Besylate and Benazepril Hydrochloride Capsules are indicatedfor the treatment of hypertension. [click link for full article] (Source: Hypertension News From Medical News Today)

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  Mylan Announces Tentative Approval for Amlodipine Besylate and Benazepril Hydrochloride Capsules

PITTSBURGH, July 13 /PRNewswire-FirstCall/ -- Mylan Laboratories Inc. (NYSE:MYL) today announced that the U.S. Food and Drug Administration has granted tentative approval for Mylan Pharmaceuticals Inc.'s Abbreviated New Drug Application for Amlodipine Besylate and Benazepril Hydrochloride Capsules, 2.5 mg (base)/10 mg, 5 mg (base)/10 mg, 5 mg (base)/20 mg and... (Source: Drug Newswire)

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  Mylan's generic Lotrel gets tentative OK

Mylan Laboratories Inc. said it received tenative approval from the Food and Drug Administration for amlodipine besylate and benazepril hydrochloride capsules, generic forms of Novartis' hypertension drug, Lotrel. (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

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  FDA Approvals: Wellbutrin XL and Lotrel

The FDA has approved a new indication for bupropion HCl extended-release tablets (Wellbutrin XL) and 5-mg-40-mg and 10-mg-40-mg formulations for amlodipine besylate-benazepril HCl capsules (Lotrel). (CME,CE)Medscape Medical NewsGary Vogin,Yael Waknine (Source: Medscape Medical News Headlines)

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  Novartis Pharmaceuticals Corporation: FDA Approves New Lotrel(R) 5/40 mg and 10/40 mg Dosage Strengths

EAST HANOVER, NJ (MARKET WIRE) Novartis Pharmaceuticals Corporation announced it has received marketing approval from the U.S. Food and Drug Administration (FDA) for two new dosing strengths of Lotrel (R) (amlodipine besylate/benazepril HCl), 5/40 mg and 10/40 mg. The new dosing strengths combine the calcium channel blocker (CCB) amlodipine with the highest available dose of the ACE inhibitor benazepril. (Source: Market Wire - Pharmaceuticals and Biotech)

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  Effects of benazepril on renal function and kidney expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in diabetic rats.

CONCLUSIONS: The changes of MMP-2 and TIMP-2 expressions in kidney tissues of diabetes rats may contribute to the occurrence and progression of diabetic nephropathy. Benazepril could exert protective effects on diabetic nephropathy, owing to the upregulation of MMP-2 and downregulation of TIMP-2 expressions, which further inhibits the excessive deposition of extracellular matrix in the glomerulus. PMID: 16732983 [PubMed - indexed for MEDLINE] (Source: Chinese Medical Journal)

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  Effects of angiotensin converting enzyme inhibitor, angiotensin II type I receptor blocker and their combination on postinfarcted ventricular remodeling in rats.

CONCLUSIONS: TGFbeta(1)-Smads signal activation is correlated with ventricular remodeling following MI. ACEI and ARB treatment prevents ventricular remodeling by inhibiting expression of Smad 2 and Smad 3. ARB and combined treatment are more effective than ACEI alone. PMID: 16635409 [PubMed - indexed for MEDLINE] (Source: Chinese Medical Journal)

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  Comparative efficacy and safety of amlodipine/benazepril combination therapy and amlodipine monotherapy in severe hypertension

Comparative efficacy and safety of amlodipine/benazepril combination therapy and amlodipine monotherapy in severe hypertension Journal of Human Hypertension advance online publication, November 5, 2009. doi:10.1038/jhh.2009.80 Authors: J L Izzo, D Purkayastha, D Hall & R J Hilkert (Source: Journal of Human Hypertension)

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Top Viagra Store

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