MedWorm: Benadryl

  Aprepitant vs. Multimodal Prophylaxis in the Prevention of Nausea and Vomiting following Extended-Release Epidural Morphine

Conclusion: While aprepitant significantly reduced the incidence of PONV compared with a multimodal antiemetic regime, used alone it did not eliminate PONV. (Source: Pain Practice)

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  ADVIL PM (Diphenhydramine Hcl, Ibuprofen) Capsule, Liquid Filled [Wyeth Consumer Healthcare]

Updated Date: Feb 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Avoid Diphenhydramine, Ranitidine After Perforated Appendicitis: Study

Giving the antihistamines ranitidine or diphenhydramine to patients with perforated appendicitis dramatically increases their risk of an intra-abdominal abscess, according to a new study. Reuters Health Information (Source: Medscape Medical News Headlines)

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  Psychopharmacological Neuroprotection in Neurodegenerative Disease: Assessing the Preclinical Data [SPECIAL ARTICLES]

This manuscript reviews the preclinical in vitro, ex vivo, and nonhuman in vivo effects of psychopharmacological agents in clinical use on cell physiology with a view toward identifying agents with neuroprotective properties in neurodegenerative disease. These agents are routinely used in the symptomatic treatment of neurodegenerative disease. Each agent is reviewed in terms of its effects on pathogenic proteins, proteasomal function, mitochondrial viability, mitochondrial function and metabolism, mitochondrial permeability transition pore development, cellular viability, and apoptosis. Effects on the metabolism of the neurodegenerative disease pathogenic proteins alpha-synuclein, beta-amyloid, and tau, including tau phosphorylation, are particularly addressed, with application to Alzheime...

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  Influence of Histamine Receptor Antagonists on the Outcome of Perforated Appendicitis: Analysis From a Prospective Trial [Original Article]

Conclusions  Ranitidine or diphenhydramine given to patients with perforated appendicitis may increase the risk of postoperative abscess. Therefore, these medications should not be used empirically in this population. (Source: Archives of Surgery)

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  IBUPROFEN AND DIPHENHYDRAMINE CITRATEtablet [Dr. Reddy'S Laboratories Limited]

Updated Date: Feb 2, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  DIPHENHYDRAMINE HYDROCHLORIDEinjection [McKesson Packaging Services Business Unit Of McKesson Corporation]

Updated Date: Feb 2, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Tylenol Recall

The recent recall of Tylenol didn't get as much coverage in the news as you might expect, likely because of all of the focus on the earthquake in Haiti. Unfortunately, that may mean that parents are unaware of the Tylenol recall and are still giving their kids unsafe products. Although originally limited to lots of Tylenol Arthritis Pain 100 count with EZ-OPEN CAP when the recall was first announced in December 2009, the recall has since been expanded to include certain lots of: Junior Strength Motrin IB Caplet 24 ct Junior Strength Motrin Grape Chewables Junior Strength Motrin Orange Chewables Children's Tylenol Bubble Gum Meltaway Tablets Children's Tylenol Grape Meltaways Tablets Benadryl Allergy Tablets Extra Strength Tylenol Caplets Extra Strength Tylenol Cool Caplets Extra Strength ...

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  CVS IBUPROFEN PM (Diphenhydramine Citrate And Ibuprofen) Tablet, Coated [CVS Pharmacy]

Updated Date: Jan 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CARE ONE IBUPROFEN PM (Diphenhydramine Citrate And Ibuprofen) Tablet [American Sales Company]

Updated Date: Jan 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Effects of histamine H(1) receptor antagonists on delayed spatial win-shift task in rats.

Authors: Okada A, Kato A, Kamei C We investigated the effects of histamine H(1) receptor antagonists in different 3 stages of spatial working memory in comparison with scopolamine. The effects of drugs were measured using an eight-arm radial maze with a delayed spatial win-shift task in rats. Drugs were injected 10min before the training phase (timing 1), immediately after the training phase (timing 2), or 10min before the test phase (timing 3). Intrahippocampal injection of pyrilamine and diphenhydramine resulted in significant effects on the number of correct choices and across-phase errors in all 3 timings. Scopolamine impaired the number of correct choices and across-phase errors in timing 1 and 3; however, no significant effect was observed in timing 2. These results indicate that...

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  McNeil Recalling Hundreds of Lots of Contaminated OTC Medications

Family physicians and their patients should be aware of a massive product recall being undertaken by manufacturer McNeil Consumer Healthcare. McNeil has recalled more than 500 lots of its OTC products -- including Benadryl, Rolaids, multiple variations of both Motrin and Children's Motrin and numerous variations of Tylenol and Children's Tylenol -- because of chemical contamination. (Source: AAFP Health of the Public)

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  Wyeth Consumer Healthcare withdraws its marketing authorisation application for Ibuprofen/Diphenhydramine Hydrochloride

Source: EMEA Area: News Wyeth Consumer Healthcare has notified the EMEA of its decision to withdraw its application for a centralised marketing authorisation for ibuprofen/diphenhydramine hydrochloride 200mg/25mg soft capsules, intended for use in the short-term treatment of mild to moderate pain in adults who experience sleeplessness as a result of the pain.   According to its official letter, the application was withdrawn based on the CHMP's view that the data provided would not allow a positive risk-benefit balance to be concluded.    A question-and-answer document and the withdrawal letter from the company will be published on the EMEA website in the near future.  (Source: NeLM - News)

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  Wyeth Consumer Healthcare Withdraws Its Marketing Authorisation Application For Ibuprofen/Diphenhydramine Hydrochloride Wyeth

The European Medicines Agency has been formally notified by Wyeth Consumer Healthcare of its decision to withdraw its application for a centralised marketing authorisation for the medicine Ibuprofen/Diphenhydramine Hydrochloride Wyeth 200 mg/25 mg soft capsules. This medicine was intended to be used for the short-term treatment of mild to moderate pain in adults who experience sleeplessness as a result of the pain. The application for the marketing authorisation for Ibuprofen/Diphenhydramine Hydrochloride Wyeth was submitted to the Agency on 4 December 2008... (Source: Health News from Medical News Today)

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  Wyeth Consumer Healthcare Withdraws Its Marketing Authorisation Application For Ibuprofen/Diphenhydramine Hydrochloride Wyeth

The European Medicines Agency has been formally notified by Wyeth Consumer Healthcare of its decision to withdraw its application for a centralised marketing authorisation for the medicine Ibuprofen/Diphenhydramine Hydrochloride Wyeth 200 mg/25 mg soft capsules... (Source: Pain / Anesthetics News From Medical News Today)

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  Tylenol Recall Expanded - Now Includes Motrin and Benadryl

Johnson and Johnson has expanded its recall of products contaminated with 2,4,6-tribromoanisole to include additional Tylenol products, Motrin, Benadryl, St. Joseph's aspirin, Rolaids, and Simply Sleep. The additional recalls come less than a month after the initial recall of select Tylenol products, yet two months after the company was made aware of the contamination. In addition to leading many consumers to become unnecessarily sick, the delayed action has brought Johnson and Johnson some FDA scrutiny. The company's McNeil Consumer Healthcare Products division has 15 days to respond to the FDA explaining why it did not take action sooner.A full list of recalled products can be found here. The contaminated drugs may have a moldy odor characteristic of the tribromoanisole. Symptoms of expo...

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  Tylenol recall expanded to other OTC drugs

FORT WASHINGTON, Pa., Jan. 15 (UPI) -- The recall of Tylenol Arthritis Pain Caplets has expanded to some lots of Tylenol, Motrin, Benadryl, Rolaids and St. Joseph's aspirin, U.S. officials said. (Source: Health News - UPI.com)

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  Tylenol, Motrin, Benadryl, St. Joseph Aspirin, Rolaids Recall

The moldy odor from the containers is to blame for the recall of 60 million over-the-counter products. WebMD Health News (Source: Medscape Today Headlines)

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  Tylenol recall expanded to Motrin, Benadryl, more

Johnson & Johnson is again expanding a recall of Tylenol caplets due to a moldy smell that made some users sick. The company ... (Source: USATODAY.com Health)

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  Tylenol, Motrin, Benadryl, St. Joseph Aspirin, Rolaids Recall

Title: Tylenol, Motrin, Benadryl, St. Joseph Aspirin, Rolaids RecallCategory: Health NewsCreated: 1/15/2010 2:05:00 PMLast Editorial Review: 1/15/2010 2:05:42 PM (Source: MedicineNet Crohn's Disease General)

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  Tylenol, Motrin, Benadryl, St. Joseph Aspirin, Rolaids Recall

Title: Tylenol, Motrin, Benadryl, St. Joseph Aspirin, Rolaids RecallCategory: Health NewsCreated: 1/15/2010 2:05:00 PMLast Editorial Review: 1/15/2010 2:05:42 PM (Source: MedicineNet Senior Health General)

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  Recalled: Tylenol, Motrin, Benadryl, Rolaids

Tylenol, Motrin, Benadryl, St. Joseph Aspirin, Rolaids Recall (Source: eMedicineHealth.com)

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  For Migraine in the ED, Prochlorperazine Is Better Than Sumatriptan

For patients in the emergency department (ED) with migraine, IV prochlorperazine with diphenhydramine is more effective than subcutaneous sumatriptan, a small prospective trial suggests. Reuters Health Information (Source: Medscape Medical News Headlines)

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  BENADRYL (Diphenhydramine Hydrochloride) Injection, Solution [Physicians Total Care, Inc.]

Updated Date: Jan 13, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  MOTRIN (Ibuprofen And Diphenhydramine Citrate) Tablet, Coated [McNeil Consumer Healthcare Div McNeil-PPC, Inc]

Updated Date: Jan 11, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  A systematic review and meta-analysis of randomized, controlled trials of moderate sedation for routine endoscopic procedures

Source: DARE Area: Evidence > Disease Focused Reviews CRD Summary: This review concluded that moderate sedation provided high levels of satisfaction and low risk of serious adverse events in patients undergoing esphagogastroduodenoscopy or colonoscopy. Midazolam-based regiments had longer sedation and recovery times than propofol. The search was limited, studies were generally poor quality and the appropriateness of the synthesis was unclear. Thus, the reliability of the conclusions was unclear. [Included studies assessed the following interventions: diazepam, midazolam, propofol or narcotic; and combinations of these agents with each other or with diphenhydramine or droperidol. ] CRD Commentary: The review question and the inclusion criteria were clear and specific. The authors sear...

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  Moderate Sedation for Echocardiography of Preschoolers

This study compared various sedation drugs at the authors’ institution, as well as the charges for moderate versus deep sedation. From 2001 to 2007, sedation was administered to 703 patients ages 2 to 4 years. Four drug regimens were used: chloral hydrate (CH), chloral hydrate with diphenhydramine (CH + D), chloral hydrate with hydroxyzine hydrochloride (CH + H), and midazolam. The mean onset of sedation was 37 min, and the mean duration of sedation was 47 min. The CH group fell asleep the most quickly (30 min; p < 0.001), and the CH + D patients experienced the most prolonged sedations (13%; p < 0.001). Studies were completed by 97% of the chloral hydrate group, 98% of the CH + D group, and 94% of ...

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  Optimizing Emetic Control in Children Receiving Antineoplastic Therapy: Beyond the Guidelines.

Authors: Dupuis LL, Nathan PC Existing guidelines for the prevention of antineoplastic chemotherapy-induced nausea and vomiting (CINV) in children are constrained by the lack of robust evidence. Current guidelines recommend the use of a serotonin 5-HT(3) receptor antagonist plus a corticosteroid to prevent acute CINV. Consequently, antiemetic agents that are recommended for use in adult cancer patients do not appear in the current pediatric guidelines. In addition, there is no information to guide the selection of alternative antiemetic agents for children who either cannot receive the recommended agents or who do not respond adequately to the treatment. Possible barriers to adherence to the pediatric antiemetic selection guidelines that are currently available are discussed, and publi...

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  In vitro antibacterial activity of some systemic and topical antihistaminic preparations.

CONCLUSION: MIC values of parenteral preparations were higher than their blood levels in clinical use. Thus, effects of parenteral preparations may not have been reflected in routine clinical practice. However, topical forms have antibacterial activity due to additive substrates and the use of high concentration levels at the site of application. Therefore, in selection of topical forms for appropriate cases, these effects should also be taken into consideration. The antibacterial activity of topical antihistaminic preparations may be useful in certain dermatological pathology. PMID: 20003827 [PubMed - in process] (Source: Clinical and Investigative Medicine)

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  Intranasal Desmopressin Versus Blood Transfusion in Cirrhotic Patients With Coagulopathy Undergoing Dental Extraction: A Randomized Controlled Trial

Conclusions: Intranasal desmopressin was as effective as blood transfusion in achieving hemostasis in cirrhotic patients with moderate coagulopathy undergoing dental extraction. Intranasal desmopressin was much more convenient, less expensive, and well tolerated. (Source: Journal of Oral and Maxillofacial Surgery)

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  Minnesota's First E-Patient

Minnesota's first virtual doctor's visit was conducted Monday evening, the Pioneer Press reports. The patient, Beth Piper or Hampton, Minn., learned that sleeping pills would interact badly with another medication she uses during the seven minute Webcam-enabled discussion. Her doctor, Eric Christianson, suggested using Benadryl instead... (Source: IT / Internet / E-mail News From Medical News Today)

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  Minnesota's First E-Patient

Minnesota's first virtual doctor's visit was conducted Monday evening, the Pioneer Press reports. The patient, Beth Piper or Hampton, Minn., learned that sleeping pills would interact badly with another medication she uses during the seven minute Webcam-enabled discussion. Her doctor, Eric Christianson, suggested using Benadryl instead. "It was the first real test of Online Care Anywhere, a virtual clinic that Fairview Health Services and Blue Cross and Blue Shield of Minnesota launched Monday... (Source: Health News from Medical News Today)

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  Transport of phenylethylamine at intestinal epithelial (Caco-2) cells: Mechanism and substrate specificity.

This study was performed to characterize the intestinal transport of beta-phenylethylamine (PEA). Uptake of [(14)C]PEA into Caco-2 cells was Na(+)-independent but strongly stimulated by an outside directed H(+) gradient. At extracellular pH 7.5, the concentration-dependent uptake of PEA was saturable with kinetic parameters of 2.6 mM (K(t)) and 96.2 nmol/min per mg of protein (V(max)). Several biogenic amines such as harmaline and N-methylphenylethylamine as well as cationic drugs such as phenelzine, tranylcypromine, D,L-amphetamine, methadone, chlorphenamine, diphenhydramine, and promethazine strongly inhibited the [(14)C]PEA uptake with K(i) values around 1 mM. Tetraethylammonium, N-methyl-4-phenylpyridinium and choline had no effect. We also studied the bidirectional transepithelial tra...

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  Toward Optimal Treatment in Women: The Effect of Sex on Metoprolol-Diphenhydramine Interaction.

The objective of this study was to determine if sex influences the pharmacokinetics and hemodynamics of the CYP2D6 substrate metoprolol and its interaction with diphenhydramine (CYP2D6 inhibitor) in healthy young participants with high (extensive metabolizer [EM]) or low (poor metabolizer [PM]) CYP2D6 activities. A prespecified comparative analysis of data from 2 sequential clinical trials that included 16 EM and 4 PM women and 10 EM and 6 PM men was performed. The participants in the 2 trials were administered a single oral dose of 100 mg metoprolol in the presence of steady-state diphenhydramine or placebo. Serial plasma and urine samples were obtained for 48 hours, and hemodynamic data was obtained for 12 hours after metoprolol. In the placebo arm, EM and PM women had 62% and 59% higher...

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  Cotrimoxazole/diphenhydramine/paracetamol: Fixed drug eruption in a child: case report

(Source: Reactions)

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  ADVIL PM (Diphenhydramine Citrate, Ibuprofen) Tablet, Coated [Wyeth Consumer Healthcare]

Updated Date: Nov 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Characterization of scratching behavior induced by intradermal administration of morphine and fentanyl in mice.

In conclusion, opioid induced itching may involve in peripheral opioid receptors. Moreover, histamine and arachidonic acid metabolites played no main role in opioid-induced scratching behavior. PMID: 19900440 [PubMed - as supplied by publisher] (Source: European Journal of Pharmacology)

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  Development of Hepatic Failure Despite Use of Intravenous Acetylcysteine After a Massive Ingestion of Acetaminophen and Diphenhydramine

3 out of 5 stars DEVELOPMENT OF HEPATIC FAILURE DESPITE USE OF INTRAVENOUS ACETYLCYSTEINE AFTER A MASSIVE INGESTION OF ACETAMINOPHEN AND DIPHENHYDRAMINE. Schwartz EA et al. Ann Emerg Med Sept. 2009;54:421-423. Abstract This uncommonly interesting case report describes a 48-year-old woman who ingested 150 tablets of Tylenol PM, each containing 500 mg acetaminophen and 25 mg diphenhydramine.  On arrival at hospital, she had clear signs of anticholinergic overdose (tachycardia, dry skin, encephalopathy) but normal liver enzymes and INR.  The initial 4 hour acetaminophen (APAP) level — 104 mcg/ml — was below the treatment line on the Rumack-Mathew nomogram, but since the history was initially unclear intravenous N-acetylcysteine (IV-NAC) was started.  However, the APAP level con...

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  Scombroid Poisoning: Eating Bad Fish?

I have been diagnosed with scombroid poisoning. I was told to take Benadryl and Zantac. I have followed this for a week. What else can I do to speed my recovery? (Source: Dr. Weil Q&A)

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  Multidrug poisoning involving nicotine and tramadol

Abstract: A fatal case of multidrug poisoning by tramadol and nicotine is reported. Tramadol is a centrally acting analgesic used in the treatment of moderate to severe acute or chronic pain. Nicotine, a lipid-soluble alkaloid, is one of the most readily available drugs in modern society. A 46-year-old man was found dead in his bed, and a suicide note was discovered near the body. He had 25 transdermal nicotine patches attached to his thorax and abdomen. Two half emptied bottles were found on the bedside table; the toxicological examination revealed that they contained tobacco and nicotine as well as other drugs such as diphenhydramine. At autopsy, areas of fresh and old myocardial infarction as well as diffuse pulmonary congestion and edema were present. The tramadol concentration was 6.6...

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  Paracetamol/diphenhydramine overdose: Liver failure and other fatal complications, despite treatment with acetylcysteine: case report

(Source: Reactions)

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  Quantitative analysis of diphenhydramine hydrochloride in pharmaceutical wafers using near infrared and Raman spectroscopy.

Authors: Haag M, Brüning M, Molt K Wafers with varying concentrations of diphenhydramine hydrochloride (DPH-HCl) as active pharmaceutical ingredient (API) were prepared and their near infrared (NIR) and Raman spectra recorded. The purpose of this study was to compare the suitability of these two vibrational spectroscopic techniques for the quantification of DPH-HCl in pharmaceutical wafers. Partial least squares (PLS1) calibration models with different data pretreatments were tested. Both NIR and Raman spectroscopy proved to be suitable to predict DPH-HCl contents at lower concentration ranges. At higher concentrations, interference by crystallization processes was observed. For investigating the general applicability of the quantification methods, two commercially available produ...

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  How to Stay Sharp as a Tack

(NaturalNews) A few days ago a song got stuck in my head- the slow, haunting violin melody that set the mood in the movie Platoon. But I couldn't recall who wrote it, and it bugged me. Later, when I wasn't thinking about it, I suddenly remembered it was Samuel Barber's Adagio for Strings.We all have episodes like this. We forget names and misplace things. We lose our train of thought, and we walk into rooms with no recollection of why we went there in the first place. This is normal human behavior. Now, forgetting a close family member's name, constantly repeating yourself, or getting lost in familiar places is another issue. Still, even run-of-the-mill memory lapses can be disconcerting, especially if you're older. You may wonder, "Am I losing it? Is Alzheimer's just around the corner?"It...

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  Alcohol and drugs in suspected impaired drivers in Ontario from 2001 to 2005

Conclusion: However, these data demonstrate that ‘‘drugged driving” does occur and that further, comprehensive investigation is needed to determine the frequency and type of drug use by Ontario drivers. (Source: Journal of Forensic and Legal Medicine)

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  Prescription writing trends of antihistamines at the university health centre

Kumar Anil, BeentaIndian Journal of Pharmaceutical Sciences 2009 71(3):307-310The aim of the present study was to establish antihistamines drug prescribing pattern in order to improve the rational prescribing of antihistamines by physicians at Panjab University Health Centre. The study was performed in between the months of November 2005 to April 2006. Five hundred out patients were monitored and data was collected on WHO-based prescription-auditing performa. Demographic analysis of this prospective study revealed that out of the 500 patients, 293 (58.6 %) were male and 207 (41.4 %) were female and maximum patients were in the age group of 21-40 (34.8 %). Chlorpheniramine maleate (235 prescriptions) was the highest prescribed among antihistamine prescriptions (36.89 &#...

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  Evaluating the positive predictive values of antidote signals to detect potential adverse drug reactions (ADRs) in the medical intensive care unit (ICU)

Signals are used to alert clinicians of potential ADRs. Positive predictive values (PPVs) of antidote signals in ICUs are unknown. The primary purpose was to determine PPVs of six signals. The secondary objective was to determine the sensitivity of various ADR detection strategies including manual chart review, administrative data review, and voluntary reporting at identifying the same ADRs discovered using antidotes as a signal.Adult patients admitted to a medical ICU from July 1, 2005 to June 30, 2006 who were prescribed select signals were eligible. Evaluated antidote signals included injectable diphenhydramine, protamine, phytonadione, dextrose 50%, injectable methylprednisolone, and sodium polystyrene. For each signal, a random sample of 50 patients was evaluated for the presence of a...

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  MAJOR IBUPROFEN (Diphenhydramine Citrate And Ibuprofen) Tablet, Coated [Major Pharmaceuticals]

Updated Date: Aug 25, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Paracetamol/diphenhydramine overdose: Psychiatric disorders, speech disorders and other toxicities: case report

(Source: Reactions)

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  How to Treat a Jellyfish Sting

One of the benefits of being a freelance writer and consultant is being able to live anywhere. I live near the beach, which is where I head whenever the surf is up. The Carolina coast is wonderful, but it is home to some jellyfish that can leave a painful sting. We encountered one of these today. How did we know? Not that many things will sting like a hundred wasps at once out in the surf. We didn't get any tentacles stuck to us, which would have been another way to tell it was a jellyfish. The real giveaway was seeing the actual animal floating in the tide. A little practical chemistry helped to minimize the pain and damage from the sting. Now, we were fortunate because we saw the jellyfish that caused the sting and could rule out a man-of-war sting, which is different from a jellyfish st...

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  Indications

Dead celebrities may come and go, but the business of Elvis marches on. In June, more than 45 Elvis-related items from the estate of his personal physician, Dr. George “Dr. Nick” Nichopoulos, were sold in Las Vegas by Julien's Auctions. Highlights included empty prescription bottles (the pills were destroyed when the legality of selling them was questioned, Bloomberg.com reported), including one for Benadryl that was prescribed Aug. 15, 1977—the day before the King's death. Also on the auction block: a laryngeal scope that went for $1,792, and the medical bag that Dr. Nichopoulos used for house calls to Graceland. The medical bag sold for $16,000. The prescription bottles, which Julien's expected to fetch $800 to $1,200 each, went for $2,880 to $8,960. The members of the Bureau of In...

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  Indications

Dead celebrities may come and go, but the business of Elvis marches on. In June, more than 45 Elvis-related items from the estate of his personal physician, Dr. George “Dr. Nick” Nichopoulos, were sold in Las Vegas by Julien's Auctions. Highlights included several empty prescription bottles (the pills were destroyed when the legality of selling them was questioned, Bloomberg.com reported), including one for Benadryl that was prescribed Aug. 15, 1977—the day before the King's death. Also on the auction block: a laryngeal scope that went for $1,792, and the medical bag that Dr. Nichopoulos used when he made house calls at Graceland, The medical bag sold for $16,000. The prescription bottles, which Julien's expected to fetch $800–$1,200 each, went for $2,880–$8,960. We here at the B...

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  Enantioselective determination of trantinterol in rat plasma by ultra performance liquid chromatography-electrospray ionization mass spectrometry after derivatization.

Authors: Yang J, Wang Y, Pan L, Li N, Lu X, Guan J, Cheng M, Li F An ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed and validated for the determination of trantinterol enantiomers in rat plasma. Diphenhydramine was employed as the internal standard. The plasma samples were prepared using liquid-liquid extraction with n-hexane-dichloromethane-isopropanol (20:10:1, v/v/v) as the extractant. Trantinterol enantiomers after pre-column derivatization using diacetyl-l-tartaric anhydride (DATAAN) were separated on a C18 column using a gradient solvent programme. The mobile phase was composed of 3mM ammonium acetate and acetonitrile. The detection was performed on a triple-quadrupole tandem mass spectrometer by multiple reaction monitoring (MR...

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  Diphenhydramine/eletriptan/venlafaxine: Hallucinations and confusion: case report

(Source: Reactions)

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  Diphenhydramine/eletriptan/venlafaxine: Hallucinations and confusion: case report.

Page: 13 (Source: Reactions Weekly)

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  Preventing Medical Errors: Warning on Accidental Ingestion of Benadryl Topical Gel

FDA and the Institute for Safe Medication Practices (ISMP) recently reported on several cases where people swallowed Benadryl Itch Stopping Gel, an OTC product that's supposed to be used topically. This has led to serious adverse reactions requiring... (Source: Food and Drug Adminstration (FDA): Patient Safety News)

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  Severe cutaneous reaction to cetuximab with possible association with the use of over-the-counter skin care products in a patient with oropharyngeal cancer.

DISCUSSION: Our report describes a sudden flare-up of a skin rash (Grade 3) after the 5th cycle of cetuximab following use of OTC skin care remedies, which was unusual for this patient, suggesting a possible relation to the therapy. Skin crucially depends on EGFR for its normal function and becomes extremely sensitive during cetuximab therapy. Topical OTC acne and dry skin remedies can suddenly change the mild acneiform rash into severe skin toxicity associated with marked desquamation and exfoliation. Avoidance of further skin damage caused by topical applications and the use of doxycycline and diphenhydramine show a significant success in the management of skin toxicity. PMID: 19514925 [PubMed - in process] (Source: Cutaneous and Ocular Toxicology)

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  Design, synthesis and histamine H1-receptor antagonistic activity of some novel 4-amino-2-(substituted)-5-(substituted) aryl-6-[(substituted aryl) amino] pyrimidines.

Authors: Chhabria MT, Patel VT, Rajan KS, Brahmkshatriya PS A series of 4-amino-2-(substituted)-5-(substituted)aryl-6-[(substituted)aryl)-amino]pyrimidines was designed based on the triangular pharmacophoric requirements for histamine H1-receptor antagonists. The designed molecules were synthesized by condensation of arylacetonitriles with respective arylisothiocyanates to form corresponding acrylonitriles followed by cyclocondensation with carboxamidines to afford substituted pyrimidines. All compounds were screened for their histamine H1-receptor antagonistic activity using the model "Inhibition of the isotonic contraction induced by histamine on isolated guinea pig ileum". Target compounds were also evaluated for their sedative potential as well as their anticholinergic activities a...

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  A randomized, controlled comparison of warm water infusion in lieu of air insufflation versus air insufflation for aiding colonoscopy insertion in sedated patients undergoing colorectal cancer screening and surveillance

Conclusion: Water infusion in lieu of air insufflation is superior to air insufflation during colonoscopy in the minimally sedated patients (ClinicalTrials.gov Identifier NCT00785889). (Source: Gastrointestinal Endoscopy)

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  ADVIL PM (Diphenhydramine Hcl, Ibuprofen) Capsule, Liquid Filled [Wyeth Consumer Healthcare]

Updated Date: Jun 22, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  ADVIL PM (Diphenhydramine Citrate, Ibuprofen) Capsule, Coated [Wyeth Consumer Healthcare]

Updated Date: Jun 22, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  CARE ONE IBUPROFEN PM (Diphenhydramine Citrate And Ibuprofen) Tablet [American Sales Company]

Updated Date: Jun 22, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Effects of anserine on the renal sympathetic nerve and blood pressure in urethane-anesthetized rats.

Authors: Tanida M, Shen J, Kubomura D, Nagai K Previous studies have demonstrated that central injection of L-carnosine (beta-alynyl-L-histidine), dipeptide synthesized in mammalian muscles, affects renal sympathetic nerve activity (RSNA) and blood pressure (BP) in anesthetized rats. In the present study, using urethane-anesthetized rats, we examined the dose-dependent effects of intravenous (IV) injection of various doses of anserine, dipeptide of similar structure to L-carnosine, on RSNA, BP and heart rate (HR). We found that injection of a low dose of anserine (1 microg) suppressed RSNA, BP and HR significantly. Conversely, a high dose (1000 microg) of anserine elevated RSNA, BP and HR significantly. Pretreatment with intralateral cerebral ventricular (LCV) injection of thioperamide...

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  Opsoclonus caused by diphenhydramine self-poisoning. - Irioka T, Yamanami A, Uchida N, Iwase M, Yasuhara H, Mizusawa H.

[Abstract unavailable] Language: Eng... (Source: SafetyLit: All (Unduplicated))

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  Some Over-the-Counter Sleep, Cold Meds Could Harm Aging Brain

Drugs containing benadryl linked to slowed thinking, delirium in elderly, report finds . Source: HealthDay (Source: MedlinePlus Health News)

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  Some OTC Sleep, Cold Meds Could Harm Aging Brain

Drugs containing benadryl linked to slowed thinking, delirium in elderly, report finds Source: HealthDay Related MedlinePlus Topics: Over-the-Counter Medicines, Seniors' Health (Source: MedlinePlus Health News)

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  Metoclopramide Plus Diphenhydramine Helpful for Severe Nausea, Vomiting During Pregnancy

In a retrospective cohort study, this combination was more effective than droperidol plus diphenhydramine, with fewer adverse events. Medscape Medical News (Source: Medscape Medical News Headlines)

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  Metoclopramide has better safety profile than droperidol for treating HG

A new protocol consisting of a combination of metoclopramide and diphenhydramine appears effective in improving symptoms of hyperemesis gravidarum, and is better tolerated than other treatments, say Canadian researchers. (Source: MedWire News - Ob/Gyn)

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  Dextromethorphan/diphenhydramine overdose: Drug intoxication and death following recreational use: 6 case reports

(Source: Reactions)

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  Diphenhydramine withdrawal: Dependence and withdrawal syndrome: case report

(Source: Reactions)

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  Dextromethorphan/diphenhydramine overdose: Drug intoxication and death following recreational use: 6 case reports.

Page: 14 (Source: Reactions Weekly)

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  Diphenhydramine withdrawal: Dependence and withdrawal syndrome: case report.

Page: 16 (Source: Reactions Weekly)

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  Behavioral and neurochemical effects of cocaine and diphenhydramine combinations in rhesus monkeys

Conclusions  The results support previous evidence of enhanced reinforcement with cocaine and DPH combinations and extend this finding to operant behavior maintained under a second-order schedule. However, the reinforcing effects of DPH alone or in combination with cocaine do not appear to be mediated via changes in dopamine overflow. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1555-yAuthors Matthew L. Banks, Emory University Yerkes National Primate Research Center 954 Gatewood Rd Atlanta GA 30329 USAMonica L. Andersen, Emory University Yerkes National Primate Research Center 954 Gatewood Rd Atlanta GA 30329 USAKevin S. Murnane, Emory University Yerkes National Primate Research Center 954 Gatewood Rd Atlanta GA 30329 USARebecca C. ...

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  Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine

Conclusion  Even though fear-potentiated startle may be used to translate preclinical evidence to human populations, methodological issues still hamper the application of this model to early screening of putative anxiolytic drugs. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1516-5Authors J. M. P. Baas, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsN. Mol, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Heidelberglaan 2 3584 CS Utrecht The NetherlandsJ. L. Kenemans, Utrecht University Department of Experimental Psychology, Faculty of Social Sciences Van Unnik Building, Hei...

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  Diphenhydramine overdose: Unconsciousness, respiratory insufficiency and arrhythmias: case report

(Source: Reactions)

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  Diphenhydramine overdose: Unconsciousness, respiratory insufficiency and arrhythmias: case report.

Page: 16 (Source: Reactions Weekly)

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  Visual compatibility of i.v. medications routinely used in bone marrow transplant recipients.

CONCLUSION: Of the 17 drug combinations tested, 5 combinations were observed to be visually incompatible during simulated Y-site injection. The combinations found to be visually incompatible included acyclovir with cyclosporine, diphenhydramine, gentamicin, granisetron, or metoclopramide. PMID: 19336832 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

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  Diphenhydramine as a topical ocular anesthetic.

CONCLUSIONS: When applied topically to rabbit corneas, 5% diphenhydramine solution has a significant anesthetizing effect compared with salt solution (control eyes). Topical diphenhydramine may be a safe alternative in patients requiring topical anesthesia who have multiple allergies to topical anesthetics. Additional studies are needed to determine a dose-response curve and to further evaluate corneal toxicity prior to use in humans. PMID: 19491952 [PubMed - in process] (Source: Canadian Journal of Ophthalmology)

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  Celecoxib-Associated Anaphylaxis (April).

CONCLUSIONS: Celecoxib can produce an anaphylactic reaction in patients who have previously tolerated sulfonamide antibiotics and who have previously tolerated celecoxib. This case also reviews the potentially biphasic presentation of anaphylaxis. Clinicians need to be aware of this biphasic anaphylactic response to ensure optimal duration of evaluation. PMID: 19299321 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

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  Benadryl Side Effects

Catalogue of side effects for the medication Diphenhydramine / Benadryl. (Source: About.com Bipolar Disorder)

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  Opsoclonus Caused by Diphenhydramine Self-Poisoning.

Page: 72DOI: 10.1097/WNO.0b013e318197f6ffAuthors: Irioka, Takashi MD, PhD; Yamanami, Ayaka MD; Uchida, Naoki MD, PhD; Iwase, Mariko PhD; Yasuhara, Hajime MD, PhD; Mizusawa, Hidehiro MD, PhD (Source: Journal of Neuro-Ophthalmology)

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  Table of Contents

Increased Risk of Sudden Cardiac Death With Atypical and Typical AntipsychoticsSertraline and Escitalopram may be Best for Acute Treatment of Major DepressionLeukopenia and Neutropenia Linked to Diphenhydramine and Clozapine UseAtypical Features of Bipolar Disorder and Long-Term Effectiveness of LithiumCost Effectiveness of Therapy and Fluoxetine for MDD in RomaniaEscitalopram Moderately Effective for Adult GADGene Polymorphisms Linked to Metabolic Syndrome With ClozapineAtomoxetine Effective for Adults With ADHD and Anxiety DisorderMemantine as Augmenting Agent for Severe Pediatric OCDFDA Requests REMS for Certain Opioid Drugs (Source: The Brown University Psychopharmacology Update)

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  Pustular psoriasis of pregnancy in a patient whose dermatosis showed features of acute generalized exanthematous pustulosis

A 23-year-old pregnant woman at 38 weeks of gestation presented with a 2-day history of a red eruption on her abdomen and upper thighs. The patient had applied baby oil to her abdomen a few days earlier, but she denied using any other topical products. Her only medications were prenatal vitamins and iron, which she had been taking since the beginning of her pregnancy. The clinical impression was contact dermatitis, and she was started on topical Sarna lotion (containing 0.5% camphor and 0.5% menthol) after she declined topical steroids. Three days later, she presented to the dermatology clinic with worsening pruritus, mild diarrhea, and subjective chills. On physical examination, there were diffuse erythematous plaques studded with 1[ndash]2-mm pustules on the upper extremities, chest, bac...

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  Trastuzumab 6 mg/kg and 4 mg/kg can be infused safely over 30 minutes.

Conclusion: Trastuzumab can be safely infused over 30 minutes for 4 and 6 mg/kg maintenance doses and this is the current practice at our institution. This change has resulted in improved efficiency and patient convenience, and decreased cost associated with the longer duration infusions. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 3150. (Source: Cancer Research)

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  DIPHENHYDRAMINE HYDROCHLORIDEinjection, Solution [Hospira, Inc.]

Updated Date: Feb 10, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  DIPHENHYDRAMINE HYDROCHLORIDEinjection, Solution [Hospira, Inc.]

Updated Date: Feb 5, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Probability of Rash Related to Gabapentin Therapy in a Child (February).

CONCLUSIONS: This case, and limited literature data, suggest that gabapentin may cause rash that is severe enough to necessitate discontinuation in a small percentage of children. Further research is needed to determine the actual incidence and severity of gabapentin-related rash in this population. PMID: 19193587 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

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  Retrospective evaluation of weekly paclitaxel hypersensitivity reactions reported utilizing an electronic medical record system at a tertiary cancer center

Conclusions  The results indicate that there is substantial variability in the type and number of premedications utilized in the management of paclitaxel hypersensitivity reactions. Interventions are needed to decrease the rate of hypersensitivity reactions from weekly paclitaxel infusions. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00520-009-0588-4Authors Lincy S. Lal, University of Texas M. D. Anderson Cancer Center Division of Pharmacy, Drug Use Policy and Pharmacoeconomics Unit 706 Houston TX USADonna L. Gerber, University of Texas M.D. Anderson Cancer Center Division of Nursing Unit 82 Houston TX USAJason Lau, University of Texas M. D. Anderson Cancer Center Division of Pharmacy, Drug Use Policy and Pharmacoeconomics Unit 706 Houston TX USAW...

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  Sequential intravesical gemcitabine and mitomycin C chemotherapy regimen in patients with non-muscle invasive bladder cancer.

CONCLUSIONS: In patients with recurrent BCG refractory bladder cancer, intravesical combination chemotherapy with gemcitabine and MMC appears to be well tolerated and yields a response in a good proportion number of patients. PMID: 19171491 [PubMed - as supplied by publisher] (Source: Urologic Oncology)

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  Use of antihistamine medications during early pregnancy and isolated major malformations

Antihistamines are commonly used during pregnancy. There is little evidence that they have teratogenic effects, but there are knowledge gaps with respect to newer products, as well as the relationship between specific antihistamines and specific birth defects.Using the National Birth Defects Prevention Study (1997-2003), the authors examined associations between maternal use of 14 antihistamines during early pregnancy and 26 isolated major birth defects. A Bayesian analysis incorporating prior knowledge about the relationships between antihistamines, birth defects, and measured covariates was conducted.Of the 364 associations investigated, 24 had 95% posterior intervals excluding 1.0. All 24 associations were positive; 23 associations were of weak to moderate magnitude (posterior OR < 3.0)...

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  Diphenhydramine abuse and detoxification: a brief review and case report

We present a brief review of the literature describing DPH abuse, and report the case of GF, a 56 year old woman who was admitted to an inpatient addictions unit for detoxification from DPH. A literature search revealed five case reports of DPH abuse including a total of six patients, published between 1986 and 2001. All reported cases exhibited features of DSM-IV criteria for substance dependence, and there was an apparent link with antipsychotic usage. GF was treated with antipsychotics, and was using up to thirty 50 mg DPH tablets each day. She described feeling `good and calm' and `it stopped the tremors'. GF tolerated a gradual dose reduction schedule, and completed the detoxification programme relatively comfortably. She was discharged from the inpatient detoxification unit as planne...

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  Diphenhydramine overdose: Fatal toxicities: case report

(Source: Reactions)

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  Diphenhydramine overdose: Fatal toxicities: case report.

Page: 16 (Source: Reactions Weekly)

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  Metoclopramide and diphenhydramine in the treatment of hyperemesis gravidarum: Effectiveness and predictors of rehospitalisation.

CONCLUSIONS: The new protocol consisting of the combination of metoclopramide and diphenhydramine appears to be a good option in the management of hyperemesis gravidarum. PMID: 19135291 [PubMed - as supplied by publisher] (Source: European Journal of Obstetrics, Gynecology, and Reproductive Biology)

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  Effects of Histamine H(1)-Antagonists on Sleep-Awake State in Rats Placed on a Grid Suspended over Water or on Sawdust.

Authors: Tokunaga S, Tsutsui R, Obara Y, Ishida T, Kamei C The present study was performed to investigate the effects of histamine H(1)-antagonists on the sleep-awake state in rats placed on a grid suspended over water in comparison with rats placed on sawdust. When rats were placed on the grid suspended over water, significant increases in the awake time and decreases in non-rapid eye movement (non-REM) sleep time were observed compared with in rats on sawdust, even when measured hourly for 6 h. Diphenhydramine, chlorpheniramine and promethazine caused a significant decrease in the awake time and increase in non-REM sleep time in rats placed on the grid suspended over water for 1-2 h and/or 2-3 h after administration. On the other hand, in rats placed on sawdust, no significant differ...

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  Clinical significance of brush allodynia in emergency patients with migraine.

CONCLUSIONS: Cutaneous brush allodynia is an uncommon finding in the ED, occurring in fewer than 1 in 5 migraineurs. It does not seem to have prognostic relevance for the ED-based management of the acute migraine attack. PMID: 19125875 [PubMed - in process] (Source: Headache)

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  Guidelines for safe surgery in patients with systemic mastocytosis.

We present two patients with systemic mastocytosis. One underwent open left inguinal hernia and umbilical hernia repair and the other laparoscopic ventral hernia repair. The literature for perioperative management of patients with SM is extensively reviewed. Both patients were treated preoperatively with intravenous antihistamines and steroids to minimize SM reactions. The first patient underwent uneventful open left inguinal hernia repair and umbilical hernia repair under spinal anesthesia. The second patient underwent general anesthesia. A composite mesh was used to repair a 9 x 12-cm Swiss cheese incisional hernia at the site of previous surgery. After the administration of neostigmine and glycopyrrolate, she developed a generalized rash without any hemodynamic instability. The patient ...

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  The occurrence of illicit and therapeutic pharmaceuticals in wastewater effluent and surface waters in Nebraska.

Authors: Bartelt-Hunt SL, Snow DD, Damon T, Shockley J, Hoagland K The occurrence and estimated concentration of twenty illicit and therapeutic pharmaceuticals and metabolites in surface waters influenced by wastewater treatment plant (WWTP) discharge and in wastewater effluents in Nebraska were determined using Polar Organic Chemical Integrative Samplers (POCIS). Samplers were installed in rivers upstream and downstream of treated WWTP discharge at four sites and in a discharge canal at a fifth location. Based on differences in estimated concentrations determined from pharmaceuticals recovered from POCIS, WWTP effluent was found to be a significant source of pharmaceutical loading to the receiving waters. Effluents from WWTPs with trickling filters or trickling filters in parallel wit...

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  Phase II trial of docetaxel (Taxotere) in patients with metastatic melanoma previously untreated with cytotoxic chemotherapy

Abstract  A phase II study was undertaken to evaluate the clinical efficacy and safety of docetaxel in patients with malignant melanoma. Between April 1992 and February 1996, 37 patients with metastatic malignant melanoma and no prior chemotherapy were treated with docetaxel 100 mg m-2 administered intravenously over 1 hour every 21 days. Patients were premedicated prior to each course with dexamethasone and diphenhydramine. Toxicity and follow-up were provided. Objective responses were seen in two out of 35 patients evaluable for response, one complete response and one partial response. These two responses were of a duration of greater than two years. The most common toxicity was grade 4 neutropenia, which occurred in 92% of patients; 49% required hospitalization for an epi...

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  Phase II trial of docetaxel (Taxotere) in patients with adenocarcinoma of the upper gastrointestinal tract previously untreated with cytotoxic chemotherapy: the Eastern Cooperative Oncology Group (ECOG) Results of Protocol E1293

Abstract  The aim of this study was to evaluate the clinical efficacy and safety of docetaxel (Taxotere) in patients with adenocarcinoma of the upper gastrointestinal tract previously untreated with cytotoxic chemotherapy. Docetaxe1100 mg m−2 was administered as a 1 hour intravenous (IV) infusion every 3 weeks to 41 patients. Patients were premedicated prior to each course with dexamethasone, diphenhydramine and cimetidine. Clinical response and toxicity were determined. Objective responses were seen in seven of 41 eligible patients (two complete responses [CRs] and five partial responses [PRs], for an objective response rate of 17% (90% confidence interval [CI], 8% to 30%). The most common toxicity was grade 4 neutropenia, which occurred in 88% of patients; 46% of patient...

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  Characterization of hydrochloride and tannate salts of diphenhydramine

The objective of this work was to characterize tannate salt and hydrochloride salt of diphenhydramine. As a part of characterization studies, Differential scanning calorimetry was used to investigate thermal effects and nature of salts, supported by X-ray powder diffraction. Scanning electron microphotographs was used to surface topography of salts of diphenhydramine. Fourier-transform infrared spectroscopy, solubility study and flowability studies were carried out as part of characterization. Differential scanning calorimetry and X-ray powder diffraction studies indicated amorphous nature of the tannate while hydrochloride salt has crystalline properties. Scanning electron microphotographs indicated the differences in surface topography between both the salts. Solubility studies at differ...

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  Effects of loratadine/montelukast on vigilance and alertness task performance in a simulated cabin environment.

CONCLUSIONS: L/M is similar to placebo in effects on daytime somnolence and psychomotor performance. L/M treatment resulted in significantly less sleepiness and impairment of vigilance and tracking than diphenhydramine. PMID: 19089321 [PubMed - as supplied by publisher] (Source: Advances in Therapy)

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  Diphenhydramine/linezolid interaction: Serotonin syndrome in an elderly patient: case report.

Page: 12 (Source: Reactions Weekly)

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  Diphenhydramine/linezolid interaction: Serotonin syndrome in an elderly patient: case report

(Source: Reactions)

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  Changes in dipole membrane potential at the mouse blood-brain barrier enhance the transport of Technetium Sestamibi more than inhibiting Abcb1, Abcc1, or Abcg2.

Authors: Cattelotte J, Tournier N, Rizzo-Padoin N, Schinkel AH, Scherrmann JM, Cisternino S ABSTRACT Cationic (99m)Tc-agents like (99m)Tc-MIBI cannot be used for brain imaging because they do not enter the brain as readily as some uncharged (99m)Tc-compounds. The mechanism by which cationic (99m)Tc-agents are transported across the blood-brain barrier (BBB) remains unclear. We explored (99m)Tc-MIBI transport by in situ mouse brain perfusion to determine the influence of BBB features like the ABC transporters (Abcb1/P-gp, Abcc1/Mrp1, Abcg2/Bcrp), organic cation transporters (Slc22a1-3/Oct1-3), the transmembrane potential and the dipole membrane potential. P-gp reduced (99m)Tc-MIBI transport across the BBB of P-gp-deficient mice 2.2-fold, as confirmed by PSC833 and GF120918 inhibition. P...

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  Clozapine/diphenhydramine: Neutropenia and leucopenia: case report.

Page: 14 (Source: Reactions Weekly)

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  Are Leukotriene Modulators Effective for Treating Atopic Dermatitis?

Discussion Atopic dermatitis is a common skin condition that occurs in 10-15% of children. It is chronic, relapsing and has an immunological basis but the exact etiology is unclear. The clinical presentation varies from mild to very severe. In acute presentations the skin can have erythematous papules and/or vesicles that overly erythematous skin. There are frequently excoriations and erosions. In subacute presentations there will be erythema, excoriations and scaling of the skin. In chronic presentations the skin will have progressed to having thick plaques of skin, lichenification and/or fibrotic papules. One recent study found that childhood atopic dermatitis increased the likelihood of childhood asthma, asthma persisting into middle age, and new-onset asthma in later life. Learnin...

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  Clozapine/diphenhydramine: Neutropenia and leucopenia: case report

(Source: Reactions)

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  Interventions for treating oral mucositis for patients with cancer receiving treatment.

Authors: Clarkson J, Worthington H, Eden O Background: Treatment of cancer is increasingly effective but associated with short and long-term side effects. Oral side effects, including oral mucositis (mouth ulceration), remain a major source of illness despite the use of a variety of agents to treat them. Objectives: To assess the effectiveness of interventions for treating oral mucositis or its associated pain in patients with cancer receiving chemotherapy or radiotherapy or both. Search strategy: Computerized searches of Cochrane Oral Health Group's Trials Register; Cochrane Pain, Palliative and Supportive Care Group's Trials Register; CENTRAL; MEDLINE and EMBASE were undertaken. Reference lists from relevant articles were searched and the authors of eligible trials were contacted to ...

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  The anesthetic efficacy of diphenhydramine and the combination diphenhydramine/lidocaine for the inferior alveolar nerve block.

Authors: Willett J, Reader A, Drum M, Nusstein J, Beck M The purpose of this prospective, randomized study was to compare the degree of pulpal anesthesia obtained in vital, asymptomatic teeth using 1.8 mL of 1% diphenhydramine with 1:100,000 epinephrine, 1.8 mL of 2% lidocaine with 1:100,000 epinephrine, and 3.6 mL of 2% lidocaine with 1:100,000 epinephrine combined with 1% diphenhydramine with 1:100,000 epinephrine in inferior alveolar nerve blocks. We also studied injection and postinjection pain. An electric pulp tester was used to test for anesthesia, in 4-minute cycles for 60 minutes, of the second molars through the central incisor. Anesthesia was considered successful when two consecutive 80 readings were obtained within 15 minutes and the 80 reading was continuously sustained t...

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  Diphenhydramine Overdose in a 26-year-old Woman.

Authors: Jeffery AD, Lytle-Saddler T PMID: 19022079 [PubMed - as supplied by publisher] (Source: Journal of Emergency Nursing: JEN)

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  Efficient assessment of neuropathic pain drugs in patients with small fiber sensory neuropathies.

Authors: Ho TW, Backonja M, Ma J, Leibensperger H, Froman S, Polydefkis M We sought to develop an enrichment crossover study design that would allow us to efficiently evaluate and compare promising candidate neuropathic pain drugs. We evaluated the efficacy of gabapentin or tramadol vs. active placebo (diphenhydramine) in subjects with biopsy-proven painful idiopathic small fiber neuropathy (SFN) who were self-reported gabapentin responders. Eligible subjects entered two single blind run-in phases. In the first phase (Period A), subjects were treated with single blinded gabapentin at their prestudy dose followed by a second run-in phase (Period B) in which they were treated with diphenhydramine active placebo. Subjects with 3 pain and a 30% increase in pain intensity in Period B compar...

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  Rash Associated with Pregabalin Use (December).

CONCLUSIONS: There are currently no other available reports of the development of a rash coinciding with the use of pregabalin. As both Food and Drug Administration-approved and off-label use of this drug increases, further consideration of risk factors associated with the development of rash is needed. PMID: 19001532 [PubMed - as supplied by publisher] (Source: The Annals of Pharmacotherapy)

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  Benadryl Itch Stopping Gel goes on the body, not into the mouth. Don't swallow it.

When adults and children mistakenly swallowed Benadryl Itch Stopping Gel, they ended up in the emergency room. (Source: Drug Topics - Drug Information)

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  Benadryl Itch Stopping Gel goes on the body, not into the mouth. Don't swallow it.

When adults and children mistakenly swallowed Benadryl Itch Stopping Gel, they ended up in the emergency room. (Source: Drug Topics - Clinical News)

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  Development of Hepatic Failure Despite Use of Intravenous Acetylcysteine After a Massive Ingestion of Acetaminophen and Diphenhydramine

We report the development of liver failure despite administration of intravenous acetylcysteine in a patient with massive ingestion of an acetaminophen and diphenhydramine combination product. An atypical, delayed, bimodal peak in the serum acetaminophen concentration was observed. This case suggests that individualized dosing of antidotal therapy may be needed for preparations of acetaminophen that result in delayed absorption or after massive overdose. (Source: Annals of Emergency Medicine)

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  Development of Hepatic Failure Despite Use of Intravenous Acetylcysteine After a Massive Ingestion of Acetaminophen and Diphenhydramine.

We report the development of liver failure despite administration of intravenous acetylcysteine in a patient with massive ingestion of an acetaminophen and diphenhydramine combination product. An atypical, delayed, bimodal peak in the serum acetaminophen concentration was observed. This case suggests that individualized dosing of antidotal therapy may be needed for preparations of acetaminophen that result in delayed absorption or after massive overdose. PMID: 18986731 [PubMed - as supplied by publisher] (Source: Annals of Emergency Medicine)

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  Perrigo Announces FDA Tentative Approval For Ibuprofen PM

Perrigo Company recently announced that it has received tentative approval from the U.S. Food and Drug Administration for its Abbreviated New Drug Application (ANDA) for over-the-counter (OTC) Ibuprofen and Diphenhydramine Citrate Tablets, 200/38 mg. (Source: Pharmaceutical Online News)

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  Phase II study of weekly paclitaxel by one-hour infusion for advanced gastric cancer

Conclusion  Weekly paclitaxel therapy is an active and safe treatment for advanced gastric cancer. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s00595-008-3769-8Authors Yasunori Emi, Kyushu University Department of Surgery and Science, Graduate School of Medical Science 3-1-1 Maidashi, Higashi-ku Fukuoka 812-8582 JapanManabu Yamamoto, Hiroshima Red Cross Hospital and Atomic-Bomb Survivors Hospital Department of Surgery Hiroshima JapanIkuo Takahashi, Matsuyama Red Cross Hospital Department of Surgery Matsuyama, Ehime JapanHiroyuki Orita, Saiseikai Yahata Hospital Department of Surgery Fukuoka JapanYoshihiro Kakeji, Kyushu University Department of Surgery and Science, Graduate School of Medical Science 3-1-1 Maidashi, Higashi-ku Fukuoka 812-8582 JapanSh...

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  How Do I Handle an In-flight Emergency?

Discussion Estimates of in-flight emergencies vary because there currently are no consistent standards for measuring them. Estimates range from 0.003% to 0.0005% (i.e. 1/333-1900 flights per year). Based on studies from the United States this translates into 13-33 emergencies/day. Luckily most in-flight emergencies are not serious and most do not require evaluation or treatment by ground personnel. Overall, vasovagal episodes such as dizziness, fainting or near fainting and hyperventilation are the most common. The most serious overall are cardiac, neurological and respiratory problems. Estimates of in-flight deaths in the United States are 21-72/year with most being elderly passengers and are attributed to cardiac or pulmonary problems. One study of pediatric in-flight emergencies f...

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  What Are the Most Common Food Allergies?

Discussion Food allergies are relatively common but it can be difficult to tease out if it is a true allergy, a food intolerance or is actually something else. Risk factors that increase the likelihood of food allergy include: Reactions that occur minutes to hours of the ingestion Accidental ingestion of same food that produces the same symptoms Onset of symptoms as an infant or young child Close family history of other allergic diseases such as allergic rhinitis, asthma, atopic dermatitis or food allergies The suspected food is known to be higher risk for producing allergic reactions Children with a possible food allergy may receive testing by skin-prick, patch testing or RAST (radioallergosorbent testing). RAST is a blood test that has a high sensitivity but has only ~50% specificity...

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  Heroin–gel capsule cocktails and groin injecting practices among ethnic Vietnamese in Melbourne, Australia

Discussion: Health education campaigns to address the potentially negative consequences of gel capsule groin injection will not be successful unless health workers and policy makers work with drug users and incorporate local understandings and meanings of risk in health promotion activities. (Source: International Journal of Drug Policy)

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  Antiemetic Medications in Children with Presumed Infectious Gastroenteritis-Pharmacoepidemiology in Europe and Northern America.

CONCLUSION: Antiemetic drugs are frequently used in children with gastroenteritis. In different industrialized countries, prescription of antiemetic medication varies considerably. Ondansetron, the only drug with evidence-based antiemetic efficacy, plays a minor role among antiemetic prescriptions. PMID: 18829050 [PubMed - as supplied by publisher] (Source: The Journal of Pediatrics)

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  Pharmacological interventions for clozapine-induced hypersalivation.

CONCLUSIONS: There are currently insufficient data to confidently inform clinical practice. The limitations of these studies are plentiful and the risk of bias is high. These trials, however, are invaluable guides for current and future study design. Well conducted randomised trials are possible. Some may be underway. Current practice outside of well designed randomised trials should be clearly justified. PMID: 18646130 [PubMed - in process] (Source: Cochrane Database of Systematic Reviews)

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  He Defied The Doctors Until Death Defied Him

The objective sign that something was wrong came from the machines and monitors that surrounded his bed in Fairfax. (Source: washingtonpost.com - Health)

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  A Sore Throat That Turned Deadly Serious

During the worst moments of her ordeal last month, her mouth gaping as wide as possible into an oxygen mask in a labored effort to keep breathing, Nancy Szokan remembers wishing she could just pass out. (Source: washingtonpost.com - Health)

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  Rocuronium-induced coronary vasospasm — “Kounis syndrome”

Abstract: A 49-year-old male became hypotensive, bradycardic, and suffered myocardial injury during induction of anesthesia with lidocaine, propofol, and rocuronium in the operating room. Coronary arteriography revealed coronary vasospasm in coronary arteries otherwise free of disease. In the ICU, the patient was again administered rocuronium for a procedure with subsequent hypotension, bradycardia, and ST elevation on telemetry that resolved with administration of diphenhydramine and hydrocortisone. An allergic reaction to rocuronium with coronary vasospasm is suspected, suggestive of the Type 1 variant of Kounis syndrome. This is the first report to describe a case of rocuronium-induced Type 1 Kounis syndrome. (Source: International Journal of Cardiology)

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  Rocuronium-induced coronary vasospasm - "Kounis syndrome"

Authors: Fagley RE, Woodbury A, Visuara A, Wall M A 49-year-old male became hypotensive, bradycardic, and suffered myocardial injury during induction of anesthesia with lidocaine, propofol, and rocuronium in the operating room. Coronary arteriography revealed coronary vasospasm in coronary arteries otherwise free of disease. In the ICU, the patient was again administered rocuronium for a procedure with subsequent hypotension, bradycardia, and ST elevation on telemetry that resolved with administration of diphenhydramine and hydrocortisone. An allergic reaction to rocuronium with coronary vasospasm is suspected, suggestive of the Type 1 variant of Kounis syndrome. This is the first report to describe a case of rocuronium-induced Type 1 Kounis syndrome. PMID: 18804883 [PubMed - as su...

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  Evaluation of the Embryotoxic Potency of Compounds in a Newly Revised High Throughput Embryonic Stem Cell Test

The ability of murine-derived embryonic stem cells (D3) to differentiate into cardiomyocytes is the basis of the embryonic stem cell test (EST). With the EST, chemicals and pharmaceuticals can be assessed for their embryotoxic potency early on in the development process. In order to come to a higher throughput EST, a 96-well based method was developed based on low attachment well plates that allow for the formation of embryonic bodies from which the stem cells can differentiate. Twelve test compounds were selected based on their reported in vitro and in vivo embryotoxic potency. In the 96-well based EST, reportedly strong embryotoxic compounds 5-fluorouracil, 6-aminonicotinamide (6AN), methylmercury chloride, and hydroxyurea were correctly ranked with corresponding Relative Embryotoxic Pot...

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  Contraindicated medication use among patients in a memory disorders clinic.

Conclusions: Despite research evidence and recommendations to avoid these CNS-active medications because of their adverse effects, they continue to be prescribed in elderly patients with cognitive impairments. Further research is needed to determine strategies that will help reduce their administration in this population. PMID: 18775389 [PubMed - in process] (Source: The American Journal of Geriatric Pharmacotherapy)

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  Emedastine difumarate inhibits histamine-induced collagen synthesis in dermal fibroblasts.

CONCLUSIONS: We found that the expression of fibroblast-derived genes is differentially regulated by different concentrations of histamine and that the robustness of the inhibitory action of H1R blockers is different for skin-derived and nasal mucosa-derived fibroblasts. We believe that our findings may contribute to a better understanding of the mechanisms of histamine-induced tissue remodeling and provide information useful for the management of refractory allergic dermatitis. PMID: 18714531 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)

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  Diphenhydramine/metronidazole: Allergic contact dermatitis: case report

(Source: Reactions)

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  Diphenhydramine/metronidazole: Allergic contact dermatitis: case report.

Page: 14 (Source: Reactions Weekly)

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  J&J Agrees to Pay Drug Import Fine

Johnson & Johnson agreed to pay $511,000 to the government over charges of improper drug imports. The payment will settle charges that Benadryl-D had been imported on 73 occasions without the necessary paperwork. (Source: WSJ.com: Health)

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  Cough and Cold Medication Use by US Children, 1999-2006: Results From the Slone Survey

CONCLUSIONS. Approximately 1 in 10 US children uses a cough and cold medication in a given week. The especially high prevalence of use among children of young age is noteworthy, given concerns about potential adverse effects and the lack of data on the efficacy of cough and cold medications in this age group. (Source: PEDIATRICS)

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  Concomitant allergic contact dermatitis from diphenhydramine and metronidazole.

Authors: Fernández-Jorge B, Goday Buján J, Fernández-Torres R, Rodríguez-Lojo R, Fonseca E PMID: 18759879 [PubMed - in process] (Source: Contact Dermatitis)

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  Acute coronary syndromes complicating the first infusion of rituximab.

Authors: Armitage JD, Montero C, Benner A, Armitage JO, Bociek G The aim of this study was to describe the occurrence of acute coronary syndromes in 3 cases of rituximab infusions. We reviewed the records of 3 patients with lymphoproliferative disorders who experienced acute coronary syndromes associated with their initial infusion of rituximab. All 3 patients received rituximab according to a standardized institutional rate schedule, and all received pre-medication with acetaminophen and diphenhydramine. The median age of patients was 61 years. One patient had known atherosclerotic heart disease, and 2 patients had risk factors for coronary artery disease. All patients had varying degrees of evidenced high tumor burden, including lymphocytosis, elevated lactate dehydrogenase values, b...

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  Effect of a Pharmaceutical Cationic Exchange Resin on the Properties of Controlled Release Diphenhydramine Hydrochloride Matrices Using Methocel K4M or Ethocel 7cP as Matrix Formers.

In conclusion, the incorporated resin could alter the release and physical properties of matrices. PMID: 18668370 [PubMed - as supplied by publisher] (Source: AAPS PharmSciTech)

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  A prospective, randomized, double-blind controlled trial of acetaminophen and diphenhydramine pretransfusion medication versus placebo for the prevention of transfusion reactions.

CONCLUSIONS: Pretransfusion medication of leukemia or BMT patients without a history of transfusion reaction does not decrease the overall risk of transfusion reactions. However, pretransfusion medication may decrease the risk of febrile nonhemolytic transfusion reactions to leukoreduced blood products. PMID: 18673350 [PubMed - as supplied by publisher] (Source: Transfusion)

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  [Genitourinary Imaging] Frequency, Outcome, and Appropriateness of Treatment of Nonionic Iodinated Contrast Media Reactions

CONCLUSION. Patients usually do well after developing acute allergiclike reactions to nonionic iodinated contrast media. Fortunately, in our series, this was true even in the rare cases in which the instituted treatment was considered to be inappropriate. Reacting patients rarely develop serious long-term sequelae. (Source: American Journal of Roentgenology)

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  Determination of illicit and medicinal drugs and their metabolites in oral fluid and preserved oral fluid by liquid chromatography-tandem mass spectrometry.

Authors: Concheiro M, de Castro A, Quintela O, Cruz A, López-Rivadulla M An LC-MS/MS method using 0.5 ml of oral fluid was developed for the determination of morphine, codeine, 6-monoacetylmorphine, methadone, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine, 3,4-methylenedioxymethamphetamine, 3,4-methylenedioxy-N-ethylamphetamine, benzoylecgonine, cocaine, delta-9-tetrahydrocannabinol, zolpidem, zopiclone, alprazolam, clonazepam, oxazepam, nordiazepam, lorazepam, flunitrazepam, diazepam, diphenhydramine and amitriptyline. The method was fully validated in terms of linearity (the method was linear between 1-5 microg/L and 100-200 microg/L) recoveries (7.5-82.6%), within-day and between-day precisions and accuracies (CV and MRE, both <15%), limits of detection (0.5 mi...

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  Diphenhydramine overdose: Anticholinergic syndrome: case report

(Source: Reactions)

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  An unusual presentation of canine distemper virus infection in a domestic ferret (Mustela putorius furo).

Authors: Zehnder AM, Hawkins MG, Koski MA, Luff JA, Benak J, Lowenstine LJ, White SD A 4.5-year-old, male castrated ferret was examined with a 27-day history of severe pruritus, generalized erythema and scaling. Skin scrapings and a trichogram were negative for mites and dermatophyte organisms. A fungal culture of hair samples was negative. The ferret was treated presumptively for scabies and secondary bacterial and yeast infection with selamectin, enrofloxacin, fluconazole, diphenhydramine and a miconazole-chlorhexidine shampoo. The ferret showed mild improvement in clinical signs over the subsequent 3 weeks, but was inappetent and required supportive feeding and subcutaneous fluids by the owner. The ferret was then examined on an emergency basis at the end of 3 weeks (53 days followi...

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  Diphenhydramine overdose: Anticholinergic syndrome: case report.

Page: 11 (Source: Reactions Weekly)

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  How Do You Treat Chronic Urticaria?

Discussion Chronic urticaria is defined as wheals that occur at least twice weekly for more than 6 weeks. Because this is broad, some people add that the wheals must be present for more than 1 hour (which distinguishes chronic urticaria from dermatographism) and less than 24-36 hours (which distinguishes it from urticaria-vasculitis). The lesions can be 'just' irritating or very painful and even indurated. Outbreaks can occur for weeks-years and affects up to 3 % of the population. Generally there are no systemic problems but some patients have greatly diminished quality of life that is equivalent to people with severe coronary artery disease. Chronic urticaria can be caused by a specific physical stimulus or often is idiopathic. Up to 1/3 of idiopathic cases appear to be autoimmune relate...

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  Taste Mask, Design and Evaluation of an Oral Formulation Using Ion Exchange Resin as Drug Carrier.

Authors: Bhise K, Shaikh S, Bora D The purpose of this research was to mask the bitter taste of Diphenhydramine Hydrochloride (DPH) using cation exchange resins. Indion 234 and Tulsion 343 that contained crosslinked polyacrylic backbone were used. The drug resin complexes (DRC) were prepared by batch process by taking drug: resin ratios 1:1, 1:2, and 1:3. The optimum drug: resin ratio and the time required for maximum complexation was determined. The drug resinates were evaluated for the drug content, taste, micromeritic properties drug release and X-ray diffraction (PXRD). Effervescent and dispersible tablets were developed from optimum drug: resin ratios of 1:2 and 1:1. The formulations were evaluated for uniformity of dispersion, disintegration time, and in vitro dissolution. The X-...

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  Time-dependent inhibition of histamine-induced cutaneous responses by oral and intramuscular diphenhydramine and oral fexofenadine

(Source: Annals of Allergy, Asthma and Immunology)

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  Time-dependent inhibition of histamine-induced cutaneous responses by oral and intramuscular diphenhydramine and oral fexofenadine.

CONCLUSION: Diphenhydramine tended to work more rapidly than fexofenadine, but the differences were not statistically significant. Given the adverse effect profile of diphenhydramine, but only marginal onset of action advantage, the risk-to-benefit ratio may be more favorable for oral fexofenadine when treating an acute urticarial or allergic reaction. PMID: 18517077 [PubMed - indexed for MEDLINE] (Source: Annals of Allergy, Asthma and Immunology)

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  A pilot study of metoclopramide, dexamethasone, diphenhydramine and acupuncture in women treated with cisplatin

Summary  A total of 26 women who submitted to cisplatin chemotherapy received as antiemetic treatment a combination of metoclopramide, dexamethasone and diphenhydramine. Acupuncture according to traditional Chinese medicine was also carried out. The results were compared with those obtained in a similar group of women with cancer, who were treated in the same setting with the same antiemetic combination but without additional acupuncture. Acupuncture was shown to increase complete protection from nausea and to decrease the intensity and duration of nausea and vomiting. However, the difficulties of performing acupuncture routinely in daily practice are a hindrance to its wider use. Content Type Journal ArticleCategory Short CommunicationDOI 10.1007/BF02897209Authors L. A...

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  Potentially inappropriate medication use in hospitalized elders

The objective of the study was to determine the rate of and factors associated with potentially inappropriate medication (PIM) prescribing in a large inpatient sample.The study was a retrospective cohort of the period between September 1, 2002, and June 30, 2005. We used multivariable logistic regression to identify patient, physician, and hospital characteristics associated with PIM prescribing.The study collected data from 384 US hospitals.The sample was composed of patients aged [ge]65 years admitted with 1 or more of 7 common medical diagnoses.The percentage of patients prescribed PIMs as defined using a modified Beers list was measured. Multivariable-adjusted odds ratios for PIM use were computed.Of the 493,971 patients, 49% received at least 1 PIM, and 6% received 3 or more, most com...

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  Cocaine-like neurochemical effects of antihistaminic medications

Journal of Neurochemistry, Volume 0, Issue 0, Page ???, October 2004. AbstractThe pattern of activation of dopamine (DA) neurotransmission in the nucleus accumbens (NAc) of rats produced by H1 histamine antagonists which have behavioral effects like those of psychostimulant drugs was examined. Diphenhydramine and (+)-... (Source: Journal of Neurochemistry)

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Top Viagra Store

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