MedWorm: Aspirin

  Novel Conjugates of Aspirin with Phenolic Acid as Anti-inflammatory Agents Having Significantly Reduced Gastrointestinal Toxicity

A series of novel conjugates of aspirin with natural phenolic acid antioxidants connected through a diol linker were designed and synthesized as potential bifunctional agents combining antioxidant and anti-inflammatory activity for reducing gastrointestinal toxicity. In general, the conjugates were found to be efficient antioxidants and many of them demonstrated much more potent anti-inflammatory activity than aspirin. Among them, 5a and 5b which bear the best anti-inflammatory activity exhibited significantly reduced ulcerogenic potency and toxicity compared to aspirin. However, it is evident that the anti-inflammatory activity of these dual-acting molecules in vivo, was not simply consistent with their antioxidant ability in vitro. (Source: Archiv der Pharmazie)

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  Cilostazol Trumps Aspirin in Secondary Stroke Prevention

A large randomized controlled trial suggests that the phosphodiesterase inhibitor cilostazol is more effective for the prevention of secondary stroke and has a superior safety profile. Medscape Medical News (Source: Medscape Today Headlines)

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  Aspirin resistance in Indian patients with coronary artery disease and cardiovascular events

Conclusion : The incidence of aspirin resistance in the cohort of patients with documented heart disease was 38.1%. Patients with elevated absolute urinary dehydrothomboxane levels (>320 pg/ml) on chronic aspirin therapy constitute a high risk subset for recurrent vascular events. (Source: Journal of Postgraduate Medicine)

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  Accumetrics To Host Industry-Expert Theater Presentation At 59th Annual American College Of Cardiology 2010 Scientific Sessions

Accumetrics, Inc., a privately-held developer and marketer of the VerifyNow® System, the first rapid and easy-to-use diagnostic system for measuring platelet reactivity to multiple antiplatelet agents (e.g. Plavix® and aspirin), announced that the company will host an industry expert theater presentation on Monday, March 15, during the 59th annual American College of Cardiology Meeting. The ACC industry expert theater presentation will focus on a rapidly evolving and exciting topic: assessing patient response to antiplatelet therapies and the impact on clinical outcomes... (Source: Health News from Medical News Today)

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  Accumetrics To Host Industry-Expert Theater Presentation At 59th Annual American College Of Cardiology 2010 Scientific Sessions

Accumetrics, Inc., a privately-held developer and marketer of the VerifyNow® System, the first rapid and easy-to-use diagnostic system for measuring platelet reactivity to multiple antiplatelet agents (e.g. Plavix® and aspirin), announced that the company will host an industry expert theater presentation on Monday, March 15, during the 59th annual American College of Cardiology Meeting... (Source: Cardiovascular / Cardiology News From Medical News Today)

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  Letter by Doraiswamy Regarding Article, "Intensifying Platelet Inhibition With Tirofiban in Poor Responders to Aspirin, Clopidogrel, or Both Agents Undergoing Elective Coronary Intervention: Results From the Double-Blind, Prospective, Randomized Tailoring Treatment With Tirofiban in Patients Showing Resistance to Aspirin and/or Resistance to Clopidogrel Study".

Authors: Doraiswamy VA PMID: 20212290 [PubMed - in process] (Source: Circulation)

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  Potential Use of 10-Year and Lifetime Coronary Risk Information for Preventive Cardiology Prescribing Decisions: A Primary Care Physician Survey [Original Investigation]

Conclusions  Providing 10-year coronary risk information improved some hypothetical aspirin-prescribing decisions and improved lipid management when the short-term risk was moderately high. High lifetime risk sometimes led to more intensive prescription of aspirin or lipid-lowering medication. This outcome suggests that, to maximize the benefits of risk-calculating tools, specific guideline recommendations should be provided along with risk estimates. (Source: Archives of Internal Medicine)

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  Wine and women's weight

Conclusion This large cohort study that followed middle-aged women for almost 13 years found that there was an association between greater alcohol consumption and slightly slower weight gain over this period. Despite the tone of press coverage, it should be remembered that this type of study can only show associations between factors, and cannot say how or whether alcohol directly causes the slower weight gain. There are also a number of limitations to this research, some of which the researchers have highlighted: The participants self-reported their weights and alcohol consumption, which may have resulted in a misclassification or underestimation of these values. The study used a single measurement of alcohol consumption taken at the start of the study. It is likely that the partici...

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  Health Headlines: Keeping an Eye on Dementia, Aspirin and Heart Health, Chocolate and Stroke Prevention, Exercising Teens

Source: HealthDay - Related MedlinePlus Pages: Alzheimer's Disease, Exercise for Children, Nutrition, Obesity in Children, Pain Relievers (Source: MedlinePlus Health News)

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  Nitric oxide, derived from inducible nitric oxide synthase, decreases hypoxia inducible factor-1α in macrophages during aspirin-induced mesenteric inflammation

Conclusions and implications: NO, associated with acute gut inflammation induced by aspirin, diminished HIF-1[alpha] stabilization in macrophages. Early inhibition of iNOS-derived NO synthesis, by increasing the activity of HIF-1 in these cells, may accelerate the clearance of leucocytes. (Source: British Journal of Pharmacology)

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  Factors influencing intercellular spaces in the rat esophageal epithelium.

CONCLUSION: Acute stress and aspirin can induce DIS of the esophageal epithelium in rats, and it is not correlated with acid reflux. PMID: 20205275 [PubMed - in process] (Source: World Journal of Gastroenterology : WJG)

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  The Levels of Inflammatory Markers in the Treatment of Stroke study (LIMITS): inflammatory biomarkers as risk predictors after lacunar stroke

Inflammation is increasingly recognised as playing a central role in atherosclerosis, and peripheral blood markers of inflammation have been associated with incident and recurrent cardiac events. The relationship of these potentially modifiable risk markers to prognosis after ischaemic stroke is less clear. The Levels of Inflammatory Markers in the Treatment of Stroke (LIMITS) study will address hypotheses related to the role of inflammatory markers in secondary stroke prevention in an efficient manner using the well-established framework of the Secondary Prevention of Small Subcortical Strokes (SPS3) trial (NCT00059306). SPS3 is an ongoing Phase III multicentre secondary prevention trial focused on preventing recurrent stroke in patients with small vessel ischaemic stroke, or lacunes. In ...

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  Painkillers may increase risk of hearing loss

In a study, men who regularly use analgesics reported hearing loss. Perhaps it wasn't those years of listening to rock 'n' roll that damaged my hearing after all; regular use of aspirin, acetaminophen and other analgesics appears to substantially increase the risk of hearing loss, especially in men younger than 50. (Source: L.A. Times - Health)

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  Comparison of Different Antithrombotic Regimens for Patients With Atrial Fibrillation Undergoing Drug-Eluting Stent Implantation.

Conclusions: The cardiovascular benefits of triple antithrombotic therapy were confirmed by reducing the MACCE rate, and its major bleeding risk might be acceptable if the INR is closely monitored. PMID: 20208381 [PubMed - as supplied by publisher] (Source: Circulation Journal)

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  Major Bleeding Uncommon After Imaging-Guided Percutaneous Core Needle Biopsy

A study shows an overall low incidence of major bleeding after imaging-guided percutaneous core needle biopsy, with little effect of recent aspirin therapy. Medscape Medical News (Source: Medscape Hematology-Oncology Headlines)

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  Regular painkillers and hearing loss

Conclusion This study found an association between regular use of three types of painkiller and a small increased risk in hearing loss. This type of study can only find associations, it cannot demonstrate that these painkillers caused the hearing loss. The researchers highlight some limitations of their study: Men were categorised as having hearing loss based on their own admission in the questionnaire on whether it had been diagnosed by a professional. Participants who did not report hearing loss were considered to not be impaired. The best way to assess hearing would have been through standard pure-tone audiometry, but this could not be performed due to cost and logistics reasons. The researchers did not have information on the participants’ lifetime noise exposure or the reasons...

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  New blow for aspirin use in CVD prevention

The role of aspirin in the prevention of cardiovascular events has been dealt another blow by the results of a randomised controlled trial by Scottish researchers. (Source: Pulse)

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  Health Buzz: New Prostate Cancer Screening Guidelines

COBRA insurance subsidy is extended to March job-losers; the benefits (and risks) of popping an aspirin (Source: U.S. News - Health)

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  No Benefit from Aspirin in Low ABI (CME/CE)

Prophylactic aspirin had no effect on the risk of vascular events in patients with a low ankle-brachial index and no evidence of cardiovascular disease, data from a randomized clinical trial showed. (Source: MedPage Today Cardiovascular)

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  Aspirin Use Does Not Significantly Reduce Vascular Events Among Individuals Identified By Certain Screening Method As Being At Higher Risk

Individuals who were identified as being at increased risk of cardiovascular or cerebrovascular events based on screening for low ankle brachial index, a type of pressure measurement used in the diagnosis of peripheral artery disease, did not significantly reduce their risk of these events with the use of aspirin, according to a study in the March 3 issue of JAMA. "The ankle brachial index (ABI), which is the ratio of systolic pressure at the ankle to the arm, is used in the diagnosis of peripheral artery disease affecting the legs... (Source: Health News from Medical News Today)

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  Journal Scan: Warfarin and Aspirin Use in Atrial Fibrillation Among Practicing Cardiologists (From the AFFECTS Registry) (Am J Cardiol 2010;Feb 22:[Epub ahead of print].)

This was an analysis of 1,461 patients (mean age 66 years) who had AF (paroxysmal in 80%) without structural heart disease and who were enrolled in a multicenter registry. Participating cardiologists were trained in the practice guidelines of the American College of Cardiology/American Heart Associa. . . (Source: Cardiosource)

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  JAMA: Aspirin use does not significantly reduce vascular events

Individuals who were identified as being at increased risk of cardiovascular or cerebrovascular events based on screening for low ankle brachial index did not significantly reduce their risk of these events with the use of aspirin, according to a randomized, controlled trial in the March 3 issue of Journal of the American Medical Association. (Source: Cardiovascular Business News)

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  DTB: Using NSAIDs in cardiovascular disease

Source: Drug and Therapeutics Bulletin Area: Evidence > Medication Safety In this review in the Drug and Therapeutics Bulletin (DTB) on the use of NSAIDs in cardiovascular disease, the authors consider the evidence in the context of other unwanted effects of NSAIDs, and offer practical advice on their use of in this setting. The following topics are addressed:   . COX enzymes . Cardiovascular effects of NSAIDs . Evidence from RCTs and other studies . Effects on blood pressure . Use in hypertension, ischaemic heart disease, heart failure, patients treated with low dose aspirin . Gastrointestinal and renal effects of NSAID . National prescribing advice (Source: NeLM - Patient Safety)

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  An Aspirin A Day?

Source: HealthDay - Related MedlinePlus Pages: Heart Attack, Pain Relievers, Stroke (Source: MedlinePlus Health News)

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  Daily aspirin 'not for the healthy'

Conclusion This trial has tried to answer an important question regarding who should be given aspirin to prevent a heart attack or stroke. It used a systematic method to screen people and followed a reasonably large group of patients for up to 10 years in some cases. The finding of “no statistical significance” can be an important result, and in this case suggests that any benefits from taking aspirin for this group of people are likely to be small. The risk of bleeding was also small and not technically of statistical significant. There is a non-significant trend in the results towards aspirin being harmful. As there is also a suggestion that the study may have been underpowered (planned for too few people), this implies that a larger study may have detected a significant increase ...

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  Aspirin Fails to Prevent Cardiovascular Events in Patients with a Low Ankle-Brachial Index

(Source: Physician's First Watch current issue)

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  Aspirin a day may HARM your health and 'does not cut heart attack risk in worried well'

They may be doing more harm than good because the risks of internal bleeding can outweigh the potential benefits, a study found. (Source: the Mail online | Health)

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  ASPIRIN BOLUS (Acetylsalicylic Acid) Tablet [Sparhawk Laboratories, Inc.]

Updated Date: Mar 3, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Aspirin fails to prevent cardiovascular events in patients with subclinical CVD

Results of the Aspirin for Asymptomatic Atherosclerosis trial show that aspirin does not reduce the risk for cardiovascular events in individuals with subclinical atherosclerosis as identified by a low ankle brachial index. (Source: MedWire News - Cardiology)

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  Could long-term analgesic use increase risk of deafness?

Source: Am J Med Area: News A large epidemiological study from the US found an increased risk of hearing loss associated with long-term use of analgesics (aspirin, NSAID, and paracetamol). The increases in risk are small, however, and should be taken with caution.   There is some experimental evidence that various analgesics (salicylates, NSAID, paracetamol) may be ototoxic, however there is also evidence that low-dose aspirin may protect hearing. The authors of this study used data from a pre-existing large cohort, the Health Professionals Follow-up Study. Participants are US male health professionals who were aged between 40 to 75 years in 1986 when the study started: at this point, they provided details on diet, health and medication history by mailed questionnaire. He...

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  Low-dose aspirin primary prevention study published

Source: JAMA Area: News The Aspirin for Asymptomatic Atherosclerosis (AAA) study, which was initially presented at a conference last year, has now been published in full.   AAA examined whether primary prevention using low-dose aspirin was beneficial in people identified as being at increased cardiovascular risk by having a low ankle-brachial index (ABI). The ABI is the ratio of systolic BP at the ankle to that in the arm and is considered to be an indicator of sub-clinical atherosclerosis.   As noted in the report of the conference presentation, carried on NHS Choices, the study did not show any significant benefit from low-dose aspirin in this group.   The original report and link to NHS Choices can be found at the link below. (Source: NeLM - ...

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  Basic Principles of Platelet Biology and Clinical Implications.

Authors: Angiolillo DJ, Ueno M, Goto S Platelet activation and subsequent accumulation at sites of vascular injury are the first steps in hemostasis. Excessive platelet activation after atherosclerotic plaque rupture or endothelial cell erosion may also lead to the formation of occlusive thrombi, which are responsible for acute ischemic events. Multiple pathways are involved in platelet activation, including those activated by adenosine diphosphate (ADP), thromboxane A(2) (TXA(2)), serotonin, collagen, and thrombin. Antiplatelet agents used for prevention of atherothrombosis have focused on blocking the formation of TXA(2) (eg, aspirin) and interfering with ADP stimulation mediated by the P2Y(12) receptor (eg, clopidogrel). These agents, used alone or in combination, significantly decr...

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  Platelet tissue factor synthesis in type 2 diabetes patients is resistant to inhibition by insulin.

Discussion We characterized the extra- and intracellular mechanisms that couple surface activation to TF-synthesis in adhering platelets. In healthy individuals, TF-synthesis is inhibited by insulin but in patients with type 2 diabetes inhibition is impaired. This leads to the novel finding that platelets from type 2 diabetes patients produce more TF than platelets from matched controls. PMID: 20200314 [PubMed - as supplied by publisher] (Source: Diabetes)

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  AAA: Aspirin Not Warranted in Healthy Subjects With Low ABI, Based on Population Screening

Authors of the study say their study does not rule out a role for ankle/brachial index screening in the clinic or for other CVD drugs to reduce risk in asymptomatic subjects. But for aspirin and for populationwide screening, the study raises some questions. Heartwire (Source: Medscape Today Headlines)

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  The Benefits of Popping an Aspirin (and Some Risks)

Daily aspirin appears not to improve the odds for people with very early peripheral artery disease. (Source: U.S. News - Health)

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  AAA: Aspirin not warranted in healthy subjects with low ABI, based on population screening

Authors of the study say their study does not rule out a role for ankle/brachial index screening in the clinic or for other CVD drugs to reduce risk in asymptomatic subjects. But for aspirin and for... For complete story visit theheart.org. (Source: theHeart.org)

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  Study Questions Value of Test for Peripheral Artery Disease

Ankle-brachial index, and resulting aspirin therapy, may not be needed for healthier patients Source: HealthDay Related MedlinePlus Pages: Blood Thinners, Peripheral Arterial Disease (Source: MedlinePlus Health News)

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  Aspirin for Prevention of Cardiovascular Events in a General Population Screened for a Low Ankle Brachial Index: A Randomized Controlled Trial [Original Contribution]

Conclusion  Among participants without clinical cardiovascular disease, identified with a low ABI based on screening a general population, the administration of aspirin compared with placebo did not result in a significant reduction in vascular events. Trial Registration  isrctn.org Identifier: ISRCTN66587262 (Source: JAMA)

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  Aspirin as Preventive Therapy in Patients With Asymptomatic Vascular Disease [Editorial]

(Source: JAMA)

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  Clinical Trial Summary: Aspirin for Asymptomatic Atherosclerosis (AAA)

The goal of the trial was to evaluate treatment with aspirin compared with placebo for primary prevention among patients with a low ankle brachial index (ABI). (Source: Cardiosource)

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  The antiplatelet effect of aspirin is reduced by proton pump inhibitors in patients with coronary artery disease

Conclusions Patients with CAD treated with PPIs had a reduced platelet response to aspirin, as shown by increased residual platelet aggregation and platelet activation, compared with patients with CAD not taking PPIs. Concomitant use of aspirin and PPIs might reduce the cardiovascular protection by aspirin. (Source: Heart)

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  Hearing Loss In Men Increased By Regular Analgesic Use

In a study published in the March 2010 issue of The American Journal of Medicine, researchers determined that regular use of aspirin, acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of hearing loss in men, particularly in younger men, below age 60. Hearing loss is the most common sensory disorder in the US, afflicting over 36 million people... (Source: Hearing / Deafness News From Medical News Today)

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  Hearing Loss In Men Increased By Regular Analgesic Use

In a study published in the March 2010 issue of The American Journal of Medicine, researchers determined that regular use of aspirin, acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of hearing loss in men, particularly in younger men, below age 60. Hearing loss is the most common sensory disorder in the US, afflicting over 36 million people. Not only is hearing loss highly prevalent among the elderly, but approximately one third of those aged 40-49 years already suffer from hearing loss... (Source: Health News from Medical News Today)

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  Aspirin Could Fight Fat's Heart Threat

What if you could be fat but avoid heart disease or diabetes? Some scientists say inflammation is the key. (Source: WDSU.com - Health)

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  Aspirin advice

Daily dose risky for people without heart disease (Source: BHF National News)

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  Can Aspirin Blur Line Between Fat, Healthy?

What if you could be fat but avoid heart disease or diabetes? Scientists trying to break the fat-and-disease link increasingly say inflammation is the key. (Source: WDSU.com - Health)

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  Fecal Occult Blood Test in Patients on Low-Dose Aspirin, Warfarin, Clopidogrel, or Non-steroidal Anti-inflammatory Drugs

Conclusion  Anticoagulants and antiplatelet medications lower the positive-predictive-value of FOBT for advance colonic neoplasia and should be stopped if clinically feasible prior to stool collection. Content Type Journal ArticleCategory Original ArticleDOI 10.1007/s10620-010-1150-4Authors Mandeep S. Sawhney, Minneapolis Veterans Affairs Medical Center Division of Gastroenterology Minneapolis MN USAHeather McDougall, Minneapolis Veterans Affairs Medical Center Division of Gastroenterology Minneapolis MN USADouglas B. Nelson, Minneapolis Veterans Affairs Medical Center Division of Gastroenterology Minneapolis MN USAJohn H. Bond, Minneapolis Veterans Affairs Medical Center Division of Gastroenterology Minneapolis MN USA Journal Digestive Diseases and SciencesOnl...

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  Aspirin, Acetaminophen and NSAID's Increase Risk of Male Hearing Loss

Regular analgesic use increases hearing loss in men - According to new study published in the American Journal of Medicine... (Source: Disabled World)

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  Painkillers linked to hearing loss

BOSTON, March 1 (UPI) -- Regular use of aspirin, acetaminophen and non-steroidal anti-inflammatory drugs increases the risk of hearing loss in men, U.S. researchers found. (Source: Health News - UPI.com)

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  Defining Patients at High Risk for Gastrointestinal Hemorrhage after Drug-Eluting Stent Placement: A Cost Utility Analysis

Conclusion: In average-risk patients, the risk of GI bleeding from DAT can be substantial without affecting the cost-effectiveness of DES. However, DES are unlikely to be cost-effective in patients with two or more risk factors for GI bleeding. (J Interven Cardiol 2010;**:1[ndash]9) (Source: Journal of Interventional Cardiology)

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  Aspirin Benefit Not Seen With Low Ankle Brachial Index

The use of aspirin may not lead to fewer vascular events in middle-aged and older individuals with a low ankle brachial index, according to research published in the March 3 issue of the Journal of the American Medical Association. (Source: Modern Medicine)

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  Aspirin Benefit Not Seen With Low Ankle Brachial Index

The use of aspirin may not lead to fewer vascular events in middle-aged and older individuals with a low ankle brachial index, according to research published in the March 3 issue of the Journal of the American Medical Association. (Source: Modern Medicine)

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  Thrombosis Prevention After Total Hip Arthroplasty: A Prospective, Randomized Trial Comparing a Mobile Compression Device with Low-Molecular-Weight Heparin

Conclusions: When compared with low-molecular-weight heparin, use of the mobile compression device for prophylaxis against venous thromboembolic events following total hip arthroplasty resulted in a significant decrease in major bleeding events. Level of Evidence: Therapeutic Level II. See Instructions to Authors for a complete description of levels of evidence. (Source: JBJS [Am])

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  Regular analgesic use increases hearing loss in men

(Elsevier Health Sciences) In a study published in the March 2010 issue of the American Journal of Medicine, researchers determined that regular use of aspirin, acetaminophen and non-steroidal anti-inflammatory drugs increases the risk of hearing loss in men, particularly in younger men, below age 60. (Source: EurekAlert! - Medicine and Health)

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  Dispatch: PLoS, Obama's Smoking, Infections, Aspirin, and Kristof

ACSH& rsquo;s Jeff Stier got the last word in the Los Angeles Times & rsquo; report on PLoS Medicine & rsquo;s recent announcement that they will no longer review studies that are funded by the tobacco industry. (Source: Health Facts and Fears)

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  Prescriptions for selective cyclooxygenase-2 inhibitors, non-selective non-steroidal anti-inflammatory drugs, and risk of breast cancer in a population-based case-control study

IntroductionNon-steroidal anti-inflammatory drugs (NSAIDs) prevent the growth of mammary tumours in animal models. Two population-based case-control studies suggest a reduced risk of breast cancer associated with selective cyclooxygenase-2 (sCox-2) inhibitor use, but data regarding the association between breast cancer occurrence and use of non-selective NSAIDs are conflicting. Methods: We conducted a population-based case-control study using Danish healthcare databases to examine if use of NSAIDs, including sCox-2 inhibitors, was associated with a reduced risk of breast cancer. We included 8,195 incident breast cancer cases diagnosed 1991 through 2006 and 81,950 population controls. Results: Overall, we found no reduced breast cancer risk in ever users (>2 prescriptions) of sCox-2 inhibit...

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  Regular Analgesic Use Increases Hearing Loss in Men

Researchers determined that regular use of aspirin, acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of hearing loss in men, particularly in younger men, below age 60. (Source: BWH for Journalists)

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  Regular Analgesic Use Increases Hearing Loss in Men

Researchers determined that regular use of aspirin, acetaminophen and non-steroidal anti-inflammatory drugs (NSAIDs) increases the risk of hearing loss in men, particularly in younger men, below age 60. (Source: BWH News)

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  Effects of aspirin, carprofen, deracoxib, and meloxicam on platelet function and systemic prostaglandin concentrations in healthy dogs.

Conclusions and Clinical Relevance-Oral administration of commonly used NSAIDs at therapeutic dosages in healthy dogs did not alter plasma TXB(2) and 6-keto PGF(1alpha) concentrations. Deracoxib administration resulted in a minor abnormality in platelet aggregation. Anti-inflammatory doses of aspirin did not affect platelet function as measured by use of optical aggregometry and a platelet-function analyzer. Further evaluation of the effects of aspirin and cyclooxygenase-2-selective inhibitors on hemostasis should be performed. PMID: 20187838 [PubMed - in process] (Source: American Journal of Veterinary Research)

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  The development of new analgesics over the past 50 years: a lack of real breakthrough drugs.

Authors: Kissin I Fifty-nine drugs identified as analgesics were introduced from 1960 to 2009 and remain in use. Seven can be regarded as having novel molecular targets; however, only one, sumatriptan, was sufficiently effective to motivate the introduction of many similar drugs acting at the same target (triptans). Publication productivity in the area of pain grew exponentially during this period. Pain-related publications on morphine were dominant among other analgesics. Very intensive research efforts directed at diverse molecular targets related to pain mechanisms produced thousands of publications, but those efforts have not yet yielded new analgesics with sufficient effectiveness to change the share of publications on opioids or nonsteroidal antiinflammatory drugs. Morphine and a...

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  Patients under anti-platelet therapy

Interruption or maintenance of anti-platelet agents (APAs) during surgical or invasive procedures is associated with an increase in cardiovascular or haemorrhagic complications, respectively. The pharmacology and indications of aspirin, clopidogrel and prasugrel are summarised. The utility and risks of interruption, the optimal delay between stent implantation and surgery, the appropriate window of preoperative interruption, the potential usefulness of bridging, the safest delay between the end of surgery and resumption of APA are detailed in this review. Some non- evidence-based suggestions are given to help the physicians in their daily clinical practice. (Source: Best Practice and Research. Clinical Anaesthesiology)

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  Analgesic Use and the Risk of Hearing Loss in Men

We examined the independent association between self-reported professionally diagnosed hearing loss and regular use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and acetaminophen in 26,917 men aged 40-74 years at baseline in 1986. Study participants completed detailed questionnaires at baseline and every 2 years thereafter. Incident cases of new-onset hearing loss were defined as those diagnosed after 1986. Cox proportional hazards multivariate regression was used to adjust for potential confounding factors.Results: During 369,079 person-years of follow-up, 3488 incident cases of hearing loss were reported. Regular use of each analgesic was independently associated with an increased risk of hearing loss. Multivariate-adjusted hazard ratios of hearing loss in regular users (2+...

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  Long-term Effect of Chronic Oral Anticoagulation with Warfarin after Acute Myocardial Infarction

Abstract: Background: Antiplatelet therapy is the principal component of the antithrombotic regimen after acute myocardial infarction. It remains unclear whether additional chronic oral anticoagulation (OAC) improves outcomes. We set out to evaluate the risk and benefit of long-term OAC after myocardial infarction.Methods: We pooled 10 randomized clinical trials comparing warfarin-containing regimens (OAC) with or without aspirin with non-OAC regimens with or without aspirin (No OAC) for patients with recent infarction. The primary endpoint was all-cause mortality. Other endpoints included recurrent infarction, stroke, and major bleeding. We calculated the odds ratio (OR) (fixed effect, OR (Source: The American Journal of Medicine)

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  Nocturia: An Uncommon Presentation of Lower-Limb Lymphedema

We report a case of nocturia as an uncommon presentation of lower-limb lymphedema in a 56-year-old man. To our knowledge, this is the first case reported in the literature. A 56-year-old man was admitted to the Department of Internal Medicine, University of Genova, on May 2008 for progressively worsening edema of the lower limbs. He had a history of nocturia (6-7 voids per night) since February 2007. Laboratory examination showed normal serum creatinine (0.7 mg/dL), urea nitrogen (13 mg/dL), and glucose (68 mg/dL). Urinalysis revealed normal urine pH (5.5), specific gravity (1.020), and osmolarity (750 mOsm/kg), and absence of proteinuria. Microalbuminuria, serum total protein, and albumin levels were in the normal range (20 mg/24 h, 7.2 g/dL, and 4.2 g/dL, respectively). Serum levels of ...

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  Thrombosis prevention after total hip arthroplasty: a prospective, randomized trial comparing a mobile compression device with low-molecular-weight heparin.

CONCLUSIONS: When compared with low-molecular-weight heparin, use of the mobile compression device for prophylaxis against venous thromboembolic events following total hip arthroplasty resulted in a significant decrease in major bleeding events. LEVEL OF EVIDENCE: Therapeutic Level II. See Instructions to Authors for a complete description of levels of evidence. PMID: 20194309 [PubMed - in process] (Source: The Journal of Bone and Joint Surgery. American volume)

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  Response to Ticagrelor in Clopidogrel Nonresponders and Responders and Effect of Switching Therapies. The RESPOND Study.

Conclusions-Ticagrelor therapy overcomes nonresponsiveness to clopidogrel, and its antiplatelet effect is the same in responders and nonresponders. Nearly all clopidogrel nonresponders and responders treated with ticagrelor will have platelet reactivity below the cut points associated with ischemic risk. Clinical Trial Registration-http://www.clinicaltrials.gov. Unique Identifier: NCT00642811. PMID: 20194878 [PubMed - as supplied by publisher] (Source: Circulation)

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  Combination Antiplatelet Therapy for Secondary Stroke Prevention: Enhanced Efficacy or Double Trouble?

Conclusion: Aspirin and clopidogrel combined are associated with more bleeding than aspirin or clopidogrel alone. Summary: Aspirin is effective as an antithrombotic agent for secondary stroke prevention. It reduces the risk of secondary stroke 15% to 20% compared with placebo (BMJ 1994;308:81-106) but fails to prevent many events; therefore, other antithrombotic agents have been investigated for secondary stroke prevention. All antithrombotic agents, however, carry a bleeding risk, and some bleeding episodes are fatal; for example, bleeding associated with antithrombotic agents for secondary prevention leads to higher mortality in patients with acute coronary syndromes (Circulation 2006;114:774-82). In this report the authors sought to compare bleeding risk associated with secondary strok...

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  Rationale, design, and baseline data of the Japanese Primary Prevention Project (JPPP)—A randomized, open-label, controlled trial of aspirin versus no aspirin in patients with multiple risk factors for vascular events

Conclusion: The JPPP is the largest primary prevention trial of aspirin in a Japanese population that is investigating whether the benefit of aspirin in reducing risk of vascular events outweighs any bleeding risk in elderly patients with multiple risk factors. (Source: American Heart Journal)

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  Evidence of disparity in the application of quality improvement efforts for the treatment of acute myocardial infarction: The American College of Cardiology's Guidelines Applied in Practice Initiative in Michigan

Conclusions: The GAP program led to significant increases in rates of evidence-based care in both white and nonwhite Medicare patients. However, nonwhite patients received less quality improvement discharge tool and smoking cessation counseling. Policies designed to reduce racial disparities in health care must address disparity in the delivery of quality improvement programs. (Source: American Heart Journal)

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  Clinical relevance of clopidogrel unresponsiveness during elective coronary stenting: Experience with the point-of-care Platelet Function Assay–100 C/ADP

Conclusions: Unresponsiveness to clopidogrel as assessed by the point-of-care test PFA-100C/ADP is an independent major risk factor for thrombotic complications after coronary intervention. (Source: American Heart Journal)

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  ASA: Antiplatelet Tops Aspirin for Secondary Stroke Prevention (CME/CE)

Cilostazol, an antiplatelet agent used in the U.S. to treat intermittent claudication, was better than aspirin at preventing recurrent stroke from noncardiogenic sources, a randomized trial conducted in Japan showed. (Source: MedPage Today Cardiovascular)

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  Resveratrol May Replace Aspirin As Heart Protector; Longevinex® First Branded Resveratrol Pill Successfully Tested During Heart Attack

With the realization that half of the people experiencing a sudden mortal heart attack were taking aspirin on the day of their demise, researchers have begun to search for a more reliable alternative, and they may have found it in a red wine molecule called resveratrol (rez-vair-ah-trawl)... (Source: Cardiovascular / Cardiology News From Medical News Today)

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  Resveratrol May Replace Aspirin As Heart Protector; Longevinex® First Branded Resveratrol Pill Successfully Tested During Heart Attack

With the realization that half of the people experiencing a sudden mortal heart attack were taking aspirin on the day of their demise, researchers have begun to search for a more reliable alternative, and they may have found it in a red wine molecule called resveratrol (rez-vair-ah-trawl). Researchers at the University of Connecticut induced heart attacks in animals and found resveratrol significantly reduces damage to heart muscle. Scarring and fibrosis were limited and the animals survived an otherwise mortal event. Dipak Das, Ph.D., Sc.D... (Source: Health News from Medical News Today)

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  Antiplatelet Drug May Be Better Than Aspirin In Preventing Recurrent Strokes

This study demonstrated for the first time that cilostazol significantly reduces the risk of recurrent ischemic [blood-clot caused] stroke and the incidence of serious cerebral hemorrhage, compared to aspirin," said Yukito Shinohara, M.D... (Source: Health News from Medical News Today)

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  Antiplatelet Drug May Be Better Than Aspirin In Preventing Recurrent Strokes

The antiplatelet drug cilostazol used in the United States to treat leg pain associated with peripheral vascular disease was more effective and safer than aspirin at preventing recurrent strokes in a Japanese trial presented as late-breaking science at the American Stroke Association's International Stroke Conference 2010... (Source: Stroke / Neuroprotection News From Medical News Today)

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  Advisers alter aspirin recommendations

ROCKVILLE, Md., Feb. 26 (UPI) -- U.S. health advisers have altered their advice on using low-dose aspirin to reduce cardiovascular risk, officials said. (Source: Health News - UPI.com)

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  This Day in Science History - February 27 - Aspirin

February 27th could be considered aspirin's birthday. The process to make aspirin was patented in 1900 by Felix Hoffman on behalf of the German pharmaceutical company, Bayer. Hoffman's aspirin was a stable form of acetylsalicylic acid and named in three parts for this active ingredient. The 'A' was from acetyl, 'spir' was from the source of slaicin, the spirea plant, and 'in' was tacked on the end to give it a good pharmacological sounding name. Find out how to make your own aspirin and what else occurred on this day in science history.This Day in Science History - February 27 - Aspirin originally appeared on About.com Chemistry on Saturday, February 27th, 2010 at 00:05:24.Permalink | Comment | Email this (Source: About.com Chemistry)

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  Current Blood Thinners Face Tough Competition

Studies provide more evidence that newcomers hold mettle against warfarin, aspirin Source: HealthDay Related MedlinePlus Pages: Blood Thinners, Stroke (Source: MedlinePlus Health News)

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  Prothrombinase formation at the site of microvascular injury and aspirin resistance: The effect of simvastatin

The production of thrombin is determined by the formation of the prothrombinase complex, which assembles predominantly on activated platelets. Aspirin that suppresses the synthesis of thromboxane A2 (TXA2) has been shown to reduce thrombin formation at the site of injury . We have reported that impaired platelet sensitivity to aspirin, called aspirin resistance, is associated with faster thrombin generation following injury . (Source: Thrombosis Research)

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  The effect of the long term aspirin administration on the progress of atherosclerosis in apoE-/- LDLR-/- double knockout mouse

Conclusion: Our results suggest that endothelial dysfunction with low dose aspirin improved, reduced progression of atherosclerosis in apoE-/- and LDLR-/- double deficient mice and provides a pathophysiological basis for the beneficial effects of aspirin in atherosclerosis, and low doses appeared to be more efficient than high doses. (Source: Thrombosis Research)

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  Cardiologists Comment on Aspirin Versus Resveratrol

FT. LEE, N.J., Feb. 26 /PRNewswire/ -- With the realization that half of the people experiencing a sudden mortal heart attack were taking aspirin on the day of their demise, and the fact that higher-than-recommended doses of aspirin are needed to... (Source: Drugs.com - Clinical Trials)

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  Methylphenidate (Ritalin) and acute myocardial infarction

3 out of 5 stars Acute Myocardial Infarction Related to Methylphenidate for Adult Attention Deficit Disorder.  Thompson J et al.  J Emerg Med 2010;38:18-21. Abstract This case report describes at 27-year-old man who presented to the emergency department with an acute anterolateral myocardial infarction after taking several extra doses of methylphenidate (Ritalin®) prescribed for adult attention deficit disorder, along with pseudoephedrine.  Cardiac catheterization showed normal coronary arteries, inferolateral hypokinesis, and an ejection fraction of 50%.  He was discharged after two days, at which time an echocardiogram showed an ejection fraction of 55% and no wall motion abnormalities.  The authors make the following points: • methylphenidate is a psychostimulant with effects si...

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  Daily aspirin therapy: Understand benefits, risks

Daily aspirin therapy can be lifesaving or life-threatening. Discover if you're a good candidate. (Source: MayoClinic.com Full Feed)

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  Group CBT has sustained benefits for back pain

Group CBT is a low-cost therapy for low-back pain with year-long benefitsRelated items from OnMedicaFalls prevention services are not evidence-basedWomen with small babies can safely wait for labourPay more heed to parent concern over sick childrenPreventative role of aspirin questionedGPs not prescribing enough beta blockers (Source: OnMedica Latest News)

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  Heart failure

New evidence; conclusions changed for: Angiotensin II receptor blockers for diastolic heart failure One RCT added comparing irbesartan versus placebo found no significant difference between irbesartan and placebo in all-cause mortality or in hospital admission for cardiovascular causes at a mean follow-up of 49.5 months. Evidence for effect of irbesartan on hospital admission for cardiovascular disease differs from evidence previously reported for candesartan for this outcome. Effects of angiotensin II receptor blockers as a class in treatment of diastolic heart failure is unclear. Categorisation changed from Likely to be beneficial to Unknown effectiveness. New evidence; conclusion confirmed for: Multidisciplinary intervent...

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  Risk of Venous Thromboembolism in Long-Term Care Residents: What Do We Know Now?

The article by Barbara Zarowitz and colleagues on the risk of venous thromboembolism (VTE) in long-term care (LTC) is a brave attempt to stratify thrombotic risk in LTC. Their systematic review of more than 8 years of data identified a total of 1165 publications relating to VTE and immobility. Rating these publications according to accepted quality criteria resulted in selection of 4 articles relating to thrombotic risk, and 1 article (1 of these 4, actually) relating to immobility. Eight mobility-related statements and 30 VTE risk statements were derived from these articles. The authors' final recommendations (reached by modified Delphi method of analysis of the mobility and VTE risk statements) include baseline thrombotic risk screening on admission; prophylaxis for up to 35 days if high...

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  Resveratrol May Replace Aspirin As Heart Protector; Longevinex® First Branded Resveratrol Pill Successfully Tested During Experimental Heart Attack

With the realization that half of the people experiencing a sudden mortal heart attack were taking aspirin on the day of their demise, researchers have begun to search for a more reliable alternative, and they may have found it in a red wine molecule called resveratrol (rez-vair-ah-trawl). (Source: Pharmaceutical Online News)

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  Aspirin Use in Vascular Disease Patients Assessed

About 70 percent of vascular disease patients take aspirin, mainly for secondary prevention. While some non-aspirin users take other antithrombotic agents, almost 15 percent of patients take no antithrombotic agent at all, according to research published in the Feb. 15 American Journal of Cardiology. (Source: Modern Medicine)

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  Cilostazol in the Management of Atherosclerosis.

Authors: Sallustio F, Rotondo F, Di Legge S, Stanzione P The burden of atherosclerosis is particularly high in western countries in terms of mortality and disability. The cerebral arteries (stroke or transient ischemic attack [TIA]), coronary arteries (myocardial infarction [MI]) and peripheral arteries (intermittent claudication [IC], ischemic limb) can be affected. Atherosclerosis may involve different mechanisms such as inflammation, platelet activation, endothelial damage, balance between proliferation and apoptosis of smooth muscle cells and oxidative stress. Research is focused to counteract each of these aspects. Many antithrombotic drugs are currently available and most of them act as inhibitors of platelet function. Aspirin, ticlopidine, clopidogrel and the combination of aspi...

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  Rethinking an Aspirin-a-Day

New Federal Guidelines Say Many Now Taking It Daily to Try to Lower Cardiac Risk Shouldn't, Due to Intestinal Bleeding Risk (Source: Health News: CBSNews.com)

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  Treatment of Coagulopathy in Intracranial Hemorrhage

Opinion statement  Intracranial hemorrhage (ICH) complicated by coagulopathy is a medical emergency, which can delay neurosurgical intervention, lead to larger hematoma size, and increase mortality until the coagulopathy is corrected. Prompt recognition of coagulopathy during ICH is essential for correct, rapid treatment to reduce ongoing bleeding and improve survival. The proper treatment of a coagulopathic ICH patient is centered on rapid identification of the coagulopathic defect and correction of the underlying coagulopathy to stop acute bleeding. Patients with coagulopathic ICH require admission to a neuro-intensive unit care with management of airway, oxygenation, and systemic arterial and cerebral perfusion pressure; optimization of serum glucose; aggressive treatmen...

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  EXCEDRIN (Acetaminophen, Aspirin (Nsaid) And Caffeine) Tablet, Film Coated [Novartis Consumer Health, Inc.]

Updated Date: Feb 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  EXCEDRIN (Acetaminophen, Aspirin And Caffeine) Tablet, Film Coated [Novartis Consumer Health, Inc.]

Updated Date: Feb 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Drug Interaction Between Clopidogrel and Proton Pump Inhibitors

Pharmacotherapy 30(3): 275-289 Abstract Proton pump inhibitors (PPIs) have been recommended for reducing the risk of gastrointestinal bleeding associated with dual antiplatelet therapy (aspirin plus clopidogrel). However, studies have found decreased efficacy of clopidogrel when concurrently administered with a PPI. To determine the mechanism of and evidence for the potential interaction between clopidogrel and PPIs, along with the clinical implications of this drug interaction, we reviewed recently published reports of trials that examined the interaction. A MEDLINE database search (1966-September 2009) for English-language reports of clinical trials in human subjects was performed, supplemented by a manual search of reference lists. Four trials that examined surrogate outcomes and eight ...

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  Dilated Cardiomyopathy and Role of Antithrombotic Therapy.

CONCLUSIONS:: To date, there is no agreement on appropriate antithrombotic treatment (if any) for primary thromboembolism prophylaxis in patients with dilated cardiomyopathy with sinus rhythm. In recent years, several promising prospective trials were terminated prematurely due to inadequate enrollment. The Warfarin Aspirin-Reduced Cardiac Ejection Fraction trial may provide evidence regarding the use of anticoagulation for patients with decreased myocardial function. PMID: 20186041 [PubMed - as supplied by publisher] (Source: The American Journal of the Medical Sciences)

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  Effect of Combined Aspirin and Extended-Release Dipyridamole Versus Clopidogrel on Functional Outcome and Recurrence in Acute, Mild Ischemic Stroke. PRoFESS Subgroup Analysis.

CONCLUSIONS: Treatment with combined Asp/ER-DP vs clopidogrel in 1360 patients with acute, mild ischemic stroke did not differ in terms of effects on functional outcome, recurrence, death, bleeding, or serious adverse events. Both treatments were practical to administer. PMID: 20181679 [PubMed - as supplied by publisher] (Source: Stroke)

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  Antithrombotic activity of F 16618, a new PAR1 antagonist evaluated in extracorporeal arterio-venous shunt in the rat.

In conclusion, F 16618 exerted a potent antithrombotic activity by intravenous and oral routes, without affecting bleeding time. Furthermore, the antithrombotic activity was potentiated when combined with aspirin or clopidogrel. PMID: 20188709 [PubMed - as supplied by publisher] (Source: Biochemical Pharmacology)

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  Cleveland Medical Malpractice Attorney Obtains Settlement in Wrongful Death Case

NASA engineer dies after instructions to stop taking Plavix® and Aspirin for elective colonoscopy. Cleveland medical malpractice attorney (http://medical-malpractice.spanglaw.com/) nets settlement for widow. (PRWeb Feb 23, 2010) Read the full story at http://www.prweb.com/releases/top-medical-malpractice/attorneys-cleveland-ohio/prweb3611524.htm (Source: PRWeb: Medical Pharmaceuticals)

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  Women Warned Aspirin Reports May Be Misleading

Recent research from the US suggests women who have been diagnosed with breast cancer may benefit from taking aspirin but the National Prescribing Service (NPS) warns people to talk to their health professional before self-medicating. The study, published in the Journal of Clinical Oncology, has received significant media attention, with some reports suggesting aspirin could be a miracle treatment... (Source: Health News from Medical News Today)

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  Women Warned Aspirin Reports May Be Misleading

Recent research from the US suggests women who have been diagnosed with breast cancer may benefit from taking aspirin but the National Prescribing Service (NPS) warns people to talk to their health professional before self-medicating... (Source: Breast Cancer News From Medical News Today)

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  Herbal products may pose danger for heart patients

3 out of 5 stars Use of Herbal Products and Potential Interactions in Patients with Cardiovascular Diseases. Tachjian A et al.  J Am Coll Cardiol Feb 9, 2010;55:515-25. Abstract Use of unregulated herbal remedies is common and increasing dramatically among patients also taking prescription medicines. Unfortunately, these herbal products can have detrimental effects of their own, as well as potential interactions with other medications.  This review, form the Mayo Clinic, searched PubMed and Medline databases for the years 1966 to 2009 to identify medical literature related to herbs and cardiovascular disease. Among the authors’ findings: • Many herbal products can potentially increase bleeding, especially in patients on warfarin, aspirin, and anti-platelet drugs.  Such herbal pr...

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  Baseline Characteristics of the Nateglinide and Valsartan Impaired Glucose Tolerance Outcomes Research (NAVIGATOR) Trial Population: Comparison with Other Diabetes Prevention Trials

In conclusion, the NAVIGATOR study comprises prediabetic subjects who typically have concurrent BP and metabolic disturbances and an enhanced risk of CVD, and are thus at higher risk for cardiovascular events than subjects in previous DM prevention trials. (Source: Cardiovascular Therapeutics)

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  Modulation of stress genes expression profile by nitric oxide-releasing aspirin in Jurkat T leukemia cells.

In this study, DNA oligo arrays with 263 genes were used to examine the gene expression profiles relating to stress and drug metabolism, and characterize the stress responses at IC(50) and subIC(50) concentrations of p-NO-ASA (20 and 10muM, respectively) in Jurkat T cells. A total of 22 genes related to heat shock response, apoptosis signaling, detoxifiers and Phase II enzymes, and regulators of cell growth were altered in expression by array analysis based on the expression fold change criteria of >/=1.5-fold or </= 0.65 -fold. Real time quantitative RT-PCR confirmed that 20muM p-NO-ASA strongly upregulated the mRNA levels of two heat shock genes HSPA1A (41.5+/-7.01-fold) and HSPA6 (100.4+/-8.11-fold), and FOS (16.2+/-3.2-fold), moderately upregulated HSPH1 (1.71+/-0.43-fold), FMO4 ...

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  Why every man should carry a giant chewy aspirin

When Chris Atkinson felt a searing pain in his chest, he knew straight away what was wrong. Then Chris remembered he had an aspirin in his car. (Source: the Mail online | Health)

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  No to homeopathy placebo | Edzard Ernst

Using homeopathy on the basis that patients benefit from the placebo effect would be unethical and short-sightedWhen I began my research as professor of complementary medicine in Exeter 17 years ago, I was entirely open to homeopathy. I had been treated for many years by a homeopathic doctor, my father had practised homeopathy and I had begun my medical career in a homeopathic hospital. But now my job was to apply science to the field and, to do this properly, one needs to be not just open but also critical.The first thing any critical mind has to note is that the two basic assumptions of homeopathy fly in the face of science. Like does not cure like and diluting remedies ad infinitum does not render them stronger but weaker. But perhaps there was something entirely new and undiscovered he...

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  Aspirin for primary prevention of cardiovascular disease?

Cardiovascular disease (CVD) is a leading cause of mortality.1 For example, in 2000, it accounted directly for around 2 million deaths in the European Union.2 Worldwide, many people take aspirin daily in the belief that doing so helps to prevent CVD. This approach is established for the secondary prevention of recurrent vascular events.1,3,4,5 However, there has been some uncertainty about the place of aspirin for the primary prevention of cardiovascular events.6 In particular, there have been doubts about whether any benefits of aspirin in people with no history of CVD outweigh the risks (e.g. the fact that long-term low-dose aspirin therapy almost doubles the likelihood of gastrointestinal haemorrhage7,8). Here we consider the place of low-dose aspirin in primary prevention of CVD. BNF 2...

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  Anticancer Effects of Aspirin: FAQ

Title: Anticancer Effects of Aspirin: FAQCategory: Health NewsCreated: 2/22/2010 11:37:00 AMLast Editorial Review: 2/22/2010 11:37:15 AM (Source: MedicineNet Cancer General)

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  Anticancer Effects of Aspirin: FAQ

(Source: eMedicineHealth.com)

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  Anticancer Effects of Aspirin: FAQ

Title: Anticancer Effects of Aspirin: FAQCategory: Health NewsCreated: 2/22/2010 11:37:00 AMLast Editorial Review: 2/22/2010 11:37:15 AM (Source: MedicineNet Mens Health General)

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  Clinical and geographical variation in prophylactic and therapeutic treatments for pre-eclampsia in the UK

Conclusions Prophylactic and treatment regimes for pre-eclampsia in the UK vary by region and risk group. (Source: BJOG: An International Journal of Obstetrics and Gynaecology)

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  Clinical and geographical variation in prophylactic and therapeutic treatments for pre-eclampsia in the UK.

Conclusions Prophylactic and treatment regimes for pre-eclampsia in the UK vary by region and risk group. PMID: 20175876 [PubMed - as supplied by publisher] (Source: BJOG : An International Journal of Obstetrics and Gynaecology)

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  Platelet-Large Cell Ratio and the extent of coronary artery disease: results from a large prospective study

This study showed that P-LCR is not related to platelet aggregation, aspirin resistance, the extent of CAD and carotid IMT. Thus, P-LCR can not be considered as a marker of platelet reactivity or a risk factor for CAD. Content Type Journal ArticleDOI 10.1007/s11239-010-0456-6Authors Giuseppe De Luca, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Eastern Piedmont University Division of Cardiology C.so Mazzini, 18 28100 Novara ItalyMatteo Santagostino, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Eastern Piedmont University Division of Cardiology C.so Mazzini, 18 28100 Novara ItalyGioel Gabrio Secco, Azienda Ospedaliera-Universitaria “Maggiore della Carità”, Eastern Piedmont University Division of Cardiology C.so Mazzini, 18 28100 Novara Ital...

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  Impact of High-Responsiveness to Dual Antiplatelet Therapy on Bleeding Complications in Patients Receiving Drug-Eluting Stents.

Conclusions: In the present study high-responsiveness to antiplatelet therapy was associated with an increased risk of bleeding with no reduction in adverse cardiac events. Measuring platelet reactivity may be useful for risk stratification according to bleeding complications, as well as adverse cardiac events, in patients treated with drug-eluting stents. PMID: 20173303 [PubMed - as supplied by publisher] (Source: Circulation Journal)

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  Incidence of Bleeding After 15,181 Percutaneous Biopsies and the Role of Aspirin

CONCLUSION. The overall incidence of major bleeding after imaging-guided percutaneous core needle biopsy is low. Recent aspirin therapy does not appear to significantly increase the risk of such bleeding complications. (Source: American Journal of Roentgenology)

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  Health Buzz: Blood Test May Detect Cancer's Spread

Aspirin for breast-cancer survivors, a connection between intense sugar cravings and later alcoholism. (Source: U.S. News - Health)

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  Aspirin "improves cancer survival"

A study has shown that breast cancer patients who take aspirin are less likely to die of the disease (Source: Nursing in Practice)

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  The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-1 [Protein Synthesis and Degradation]

Nedd4 (Nedd4-1) is a Hect domain E3 ubiquitin ligase that also contains a C2 domain and three WW domains. Despite numerous in vitro studies, its biological function in vivo is not well understood. Here we show that disruption of Nedd4-1 in mice (leaving Nedd4-2 intact) caused embryonic lethality at mid gestation, with pronounced heart defects (double-outlet right ventricle and atrioventricular cushion defects) and vasculature abnormalities. Quantitative mass spectrometry and immunoblot analyses of lysates from the wild type and knock-out mouse embryonic fibroblasts to identify Nedd4-1 in vivo targets revealed dramatically increased amounts of thrombospondin-1 (Tsp-1) in the knock-out mouse embryonic fibroblasts and embryos. Tsp-1 is an inhibitor of angiogenesis, and its elevated level was ...

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  AJR: Complications rates are low with core-needle biopsies

The overall incidence of major bleeding after imaging-guided percutaneous core-needle biopsy is low, and recent aspirin therapy does not appear to significantly increase the risk of such bleeding complications, according to a retrospective study in the March issue of the American Journal of Roentgenology. (Source: Health Imaging News)

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  AJR: Complications rates are low with core-needle biopsies

The overall incidence of major bleeding after imaging-guided percutaneous core-needle biopsy is low, and recent aspirin therapy does not appear to significantly increase the risk of such bleeding complications, according to a retrospective study in the March issue of the American Journal of Roentgenology. (Source: Health Imaging News)

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  Bleeding Risk Associated With Image-Guided Biopsies Is Low

Even among patients who have taken aspirin in proximity to an image-guided percutaneous biopsy, risk of major bleeding associated with the procedure is low, according to a study in the March issue of the American Journal of Roentgenology. Image-guided percutaneous biopsies are an important means of diagnosing disease in organs and other soft tissues. They involve the removal of cells or tissues for examination. "With the evolution of imaging guidance, percutaneous biopsy has become a valuable tool in obtaining tissue for diagnosis," said Thomas D. Atwell, MD, lead author of the study... (Source: Health News from Medical News Today)

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  Aspirin linked to breast cancer survival rates

Aspirin could boost survival chances in breast cancer patients, according to a study by Cancer Research UK (Source: Nursing Times Breaking News)

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  Bleeding risk associated with image-guided biopsies is low

(American College of Radiology / American Roentgen Ray Society) Even among patients who have taken aspirin in proximity to an image-guided percutaneous biopsy, risk of major bleeding associated with the procedure is low, according to a study in the March issue of the American Journal of Roentgenology. Image-guided percutaneous biopsies are an important means of diagnosing disease in organs and other soft tissues. They involve the removal of cells or tissues for examination. (Source: EurekAlert! - Medicine and Health)

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  Anticancer Effects of Aspirin: FAQ

Regular aspirin lowers the risk of breast cancer recurrence. WebMD answers frequently asked questions about aspirin and cancer. (Source: WebMD Health)

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  Aspirin Cuts Cancer Deaths; Painkiller Can Boost Breast Cancer Survival Rates by 71%

Women with breast cancer who take aspirin at least twice a week can more than double their chance of surviving, researchers say. The greatest protection comes from taking the drug on two to five days, a study has found. (Source: Cancercompass News: Breast Cancer)

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  Comparison of efficacy of antiplatelet treatments for patients with claudication. A meta-analysis.

Authors: Basili S, Raparelli V, Vestri A, Di Tanna GL, Violi F It was the aim of the present study to investigate if antiplatelet treatment reduced cardiovascular events in patients with claudication and/or an ankle/brachial index (ABI) pound0.99 and to analyse if specific antiplatelet treatment had a different impact on clinical outcome. We performed a meta-analysis of 29 clinical randomized trials on antiplatelet therapy for prevention of vascular death, myocardial infarction, and stroke in 10,735 peripheral artery disease patients. The primary end-point utilizing in the meta-analysis construction was Cardiovascular Adverse Event. We found 1,900 (17.70%) patients in trials with aspirin, 5,326 (49.61%) in those with thienopyridines, 2,324 (21.65%) in those with picotamide and 1,185 (1...

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  [Status of leukotrienes in the pathophysiology of asthma. Necessity for antileukotrienes treatment.]

Authors: Fal AM, Kopeć A Asthma is a chronic inflammatory airway disease in which many inflammatory cells and mediators participate. Inhaled corticosteroids (ICs) are recommended as the most effective anti-inflammatory medications currently available for the treatment of asthma. However, some patients don't achieve asthma control even when these agents are used in high doses in monotherapy or in combination with long-acting beta2-mimetics. During asthmatic inflammation various cellular pathways are activated. Among them, leukotriene synthesis pathway is of great importance. Leukotrienes, such as leukotriene C4, D4, E4 (named "cysteinyl-leukotrienes") are known as both strong bronchoconstrictors and inflammation stimulators. They increase vascular permeability, mucus production in...

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  Aspirin: A Blockbuster Therapy for Breast Cancer Survivors?

Aspirin’s anti-inflammatory effects appear to cut the risk of a breast cancer recurrence. (Source: U.S. News - Health)

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  Aspirin: A Blockbuster Therapy for Breast Cancer Survivors?

Aspirin’s anti-inflammatory effects appear to cut the risk of a breast cancer recurrence. (Source: U.S. News - Health)

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  Researchers pioneer liquid aspirin

A liquid aspirin 'lotion' could be developed using pharmaceutically active ionic liquids, a university expert has said. (Source: Pharmacy Europe)

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  Aspirin Could Lower Chance Of Breast Cancer Recurrence, Death, Study Finds

Breast cancer survivors who regularly took aspirin after completing treatment were 50% less likely than survivors who did not take aspirin to die or have a recurrence, according to a study published Wednesday in the Journal of Clinical Oncology, USA Today reports (Szabo, USA Today, 2/17). According to the Los Angeles Times, the results were "surprising" because at least five large studies have shown that an aspirin regimen has little to no effect on the risk of developing breast cancer. Tumor growth is linked to inflammation, which is reduced by aspirin, the Times reports... (Source: Health News from Medical News Today)

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  Aspirin Could Lower Chance Of Breast Cancer Recurrence, Death, Study Finds

Breast cancer survivors who regularly took aspirin after completing treatment were 50% less likely than survivors who did not take aspirin to die or have a recurrence, according to a study published Wednesday in the Journal of Clinical Oncology, USA Today reports (Szabo, USA Today, 2/17)... (Source: Pain / Anesthetics News From Medical News Today)

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  An Ibuprofen A Day Could Keep Parkinson's Disease Away

New research shows people who regularly take ibuprofen may reduce their risk of developing Parkinson's disease, according to a study released that will be presented at the American Academy of Neurology's 62nd Annual Meeting in Toronto April 10 to April 17, 2010. The research involved 136,474 people who did not have Parkinson's disease at the beginning of the research. Participants were asked about their use of non-steroid anti-inflammatory drugs (NSAIDs), including aspirin, ibuprofen and acetaminophen. After six years, 293 participants had developed Parkinson's disease... (Source: Health News from Medical News Today)

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  Aspirin cuts cancer deaths: Painkiller can boost breast cancer survival rates by 71%

The greatest protection comes from taking the drug on two to five days, a study has found. (Source: the Mail online | Health)

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  Pain Meds Disconnected from Skin Cancer

(Ivanhoe Newswire) -- Non-steroidal anti-inflammatory (NSAID) drugs like aspirin and ibuprofen do not appear to decrease the risk of common types of skin cancer. (Source: Medical Headlines From Ivanhoe.com)

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  Maalox Total Relief and Maalox Liquid Products: Medication Use Errors

Consumers who have a history of gastrointestinal ulcers or a bleeding disorder should not use Maalox Total Relief because it contains bismuth subsalicylate, a substance chemically related to aspirin. (Source: FDA MedWatch)

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  Aspirin May Boost Survival in Breast Cancer

Regular aspirin use was associated with a decreased risk for distant recurrence and cancer-related death among breast cancer survivors. Medscape Medical News (Source: Medscape Today Headlines)

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  Cancer survival with aspirin explored

Conclusion This preliminary study found an association between the frequency of aspirin use and the risk of recurrence of breast cancer and breast cancer-associated deaths. The researchers highlight the following limitations of the study: The women’s aspirin intake, treatments and whether their cancer reoccurred were given by self-report. It is possible that participants may not have accurately recalled this information. The study only asked about the weekly frequency of aspirin use and did not ask about the daily dose of aspirin that participants took. This is likely to vary between individuals. The study population were all nurses who worked within the health system. It is possible that their health and lifestyle may differ from the general population. This type of study c...

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  Study: Aspirin Aids Breast Cancer Defense

Patients Who Took Aspirin After Completing Treatment for Breast Cancer Were Less Likely to Die, See Tumors Spread (Source: Health News: CBSNews.com)

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  Study: Aspirin May Slow Cancer Spread

Study Shows Regular Aspirin Use May Keep Cancer From Spreading, Cut Death Risk (Source: Health News: CBSNews.com)

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  Aspirin Use Associated with Reduced Risk for Breast Cancer Mortality

(Source: Physician's First Watch current issue)

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  Aspirin could halve risk of women dying from breast cancer

Women who take aspirin regularly are half as likely to die from breast cancer, a startling new study has found. (Source: the Mail online | Health)

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  Large Analysis Finds Breast Cancer Patients Who Take Aspirin Reduced Risk Of Metastasis And Death By Half

An analysis of data from the Nurse's Health Study, a large, ongoing prospective observational study, shows that women who have completed treatment for early-stage breast cancer and who take aspirin have a nearly 50 percent reduced risk of breast cancer death and a similar reduction in the risk of metastasis... (Source: Health News from Medical News Today)

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  Large Analysis Finds Breast Cancer Patients Who Take Aspirin Reduced Risk Of Metastasis And Death By Half

An analysis of data from the Nurse's Health Study, a large, ongoing prospective observational study, shows that women who have completed treatment for early-stage breast cancer and who take aspirin have a nearly 50 percent reduced risk of breast cancer death and a similar reduction in the risk of metastasis... (Source: Breast Cancer News From Medical News Today)

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  Aspirin Linked To Increased Breast Cancer Survival

A new US study suggests that regular taking of aspirin is linked to increased survival after a breast cancer diagnosis and also to a lower risk of the disease recurring... (Source: Breast Cancer News From Medical News Today)

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  Aspirin Linked To Increased Breast Cancer Survival

A new US study suggests that regular taking of aspirin is linked to increased survival after a breast cancer diagnosis and also to a lower risk of the disease recurring. However, as this was an observational study that suggests a possible link and not a clinical trial, the researchers recommended women do not use these findings as a reason to start taking aspirin as a way to increase survival from, and prevent recurrence of, breast cancer... (Source: Health News from Medical News Today)

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  Aspirin might reduce recurrence risk for breast cancer survivors, study finds

Women who took aspirin two to five days per week were 60% less likely to have a recurrence and 71% less likely to die from the disease. But researchers caution that the results are preliminary. Women who take aspirin regularly after their breast cancer goes into remission are about 50% less likely to suffer a recurrence or to die from the disease, according to new findings from the ongoing Nurses' Health Study. (Source: Los Angeles Times - Science)

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  Aspirin might reduce recurrence risk for breast cancer survivors, study finds

Women who took aspirin two to five days per week were 60% less likely to have a recurrence and 71% less likely to die from the disease. But researchers caution that the results are preliminary. Women who take aspirin regularly after their breast cancer goes into remission are about 50% less likely to suffer a recurrence or to die from the disease, according to new findings from the ongoing Nurses' Health Study. (Source: L.A. Times - Health)

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  Aspirin May Boost Breast Cancer Survival

Title: Aspirin May Boost Breast Cancer SurvivalCategory: Health NewsCreated: 2/16/2010 4:10:00 PMLast Editorial Review: 2/17/2010 (Source: MedicineNet Chronic Pain General)

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  Aspirin May Boost Breast Cancer Survival

Title: Aspirin May Boost Breast Cancer SurvivalCategory: Health NewsCreated: 2/16/2010 4:10:00 PMLast Editorial Review: 2/17/2010 (Source: MedicineNet Cancer General)

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  Aspirin May Boost Breast Cancer Survival

Title: Aspirin May Boost Breast Cancer SurvivalCategory: Health NewsCreated: 2/16/2010 4:10:00 PMLast Editorial Review: 2/17/2010 (Source: MedicineNet Arthritis General)

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Top Viagra Store

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