MedWorm: Ambien

  GABA(A) alpha-1 subunit mediated desynchronization of elevated low frequency oscillations alleviates specific dysfunction in stroke – A case report

Conclusions: In JP, functional deficits and pathological oscillations appear coincidentally reduced following administration of low-dose zolpidem.Significance: GABA(A) alpha-1 sensitive desynchronisation of pathological oscillations may represent a biomarker and potential therapeutic target in brain injury. (Source: Clinical Neurophysiology)

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  General and Efficient Copper-Catalyzed Three-Component Coupling Reaction towards Imidazoheterocycles: One-Pot Synthesis of Alpidem and Zolpidem.

Authors: Chernyak N, Gevorgyan V PMID: 20213787 [PubMed - as supplied by publisher] (Source: Angewandte Chemie)

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  Sheldon Gilgore, Physician Who Led Drug Giants Pfizer and Searle, Dies at 77

Mr. Gilgore, an opera lover, had roles in the advancement of drugs like Ambien and Celebrex. (Source: NYT > Health)

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  Thoracic Spine Injury after a High-Speed Motor Vehicle Crash

In late October, a hospital-based flight team was activated at 9:30 pm for an approximately 30-year-old man involved in a high-speed motor vehicle crash into a tree. Per emergency medical services (EMS) documentation, flight service was requested for advanced airway management and rapid transport of the patient to a Level 1 trauma center. Ground transport was estimated at 60+ minutes, whereas actual flight time was less than 15 minutes. On the crew's arrival at the designated landing zone, they were escorted to an ambulance where a 100-kg man was immobilized on a stretcher. Because the landing area was at a remote location, the flight team did not witness the scene; however, the ground paramedic reported that the patient was the single-occupant driver of a small sedan. Given the extent...

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  How Is Zolpidem Dependence Managed?

Zolpidem use can result in abuse, dependence, and withdrawal, often necessitating medical intervention. Medscape Pharmacists (Source: Medscape Today Headlines)

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  ZOLPIDEM TARTRATEtablet [Caremark L.L.C.]

Updated Date: Feb 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Transcept Pharmaceuticals Provides Update on Intermezzo Regulatory Review

POINT RICHMOND, Calif., Feb. 22 /PRNewswire-FirstCall/ -- Transcept Pharmaceuticals, Inc. announced today an update on its plans to seek U.S. Food and Drug Administration (FDA) approval of Intermezzo (zolpidem tartrate sublingual tablet) for... (Source: Drugs.com - New Drug Applications)

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  Transcept Pharmaceuticals Provides Update on Intermezzo(R) Regulatory Review

POINT RICHMOND, Calif., Feb. 22 (HSMN NewsFeed) -- Transcept Pharmaceuticals, Inc. (Nasdaq:TSPT ) announced today an update on its plans to seek U.S. Food and Drug Administration (FDA) approval of Intermezzo® (zolpidem tartrate sublingual tablet) for... Biopharmaceuticals, FDATranscept Pharmaceuticals, Intermezzo, zolpidem, insomnia (Source: HSMN NewsFeed)

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  Adding zolpidem to CBT produces limited benefits in persistent insomnia

(Source: Evidence-Based Mental Health)

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  Effects of eszopiclone and zolpidem on sleep-wake behavior, anxiety-like behavior and contextual memory in rats.

Authors: Huang MP, Radadia K, Macone BW, Auerbach SH, Datta S At present, eszopiclone and zolpidem are the most commonly prescribed drugs for treating insomnia. Despite the established relationship between sleep disturbance and anxiety, it remains unknown whether targeted treatment for insomnia may affect acute anxiety. Therefore, the objective of this study was to examine the effects of three different doses (1, 3, and 10mg/kg) of eszopiclone and zolpidem on the states of sleep and wakefulness, levels of anxiety-like behavior, and long-term contextual memory in footshock-induced anxious rats. The results of this study demonstrated that the administration of eszopiclone and zolpidem both were equally effective in attenuating footshock stressor-induced suppression of slow-wave sleep (SW...

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  Zolpidem: Sleep-related eating disorder: case report

(Source: Reactions)

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  Potential antipsychotic effects of zolpidem.

Authors: Wong GY, Bastiampillai T, Dhillon R PMID: 20113310 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)

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  AMBIEN (Zolpidem Tartrate) Tablet, Film Coated [Caremark L.L.C.]

Updated Date: Jan 27, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  GABA(A) alpha-1 subunit mediated desynchronization of elevated low frequency oscillations alleviates specific dysfunction in stroke - A case report.

CONCLUSIONS: In JP, functional deficits and pathological oscillations appear coincidentally reduced following administration of low-dose zolpidem. SIGNIFICANCE: GABA(A) alpha-1 sensitive desynchronisation of pathological oscillations may represent a biomarker and potential therapeutic target in brain injury. PMID: 20097125 [PubMed - as supplied by publisher] (Source: Clinical Neurophysiology)

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  Zolpidem: Dependence and seizure on drug withdrawal: case report

(Source: Reactions)

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  Zolpidem: Somnambulism, sleep-related eating disorder and sleep-driving: case report

(Source: Reactions)

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  Do medicines with the same or similar brand names contain identical active ingredients in different countries?

Source: Wessex Drug and Medicines Information Centre Area: Evidence > Medicines Q & A The US (United States) Food and Drug Administration (FDA) has warned healthcare professionals and the public about the risks of having US prescriptions dispensed in another country.  This is because foreign drugs may have identical or very similar brand names as US products but contain different active ingredients.  This could result in serious adverse effects from taking the wrong active ingredient, without any health benefits.   For example Amyben® is a UK brand name for amiodarone, which is used to treat abnormal heart rhythms.  Supplying Amyben® instead of Ambien,® a US brand name for zolpidem, a sleeping tablet, could have a serious adverse outcome.    The FD...

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  Anxiolytic, hypnotic and sedative medication use in Australia

We examined the trends in the prescribing of subsidised anxiolytic, hypnotic and sedative (AHS) medication use in the Australian population from 2002 to 2007.We analysed the Medicare Australia and Drug Utilisation Sub-Committee databases for AHS script data from 2002 to 2007 by source, class of prescriber, gender and 5-year age groups. Scripts were converted to defined daily dose per 1000 population per day (DDD/1000 population/day) using Australian Bureau of Statistics population data.Overall use of AHS increased from 23.76 to 24.11 DDD/1000 population/day between 2002 and 2007. Anxiolytic medication utilisation increased as hypnotic medication utilisation decreased. Diazepam was the most widely used anxiolytic followed by alprazolam and oxazepam. Temazepam was the most widely used hypnot...

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  A quantitative assessment of the accuracy of centroid molecular dynamics for the calculation of the infrared spectrum of liquid water

Francesco Paesani and Gregory A. Voth A detailed analysis of the infrared lineshapes corresponding to the intramolecular bond vibrations of HOD in either HO or DO is presented here in order to quantitatively assess the accuracy of centroid molecular dynamics in reproducing the correct features of the infrared spectrum of water at ambien ... [J. Chem. Phys. 132, 014105 (2010)] published Wed Jan 6, 2010. (Source: Journal of Chemical Physics)

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  A safety trial of sodium oxybate in patients with obstructive sleep apnea: Acute effects on sleep-disordered breathing

Conclusion: These results suggest that nighttime administration of 9g SXB in patients with mild to moderate OSAS does not negatively impact SDB, as measured by mean change from baseline in AHI and SaO2, but might increase central apneas and cause oxygen desaturation in some individuals and should be used with caution. (Source: Sleep Medicine)

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  Eplivanserin Beats Flurazepam On Next-Day Cognitive Effects

ISTANBUL, TURKEY — The novel sleep aid eplivanserin proved to be well tolerated, with no effects on next-day cognitive or psychomotor performance, whether given alone or in combination with zolpidem in a randomized, double-blind, placebo- and benzodiazepine-controlled crossover trial. (Source: Clinical Psychiatry News)

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  Does Ambien Enhance Sex?

According to recent reports, Tiger Woods may have used Ambien to enhance his sexual exploits. This has led to many websites advocating "Ambien sex." But does Ambien enhance sex? It is unlikely that sex is better with this particular sleeping pill. As a sedative, Ambien may lower inhibitions, but other than that it would have little obvious benefit for sex. It certainly would not have aphrodisiac qualities. The idea of Ambien sex seems to be part of a swirl of rumors that may have left the facts behind. Follow me on Twitter to receive notice of all the latest updates to this site.Does Ambien Enhance Sex? originally appeared on About.com Sleep Disorders on Thursday, December 31st, 2009 at 21:16:01.Permalink | Comment | Email this (Source: About Sleep Disorders)

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  ZOLPIDEM TARTRATEtablet [Torrent Pharmaceuticals Limited]

Updated Date: Dec 22, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Actelion Pharmaceuticals Ltd (EN) - Investigational dual orexin receptor antagonist almorexant meets primary endpoint in two-week phase III study in patients suffering from primary insomnia

Evidence for differentiation from traditional GABA-agonist zolpidem observed ALLSCHWIL, SWITZERLAND – 21 December 2009 – Actelion Ltd (SIX: ATLN) announced today that the first phase III study with almorexant (RESTORA 1) has met its... (Source: Drugs.com - Clinical Trials)

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  In vitro-in vivo extrapolation of zolpidem as a perpetrator of metabolic interactions involving CYP3A

Conclusions  Zolpidem is a relatively weak mechanism-based inactivator of human CYP3A in vitro. Zolpidem is unlikely to act as a significant perpetrator of metabolic interactions involving CYP3A. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0760-2Authors Thomas M. Polasek, Flinders University School of Medicine Department of Clinical Pharmacology Adelaide AustraliaJanani S. Sadagopal, Flinders University School of Medicine Department of Clinical Pharmacology Adelaide AustraliaDavid J. Elliot, Flinders University School of Medicine Department of Clinical Pharmacology Adelaide AustraliaJohn O. Miners, Flinders University School of Medicine Department of Clinical Pharmacology Adelaide Australia Journal European Journal ...

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  Zolpidem abuse/withdrawal: Zolpidem dependence in an elderly patient followed by anxiety, irritability and insomnia on withdrawal: case report

(Source: Reactions)

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  ZOLPIDEM TARTRATEtablet [Major Pharmaceuticals]

Updated Date: Dec 7, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Poll: Did Tiger Get Special Treatment?

A recently released police report revealed that when golfing great Tiger Woods crashed his SUV November 30 into a fire hydrant and a tree in a neighbor's yard, he was unresponsive at the scene, a witness said he had been drinking earlier and taking prescription medications (Ambien and Vicodin) and he had obviously been driving erraticaly. However, when a Florida State Trooper, who suspected Tiger Woods was driving under the influence, sought a subpoena for his blood results from the hospital, prosecutors rejected the petition for "insufficient information." The Florida Highway Patrol wound up citing Woods for careless driving and fined him $164. Do You Think Tiger Woods Received Special Treatment Because He Is a Celebrity? 1) Yes, Anyone Else Would Have Been Charged 2) No, There Was No...

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  Use of zolpidem in pregnancy

Source: National Teratology Information Service (NTIS) Area: Evidence > Drugs in Pregnancy Zolpidem is a non-benzodiazepine hypnotic agent with a short duration of action. There are few data available on the use of zolpidem in human pregnancy. However, these limited data do not suggest an increased risk of fetal malformations.   Sedating antihistamines and benzodiazepines are the preferred agents for treatment of sleeping disorders in pregnancy. However, providing there are no other risk factors involved, inadvertent exposure to zolpidem during pregnancy does not constitute grounds for invasive diagnostic testing or for termination of pregnancy.   As with all centrally acting drugs, zolpidem exposure during pregnancy may be associated with withdrawal effects in the neona...

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  Ambien, Trazodone May Be Helpful for Insomnia

Insomnia relates to difficulties falling or staying asleep. There are many potential treatment options, including the use of medications. Two of the more common prescription medications for insomnia are Ambien and Trazodone. Learn what Ambien and Trazodone are, including their use in the treatment of insomnia. Find out the indications for use, how they work, who should not use them, what the potential side effects are, and what safety monitoring should occur. You can use this information to determine if Ambien or Trazodone may be a good treatment option for you. Follow me on Twitter to receive notice of all the latest updates to this site.Ambien, Trazodone May Be Helpful for Insomnia originally appeared on About.com Sleep Disorders on Tuesday, December 1st, 2009 at 06:10:34.Permalink | ...

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  Zolpidem 5mg tablets - Revised SPC

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes ?SPC revsised to include additonal warnings added to section 4.4 (Special warnings and precautions for Use) and 4.8 (Undesirable Effects) re somnambulism and additional warning added to 4.6 (Pregnancy and Lactation) re neonatal respiratory depression. (Source: NeLM - Neurology)

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  Zolpidem 5mg, 10mg tablets - Revised SPC

Source: eMC (electronic Medicines Compendium) Area: Other Library Updates > SPC Changes ?SPC revised to include additional warnings added to section 4.4 (Special warnings and precautions for Use) and 4.8 (Undesirable Effects) re: somnambulism and additional warning added to 4.6 (Pregnancy and Lactation) re: neonatal respiratory depression. (Source: NeLM - Neurology)

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  Insomnia Treatment Options for Women

This article describes the circumstances under which women may develop insomnia and the various treatment options, including hypnotic medication and nonpharmacologic approaches. The efficacy and safety of these treatments are reviewed. The choice of treatment depends on the nature of the insomnia, the stage of a woman's life, the presence of medical or mental health conditions, the availability of treatments, and personal preference. For immediate, short-term relief of acute insomnia, hypnotic medication, especially the nonbenzodiazepines (zolpidem, zopiclone, eszopiclone) are options. For chronic insomnia, insomnia-specific cognitive and behavioral therapies are generally the interventions of choice. (Source: Obstetrics and Gynecology Clinics)

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  The toxicological challenges in the European research project DRUID

Abstract: Within the epidemiological studies of the integrated European research project DRUID (Driving Under the Influence of Drugs, alcohol and medicines), 13 laboratories from across Europe will analyse whole blood, oral fluid (OF) or urine from the general driving population and injured drivers. To ensure the comparability of toxicological results from the different studies, the collection of samples, analytical methods, target analytes and analytical cut-offs have been standardized for all laboratories involved.Target analytes were selected based on suspected impairing effects and prevalence. Twenty-three drugs are included in the ‘core list’ for which analysis is mandatory: ethanol, amphetamine, MDMA, MDA, MDEA, methamphetamine, cocaine, benzoylecgonine, THC, THC-COOH, 6-acetylmo...

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  Transcept Pharmaceuticals Scheduled To Meet With FDA To Discuss Intermezzo(R) Complete Response Letter

Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT) announced that it is scheduled to meet with the U.S. Food and Drug Administration (FDA) on January 20, 2010 to discuss the Complete Response Letter regarding the New Drug Application (NDA) for Intermezzo® (zolpidem tartrate sublingual tablet). (Source: Health News from Medical News Today)

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  Transcept Pharmaceuticals Scheduled To Meet With FDA To Discuss Intermezzo(R) Complete Response Letter

Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT) announced that it is scheduled to meet with the U.S. Food and Drug Administration (FDA) on January 20, 2010 to discuss the Complete Response Letter regarding the New Drug Application (NDA) for Intermezzo® (zolpidem tartrate sublingual tablet). As previously announced, the Complete Response Letter, received by Transcept on October 28, 2009, indicated that the FDA could not approve the NDA in its present form. (Source: Pharma Industry News From Medical News Today)

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  AMBIEN CR (Zolpidem Tartrate) Tablet, Coated [Sanofi-Aventis U.S. LLC]

Updated Date: Nov 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Determination of 19 drugs of abuse and metabolites in whole blood by high-performance liquid chromatography-tandem mass spectrometry.

Authors: Bjørk MK, Nielsen MK, Markussen LO, Klinke HB, Linnet K A high-performance liquid chromatography (LC)-tandem mass spectrometry (MS/MS) method has been developed and validated for the determination of 19 drugs of abuse and metabolites and used in whole blood. The following compounds were included: amphetamine, methylenedioxyamphetamine, methylenedioxyethylamphetamine, methylenedioxymethamphetamine, methamphetamine, cocaine, benzoylecgonine, morphine, 6-acetylmorphine, codeine, methadone, buprenorphine, norbuprenorphine, ketobemidone, tramadol, O-desmethyltramadol, zaleplone, zolpidem, and zopiclone. The sample pretreatment consisted of solid-phase extraction using mixed-mode columns (Isolute Confirm HCX). Deuterated analogues were used as internal standards for all analyte...

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  ZOLPIDEM TARTRATE (Zolpidem) Tablet, Coated [Physicians Total Care, Inc.]

Updated Date: Nov 13, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Zolpidem: Sleepwalking in an elderly patient: case report

(Source: Reactions)

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  Hopes for new brain-damage drug

SPECT trial reportedly shows that zolpidem drug counteracts loss of cognitive and motor functions associated with brain damage (Source: Pharmacy Europe)

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  ZOLPIDEM TARTRATEtablet, Film Coated [Roxane Laboratories, Inc]

Updated Date: Nov 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  ZOLPIDEM TARTRATEtablet [American Health Packaging]

Updated Date: Nov 4, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Transcept Pharmaceuticals Receives Complete Response Letter from FDA on Intermezzo New Drug Application

RICHMOND, Calif., Oct. 29 /PRNewswire-FirstCall/ -- Transcept Pharmaceuticals announced today that the U.S. Food and Drug Administration (FDA) issued a Complete Response Letter regarding the New Drug Application (NDA) for Intermezzo (zolpidem... (Source: Drugs.com - New Drug Applications)

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  Transcept Pharmaceuticals Receives Complete Response Letter From FDA On Intermezzo(R) New Drug Application

Transcept Pharmaceuticals (Nasdaq: TSPT) announced that the U.S. Food and Drug Administration (FDA) issued a Complete Response Letter regarding the New Drug Application (NDA) for Intermezzo® (zolpidem tartrate sublingual tablet). The NDA, submitted by Transcept in September 2008, seeks approval to market Intermezzo® for use as-needed for the treatment of insomnia when a middle of the night awakening is followed by difficulty returning to sleep. (Source: Pharma Industry News From Medical News Today)

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  Transcept Pharmaceuticals Receives Complete Response Letter from FDA on Intermezzo(R) New Drug Application

Conference Call Scheduled for 8:30 a.m. EDT on October 29, 2009 RICHMOND, Calif., Oct. 29 (HSMN NewsFeed) -- Transcept Pharmaceuticals (Nasdaq: TSPT ) announced today that the U.S. Food and Drug Administration (FDA) issued a Complete Response Letter r... Biopharmaceuticals, FDATranscept Pharmaceuticals, Intermezzo, zolpidem, insomnia (Source: HSMN NewsFeed)

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  Transcept Pharmaceuticals Receives Complete Response Letter From FDA On Intermezzo® New Drug Application

Transcept Pharmaceuticals (Nasdaq: TSPT) announced today that the U.S. Food and Drug Administration (FDA) issued a Complete Response Letter regarding the New Drug Application (NDA) for Intermezzo® (zolpidem tartrate sublingual tablet). (Source: Pharmaceutical Online News)

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  Caring for the Elderly in an Inpatient Setting: Managing Insomnia and Polypharmacy

This article addresses these concerns by highlighting key points from the available literature. Insomnia may be a problem in the elderly because of their increased sensitivity to changes in environment among other factors. First, obtain a sleep history and a comprehensive medical and medication history to identify the cause. Next, treat the underlying cause with nonpharmacological interventions to restore restful and qualitative sleep. When nonpharmacological interventions are not successful, pharmacological means are indicated. Remember to start low, go slow, and treat for a short duration of time (less than 4 weeks) to avoid withdrawal or rebound insomnia. First-line agents are trazodone, triazolam, temazepam, and lorazepam followed by zaleplon and zolpidem. As people age, it is common f...

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  Discriminative stimulus effects of L-838,417 (7-tert-Butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine): Role of GABA(A) receptor subtypes.

Authors: Licata SC, Platt DM, Rüedi-Bettschen D, Atack JR, Dawson GR, Van Linn ML, Cook JM, Rowlett JK Previous reports suggest that gamma-aminobutyric acid type A (GABA(A)) receptors containing alpha1 subunits may play a pivotal role in mediating the discriminative stimulus effects of benzodiazepines (BZs). L-838,417 (7-tert-Butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine) is a GABA(A) receptor modulator with intrinsic efficacy in vitro at alpha2, alpha3, and alpha5 subunit-containing GABA(A) receptors, and little demonstrable intrinsic efficacy in vitro at alpha1 subunit-containing GABA(A) receptors. The present study evaluated the discriminative stimulus effects of L-838,417 in order to determine the extent to which the ...

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  ZOLPIDEM TARTRATE (Zolpidem) Tablet, Coated [Physicians Total Care, Inc.]

Updated Date: Oct 20, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Zolpidem-Induced Sleepwalking, Sleep Related Eating Disorder, and Sleep-Driving: Fluorine-18-Flourodeoxyglucose Positron Emission Tomography Analysis, and a Literature Review of Other Unexpected Clinical Effects of Zolpidem

We report the results and a review of the literature regarding other unintended effects seen with zolpidem use. Keywords: Zolpidem, fluorine-18-flourodeoxyglucose positron emission tomography, sleep related eating disorder, sleepwalking, sleep-driving (Source: Journal of Clinical Sleep Medicine : JCSM)

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  AMBIEN CR (Zolpidem Tartrate) Tablet, Coated [Sanofi-Aventis U.S. LLC]

Updated Date: Oct 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  AMBIEN (Zolpidem Tartrate) Tablet, Film Coated [Sanofi-Aventis U.S. LLC]

Updated Date: Oct 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Zolpidem-induced sleep-related eating disorder

Abstract: An association between zolpidem administration and sleep-related eating disorder (SRED) has been suggested. The authors observed zolpidem-induced SRED in restless legs syndrome (RLS). With the review of previous reports, we identified a common occurrence of RLS in zolpidem-induced SRED. (Source: Journal of the Neurological Sciences)

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  Residual effects of hypnotic drugs in aging drivers submitted to simulated accident scenarios: an exploratory study

Conclusions  This study did not reveal any major residual effects of the hypnotics studied on driving performance in aging drivers. However, the urban driving situations used here for the first time in the evaluation of drugs revealed some modifications in driving habits which could lead to risky behavior. It thus appears that urban driving simulations are useful for gaining knowledge about the effects of drugs on driving behavior. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1677-2Authors Mohamed Meskali, INRETS (French National Institute for Transport and Safety Research) Département Mécanismes d’Accidents 13300 Chemin de la croix-blanche Salon de Provence FranceCatherine Berthelon, INRETS (French National Institute for Trans...

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  Sleep Aid Suppresses Reflux-Related Awakening

Zolpidem, a frequently prescribed sleep aid, suppresses nocturnal awakenings that are an important CNS response to acid reflux events. By enabling users to sleep through reflux events, the drug has the unintended effect of increasing esophageal exposure to stomach acid. This in turn opens the door to gastroesophageal reflux disease (GERD) complications such as erosive esophagitis, stricture formation, Barrett's esophagus, and esophageal adenocarcinoma, said Dr. Gregg Gagliardi of Thomas Jefferson University, Philadelphia, and his associates. (Source: Clinical Psychiatry News)

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  Lipitor, Seroquel and Ambien CR Web Sites Rank Highest for Ease of Use, Content Quality

Report Assesses Degree to Which Pharma Sites Connect With Consumers Online (PRWeb Sep 23, 2009) Read the full story at http://www.prweb.com/releases/2009/09/prweb2919554.htm (Source: PRWeb: Medical Pharmaceuticals)

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  Sleep Aid May Lead to More Acid Reflux Exposure

The sleep-inducing drug zolpidem may help patients with gastroesophageal reflux sleep through reflux events, increasing their acid exposure, according to research published in the September issue of Clinical Gastroenterology and Hepatology. (Source: Modern Medicine)

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  Zolpidem increases bladder capacity and decreases urine excretion in rats

To clarify the effects of zolpidem, a [gamma]-aminobutyric acid (GABA)A receptor agonist, on bladder function, and urine production, we investigated the effects of zolpidem administration on bladder overactivity induced by cerebral infarction (CI) and on urine excretion increased by water overloading in Wistar rats.CI was induced by left middle cerebral artery occlusion. The effects on bladder function of zolpidem alone or in combination with the GABAA receptor antagonist bicuculline, were then examined in the CI rats using cystometry. The antidiuretic effect of zolpidem was investigated in water-loaded and Brattleboro rats (genetically vasopressin-deficient). Blood samples were collected from water-loaded rats to determine the aldosterone level 1 and 6 hr after zolpidem administration.Zol...

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  Synthetic and Natural Compounds that Interact with Human Cytochrome P450 1A2 and Implications in Drug Development.

Authors: Wang B, Zhou SF Human cytochrome P450 1A2 (CYP1A2) is one of the major CYPs in the liver ( approximately 13%) and metabolizes about 20% of clinically used drugs. CYP1A2 is a 515-residue protein with a molecular mass of 58,294 Dal. The recently published crystal structure of CYP1A2 in complex with alpha-naphthoflavone has showed a rather compact active site with a relatively small volume of the cavity of 375 A(3), which is 44.2% and 49.3% larger than that of CYP2A6 (260 A(3)) and CYP2E1 (190 A(3)), respectively. A series of residues in the substrate recognition regions of CYP1A2 (e.g. Arg108, Thr124, Thr223, Glu225, Phe226, Lys250, Arg251, Lys253, Asn312, Asp313, Glu318, Thr319, Asp320, Thr321, Val322, Leu382, Thr385, and Ile386) have been shown to play important roles in ligan...

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  Excellent response to oral zolpidem in a sporadic case of the myoclonus dystonia syndrome

No abstract. (Source: Movement Disorders)

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  Moss Rehabilitation Research Institute Launches Largest Study To Date To Explore "Awakening" Effects Of Common Sleep Drug On Vegetative Patients

Moss Rehabilitation Research Institute (MRRI), the research arm of MossRehab, one of the world's leading clinical rehabilitation centers, has launched an ambitious research study to investigate how the sleep drug zolpidem might restore consciousness for patients in the vegetative state. (Source: Health News from Medical News Today)

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  Zolpidem: Amnesia: case report

(Source: Reactions)

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  ZOLPIDEM TARTRATEtablet, Film Coated [Qualitest Pharmaceuticals]

Updated Date: Aug 26, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Acute mesenteric vein thrombosis after laparoscopic gastric sleeve surgery for morbid obesity

Mesenteric vein thrombosis has not been reported as complication of laparoscopic gastric sleeve surgery for morbidly obese patients. A 50-year-old morbidly obese man of Italian descent with a medical history of high cholesterol, chronic back pain, hypothyroidism, idiopathic deep venous thrombosis, who had undergone laparoscopic gastric sleeve surgery 3 weeks previously, was admitted to the hospital with ongoing abdominal pain postoperatively. The pain had progressively worsened during the week before admission, but with a significant increase in the 24 hours before admission. The pain was described as severe (10 of 10 on a pain scale), sharp, stabbing, epigastric in location, and radiating to the back and flanks. The pain was associated with nausea, vomiting, and anorexia. The patient den...

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  EDLUAR (Zolpidem Tartrate) Tablet [Meda Pharmaceuticals]

Updated Date: Aug 17, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Meta-Analyses of Hypnotics and Infections: Eszopiclone, Ramelteon, Zaleplon, and Zolpidem

Conclusions: Research is needed to objectively determine whether the use of hypnotics increases the risk of infections. Immune compromise or esophageal reflux and aspiration should be studied as possible mechanisms. Keywords: Eszopiclone, ramelteon, zaleplon, zolpidem, infection, inflammation, meta-analysis (Source: Journal of Clinical Sleep Medicine : JCSM)

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  Retrograde effects of triazolam and zolpidem on sleep-dependent motor learning in humans

Drugs that act as allosteric activators at the benzodiazepine site of the gamma-aminobutyric acid (GABAA) receptor complex are used commonly to treat insomnia but relatively little is known of how such use affects learning and memory. Although anterograde effects on memory acquisition have been shown, possible retrograde effects on consolidation are more relevant when such agents are administered at bedtime. We tested the effects of two GABAA allosteric activators on sleep-dependent motor skill memory consolidation in 12 healthy male subjects. Subjects slept in a sleep laboratory for four consecutive nights (one accommodation night followed by three experimental nights). Placebo, triazolam 0.375 mg, and zolpidem 10 mg were given to each subject in counterbalanced order on the experimental ...

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  EDLUAR (Zolpidem Tartrate) Tablet [Meda Pharmaceuticals Inc.]

Updated Date: Aug 13, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Retrograde effects of triazolam and zolpidem on sleep-dependent motor learning in humans.

Authors: Morgan PT, Kehne JH, Sprenger KJ, Malison RT Drugs that act as allosteric activators at the benzodiazepine site of the gamma-aminobutyric acid (GABA(A)) receptor complex are used commonly to treat insomnia but relatively little is known of how such use affects learning and memory. Although anterograde effects on memory acquisition have been shown, possible retrograde effects on consolidation are more relevant when such agents are administered at bedtime. We tested the effects of two GABA(A) allosteric activators on sleep-dependent motor skill memory consolidation in 12 healthy male subjects. Subjects slept in a sleep laboratory for four consecutive nights (one accommodation night followed by three experimental nights). Placebo, triazolam 0.375 mg, and zolpidem 10 mg were given...

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  Treatment of sleep dysfunction and psychiatric disorders

Opinion statement  Patients with neurologic disorders commonly experience sleep dysfunction and psychiatric disorders. The most common sleep dysfunction is insomnia, which is a primary symptom in 30% to 90% of psychiatric disorders. Insomnia and fatigue are prominent symptoms of anxiety disorders and major depression that may occur in patients who are treated but have residual sleep dysfunction. Anxiety and depressive disorders account for 40% to 50% of all cases of chronic insomnia. It is also recognized that primary insomnia and other primary sleep disorders produce symptoms that are similar to those reported by patients with psychiatric disorders. A clinician must judge whether sleep deprivation causes mood disturbance or whether depressive or anxiety disorder represents...

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  Treatment of nocturnal eating disorders

Opinion statement  Identifying abnormal nocturnal eating is critically important for patient care and public health. Obesity is a global pandemic and a leading cause of preventable mortality in the United States, with more than 100,000 deaths annually. Normally, nighttime energy homeostasis is maintained, despite an absence of food intake, through appetite suppression and alterations in glucose metabolism that result in stable energy stores. Two conditions break this nighttime fast and are associated with weight gain as well as medical and neuropsychiatric comorbidities. Sleep-related eating disorder (SRED) is characterized by isolated nocturnal eating, whereas the night-eating syndrome (NES) is a circadian delay in meal timing leading to evening hyperphagia, nocturnal eati...

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  My story...

Author: mwflorida Posted: Mon Aug 10, 2009 4:37 am hello! Thanks for sharing your story... I too am in the health care field, just slightly different, I am in the mental health field, a family therapist. I was on suboxone for 18 days and then stopped at 1 mg. truthfully, it was a relatively mild transition. about 5-7 days of feeling off, achy, not comfortable in my own skin, but not terrible at all. Ambien helped at night, amino acids helped alot during the day... maybe this is the clinical side of me coming out to you, but whatever you do, make sure you are honest with yourself. we all know how sneaky addiction is, how we will tell ourselves anything and rationalize it somehow... your habit was sizeable, and the cravings will be t...

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  Sleep aids may pose a risk to the elderly

My 88-year-old husband was prescribed Ambien for insomnia. After the first dose, he fell while getting up to go to the bathroom, gashed his head and had to go to the emergency room for stitches. A year later, I gave him a half-dose (again prescribed), and within minutes, his legs collapsed on him. I had the hardest time getting him into bed. Ambien? Never again! (Source: L.A. Times - Health)

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  Zolpidem (Ambien®) in pregnancy: placental passage and outcome

Abstract  To examine the extent and clinical sequelae of fetal exposure to zolpidem, a commonly prescribed hypnotic agent. Pregnant women with psychiatric illness participating in a study of psychotropic pharmacokinetics were included. Zolpidem concentrations were analyzed in maternal and umbilical cord plasma collected at delivery. Outcomes were compared between the zolpidem-exposed group and a 1:1 matched comparator group. Forty-five women taking zolpidem during pregnancy were studied. Rates of preterm delivery and low birth weight were 26.7% and 15.6% respectively in the zolpidem-exposed group versus 13.3% and 4.4% in the matched comparator group, but no significant differences were found. The ratio of umbilical cord to maternal plasma zolpidem concentrations in 6 pairs ...

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  Purdue Pharmaceutical Products L.P. And Transcept Pharmaceuticals, Inc. Sign Exclusive Agreement To Commercialize Intermezzo® In The United States

Purdue Pharmaceutical Products L.P. and Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT) today announced entry into an exclusive license and collaboration agreement to commercialize Intermezzo® (zolpidem tartrate sublingual tablet) in the United States. (Source: Pharmaceutical Online News)

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  Zolpidem: Erythroderma (first report) in an elderly patient: case report

(Source: Reactions)

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  Med Sci Monit 2009; 15(8):CS129-131 "Catatonia recognition and treatment"

Conclusions: This case seems to confirm that catatonia can represents a nonspecific response to stress factors. The withdrawal of multiple medications was already described as a basis for catatonia. Alcohol withdrawal could constitute an additional risk factor for catatonia. The zolpidem test is a useful diagnostic and therapeutic test. (Source: Medical Science Monitor)

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  Warning To Consumers About Recreational Use Of Medicines, Australia

The National Prescribing Service (NPS) warns people are playing Russian roulette with their health when they take medicines inappropriately. Media reports this week about people mixing sleeping tablet, zolpidem (Stilnox), with energy drink Red Bull™ have failed to highlight the risks people are taking when they intentionally misuse pharmaceuticals. (Source: Health News from Medical News Today)

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  Sleep toooooo much! Help

Author: Calliope Posted: Tue Jul 28, 2009 2:26 am jsp4th wrote: yah sometimes I only take 1/4 of the zanaflex...they knock out the headache but they knock me out too. I keep hearing about clonidine...it's a blood pressure med right? i'm only 26 and i'm not sure if I want to go that route. I hear of a naltrexone implant that you can get after subs...thinking about that for after I get off subs. Trying to cut down to 16mg third day down 1 pill...feel ok not great but better than I thought. Sleep has been great w/out ambien. Don't know if i'm gonna take that ever again. JayJay P. Clonidine is a high blood pressure medication that is also used to help with opiate detoxification. It made my heart beat reeaally sllooww....

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  A 2-week efficacy and safety study of gaboxadol and zolpidem using electronic diaries in primary insomnia outpatients

Abstract: Objectives: To evaluate the efficacy and safety profile of gaboxadol, a selective extrasynaptic GABAA agonist (SEGA) previously in development for the treatment of insomnia.Methods: This was a randomised, double-blind, placebo-controlled, parallel-group, 2-week, Phase III study of gaboxadol 5, 10 and 15mg in outpatients meeting the DSM-IV criteria of primary insomnia (N=742). Zolpidem 10mg was used as active reference.Results: At weeks 1 and 2, significant improvement in total sleep time (sTST) compared to placebo was seen for all doses of gaboxadol (all p (Source: Sleep Medicine)

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  The Mothers Act Disease Mongering Campaign - Part I

(NaturalNews) The Mothers Act represents the ultimate example of disease mongering at its worst because the eight-year attempt to pass this federal legislation has evolved into profiteering never before exhibited so conspicuously.Disease mongering "is the selling of sickness that widens the boundaries of illness and grows the markets for those who sell and deliver treatments," according to Ray Moyniahan and David Henry in the April 11, 2006 paper in PLoS Med, titled, "The Fight against Disease Mongering." "It is exemplified most explicitly by many pharmaceutical industry -- funded disease-awareness campaigns -- more often designed to sell drugs than to illuminate or to inform or educate about the prevention of illness or the maintenance of health," the authors explain. "Drug companies are ...

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  Occupational airborne contact dermatitis to simvastatin, carvedilol, and zolpidem

(Source: Contact Dermatitis)

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  Brotizolam/triazolam/zolpidem: Anxiety, psychomotor agitation and confusion: 2 case reports

(Source: Reactions)

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  Brotizolam/triazolam/zolpidem: Anxiety, psychomotor agitation and confusion: 2 case reports.

Page: 9 (Source: Reactions Weekly)

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  ZOLPIDEM TARTRATEtablet [Mylan Pharmaceuticals Inc.]

Updated Date: Jul 9, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  My journey to sobriety

Author: Unsponsored Posted: Thu Jul 09, 2009 12:38 am Hello, I'm 23 years old and discovered oc , and binged for 8 months : 160mg- 320 mg OC a day. I believed that I could quit cold turkey in January but it was too hard with work and school.. So I decided to go on suboxone, which I have been taking for about 6 months. I am tapering off pretty quickly actually and it has been working out nicely. week 1 - 1.5 mg -> 1mg, gradual reduction (each pill slightly smaller than the other) week 2 - 1 mg - stabilize week 3 - 0.75 - >0.5 mg gradual reduction(each pill slightly smaller than the other) week 4 - 0.5 for 3 days, 0.25 - 5 days (Currently at this step) Week 5 - Stop 7/10 The most of my withdrawal symptoms have been malaise, ...

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  Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem. - Leufkens TR, Lund JS, Vermeeren A.

Gaboxadol is a selective extrasynaptic GABA(A) receptor agonist previously in development for the treatment of insomnia. Due to its short half-life (1.5-2 h) it is expected to be free from residual effects the next morning. The present study assessed the r... (Source: SafetyLit: All (Unduplicated))

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  [Cooking in dreams: a peculiar side effect of zolpidem.]

Authors: Perez-Perez H, Perez-Lorensu PJ PMID: 19598143 [PubMed - in process] (Source: Revista de Neurologia)

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  'Sleep Walking' And Talking That Can Occur With Popular Sleep-aid Ambien Explained

Some people who take the fast-acting sleep-aid zolpidem (Ambien) have been observed walking, eating, talking on the phone and even driving while not fully awake. Many often don't remember doing any of these activities the next morning. Similarly, this drug has been shown to awaken the minimally conscious into a conscious state. A new study may help explain why these "awakenings" occur. (Source: ScienceDaily Headlines)

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  Study in mice sheds light on Ambien side effects

CHICAGO (Reuters) - A new study in mice may help explain some of the rare but strange side effects in people taking the sleep drug Ambien, including sleep walking, midnight binges and even driving while not fully awake. (Source: Reuters: Health)

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  'Awakenings' That Occur With Popular Sleep-Aid Ambien May Be Explained By GUMC Study

Some people who take the fast-acting sleep-aid zolpidem (Ambien) have been observed walking, eating, talking on the phone and even driving while not fully awake. Many often don't remember doing any of these activities the next morning. Similarly, this drug has been shown to awaken the minimally conscious into a conscious state. (Source: Health News from Medical News Today)

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  Study in mice sheds light on Ambien side effects

CHICAGO (Reuters) - A new study in mice may help explain some of the rare but strange side effects in people taking the sleep drug Ambien, including sleep walking, midnight binges and even driving while not fully awake. (Source: Reuters: Health)

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  Zolpidem: Nocturnal sleep-related eating disorder: case report

(Source: Reactions)

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  Zolpidem: Nocturnal sleep-related eating disorder: case report.

Page: 31 (Source: Reactions Weekly)

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  Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem

Gaboxadol is a selective extrasynaptic GABAA receptor agonist previously in development for the treatment of insomnia. Due to its short half-life (1.5[ndash]2 h) it is expected to be free from residual effects the next morning. The present study assessed the residual effects of evening and middle-of-the-night administration of 15 mg of gaboxadol on cognitive, psychomotor and driving performance. Twenty-eight healthy volunteers entered the study with 25 (12 women; mean age 31.4 years) completing a double-blind, placebo-controlled, active-referenced five-way cross-over study. Each treatment night subjects ingested one capsule at 23:00 hours and one at 04:00 hours. Treatments were placebo at both times, 15 mg gaboxadol or 7.5 mg zopiclone followed by placebo, and placebo followed by 15 mg gab...

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  Highway driving performance and cognitive functioning the morning after bedtime and middle-of-the-night use of gaboxadol, zopiclone and zolpidem.

Authors: Leufkens TR, Lund JS, Vermeeren A Gaboxadol is a selective extrasynaptic GABA(A) receptor agonist previously in development for the treatment of insomnia. Due to its short half-life (1.5-2 h) it is expected to be free from residual effects the next morning. The present study assessed the residual effects of evening and middle-of-the-night administration of 15 mg of gaboxadol on cognitive, psychomotor and driving performance. Twenty-eight healthy volunteers entered the study with 25 (12 women; mean age 31.4 years) completing a double-blind, placebo-controlled, active-referenced five-way cross-over study. Each treatment night subjects ingested one capsule at 23:00 hours and one at 04:00 hours. Treatments were placebo at both times, 15 mg gaboxadol or 7.5 mg zopiclone followed by...

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  Characterisation of the effects of caffeine on sleep in the rat: a potential model of sleep disruption

This study evaluated the potential use of caffeine as a model of sleep disruption in the rat, by assessing its effects on sleep architecture and electroencephalogram (EEG) frequency spectrum, and using sleep-promoting drugs to reverse these effects. Rats were implanted with radiotelemetry devices for body temperature, EEG, electromyogram and locomotor activity. Following recovery, animals were dosed with caffeine (10 mg/kg) alone or in combination with zolpidem (10 mg/kg) or trazodone (20 mg/kg). Sleep was scored for the subsequent 12 h using automated analysis software. Caffeine dose-dependently disrupted sleep: it increased WAKE time, decreased NREM (non-REM) sleep time and NREM bout duration (but not bout number), and decreased delta activity in NREM sleep. It also d...

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  Effects on sleep stages and microarchitecture of caffeine and its combination with zolpidem or trazodone in healthy volunteers

This study assessed the effects of caffeine on sleep architecture and electroencephalography (EEG) spectrum alone and in combination with two different sleep-promoting medications. Home polysomnography was performed in 12 healthy male volunteers in a double-blind study whereby subjects received placebo, caffeine (150 mg), caffeine plus zolpidem (10 mg) and caffeine plus trazodone (100 mg) at bedtime in a randomised crossover design. In addition to delaying sleep onset, caffeine decreased total sleep time (TST), sleep efficiency (SE) and stage 2 sleep without significantly altering wake after sleep onset or the number of awakenings. Zolpidem attenuated the caffeine-induced decrease in SE and increased spindle density in the caffeine plus zolpidem combination compared with pla...

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  Transcept Pharmaceuticals Announces Expected FDA Extension Of Regulatory Review Period For Intermezzo(R)

Transcept Pharmaceuticals, Inc. (Nasdaq: TSPT) announced that the U.S. Food and Drug Administration (FDA) has informed the company that it should expect to receive formal notice of a three month extension of the review period for the new drug application (NDA) for Intermezzo(R) (zolpidem tartrate sublingual tablet). (Source: Health News from Medical News Today)

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  1st Post!!!

Author: jsp4th Posted: Tue Jun 09, 2009 9:55 pm Hi everybody, and Doc. Junig. My name is JayJay and i'm 26 years old. I've been abusing opiates since age 15. It has been a long road. I first used vicodin a couple times and it never did anything for me, then one day some "friends" of mine gave me a O.C.80. well it was love at first sniff. I've used anything I could get my hands on since, always looking for O.C.'s but when I couldn't find them I would take ANY opiate I could find. On July 10th, 2008 I finally got caught. Let's just say it was bad enough to hire a lawyer for the sum of around $8,000.00 to stay out of jail, and I'm still on probation. I got sober the day after, and on to suboxone the day after that. So as of ...

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  Doctors should start to prescribe this!!!!!!

Author: LogicalTruth Posted: Tue Jun 09, 2009 5:35 pm Technically, Lunesta (eszopiclone) is a nonbenzodiazepine hypnotic sedative, but it acts on benzodiazepine receptors on GABA neurons as an agonist so yeah, same kinda animal in my book. Plus, it's one of the newer string of sleep aids (like Ambien, etc...) that sometimes makes people do freaky things like sleep-driving, sleep-cooking, etc... where they do these activities in a trance-like state and have no memory of the event once fully awake. Drugs like that scare me. (Source: Suboxone Forum)

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  Zolpidem in Fatigue Management for Surge Operations of Remotely Piloted Aircraft

(Source: Aviation, Space, and Environmental Medicine)

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  Zolpidem abuse: Finger ischaemia following unintentional intra-arterial injection of a crushed tablet, treated with iloprost: case report

(Source: Reactions)

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  CBT Effective for Persistent Insomnia

Cognitive-behavioral therapy (CBT) with or without the addition of zolpidem, is effective against persistent insomnia, according to study findings. After 6 weeks of treatment, 60% of patients showed a response to the therapy, including 42% who achieved remission of insomnia; these rates increased to 65% and 51% after 6 additional months of extended treatment, reported Charles M. Morin, Ph.D., of the Université Laval Robert-Giffard, Quebec, and associates. (Source: Family Practice News)

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  Sublingual zolpidem is more effective than oral zolpidem in initiating early onset of sleep in the post-nap model of transient insomnia: A polysomnographic study

Abstract: Objective: OX22 is zolpidem formulated for sublingual administration. The primary objective of the present study was to evaluate the efficacy of single doses of sublingual zolpidem (5 and 10mg) versus oral zolpidem (10mg), with regard to latency to persistent sleep (LPS), in a post-nap model of insomnia.Methods: Twenty-one healthy volunteers included in this study were recorded by polysomnography during 2 consecutive nights and, on the day in between, during a 2h nap. Eighteen out of these 21 subjects were finally analyzed. Treatment was randomly administered before the second recording night to subjects demonstrating at least 30min of sleep during the nap recording.Results: Contrast analyses show that 10mg OX22 significantly shortened LPS compared to oral zolpidem administration...

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  CBT Increases Rates of Remission in Persistent Insomnia

Cognitive-behavioral therapy, with or without the addition of zolpidem, is effective against persistent insomnia, a report by Canadian researchers shows. After 6 weeks of treatment, 60% of patients showed a response to the therapy, including 42% who achieved remission of insomnia; these rates increased to 65% and 51% after 6 additional months of extended treatment, reported Charles M. Morin, Ph.D., of the Universite Laval Robert-Giffard, Quebec, and his associates. (Source: Clinical Psychiatry News)

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  Zolpidem abuse: Finger ischaemia following unintentional intra-arterial injection of a crushed tablet, treated with iloprost: case report.

Page: 41 (Source: Reactions Weekly)

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  CBT has long-term effect on insomnia

Sleep disturbance - Study finds cognitive behavioural therapy as effective as zolpidem. (Source: HealthcareRepublic GP News)

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  Transcept Pharmaceuticals Presents Data from Studies of Two Product Candidates at Annual Meeting of the American Psychiatric Association

<p><b>Safety and Efficacy Study of Zolpidem Tartrate Sublingual Tablet in Treating Middle-of-the-Night Awakening on an As-Needed Basis</b></p> <p><b>Evaluation of Ondansetron Augmentation in the Treatment of... (Source: Drugs.com - Clinical Trials)

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  Combination Therapy Appears Helpful For Short-Term Treatment Of Insomnia; Cognitive Behavior Therapy May Be Better For Long-Term

For patients with persistent insomnia, a combination of cognitive behavior therapy (CBT) and the medication zolpidem for 6 weeks was associated with improvement in sleep, although for a longer treatment period CBT alone was more beneficial, according to a study in the May 20 issue of JAMA. (Source: Health News from Medical News Today)

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  Therapy, drug help to treat insomnia

QUEBEC CITY, May 20 (UPI) -- Cognitive behavior therapy and the medication zolpidem taken for six weeks improved sleep in those with persistent insomnia, Canadian researchers found. (Source: Health News - UPI.com)

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  ORIGINAL CONTRIBUTION: Cognitive Behavioral Therapy, Singly and Combined With Medication, for Persistent Insomnia: A Randomized Controlled Trial

Conclusion  In patients with persistent insomnia, the addition of medication to CBT produced added benefits during acute therapy, but long-term outcome was optimized when medication is discontinued during maintenance CBT. Trial Registration  clinicaltrials.gov Identifier: NCT00042146 (Source: JAMA)

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  Total Absence of Recall of Discussion Occurred Shortly after Ingestion of 10 mg Zolpidem

Pharmacopsychiatry 2009; 42: 126-127DOI: 10.1055/s-0029-1220772© Georg Thieme Verlag KG Stuttgart · New YorkGet connected:Table of contents  |  Full text (Source: Pharmacopsychiatry)

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  Hypnotics

Several classes of hypnotic medication are available: the older barbiturates and their derivatives; benzodiazepines; chemically distinct “z-compounds”; antihistamines and antihistaminic antidepressants; and melatoninergic compounds. The use of hypnotic medications continues at a high rate. However, some switching to the shorter-acting benzodiazepines has occurred. The z-compounds—eszopiclone, zolpidem, and zaleplon—have become popular; they seem to have fewer residual effects than the benzodiazepines. Even so, care is needed in prescribing such hypnotics for the elderly. (Source: Psychiatric Times)

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  Impairment related to blood drug concentrations of zopiclone and zolpidem compared to alcohol in apprehended drivers. - Gustavsen I, Al-Sammurraie M, Mørland J, Bramness JG.

BACKGROUND: About 3-7% of the adult population receives prescribed hypnotics. The benzodiazepine-like hypnotics, zopiclone and zolpidem, are the most commonly prescribed and may cause traffic-relevant impairment similar to that found for benzodiazepines. W... (Source: SafetyLit: All (Unduplicated))

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  Effect of Zolpidem on the Sleep Arousal Response to Nocturnal Esophageal Acid Exposure

Conclusions: Zolpidem reduced the arousal response to nocturnal acid exposure and increased the duration of each esophageal acid reflux event in healthy individuals and patients with GER. Because nocturnal acid exposure was prolonged, hypnotic use by patients with GER could lead to increased risk for complicated disease. (Source: Clinical Gastroenterology and Hepatology)

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  Metformin overdose/zolpidem overdose: Lactic acidosis and acute respiratory acidosis: case report

(Source: Reactions)

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  Metformin overdose/zolpidem overdose: Lactic acidosis and acute respiratory acidosis: case report.

Page: 27 (Source: Reactions Weekly)

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  Sleepwalking in psychiatric patients: comparison of childhood and adult onset.

CONCLUSIONS: Adult-onset sleepwalking in a psychiatric sample has unique clinical characteristics and specific risk factors. These patients were more likely to present with sleep-related eating features, comorbid insomnia, had and lifetime usage of non-benzodiazepine hypnotics, especially zolpidem. A heightened awareness of the presence of sleepwalking and their associated risk factors among the adult psychiatric population is needed. PMID: 19373703 [PubMed - in process] (Source: The Australian and New Zealand Journal of Psychiatry)

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  Zolpidem: Somnambulism: case report.

Page: 46 (Source: Reactions Weekly)

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  Controlled Clinical Trial of Zolpidem for the Treatment of Insomnia Associated With Attention-Deficit/ Hyperactivity Disorder in Children 6 to 17 Years of Age

CONCLUSION. Zolpidem at a dose of 0.25 mg/kg per day to a maximum of 10 mg failed to reduce the latency to persistent sleep on polysomnographic recordings after 4 weeks of treatment in children and adolescents 6 through 17 years of age who had attention-deficit/hyperactivity disorder-associated insomnia. (Source: PEDIATRICS)

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  Zolpidem: Somnambulism: case report

(Source: Reactions)

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  EDLUAR (Zolpidem Tartrate) Tablet [Meda Pharmaceuticals]

Updated Date: Apr 21, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Improvement of Idiopathic Central Sleep Apnea with Zolpidem

Conclusion: In an open-label trial, ICSA patients studied experienced a decrease in central apnea/hypopneas with zolpidem. They also had improved sleep continuity and decreased subjective daytime sleepiness, without a worsening of oxygenation or obstructive events in the majority of patients. However, in the absence of a randomized, controlled trial, zolpidem cannot be recommended for treatment of ICSA at this time. Keywords: Central sleep apnea, sleep disordered breathing, zolpidem (Source: Journal of Clinical Sleep Medicine : JCSM)

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  Commentary on Quadri S, et al.: Effective Treatment for Idiopathic Central Sleep Apnea?

Commentary on Quadri S, et al. Improvement of idiopathic central sleep apnea with zolpidem. J Clin Sleep Med 2009;5:122-129. (Source: Journal of Clinical Sleep Medicine : JCSM)

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  Edluar (Zolpidem Tartrate Sublingual Tablets) - new on RxList

Edluar (Zolpidem Tartrate Sublingual Tablets) drug description - FDA approved labeling for prescription drugs and medications at RxList (Source: RxList - New and Updated Drug Monographs)

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  Another Antidepressant Journey

Today I have spent a lot of time on the phone with both a nurse and my psychiatrist. Our big topic of the day? How to get me off Celexa. I started taking Celexa a few weeks ago. I had previously been on Remeron, but it didn’t seem to be doing much. At the suggestion of my psychologist, I asked my psychiatrist about switching to Celexa. My psychiatrist explained that Celexa is part of a class of drugs called selective serotonin reuptake inhibitors (SSRIs). While I can’t honestly say I understand the precise differences between an SSRI and any other type of antidepressants, I know that SSRIs work on different neurotransmitters and are widely prescribed. They do great things for a lot of people. My psychiatrist also explained that Celexa can have some bad side effects. She asked me if I...

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  Almorexant

Orexins (hypocretins) are a class of hypothalamic neuropeptides first described in the late 1990s. They have since been shown to regulate the sleep/wake cycle by maintaining wakefulness, as well as being involved in appetite regulation and energy homeostasis. Orexins A and B bind to two CNS receptors, designated orexin-1 and orexin-2. The cell bodies of orexin-producing neurons are restricted to the dorsal, lateral and posterior hypothalamus and its perifornical nucleus. Axonal projections of these cells are dense in the hypothalamus and extend to the limbic system, thalamus, substantia nigra, raphe, locus coeruleus, ventral tegmental area, medullary reticular formation, nucleus of the solitary tract and other brain stem regions. Orexin neurons have been shown in electrophysiological studi...

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  Health News of the Day

is a daily summary made from the selected links I post on Twitter. It is in a bullet points format with links to the original sources which include 350 RSS feeds that produce about 2,500 items per day.Age-related mental decline starts in the late-20s, dips in memory became apparent around age 37. Indicators of a person's accumulated knowledge (vocabulary and general knowledge) improve with age. Mental functions - abstract reasoning, mental speed and puzzle-solving - started to dull as early as age 27 http://bit.ly/vMq3iAnimal allergy cases are increasing, as are human allergy cases: Ten percent of dogs develop allergies http://bit.ly/LwrHRSubarachnoid hemorrhage (often fatal type of stroke) most common in winter, mortality of 50 percent http://bit.ly/PDNCXWhich prescription drugs are the ...

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  The impact of age on the hypnotic effects of eszopiclone and zolpidem in the guinea pig

Conclusions  In aged as well as adult guinea pigs, eszopiclone is a more effective hypnotic insofar as it produces a shorter latency to NREM sleep, a greater amount of NREM sleep and EEG delta waves. Differences in the effects produced by eszopiclone and zolpidem as a function of the aging process likely reflect the fact that they bind to different subunits of the GABAA receptors, which are differentially reactive to the aging process. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1520-9Authors Mingchu Xi, WebSciences International 1251 Westwood Blvd. Los Angeles CA 90024 USAMichael H. Chase, WebSciences International 1251 Westwood Blvd. Los Angeles CA 90024 USA Journal PsychopharmacologyOnline ISSN 1432-2072Print ISSN 0033-31...

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  Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam.

Authors: Vlainić J, Peričić D Zolpidem and diazepam are widely used drugs acting via benzodiazepine binding sites on GABA(A) receptors. While diazepam is nonselective, zolpidem has a high affinity for alpha1-, and no affinity for alpha5-containing receptors. Several studies suggested that behavioral effects of zolpidem might be more similar to classical benzodiazepines than previously thought. To compare the sedative and anticonvulsant properties of these drugs and to evaluate the importance of GABA(A) receptor subunits for development of tolerance during chronic treatment, we tested the effects of acute and repeated administration of zolpidem and diazepam on ambulatory locomotor activity (a measure of sedation) and on the threshold for myoclonic, clonic and tonic sei...

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  FDA Approvals: Symbyax and Edluar

The FDA has approved an expanded indication for fluoxetine HCl plus olanzapine capsules (Symbyax) and zolpidem tartrate sublingual tablets (Edluar). Medscape Medical News (Source: Medscape Today Headlines)

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  FDA Approvals: Symbyax and Edluar

The FDA has approved an expanded indication for fluoxetine HCl plus olanzapine capsules (Symbyax) and zolpidem tartrate sublingual tablets (Edluar). Medscape Medical News (Source: Medscape Today Headlines)

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  Comparison Shopping for Medicine

What's best for insomnia -- Lunesta, at about $6 a pill, or Zolpidem, at $2? (Source: washingtonpost.com - Health)

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  Stimulus will fund studies on merits of competing medical treatments

WASHINGTON -- What's best for insomnia -- Lunesta at about $6 a pill or Zolpidem at $2? Should a man with prostate cancer choose radiation, surgery or "watchful waiting"? Is it better to operate on a bad knee or get an injection of the joint fluid known... (Source: OrlandoSentinel: Medical Research)

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  Dog Has Always Been Man’s (And Woman’s) Best Friend

The great psychologist, Carl Rogers, was known for his concept of unconditional positive regard. Think of a self-help group like AA and the rooms are filled with it. Perhaps there is no better example of unconditional positive regard then that which your dog exhibits. All he asks for is water, food, a walk, and a pat on the head -- you could be the biggest jerk in the world and he would still wag his tail and give you a face full of lickies. My dog Charlie got me through the birth of my daughter, my doctorate, and the death of both my parents before he died. He was always there for me just gently being happy and loving, never asking for more than the basics. I don't know what made Charlie so sweet and loving and joyful. He loved to go out on a sunny day and sniff around, liked to sail, kee...

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  Transient Global Amnesia-like Episode Due to Mistaken Intake of Zolpidem: Drug Safety Concern in the Elderly.

Page: 32DOI: 10.1097/PTS.0b013e3181990d62Authors: Tsai, Ming-Yen MD *; Tsai, Meng-Han MD +; Yang, Shih-Chung MD *; Tseng, Yu-Lung MD +; Chuang, Yao-Chung MD, PhD + (Source: Journal of Patient Safety)

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  Zolpidem-induced sleep-driving. - Doane JA, Dalpiaz AS.

[Abstract unavailable] Language: Eng... (Source: SafetyLit: All (Unduplicated))

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  Simple method for reducing shock-wave equation of state to zero Kelvin isotherm for metals

Ke Jin, Qiang Wu, Fuqian Jing, and Xinzhu Li A thermodynamic formulation is proposed for deducing 0 K isotherm from shock Hugoniot data. In comparison to previous published thermodynamic approaches, the characteristic of this one is not requiring heat capacity as input and the used values of Gruneisen parameter merely confined to around ambien ... [J. Appl. Phys. 105, 043510 (2009)] published Thu Feb 19, 2009. (Source: Journal of Applied Physics)

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  An Evaluation of the Neuroendocrine Response to Sleep in Pediatric Burn Patients.

CONCLUSIONS: This work characterizes the relationship between sleep deprivation and select endocrine parameters post-burn. Drug interventions utilized in this study were either ineffective or insufficient in modulating improved hormonal response. Significance of zolpidem's and haloperidol's effect on serum levels of DHEA is unclear. The inverse correlation of epinephrine with REM may suggest that hypermetabolism associated with burns is partly due to lack of REM sleep. Questions remain regarding the effects of sleep deprivation on metabolism and clinical outcome. (JPEN J Parenter Enteral Nutr. XXXX;XX:xx-xx). PMID: 19223527 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)

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  Effect of Ramelteon on Middle-of-the-Night Balance in Older Adults with Chronic Insomnia

Conclusion:In older adults, ramelteon did not impair middle-of-the night balance, mobility, or memory relative to placebo. Keywords:Balance, stability, memory, elderly, melatonin receptor agonist, zolpidem (Source: Journal of Clinical Sleep Medicine : JCSM)

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  A comparison of the effects of a subtype selective and non-selective benzodiazepine receptor agonist in two CO2 models of experimental human anxiety

In conclusion, our results show that zolpidem shows some anxiolytic efficacy in the 7.5% CO2 model, similar to alprazolam, and this is the first report of such an effect of zolpidem in a model of anxiety. These and other studies of benzodiazepines in clinical and volunteer studies suggest a definite role of the GABA-A receptor in CO2-induced anxiety, and it would be of interest to examine other GABA-A receptor subtype selective drugs, which are now in early phase clinical studies and are showing selective efficacy in pharmacodynamic studies. (Source: Journal of Psychopharmacology)

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  Ambipolar pentacene/C-based field-effect transistors with high hole and electron mobilities in ambient atmosphere

Hu Yan, Tsubasa Kagata, and Hidenori Okuzaki Ambipolar field-effect transistors (FETs) were fabricated with a heterostructure of pentacene/C in which the C layer functioned as an n-type channel while the pentacene layer functioned as both a p-type channel and a sealing capsule for the unstable C layer. The ambipolar FET, operating in an ambien ... [Appl. Phys. Lett. 94, 023305 (2009)] published Fri Jan 16, 2009. (Source: Applied Physics Letters)

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  [Use of zolpidem and zopiclone on private prescriptions between 1993 and 2007.]

CONCLUSION: Since their approval in Germany, zopiclone and especially zolpidem have frequently been dispensed on private prescriptions. PMID: 19169658 [PubMed - as supplied by publisher] (Source: Der Nervenarzt)

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  Dissociating anxiolytic and sedative effects of GABAAergic drugs using temperature and locomotor responses to acute stress

Conclusions  The present study confirms a putative role for the GABAA receptor α1 subunit in hypothermia and sedation and supports a role for α2/3 subunit GABAA receptor agonists in anxiety processes. In conclusion, we show that home cage temperature and locomotor responses to novel home cage stress provide an excellent tool to assess both anxiolytic and sedative effects of various (subunit-selective) GABAAergic compounds. Content Type Journal ArticleCategory Original InvestigationDOI 10.1007/s00213-009-1460-4Authors Christiaan H. Vinkers, Utrecht University Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences (UIPS) and Rudolf Magnus Institute of Neuroscience Sorbonnelaan 16 3584 CA Utrecht The NetherlandsMarianne Klanker, Utrecht Universit...

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  Ambipolar pentacene/C[sub 60]-based field-effect transistors with high hole and electron mobilities in ambient atmosphere

Hu Yan, Tsubasa Kagata, and Hidenori Okuzaki Ambipolar field-effect transistors (FETs) were fabricated with a heterostructure of pentacene/C in which the C layer functioned as an n-type channel while the pentacene layer functioned as both a p-type channel and a sealing capsule for the unstable C layer. The ambipolar FET, operating in an ambien ... [Appl. Phys. Lett. 94, 023305 (2009)] published Fri Jan 16, 2009. (Source: Applied Physics Letters)

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  Pattern of Pediatric Zolpidem Ingestions Reported to Texas Poison Control Centers, 2000 to 2006.

Page: 26DOI: 10.1097/PEC.0b013e318191db3fAuthors: Forrester, Mathias B. BS (Source: Pediatric Emergency Care)

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  In vivo saturation binding of GABA-A receptor ligands to estimate receptor occupancy using liquid chromatography/tandem mass spectrometry

This study describes in vivo binding experiments without the use of tracer ligands. Bound and free fractions were measured directly using a highly sensitive LC/MS/MS detection method after in vivo administration of the GABA-A ligands zolpidem, (RS)-zopiclone, L-838417 and flumazenil, to demonstrate affinity and saturation of the filter-retained, membrane-bound fraction. The in vivo binding of flumazenil and L-838417 both saturated around 200 nm, at a similar level to the specific binding of (S)-zopiclone after doses of the racemic zopiclone, using (R)-zopiclone to estimate non-specific binding. This saturable component represented an estimate of benzodiazepine binding sites available on GABA-A receptors in vivo (200 nm). Dose-occupancy curves were constructed to estimate the dose required ...

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  Ambien May Have Led To Sleepwalking Death

A man who took a barefoot walk in arctic air may have taken a sleeping pill associated with bizarre behavior before going to bed. (Source: WDSU.com - Health)

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