MedWorm: Allegra

  ALLEGRA D-12 HOUR (Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Extended Release [Sanofi-Aventis U.S. LLC]

Updated Date: Mar 10, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  ALLEGRA--D 24 HOUR (Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated [Sanofi-Aventis U.S. LLC]

Updated Date: Feb 25, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FEXOFENADINE HCL AND PSEUDOEPHEDRINE HCLtablet, Extended Release [Caremark L.L.C.]

Updated Date: Feb 24, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Physicians Total Care, Inc.]

Updated Date: Feb 19, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Preparation and evaluation of spray-dried hyaluronic acid microspheres for intranasal delivery of fexofenadine hydrochloride.

Authors: Huh Y, Cho HJ, Yoon IS, Choi MK, Kim JS, Oh E, Chung SJ, Shim CK, Kim DD Hyaluronic acid (HA)-based microspheres containing PEG 6000 and/or sodium taurocholate (NaTC) were prepared by the spray-drying method for nasal delivery of fexofenadine hydrochloride (HCl). Their physicochemical properties including particle size and drug contents were determined, while their morphology examined by a scanning electron microscope (SEM). The effects of the solubilizer (PEG 6000) and the permeation enhancer (NaTC) on the in vitro release characteristics of fexofenadine.HCl were observed. Moreover, the in vitro permeation of fexofenadine.HCl was determined using the human nasal cell (HNE) monolayers cultured on Transwell((R)) inserts. After nasal administration, fexofenadine.HCl in rabbit pl...

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  National Institutes of Health State-of-the-Science Conference Statement: Diagnosis and Management of Ductal Carcinoma In Situ September 22-24, 2009

Conclusions Clearly, the diagnosis and management of DCIS is highly complex with many unanswered questions, including the fundamental natural history of untreated disease. Because of the noninvasive nature of DCIS, coupled with its favorable prognosis, strong consideration should be given to elimination of the use of the anxiety-producing term "carcinoma" from the description of DCIS. The outcomes in women treated with available therapies are excellent. Thus, the primary question for future research must focus on the accurate identification of patient subsets diagnosed with DCIS, including those persons who may be managed with less therapeutic intervention without sacrificing the excellent outcomes presently achieved. Essential in this quest will be the development and validation of accura...

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  FEXOFENADINE HYDROCHLORIDEtablet [American Health Packaging]

Updated Date: Jan 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  ALLEGRA-D (Fexofenadine And Pseudoephedrine) Tablet, Extended Release [Bryant Ranch Prepack]

Updated Date: Jan 28, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDEtablet, Film Coated, Extended Release [Physicians Total Care, Inc.]

Updated Date: Jan 25, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDEtablet, Film Coated, Extended Release [Winthrop U.S.]

Updated Date: Jan 21, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDEtablet, Film Coated, Extended Release [TEVA PHARMACEUTICALS USA INC]

Updated Date: Jan 21, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Microdose study of a P-glycoprotein substrate, fexofenadine, using a non-radioisotope-labelled drug and LC/MS/MS

Conclusion: For the P-glycoprotein substrate fexofenadine, the predictability of therapeutic-dose pharmacokinetics from microdose data was good. A microdose study using a non-radioisotope-labelled drug and LC/MS/MS is convenient, and has the potential to aid the early selection of drug candidates. (Source: Journal of Clinical Pharmacy and Therapeutics)

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  ALLEGRA D-12 HOUR (Fexofenadine Hcl And Pseudoephedrine Hcl ) Tablet, Extended Release [Caremark L.L.C.]

Updated Date: Jan 13, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Caremark L.L.C.]

Updated Date: Jan 13, 2010 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Comorbidity, Hospitalization, and Mortality in COPD: Results from a Longitudinal Study

Abstract  We evaluated comorbidity, hospitalization, and mortality in chronic obstructive pulmonary disease (COPD), with special attention to risk factors for frequent hospitalizations (more than three during the follow-up period), and prognostic factors for death. Two hundred eighty-eight consecutive COPD patients admitted to respiratory medicine wards in four hospitals for acute exacerbation were enrolled from 1999 to 2000 in a prospective longitudinal study, and followed up until December 2007. The Charlson index without age was used to quantify comorbidity. Clinical and biochemical parameters and pulmonary function data were evaluated as potential predictive factors of mortality and hospitalization. FEV1, RV, PaO2, and PaCO2 were used to develop an index of respiratory f...

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  Modified supracricoid laryngectomy

The objective of this study was to maintain the surgical strategy of supracricoid laryngectomy while focusing on reconstruction of the glottic plane. An essential part of the study was to recreate the anatomical conditions that allow phonation using the sternohyoid muscles for neoglottis reconstruction. (Source: Otolaryngology - Head and Neck Surgery)

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  Clinical research Fexofenadine with either montelukast or a low-dose inhaled corticosteroid (fluticasone) in the treatment of patients with persistent allergic rhinitis and newly diagnosed asthma

Conclusions: The combination of fexofenadine with either montelukast or a low-dose inhaled corticosteroid (fluticasone) equally reduces the serum sICAM-1 concentration and gives the same clinical effect in patients with persistent allergic rhinitis and newly diagnosed asthma. (Source: Articles of Archives of Medical Science - TERMEDIA publishing house)

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  RP-HPLC method for the quantitative determination of fexofenadine hydrochloride in coated tablets and human serum

This article deals with a simple, feasible, and sensitive isocratic reverse-phase high-performance liquid chromatographic method for the determination of fexofenadine hydrochloride in bulk drug, pharmaceutical dosage forms and in human serum. The chromatography was carried out at 20 ± 2°C using two different chromatographs and five different stationary phases. The isocratic mobile phase was phosphate buffer pH 7.4 and methanol (methanol–phosphate buffer, 35:65, v/v), detection was made at 218 nm and the mobile phase flowed at 1 ml min−1. Validation parameters included linearity, accuracy, precision, specificity, limit of detection (LOD), limit of quantification (LOQ), and robustness over a linearity range 5–15 μg ml−1 according to the ICH ...

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  Sanofi's Allegra Gambit

By buying Chattem, Sanofi-Aventis gets skilled marketers who can launch its allergy drug in the lucrative U.S. over-the-counter market. (Source: Forbes.com Healthcare News)

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  Copenhagen special: Climate change talks end in failure

A deal is done in Copenhagen but the climate change summit has been condemned as a failure. From the middle of the media hall in the Bella centre, where the negotiations have been taking place, the Guardian's environment editor, John Vidal, US environment correspondent Suzanne Goldenberg and Asia environment correspondent, Jonathan Watts , analyse the deal made by world leaders.We look at Barack Obama's influence as well as his disappointing speech. We ask whether it was China that held up the talks. Political correspondent Allegra Stratton, who has been travelling with the Downing Street team, tells us how Gordon Brown helped shape the negotiations. Four major NGOs give their reaction to the deal. We take a look at some of the lighter aspects of the final day in Copenhagen including the s...

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  Soluble CD138 serum levels are not associated with other poor prognostic markers in patients with B-chronic lymphocytic leukaemia

Abstract  The clinical course of CLL is highly variable, and survival from the time of diagnosis of CLL can range from months to decades. Novel biological markers such as IgVH mutation, CD38, and ZAP-70 expression have shown to offer important prognostic informations. Few reports deal with the sCD138 levels and bad prognostic factors in patients with CLL, and contrasting data are reported in literature. In our study, we evaluated the serum level of sCD138 in patients with B-CLL and its relationship with other prognostic markers. There was a significant association between advanced Rai stage and serum sCD138 levels in CLL subjects. Patients with Rai stage III-IV had significantly higher levels of sCD138 with respect to controls (48.85 ± 34 ng/ml vs. 31.1 ...

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  ALLEGRA D-12 HOUR (Fexofenadine Hcl And Pseudoephedrine Hcl ) Tablet, Extended Release [Caremark L.L.C.]

Updated Date: Dec 11, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Olfactory priming reinstates extinguished chocolate-induced conditioned place preference.

Authors: La Mela I, Latagliata EC, Patrono E, Puglisi-Allegra S, Ventura R A major problem in the dietary treatment of disorders associated with excessive eating, such as obesity, is the high rate of relapse into maladaptive eating habits after withdrawal from consumption of palatable, energy-dense food. As olfaction has a major role in appetite and eating behavior, in this study we used a reinstatement model based on conditioned place preference to investigate the ability of olfactory priming to reinstate extinguished chocolate-induced conditioned place preference in sated mice. We found that olfactory priming, which was ineffective in inducing conditioned place preference in the control group, reactivated place preference following the extinction procedure in the experimental group. ...

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  Tramadol-induced seizurogenic effect: a possible role of opioid-dependent histamine (H1) receptor activation-linked mechanism

Abstract  The present study has been designed to investigate the role of opioid receptors, mast cells, and histamine receptors (H1 subtype) in the seizurogenic effect of tramadol on pentylenetetrazole-treated mice. A single injection of pentylenetetrazole (80 mg kg−1) was used to elicit seizure activity in mice. Seizures were assessed in terms of the time latency of the onset of Straub-like tail, onset of jerky movements of whole body, convulsions, and death. Tramadol administration (50 mg kg −1) caused a marked increase in seizurogenic activity of pentylenetetrazole as measured in terms of a significant decrease in the time latency of the onset of Straub-like tail, jerky movements of whole body, convulsions, and death. Moreover, prior administration o...

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  ALLEGRA D-12 HOUR (Fexofenadine Hcl And Pseudoephedrine Hcl ) Tablet, Extended Release [Caremark LLC]

Updated Date: Dec 3, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  The effect of temperature on illness severity in emergency department congestive heart failure patients.

CONCLUSIONS: Contrary to our hypothesis, we found a statistically significant increase in the percentage of CHF visits admitted to the hospital during the warmer months. This suggests that although there are less ED CHF visits in the warmer months, a greater percentage tend to be severe. PMID: 20052444 [PubMed - in process] (Source: Annals of the Academy of Medicine, Singapore)

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  The effects of bilastine compared with cetirizine, fexofenadine, and placebo on allergen-induced nasal and ocular symptoms in patients exposed to aeroallergen in the Vienna Challenge Chamber

Abstract Objective and design  This double-blind cross-over study compared the potential of bilastine, cetirizine, and fexofenadine to relieve the symptoms of allergic rhinitis. Subjects and methods  Seventy-five allergic volunteers were challenged with grass pollen in the Vienna Challenge Chamber (VCC) on two consecutive days of allergen provocation; 6 h on day 1 and 4 h day 2. Bilastine 20 mg, cetirizine 10 mg, fexofenadine 120 mg, or placebo were taken orally 2 h after the start of provocation on day 1 only. Total nasal symptom scores, the global symptom scores, nasal secretions, and eye symptoms were assessed on both day 1 and day 2. Results and conclusions  Bilastine had a rapid onset of action, within 1&nb...

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  Avascular Necrosis of Bone in Leukemia and Osteonecrosis of Jaw by Bisphosphonates

Aseptic osteonecrosis, also known as avascular necrosis of bone or simply osteonecrosis (ON), is a disorder characterized by segmental death of 1 or more osseous sites due to a late toxicity of treatment for childhood leukemia and lymphoma. (Source: Journal of Oral and Maxillofacial Surgery)

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  FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDEtablet, Film Coated, Extended Release [Winthrop U.S.]

Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FEXOFENADINE HYDROCHLORIDE AND PSEUDOEPHEDRINE HYDROCHLORIDEtablet, Film Coated, Extended Release [TEVA PHARMACEUTICALS USA INC]

Updated Date: Nov 19, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FEXOFENADINE HCL AND PSEUDOEPHEDRINE HCLtablet, Extended Release [Caremark LLC]

Updated Date: Nov 12, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Preoperative Multimodality Therapy Improves Disease-Free Survival in Patients With Carcinoma of the Rectum: NSABP R-03 [Gastrointestinal Cancer]

Conclusion Preoperative chemoradiotherapy, compared with postoperative chemoradiotherapy, significantly improved DFS and showed a trend toward improved OS. (Source: Journal of Clinical Oncology)

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  Circadian pattern of intubation rates in ED patients with congestive heart failure

Conclusion: We found significant circadian variation in intubation rates, with a marked increase around midnight. Pathological mechanisms causing patients with congestive heart failure to require intubation may differ from those resulting in myocardial infarction or death. (Source: The American Journal of Emergency Medicine)

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  A structure filter for the Eukaryotic Linear Motif Resource

Conclusions: New occurrences of known linear motifs require experimental validation as the bioinformatics tools currently have limited reliability. The ELM structure filter will aid users assessing candidate motifs presenting in globular structural regions. Most importantly, it will help users to decide whether to expend their valuable time and resources on experimental testing of interesting motif candidates. (Source: BMC Bioinformatics - Latest articles)

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  Application of antihistamines in ear, nose and throat disorders

This study was a review of the antihistamines (AH) in allergic rhinitis (AR). Most patients had comorbid ocular symptoms, asthma and anxiety. Fifty-five percent consulting for the first time were diagnosed with AR, of whom 2/3 also had conjunctivitis and 1/3 asthma. In other study 3/4 asthma patients had AR and 1/4 did not. Every five required in the preceding year a treatment in emergency departments. The routine use of antihistamines for treating otitis exudativa in children cannot be recommended. Antihistamines were the most commonly prescribed or recommended symptomatic medicines in sinusitis (1/4 of the patients). About 30% reported sleep disturbance, increased to 44% in sedating AH (sAH) users, with reduced cognition and productivity loss. As histamine is a wake-promoting amine known...

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  Dopamine Type 2/3 Receptor Availability in the Striatum and Social Status in Human Volunteers

Conclusions: The results of this study support the hypothesis that social status and social support is correlated with D2/3 receptor binding. (Source: Biological Psychiatry)

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  Absence of the V617F JAK2 Mutation in the Lymphoid Compartment in a Patient with Essential Thrombo- cythemia and B-Chronic Lymphocytic Leukemia and in Two Relatives with Lymphoproliferative Disorders.

Conclusion: Our results seem to confirm that CLL cases are negative for JAK2(V617F) mutation in B- and T-lymphocyte populations.Presence of JAK2(V617F) mutation in subjects without myeloproliferative diseases could indicate an increased risk of a future myeloproliferative neoplasm development. PMID: 19816006 [PubMed - as supplied by publisher] (Source: Acta Haematologica)

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  Drug interaction studies of gliquidone with fexofenadine, cetirizine, and levocetirizine

This study thus supports the safe coadministration of gliquidone and H1-receptor blockers as an effective diabetic health management regimen. Content Type Journal ArticleCategory Original ResearchDOI 10.1007/s00044-009-9252-2Authors M. Saeed Arayne, University of Karachi Lab 9, Department of Chemistry Karachi 75270 PakistanNajma Sultana, University of Karachi Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy Karachi 75270 PakistanHina Shamshad, University of Karachi Research Institute of Pharmaceutical Sciences, Faculty of Pharmacy Karachi 75270 PakistanAgha Zeeshan Mirza, University of Karachi Lab 9, Department of Chemistry Karachi 75270 Pakistan Journal Medicinal Chemistry ResearchOnline ISSN 1554-8120Print ISSN 1054-2523 (Source: Medicinal Chemistry Research...

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  Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine

Molecular Pharmaceutics, Volume 0, Issue 0, Articles ASAP (As Soon As Publishable). (Source: Molecular Pharmaceutics)

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  Impact of OATP transporters on pharmacokinetics

Membrane transporters are now recognized as important determinants of the transmembrane passage of drugs. Organic anion transporting polypeptides (OATP) form a family of influx transporters expressed in various tissues important for pharmacokinetics. Of the 11 human OATP transporters, OATP1B1, OATP1B3 and OATP2B1 are expressed on the sinusoidal membrane of hepatocytes and can facilitate the liver uptake of their substrate drugs. OATP1A2 is expressed on the luminal membrane of small intestinal enterocytes and at the blood-brain barrier, potentially mediating drug transport at these sites. Several clinically used drugs have been identified as substrates of OATP transporters (e.g. many statins are substrates of OATP1B1). Some drugs may inhibit OATP transporters (e.g. cyclosporine) causing pha...

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  Exacerbation of chronic idiopathic thrombocytopenic purpura following reactivation of an occult hepatitis B

We report a case of autoimmune thrombocytopenia associated with acute reverse seroconversion of hepatitis B in a patient who was initially hepatitis B virus surface antigen negative and hepatitis B virus surface antibody positive. The search for occult HBV infection before immunosuppressive therapy and monitoring for reactivation is today diagnostic standard and several reports have been presented in literature about HBV reactivation following immunosuppressive therapy. In our patient, reactivation of dormant HBV happened prior to any immunosuppressive therapy. The case we report offers the occasion to emphasize the importance of medium-term and long-term hemovigilance also in other kind of patients than in subjects on immunosuppressive therapy. A deeper follow-up is advisable even i...

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  Possible montelukast-induced angioedema.

CONCLUSION: A patient developed angioedema four times during one month of treatment with montelukast. PMID: 19767375 [PubMed - in process] (Source: American Journal of Health-System Pharmacy : AJHP)

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  AMRI files 2 patent-infringement lawsuits

Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Health Insurance headlines)

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  AMRI files 2 patent-infringement lawsuits

Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Physician Practices headlines)

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  AMRI files 2 patent-infringement lawsuits

Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Industry Regulation headlines)

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  AMRI files 2 patent-infringement lawsuits

Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

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  AMRI files 2 patent-infringement lawsuits

Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Biotechnology headlines)

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  AMRI files 2 patent-infringement lawsuits

Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Hospitals headlines)

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  AMRI files 2 patent-infringement lawsuits

Albany Molecular Research Inc. has filed two new patent-infringement lawsuits with regard to fexofenadine, the active ingredient in Allegra. (SNY) (RDY) (Source: bizjournals.com Health Care:Health Insurance headlines)

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  FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Major Pharmaceuticals]

Updated Date: Sep 14, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Is there a uniform basal endometrial gene expression profile during the implantation window in women who became pregnant in a subsequent ICSI cycle?

CONCLUSIONS Our data suggest that very few genes, which change their expression level during the WOI, show a quantitative homogeneous expression in endometrially-receptive patients. In conclusion, in this study only six genes showed a homogeneous expression, and are probably involved in embryo implantation mechanisms. (Source: Human Reproduction)

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  Leukotriene receptor antagonist in the treatment of childhood allergic rhinitis - a randomized placebo-controlled study

This study was designed to assess the hypothesis that leukotriene receptor antagonists (LTRAs) would provide additional symptom relief in asthmatic children with persistent AR already taking regular antihistamine. The effects of 16-week treatment of LTRA in addition to fexofenadine (FEX) on persistent AR in asthmatic children were examined.Consecutive children with stable asthma and persistent AR were invited in this randomized, double-blind, placebo-controlled study. After a 2-week run-in period in which subjects were given FEX alone, they were randomly assigned to take LTRA or placebo in addition to FEX for 16 weeks, followed by 8 weeks of follow-up phase with FEX taken alone. Symptom scoring, rhinoscopy, acoustic rhinometry, spirometry, nasal secretion extraction and blood taking for IL...

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  Bioequivalence of fexofenadine tablet formulations assessed in healthy Iranian volunteers.

CONCLUSION: Based on the obtained results the two fexofenadine formulations are considered to be equivalent. PMID: 19728561 [PubMed - in process] (Source: Arzneimittel-Forschung)

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  FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Major Pharmaceuticals]

Updated Date: Sep 4, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Dr. Reddy'S Laboratories Limited]

Updated Date: Sep 1, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Temperature-dependent specific transport of levofloxacin in human intestinal epithelial LS180 cells

It was reported previously that specific levofloxacin uptake in Caco-2 cells was inhibited by nicotine, enalapril, L-carnitine and fexofenadine. The aim of the present study was to characterize the cellular uptake of levofloxacin using another human intestinal cell line, LS180. Levofloxacin uptake in LS180 cells was temperature-dependent and optimal at neutral pH, but was Na+-independent. The rank order of inhibitory effects of the four compounds on [14C] levofloxacin uptake in LS180 cells was nicotine>enalapril>L-carnitine>fexofenadine, which is consistent with that in Caco-2 cells. The mRNA levels of OATP1A2, 1B1, 1B3 and 2B1 in LS180 cells were markedly different from those in Caco-2 cells, and OATP substrates/inhibitors had no systematic effect on the levofloxacin uptake. The mRNA leve...

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  Histamine H1 receptor antagonists: Enhancement of ST segment changes (first reports with homochlorcyclizine, fexofenadine, epinastine and dexchlorpheniramine) in a patient with Brugada syndrome: case report

(Source: Reactions)

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  Long-Term Effects of Panax Ginseng on Disposition of Fexofenadine in Rats in vivo.

This study was designed to explore the pharmacokinetic interaction of Panax Ginseng with fexofenadine in rats. Sprague-Dawley (SD) male rats were divided randomly into four groups: control oral and treatment oral dose groups (n = 6, respectively); control intravenous and treatment intravenous dose groups (n = 5, respectively). A single dose of fexofenadine (10 mg/kg for intravenous group rats and 100 mg/kg for oral dose group rats) was administered after 14 consecutive days of gastric gavage feeding of panax ginseng suspension (150 mg/kg/day) to treatment groups while the same volume of vehicle (1.6% ethanol) was administered as placebo to control groups. Blood samples were collected from 0 to 12 hours and levels of fexofenadine were measured by LC-MS/MS. Tissues were harvested to determin...

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  Evaluation of the efficacy and safety of olopatadine and fexofenadine compared with placebo in Japanese cedar pollinosis using an environmental exposure unit.

CONCLUSIONS: These findings suggest that olopatadine is more effective than placebo and fexofenadine in improving nasal symptoms of Japanese cedar pollinosis. PMID: 19639726 [PubMed - in process] (Source: Journal of Investigational Allergology & Clinical Immunology)

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  Injury Patterns are Different for Older and Younger Patients in Equestrian Accidents

Conclusions: We found different patterns of injuries associated with equestrian accidents for older and younger patients. There were a statistically significant greater percentage of rib and spinal fractures for ages > 50 years. Older horseback riders may benefit from steps to prevent osteoporosis and by using chest protector vests. (Source: The Journal of Emergency Medicine)

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  Rise in Emergency Department Visits of Pediatric Patients for Renal Colic from 1999 to 2008

Conclusion: We found a marked increase in ED pediatric visits for renal colic over the past decade. This may reflect a real increase in the incidence of renal colic in the pediatric population or an increased use of imaging modalities for abdominal and flank pain. (Source: The Journal of Emergency Medicine)

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  A Regional Study of Emergency Department Visits for Acute Exacerbation of Chronic Obstructive Pulmonary Disease, 1996–2008

Conclusion: Similar to a previous study, we found no statistically significant change in the rate of visits to the ED for acute exacerbations of COPD or of intubation. However, contrary to that study, and despite availability of newer treatments, hospitalization rates for COPD patients in our area have increased. (Source: The Journal of Emergency Medicine)

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  Evaluating health-related quality of life, work ability, and disability in pulmonary arterial hypertension: an unmet need.

Authors: Rubenfire M, Lippo G, Bodini BD, Blasi F, Allegra L, Bossone E To our knowledge, there are no specific and validated measures of quality of life (QoL) or degree of disability for pulmonary arterial hypertension (PAH). A review of the literature shows that, with the exception of one recently designed specifically for pulmonary hypertension, QoL questionnaires used in PAH studies are generic measures. These are selected because of shared symptoms that do not necessarily correlate well with functional or physiologic measures and have not been validated for applicability in PAH. In this review, we present the available QoL tools for pulmonary artery hypertension and describe the need for more specific instruments that consider the physical and emotional implications of the disease...

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  The Anne Ford and Allegra Ford Scholarship 2009-2010 National Center for Learning Disabilities, Inc.

Deadline for Submission: Postmarked December 31, 2009 The Anne Ford and Allegra Ford Scholarship is a $10,000 award given to two high schoolseniors with identified learning disabilities (LD) who will be pursuing four-yearundergraduate degrees. Eligibility and Selection Criteria The National Center for Learning Disabilities, Inc. (NCLD) is seeking applicants for the Anne Ford and AllegraFord Scholarship, which is available to students of high merit with an identified learning disability (LD). To beeligible for the Anne Ford and Allegra Ford Scholarship, an applicant must:• Have an overall grade point average (GPA) of 3.0 or higher on a 4 point scale (or equivalent)• Demonstrate financial need• Provide most current documentation of an identified learning disabilityNote: ADD/A...

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  Double Posteromedial Portals for Posterior Ankle Arthroscopy in Supine Position.

We describe a two-portal posteromedial hindfoot procedure that allows the surgeon to reach both the posterior joint space and the extraarticular compartment of the hindfoot with the scope and instruments, regardless of diagnosis, with the patient supine. After arthroscopy on the anterior portion of the foot using standard anterior portals, the two posteromedial portals allow endoscopic inspection and management of abnormalities in this region without repositioning the patient and without any remarkable local complication. Level of Evidence: Level IV. See Guidelines for Authors for a complete description of levels of evidence. PMID: 19629608 [PubMed - as supplied by publisher] (Source: Clinical Orthopaedics and Related Research)

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  Measurement of fexofenadine concentration in micro-sample human plasma by a rapid and sensitive LC-MS/MS employing protein precipitation: application to a clinical pharmacokinetic study.

Authors: Guo D, Zou J, Zhu Y, Lou S, Fan H, Qin Q A simple, rapid and sensitive liquid chromatography/positive ion electro-spray tandem mass spectrometry method (LC-MS/MS) was developed and validated for the quantification of fexofenadine with 100 muL human plasma employing glipizide as internal standard (IS). Protein precipitation was used in the sample preparation procedure. Chromatographic separation was achieved on a reversed-phase C(18 )column (5 mum, 100 x 2.1 mm) with methanol : buffer (containing 10 mmol/L ammonium acetate and 0.1% formic acid; 70 : 30, v/v) as mobile phase. The total chromatographic runtime was approximately 3.0 min with retention time for fexofenadine and IS at approximately 1.9 and 2.1 min, respectively. Detection of fexofenadine and IS was achieved by LC-MS...

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  [Gastrointestinal Cancer] Initial Safety Report of NSABP C-08: A Randomized Phase III Study of Modified FOLFOX6 With or Without Bevacizumab for the Adjuvant Treatment of Patients With Stage II or III Colon Cancer

Conclusion Bevacizumab with modified FOLFOX6 is well tolerated in the surgical adjuvant setting in these patients. No significant increase in GI perforation, hemorrhage, arterial or venous thrombotic events, or death with the addition of bevacizumab to modified FOLFOX6 has been observed. Follow-up for potential delayed adverse effects and efficacy is ongoing. (Source: Journal of Clinical Oncology)

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  Initial Safety Report of NSABP C-08: A Randomized Phase III Study of Modified FOLFOX6 With or Without Bevacizumab for the Adjuvant Treatment of Patients With Stage II or III Colon Cancer [Gastrointestinal Cancer]

Conclusion Bevacizumab with modified FOLFOX6 is well tolerated in the surgical adjuvant setting in these patients. No significant increase in GI perforation, hemorrhage, arterial or venous thrombotic events, or death with the addition of bevacizumab to modified FOLFOX6 has been observed. Follow-up for potential delayed adverse effects and efficacy is ongoing. (Source: Journal of Clinical Oncology)

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  Endothelial progenitor cells: pathogenetic role and therapeutic perspectives.

Authors: Allegra A, Coppolino G, Bolignano D, Giacobbe MS, Alonci A, D'Angelo A, Bellomo G, Teti D, Loddo S, Musolino C, Buemi M Bone marrow-derived, CD34+ progenitor cells have been shown to promote the repair of damaged tissues, offering promise for the treatment of hereditary and acquired human diseases. These cells in fact differentiate into endothelia, hematopoietic cells and possibly neurons, fibroblasts and muscle. CD34+ and AC133+ progenitor cells may participate in neovascularization by differentiating into endothelial cells. Circulating bone marrow-derived endothelial cells home to sites of neovascularization and stimulate healing of injured tissues but also promote restenosis, tumor growth and inflammatory disease. These cells may thus participate in tissue regeneration or p...

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  Pharmacokinetic drug interaction between fexofenadine and fluvastatin mediated by organic anion-transporting polypeptides in rats.

This study aimed to examine the transporter-mediated drug interaction between fexofenadine and fluvastatin in rats. Compared to the control group given fluvastatin alone, the concurrent use of fexofenadine (10 or 20mg/kg) prior to the oral administration of fluvastatin (5mg/kg) decreased the systemic exposure of fluvastatin by 17-51% in rats. Consequently, the bioavailability of oral fluvastatin was significantly lower (p<0.05) in the presence of fexofenadine compared to that from the control group. Furthermore, the intravenous pharmacokinetics of fluvastatin (2mg/kg) was significantly altered by the pretreatment with fexofenadine (20mg/kg, p.o.). The plasma clearance of fluvastatin was reduced by 44% in the presence of fexofenadine. The effect of fluvastatin on the pharmacokinetics of ...

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  Regenerative Medicine: does Erythropoietin have a role?

Authors: Buemi M, Lacquaniti A, Maricchiolo G, Bolignano D, Campo S, Cernaro V, Sturiale A, Grasso G, Buemi A, Allegra A, Donato V, Genovese L Regenerative Medicine, a recent new medical domain, aims to develop new therapies through the stimulation of natural regenerative processes also in human beings. In this field, Erythropoietin (EPO) represents a significant subject of research. Several studies allow the assertion that EPO, in different concentrations, has protective effects mainly on the central nervous system, cardiovascular system and renal tissue. This action is carried out through one of few regenerative activities of human beings: angiogenesis. This mechanism, which involves endothelial stem cells and VEGF (Vascular Endothelial Growth Factor), has been experimentally demonst...

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  Fexofenadine: biochemical, pharmacokinetic and pharmacodynamic properties and its unique role in allergic disorders

Expert Opinion on Drug Metabolism & Toxicology , July 2009, Vol. 5, No. 7, Pages 813-822. (Source: Expert Opinion: Expert Opinion on Drug Metabolism & Toxicology: Table of Contents)

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  Suppression of histamine- and allergen-induced skin reactions: comparison of first- and second-generation antihistamines.

CONCLUSIONS: These results indicate that hydroxyzine is more effective than nsAHs when given as recommended in suppressing histamine-induced or allergic skin reactions. Our results suggest that higher doses of nsAHs than those currently recommended are required for the treatment of skin responses to obtain antihistaminic and antiallergic effects that are equivalent to those of fgAHs. PMID: 19558008 [PubMed - in process] (Source: Annals of Allergy, Asthma and Immunology)

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  JAK2-Positive Latent Essential Thrombocythemia and Splanchnic Vein Thrombosis: The Role of Bone Marrow Biopsy for the Diagnosis of Myeloproliferative Disease.

Conclusions: In these patients with SVT, the detection of JAK2(V617F) mutation is diagnostic for masked MPD as could be documented by bone marrow histopathology. The presence of JAK2(V617F) mutation should be considered per se a prothrombotic state for cerebral, coronary and peripheral microvascular disturbances and for SVT but not for deep vein thrombosis. Anticoagulation is the treatment of choice for all SVT and proper treatment of the MPD is recommended in patients with SVT associated with the JAK2(V617F) mutation. PMID: 19478480 [PubMed - as supplied by publisher] (Source: Acta Haematologica)

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  Fluticasone furoate nasal spray is more effective than fexofenadine for nighttime symptoms of seasonal allergy

(Source: Allergy and Asthma Proceedings)

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  Why turmeric could be the spice of life

Eating high-fat curries may not be as bad for us as we thought - at least, not if we lace them with turmeric. Scientists at Boston's Tufts University found that mice fed a high-fat diet that contained curcumin, a component of turmeric, put on less weight. This puts the spice in that magic group of foods with health-giving properties - along with garlic, ginger and fish oils.Like ginger, turmeric is a rhizome, a horizontal stem of a plant that grows underground. Generally speaking, it is prized more for its colour than its flavour: turmeric is the oldest natural food dye in the world, and is now seen in ingredients lists as E100. In my opinion, however, this downgrading from flavour to colour is largely due to the spice we get in Britain being old and dull by the time it reaches us. In Zanz...

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  Phase III C-08 Study Of Avastin In Early-Stage Colon Cancer Did Not Meet Primary Endpoint

Genentech, Inc. announced that a Phase III study of Avastin ?? (bevacizumab) plus chemotherapy following surgery in patients with early-stage (adjuvant) colon cancer (NSABP C-08) did not meet its primary endpoint of reducing the risk of cancer returning (improvement in disease-free survival). Results are from a planned final analysis of the study. This is the first trial of Avastin in early-stage cancer and results do not affect approved indications in advanced (metastatic) disease. Safety findings were consistent with those presented from this study at the 2008 American Society of Clinical Oncology (ASCO) annual meeting (Allegra et al.). Data from the trial have been submitted for presentation at the upcoming ASCO annual meeting, May 29... (Source: Cancercompass News: Colorectal Cancer)

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  A review of the efficacy of desloratadine, fexofenadine, and levocetirizine in the treatment of nasal congestion in patients with allergic rhinitis.

Conclusions: In the studies reviewed, desloratadine, fexofenadine, and levocetirizine were effective in relieving the nasal congestion associated with AR compared with placebo. This effect began as early as day 2 and was consistent and progressive throughout treatment. Desloratadine, fexofenadine, and levocetirizine are appropriate options for the treatment of nasal congestion in patients with AR. PMID: 19539095 [PubMed - in process] (Source: Clinical Therapeutics)

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  Fexofenadine hydrochloride enhances the efficacy of contact immunotherapy for extensive alopecia areata: Retrospective analysis of 121 cases

To study the effect of fexofenadine on extensive alopecia areata (AA), we evaluated retrospectively 121 patients with AA having alopecia in more than 50% of the scalp and followed them for at least 6 months. Patients were treated by immunotherapy using diphenylcyclopropenone or squaric acid dibutylester with or without oral fexofenadine. The regrowth score was estimated as decrease of Severity of Alopecia Tool (SALT) score. In AA with atopic background (atopic AA), the mean regrowth score of the fexofenadine group was 1.333 (n = 33) and that of the control 0.471 (n = 34). The fexofenadine group showed significantly better regrowth than control by Mann[ndash]Whitney's U-test (P = 0.00213). In non-atopic AA, the mean regrowth score of the fexofenadine group was 1.303 (n = 33) and that of the...

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  Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity

Conclusions: Nelfinavir induced methadone clearance by increasing renal clearance, and more so by stereoselectively increasing hepatic metabolism, extraction and clearance. Induction occurred despite 50% inhibition of hepatic CYP3A4/5 activity and more than 75% inhibition of first-pass CYP3A4/5 activity, suggesting little or no role for CYP3A in clinical methadone disposition. Nelfinavir may alter methadone pharmacodynamics, increasing clinical effects. (Source: Drug and Alcohol Dependence)

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  [ASCO SPECIAL ARTICLES] American Society of Clinical Oncology Provisional Clinical Opinion: Testing for KRAS Gene Mutations in Patients With Metastatic Colorectal Carcinoma to Predict Response to Anti-Epidermal Growth Factor Receptor Monoclonal Antibody Therapy

Purpose An American Society of Clinical Oncology (ASCO) provisional clinical opinion (PCO), offers timely clinical direction to ASCO's oncologists following publication or presentation of potentially practice-changing data from major studies. This PCO addresses the utility of KRAS gene mutation testing in patients with metastatic colorectal carcinoma to predict response to anti–epidermal growth factor receptor (anti-EGFR) monoclonal antibody (MoAb) therapy with cetuximab or panitumumab (see Note). Clinical Context Recent results from phase II and III clinical trials demonstrate that patients with metastatic colorectal cancer benefit from therapy with monoclonal antibodies directed against the EGFR, when used either as monotherapy or combined with chemotherapy. Retrospective subset a...

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  The occurrence of antihistamines in sewage waters and in recipient rivers.

CONCLUSIONS: Antihistamines are poorly degraded/eliminated under the biological treatment processes applied in the wastewater treatment plants and, consequently, they are continuously being discharged along with other drugs to the aquatic environment. RECOMMENDATIONS AND PERSPECTIVES: As a huge quantity and variety of drugs and their metabolites are continuously discharged to rivers and the sea, the compounds should be considered as contaminants that may possess risks to the aquatic ecosystem. Further studies are urgently needed on the environmental fate of the antihistamines and other pharmaceuticals in the aquatic environment. These studies should be concerned with the stability of the compounds, their transformation reactions and the identity of the transformation products, the distribu...

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  [COMMENTS AND CONTROVERSIES] The Marriage of Growth Factor Inhibitors and Chemotherapy: Bliss or Bust?

(Source: Journal of Clinical Oncology)

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  FEXOFENADINE HYDROCHLORIDEtablet, Film Coated [Dr. Reddy'S Laboratories Limited]

Updated Date: Mar 13, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Neural activation of swallowing and swallowing-related tasks in healthy young adults: An attempt to separate the components of deglutition

Understanding the underlying neural pathways that govern the highly complex neuromuscular action of swallowing is considered crucial in the process of correctly identifying and treating swallowing disorders. The aim of the present investigation was to identify the neural activations of the different components of deglutition in healthy young adults using functional magnetic resonance imaging (fMRI). Ten right-handed young healthy individuals were scanned in a 3-Tesla Siemens Allegra MRI scanner. Participants were visually cued for both a "Swallow" task and for component/control tasks ("Prepare to swallow", "Tap your tongue", and "Clear your throat") in a randomized order (event-related design). Behavioral interleaved gradient (BIG) methodology was used to address movement-related artifacts...

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  Short-term effect of quercetin on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein, in healthy volunteers

Conclusion  The results of the present study showed that short-term use of quercetin elevated the plasma concentrations of fexofenadine, probably by the inhibition of P-gp-mediated efflux in humans. Content Type Journal ArticleCategory Pharmacokinetics and DispositionDOI 10.1007/s00228-009-0627-6Authors Kyoung-Ah Kim, Korea University College of Medicine Department of Clinical Pharmacology and Toxicology, Anam Hospital 126-1, Anam-dong 5-ga, Sungbuk-gu Seoul 136-705 KoreaPil-Whan Park, Gil Medical Center, Gachon Medical School Department of Laboratory Medicine Incheon KoreaJi-Young Park, Korea University College of Medicine Department of Clinical Pharmacology and Toxicology, Anam Hospital 126-1, Anam-dong 5-ga, Sungbuk-gu Seoul 136-705 Korea Journal European Jour...

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  Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity.

CONCLUSIONS: Nelfinavir induced methadone clearance by increasing renal clearance, and more so by stereoselectively increasing hepatic metabolism, extraction and clearance. Induction occurred despite 50% inhibition of hepatic CYP3A4/5 activity and more than 75% inhibition of first-pass CYP3A4/5 activity, suggesting little or no role for CYP3A in clinical methadone disposition. Nelfinavir may alter methadone pharmacodynamics, increasing clinical effects. PMID: 19232844 [PubMed - as supplied by publisher] (Source: Drug and Alcohol Dependence)

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  Update on prescription and over-the-counter histamine inverse agonists in rhinitis therapy

Abstract  Allergic rhinitis (AR) is associated with histamine-mediated physiologic events. The currently used histamine antagonists are all inverse agonists that bind and inactivate histamine H1 receptors. Second- generation antihistamines are much more H1-receptor selective with less central nervous system penetration than first-generation agents. Antihistamines typically are more effective in seasonal than perennial AR and do not demonstrate significant relief of nasal congestion. The recent availability of some second-generation antihistamines as over-the-counter products clearly places them as the preferred first-line treatment for mild to moderate AR based on safety when compared with first-generation over-the-counter antihistamines. The remaining prescription-only sec...

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  Dopamine D1 Receptors in Cocaine Dependence Measured with PET and the Choice to Self-Administer Cocaine

Authors: Diana Martinez, Mark Slifstein, Rajesh Narendran, Richard W Foltin, Allegra Broft, Dah-Ren Hwang, Audrey Perez, Anissa Abi-Dargham, Marian W Fischman, Herbert D Kleber & Marc Laruelle Keywords: PET, D1 receptor, cocaine, cocaine-seeking behavior, striatum, limbic striatum (Source: Neuropsychopharmacology)

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  ALLEGRA (Fexofenadine Hydrochloride) Tablet, Orally Disintegrating ALLEGRA (Fexofenadine Hydrochloride) Tablet, Film Coated ALLEGRA (Fexofenadine Hydrochloride) Suspension [Sanofi-Aventis]

Updated Date: Jan 5, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  ALLEGRA--D 24 HOUR (Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated [Sanofi-Aventis U.S. LLC]

Updated Date: Jan 5, 2009 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  A Qualitative Approach to the Intersection of Sexual, Ethnic, and Gender Identities

(Source: Identity)

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  Teva paying more than $30M to settle Sanofi-Aventis suit

Teva Pharmaceuticals USA Inc. and Barr Laboratories Inc. signed an agreement Wednesday with Aventis Pharmaceuticals Inc., Sanofi-Aventis and Albany Molecular Research Inc. to settle patent infringement litigation over Teva’s and Barr’s U.S. generic versions of Aventis Pharmaceuticals’ Allegra allergy medicine. (TEVA) (SNY) (AZN) (Source: bizjournals.com Health Care:Hospitals headlines)

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  AMRI settles patent dispute with rivals

Albany Molecular Research Inc. has settled a patent dispute with two rivals regarding generic versions of the antihistamine Allegra. (Source: bizjournals.com Health Care:Hospitals headlines)

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  Barr Announces Agreements on Nasacort AQ, Allegra D-12 and Allegra Patent Challenges

- Settlement and License Agreement for Generic Versions of Nasacort(R) AQ - Settlement and License Agreement with Aventis and Albany Molecular Research, Inc. for Generic Versions of Allegra(R) D-12 - Settlement Agreement with Aventis and Albany... (Source: Drugs.com - Pharma News)

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  Sanofi reaches settlements on generics

Sanofi-Aventis has agreed to settle patent infringement suits in the US with Barr Pharmaceuticals and Teva Pharmaceuticals over their generic copies of its allergy drugs Allegra and Nasacort (Source: FT.com - Drugs and Healthcare)

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  ACAAI 2008: Intranasal Steroid Outperforms Antihistamine in Relieving Nighttime Allergy Symptoms

A direct comparison of fluticasone furoate nasal spray and oral fexofenadine showed that fluticasone better relieves nighttime symptoms of seasonal allergic rhinitis. Medscape Medical News (Source: Medscape Medical News Headlines)

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  Kiehl’s and celebrities support Terrence Higgins Trust for World AIDS Day – will you?

Skin and haircare specialist Kiehl’s is launching a major fundraising and awareness campaign for Terrence Higgins Trust (THT) in the run up to World AIDS Day – 1 December. Six celebrities have designed Kiehl’s canvas shopping bags which will be raising money for the charity during a number of events.  These are the dates for your diary:22 November to 1 December - eBay auction: Allegra Hicks, Mathew Horne, Gail Porter, Petra Nemcova, Tamara Beckwith and David James have all designed Kiehl’s canvas shopping bags which will be auctioned on eBay to raise money for THT.  Some bags will be signed by the high profile designers and all will be filled with the celebrities’ favourite Kiehl’s products.  Visit www.ebay.co.uk/tht_celebrity_bags18 November - Fundraising day at Selfridges:...

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  Authors' reply.

Authors: Checcucci G, Allegra A, Bigazzi P, Gianesello L, Ceruso M, Gritti G PMID: 18971071 [PubMed - in process] (Source: Arthroscopy)

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  Increases in Heart Failure Visits After Christmas and New Year's Day.

Authors: Reedman LA, Allegra JR, Cochrane DG The authors hypothesized increased emergency department (ED) visits for heart failure (HF) during a 2-week Christmas holiday period similar to a recent study showing increased cardiac death rates. A retrospective analysis was performed from a database of 18 EDs in New Jersey and New York from January 1, 1996, to November 30, 2004, analyzing HF visits from December 1 to January 31. The authors compared the mean daily visits for the 2-week holiday period of December 25 to January 7, as well as December 26 to December 30 and January 2 to January 5, using the Student t test. A total of 4.7 million patients were studied, 65,646 with an ED diagnosis of HF and 11,525 during January and December. There was a 23% (95% confidence interval [CI], 14%-31...

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  Fexofenadine: First report of eosinophilic hepatitis: case report

(Source: Reactions)

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  Fexofenadine: First report of eosinophilic hepatitis: case report.

Page: 13 (Source: Reactions Weekly)

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  Flow cytometry is able to monitor legionella viability.

FLOW CYTOMETRY IS ABLE TO MONITOR LEGIONELLA VIABILITY. Appl Environ Microbiol. 2008 Oct 10; Authors: Allegra S, Berger F, Berthelot P, Grattard F, Pozzetto B, Riffard S Legionella viability was monitored during heat-shock treatment at 70 degrees C by flow cytometric assay (FCA). After 30 minutes of treatment, for 6 of the 12 tested strains, FCA still detected 10 to 25% of viable but not culturable (VBNC) cells able to produce ATP and to be resuscitated after culture on amoebae. PMID: 18849449 [PubMed - as supplied by publisher] (Source: Applied and Environmental Microbiology)

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  [Letter to JMG] Alteration of expression of muscle specific isoforms of the fragile X related protein 1 (FXR1P) in facioscapulohumeral muscular dystrophy patients

Conclusion: Our data suggest that the molecular basis of FSHD not only involves splicing alterations, as previously proposed, but may also involve a deregulation of mRNA stability. In addition, since FXR1P is an RNA binding protein likely to regulate the metabolism of muscle specific mRNAs during myogenesis, its altered expression in FSHD myoblasts may contribute to the physiopathology of this disease. (Source: Journal of Medical Genetics)

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  Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test

Conclusions: &lt;/b&gt; Fexofenadine had the earliest onset of action while levocetirizine showed maximum inhibition of wheal response after three and six hours. (Source: Indian Journal of Dermatology, Venereology and Leprology)

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  Comparative efficacy of levocetirizine, desloratidine and fexofenadine by histamine wheal suppression test

Conclusions: &lt;/b&gt; Fexofenadine had the earliest onset of action while levocetirizine showed maximum inhibition of wheal response after three and six hours. (Source: Indian Journal of Dermatology, Venereology and Leprology)

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  Narrowband ultraviolet B phototherapy is beneficial in antihistamine-resistant symptomatic dermographism: A pilot study.

CONCLUSIONS: NB UVB phototherapy is an effective second-line treatment for patients with severe symptomatic dermographism responding poorly to fexofenadine. This therapy can lead to subjective relief of pruritus and whealing and objective reduction of whealing. NB UVB phototherapy may restore symptom control with antihistamines in some patients. PMID: 18774200 [PubMed - as supplied by publisher] (Source: Journal of the American Academy of Dermatology)

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  Chain folding and polymer crystallization: A statistical--mechanical approach

G. Allegra The essential factor controlling the formation of chain folded polymer crystals is attributed to the statistical distribution of many subcritical nuclei pre-existing within the chains. Each nucleus should consist of at least three parallel segments belonging to the same chain; its statistical probab ... [J. Chem. Phys. 66, 5453 (2008)] published Tue Aug 26, 2008. (Source: Journal of Chemical Physics)

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  Specialists question decision not to fund drugs for kidney cancer

Advisory body says treatment is too expensive but doctors say they have got their sums wrong (Source: Guardian Unlimited Science)

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  Fexofenadine Effects on Cognitive Performance in Aviators at Ground Level and Simulated Altitude

(Source: Aviation, Space, and Environmental Medicine)

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  Relationship between airborne pollen count and treatment outcome in Japanese cedar pollinosis patients

Abstract  In Japan, information on daily Japanese cedar pollen counts is made public during pollen season. If symptom severity and treatment outcome are predictable according to these pollen counts, management of seasonal allergic rhinitis may become more precise. The aims of the study were to evaluate the relationship between airborne pollen counts, symptom severity and treatment outcome in Japanese cedar pollinosis patients. In the randomized study, patients with moderate to most severe Japanese pollinosis were treated with fexofenadine (60 mg BD) or fexofenadine and nasal corticosteroids for 2 weeks. During the same period daily airborne pollen counts were measured. A total of 105 adult patients were enrolled. No difference of treatment efficacy was seen among ...

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  Pharmacokinetics, safety and tolerability of an oral suspension of fexofenadine for children with allergic rhinitis

(Source: Allergy and Asthma Proceedings)

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  Clinical drugs that interact with St. John's wort and implication in drug development.

Authors: Di YM, Li CG, Xue CC, Zhou SF St. John's wort (Hypericum perforatum, SJW) is one of the most commonly used herbal antidepressants for the treatment of minor to moderate depression. A major safety concern about SJW is its ability to alter the pharmacokinetics and/or clinical response of a variety of clinically important drugs that have distinctive chemical structure, mechanism of action and metabolic pathways. This review highlights and updates the knowledge on clinical interactions of prescribed drugs with SJW and the implication in drug development. A number of clinically significant interactions of SJW have been identified with conventional drugs, including anticancer agents (imatinib and irinotecan), anti-HIV agents (e.g. indinavir, lamivudine and nevirapine), anti-inflamma...

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  [Articles] Diffusion Tensor Imaging Findings in First-Episode and Chronic Schizophrenia Patients

CONCLUSIONS: The cross-sectional data reported here suggest less widespread changes in white matter at illness onset in schizophrenia which progress in more chronic states. More definitive conclusions will require follow-up imaging of first-episode schizophrenia patients. (Source: Am J Psychiatry)

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  Health ministers stunned by embryo bill delay

'Flagship' government bill allowing research using animal-human hybrid embryos is withdrawn (Source: Guardian Unlimited Science)

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  Mechanism of Ritonavir Changes in Methadone Pharmacokinetics and Pharmacodynamics: II. Ritonavir Effects on CYP3A and P-Glycoprotein Activities.

Authors: Kharasch E, Bedynek P, Walker A, Whittington D, Hoffer C Ritonavir diminishes methadone plasma concentrations, an effect attributed to CYP3A induction, but the actual mechanisms are unknown. We determined short-term (2-day) and steady-state (2-week) ritonavir effects on intestinal and hepatic CYP3A4/5 (probed with intravenous (IV) and oral alfentanil (ALF) and with miosis) and P-glycoprotein (P-gp) (fexofenadine), and on methadone pharmacokinetics and pharmacodynamics in healthy volunteers. Acute ritonavir increased the area under the concentration-time curve (AUC)(0-infinity)/dose ratio (ritonavir/control) for oral ALF 25-fold. Steady-state ritonavir increased the AUC(0-infinity)/dose ratio for IV and oral ALF 4- and 10-fold, respectively; reduced hepatic extraction (from 0.2...

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  Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1

Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1 Molecular Psychiatry advance online publication, July 8, 2008. doi:10.1038/mp.2008.63 Authors: L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager, F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, S Puglisi-Allegra, K-L Reichelt & A M Persico (Source: Molecular Psychiatry)

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  Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1

Altered calcium homeostasis in autism-spectrum disorders: evidence from biochemical and genetic studies of the mitochondrial aspartate/glutamate carrier AGC1 Molecular Psychiatry advance online publication, July 8, 2008. doi:10.1038/mp.2008.63 Authors: L Palmieri, V Papaleo, V Porcelli, P Scarcia, L Gaita, R Sacco, J Hager, F Rousseau, P Curatolo, B Manzi, R Militerni, C Bravaccio, S Trillo, C Schneider, R Melmed, M Elia, C Lenti, M Saccani, T Pascucci, S Puglisi-Allegra, K-L Reichelt & A M Persico (Source: Molecular Psychiatry)

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  Reduced serum levels of Interleukin 17 in patients with osteonecrosis of the jaw and in multiple myeloma subjects after bisphosphonates administration.

Authors: Oteri G, Allegra A, Bellomo G, Alonci A, Nastro E, Penna G, Catalfamo L, Cicciù D, Ponte FS, Musolino C PMID: 18585926 [PubMed - as supplied by publisher] (Source: Cytokine)

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  The effects of fexofenadine at steady-state on sleep architecture: a study using polysomnography in healthy Korean volunteers

Expert Opinion on Pharmacotherapy , July 2008, Vol. 9, No. 10, Pages 1655-1665. Objectives: To compare the effects of a first-generation antihistamine, chlorpheniramine, with those of the second-generation antihistamine, fexofenadine, at steady-state, on nocturnal sleep architecture in healthy Korean volunteers using polysomnography ... (Source: Expert Opinion: Expert Opinion on Pharmacotherapy: Table of Contents)

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  Diffusion Tensor Imaging Findings in First-Episode and Chronic Schizophrenia Patients.

Conclusions The cross-sectional data reported here suggest less widespread changes in white matter at illness onset in schizophrenia which progress in more chronic states. More definitive conclusions will require follow-up imaging of first-episode schizophrenia patients. PMID: 18558643 [PubMed - as supplied by publisher] (Source: The American Journal of Psychiatry)

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  Fexofenadine Hydrochloride(Fexofenadine Hydrochloride) Tablet, Film Coated [Prasco Laboratories]

Updated Date: Jun 5, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  A new technique for regional anesthesia for arthroscopic shoulder surgery based on a suprascapular nerve block and an axillary nerve block: an evaluation of the first results.

CONCLUSIONS: Combining SSNB and ANB is an effective and safe technique for intraoperative anesthesia and postoperative analgesia for certain procedures of shoulder arthroscopic surgery. PMID: 18514113 [PubMed - in process] (Source: Arthroscopy)

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  [Editorials] Don Quixote and the Quest for Personalized Medicine

(Source: Journal of Clinical Oncology)

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  Evaluation of circulating endothelial cells, VEGF and VEGFR2 serum levels in patients with chronic myeloproliferative diseases

In this study by using a cytofluorimetric analysis we evaluated circulating endothelial progenitor cells (EPCs) in patients with chronic myeloproliferative disease. Moreover, in the same group of subjects, we evaluated serum levels of vascular endothelial growth factor (VEGF) and vascular endothelial growth factor receptor-2 (VEGFR2). In our patients, we have found an increase in the number of endothelial progenitor cells in primary myelofibrosis (PMF) and polycythaemia vera (PV) patients, while an increase of circulating endothelial cells (CECs) was found in all patients with CMD. Moreover, we found higher serum levels of VEGF with respect to control subjects in every group of patients with CMD, and a not significant reduction of VEGFR2 levels in essential thrombocythaemia (ET) patients. ...

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  How Do You Treat Chronic Urticaria?

Discussion Chronic urticaria is defined as wheals that occur at least twice weekly for more than 6 weeks. Because this is broad, some people add that the wheals must be present for more than 1 hour (which distinguishes chronic urticaria from dermatographism) and less than 24-36 hours (which distinguishes it from urticaria-vasculitis). The lesions can be 'just' irritating or very painful and even indurated. Outbreaks can occur for weeks-years and affects up to 3 % of the population. Generally there are no systemic problems but some patients have greatly diminished quality of life that is equivalent to people with severe coronary artery disease. Chronic urticaria can be caused by a specific physical stimulus or often is idiopathic. Up to 1/3 of idiopathic cases appear to be autoimmune relate...

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  Time-dependent inhibition of histamine-induced cutaneous responses by oral and intramuscular diphenhydramine and oral fexofenadine

(Source: Annals of Allergy, Asthma and Immunology)

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  Time-dependent inhibition of histamine-induced cutaneous responses by oral and intramuscular diphenhydramine and oral fexofenadine.

CONCLUSION: Diphenhydramine tended to work more rapidly than fexofenadine, but the differences were not statistically significant. Given the adverse effect profile of diphenhydramine, but only marginal onset of action advantage, the risk-to-benefit ratio may be more favorable for oral fexofenadine when treating an acute urticarial or allergic reaction. PMID: 18517077 [PubMed - indexed for MEDLINE] (Source: Annals of Allergy, Asthma and Immunology)

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  Colossal squid

Scientists in New Zealand dissecting a rarely seen colossal squid say they have discovered the largest known eye.Over the last few days the creature has been examined as it emerges from the deep freeze in which it has been kept since it was accidentally caught by fishermen off the coast of Antarctica last February. While defrosting the 495kg (78lb) animal took longer than expected, scientists working at Museum of New Zealand Te Papa Tongarewa found that its two eyes measured 27cm (11in) across, with lenses 10 to 12 centimetres in diameter — the size of an orange. "This is the only intact eye (of a colossal squid) that's ever been found. It's spectacular," said Auckland University of Technology squid specialist Kat Bolstad, one of a team of international scientists brought in to examine t...

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  [Gastrointestinal Cancer] Potential Regional Differences for the Tolerability Profiles of Fluoropyrimidines

Conclusion Regional differences exist in the tolerability profiles of fluoropyrimidines. More treatment-related toxicity was reported in the US compared with the rest of the world for bolus FU/LV and capecitabine in first-line MCRC and adjuvant colon cancer. In the adjuvant setting, a range of fluoropyrimidine tolerability was observed, with East Asian patients having the lowest, and US patients the highest, RR. (Source: Journal of Clinical Oncology)

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  New Zealand scientists begin examination of colossal squid

Scientists in New Zealand begin delicate operation of defrosting colossal squid caught off coast of Antarctica last year (Source: Guardian Unlimited Science)

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  Study sheds light on octopus sex

Far from being the loners marine biologists had categorised them as for decades, octopuses are pretty lascivious, study reveals (Source: Guardian Unlimited Science)

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  Clinical Pharmacokinetics and Pharmacodynamics of Desloratadine, Fexofenadine and Levocetirizine: A Comparative Review

(Source: Clinical Pharmacokinetics)

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  Archaeologists discover ruins of Inca temple in Peru

Scientists find ancient road and irrigation systems at fortress close to civilisation's capital, Cuzco (Source: Guardian Unlimited Science)

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  Recreating a Residency Through a Comprehensive Community-centered Care Model (Allegra Melillo MD)

Presentation at the 28th Annual STFM Families and Health Conference New Orleans, 2008 (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

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  Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression

Authors: C Lintas, R Sacco, K Garbett, K Mirnics, R Militerni, C Bravaccio, P Curatolo, B Manzi, C Schneider, R Melmed, M Elia, T Pascucci, S Puglisi-Allegra, K-L Reichelt & A M Persico (Source: Molecular Psychiatry)

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  A Learning Partnership: A Family Medicine Residency, a Foundation, and a Community Council (Allegra Melillo MD)

Presentation at the 28th Annual STFM Families and Health Conference New Orleans, 2008 (Source: Family Medicine Digital Resources Library (FMDRL) Recently Uploaded)

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  Evaluation of the antihistamine effects of olopatadine, cetirizine and fexofenadine during a 24 h period: a double-blind, randomized, crossover, placebo-controlled comparison in skin responses induced by histamine iontophoresis

Abstract  Potency of the antihistamine effects of olopatadine, cetirizine and fexofenadine in standard-dose application were compared from 11.5 to 24 h after application. The test was designed in a double-blind, randomized, crossover, placebo-controlled study of ten healthy volunteers on histamine-induced flare and wheal response using an iontophoresis technique. The suppressive effect of olopatadine on the wheals induced by a 0.1-mA histamine iontophoresis lasted for 24 h after dosing. Fexofenadine administered using the same regimen was the least effective among three drugs tested. Suppression of the wheal response by cetirizine, taken once-daily, decreased with time. Olopatadine completely suppressed even the wheal response induced by a 0.2-mA histamine iontoph...

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  A bitter pill

They're widely prescribed, but questions now hang over the effectiveness of Prozac and similar drugs (Source: Guardian Unlimited Science)

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  Sciele Expands Alliance with Sanofi-Aventis to Market Allegra(R) (Fexofenadine HCL) Orally Disintegrating Tablets (ODT) and Allegra(R) Oral Suspension (OS) in the U.S.

ATLANTA--(HSMN NewsFeed)--Sciele Pharma, Inc. (NASDAQ:SCRX ) today announced it has extended its alliance with sanofi-aventis (NYSE:SNY ) by entering into a new exclusive, three-year agreement to market Allegra® Orally Disintegrating Tablets (ODT) and ... BiopharmaceuticalsSciele Pharma, sanofi-aventis, Allegra, Fexofenadine (Source: HSMN NewsFeed)

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  Sciele lands Allegra deal

Sciele Pharma Inc. has inked an exclusive three-year deal with Sanofi-Aventis to market Allegra Orally Disintegrating Tablets (ODT) and Allegra Oral Suspension in the U.S. pediatric market. (SCRX) (Source: bizjournals.com Health Care:Pharmaceuticals headlines)

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  The different effects of itraconazole on the pharmacokinetics of fexofenadine enantiomers

British Journal of Clinical Pharmacology, Volume 0, Issue 0, Page ???, June 2003. WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • Recently, we have shown that the plasma concentration of R-fexofenadine is greater than that of the S-enantiomer. • Although itraconazole co-administration is known to increase the bioavailability of a racemic ... (Source: British Journal of Clinical Pharmacology)

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  Fexofenadine in pediatrics: oral tablet and suspension formulations

Expert Opinion on Pharmacotherapy , February 2008, Vol. 9, No. 2, Pages 329-337. Allergic rhinitis is a common chronic condition in children. Oral antihistamines are a first-line treatment option in allergic rhinitis and different formulations are available to aid administration to children. The tablet formulation of the second-... (Source: Expert Opinion: Expert Opinion on Pharmacotherapy: Table of Contents)

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  Fexofenadine Safe and Well Tolerated in Young Children With Allergic Rhinitis

Fexofenadine hydrochloride has a good safety profile in treating allergic rhinitis in children 6-24 months of age, researchers report in the December issue of the Annals of Allergy, Asthma, and Immunology. Reuters Health Information (Source: Medscape Allergy Headlines)

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  Fexofenadine safe for treatment of allergic rhinitis in children aged six months to 2 years?

According to research published in the Annals of Allergy, Asthma, and Immunology, fexofenadine hydrochloride has a good safety profile in treating allergic rhinitis in children 6-24 months of age. Researchers investigated the safety and tolerability of fexofenadine hydrochloride in children aged 6 months to 2 years in 2 studies (T/3001 [n=174] and T/3002 [n=219]). Patients were randomised to receive twice-daily fexofenadine hydrochloride, 15 or 30 mg, or placebo mixed with a standard vehicle (for a mean duration of 8 days). The following results were reported for the combined population: • The incidence of treatment-emergent adverse events (TEAEs) was comparable between groups (placebo, 48.2% [96/199]; fexofenadine hydrochloride, 15 mg, 40.0% [34/85]; and fexofenadine hydrochloride, 30...

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  Allegra--D(Fexofenadine Hydrochloride And Pseudoephedrine Hydrochloride) Tablet, Film Coated [Sanofi-Aventis U.S. LLC]

Updated Date: Jan 11, 2008 EST (Source: DailyMed Drug Label Updates for the last seven days (since May 20, 2007 EST))

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  Letter from Student Allegra Stout to Northern Valley Regional High School Community

This is a letter from a student opposing random student drug testing in a New Jersey school district. (Source: Drug Policy Alliance News and Action Alerts)

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  New Jersey Fights Back Against Student Drug Testing

New Jersey’s Northern Valley Regional School District, which includes Demarest and Old Tappan high schools, recently recommended against moving forward with a proposed random student drug testing policy. The Drug Policy Alliance of New Jersey played an active role in educating the school community about the limitations and potential harms of drug testing programs. The school district’s Substance Abuse Task Force, which consisted of Student Assistance Counselors, school nurses, principals, assistant principals, athletic directors, a member of the Board of Education, and two students (one from each high school) voted 15 – 3 against implementing a random student drug testing policy. The proposal under consideration would have allowed random drug testing of 9th- through 12th-grade student...

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  Safety and tolerability of fexofenadine hydrochloride, 15 and 30 mg, twice daily in children aged 6 months to 2 years with allergic rhinitis

(Source: Annals of Allergy, Asthma and Immunology)

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  Comparative efficacy of fexofenadine and levocetirizine in chronic idiopathic urticaria

Godse KV, Jain A, Pharande PIndian Journal of Dermatology 2007 52(4):212-213 (Source: Indian Journal of Dermatology)

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